HFNC Versus NIV in Hypercapneic COPD Patients
Gas Exchange, Clinical Outcomes, and Tolerability of High-Flow Nasal Cannula Versus Non-Invasive Ventilation in COPD Patients With Mild-to-Moderate Hypercapnic Respiratory Failure
Aim: To compare gas exchange trends, clinical outcomes, and tolerability between HFNC and NIV in COPD patients with mild-to-moderate hypercapnic respiratory failure.
研究概览
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Mohammed Shehta, associate professor-chest med.
- 电话号码：01004344106
- 邮箱：dr_mshehta@mans.edu.eg
学习地点
-
-
Dakahlia Governorate
-
Al Mansurah、Dakahlia Governorate、埃及、35516
- 招聘中
- Faculty of Medicine, Mansoura University
-
接触：
- Mohammed Shehta
- 邮箱：dr_mshehta@mans.edu.eg
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- COPD patients hospitalized with mild-to-moderate hypercapnic respiratory failure, defined as arterial pH [range, e.g., 7.25-7.35] and PaCO2 [threshold, e.g., >45 mmHg and less 60 mmHg].
Exclusion Criteria:
- patients with altered mental state, confused, severe agitation or not cooperative were excluded. Also, severe acidosis (pH <7.25), hemodynamic instability, facial trauma or surgery, cases with severe nasal deformity, immediate indication for invasive ventilation, patient refusal, cases with respiratory rate more than 35 breaths per minute. Respiratory exhaustion, excess use of respiratory accessory muscles, Patients with breathing disorders during sleep as well as cases of upper airway obstruction and patients with history of chronic home ventilation prior admission were another items for exclusion
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Arm 1: high flow nasal canula
patients recieve high flow nasal canula oxygen therapy according to study protocol |
high flow nasal canula oxygen therapy according to study protocol |
|
有源比较器：Arm 2: non invasive ventilation (NIV)
patients recieve NIV according to study protocol |
non invasive ventilation according to study protocol |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
treatment failure
大体时间：From initiation of the assigned respiratory support until hospital discharge, assessed throughout the hospitalization (up to 30 days).
|
treatment failure defined as the need for escalation from assigned respiratory support to a higher level of ventilatory support during hospitalization. In HFNC group, treatment failure is defined as the need for rescue NIV or invasive mechanical ventilation. In the NIV group ,treatment failure is defined as the need of invasive mechanical ventilation. ( number and percentages of patients experiencing treatment failure in each treatment group) |
From initiation of the assigned respiratory support until hospital discharge, assessed throughout the hospitalization (up to 30 days).
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
serial arterial blood gas parameters at 12, 24 and 48 hours
大体时间：at 12, 24, 48 hours after start of respiratory support
|
serial arterial blood gas parameters (pH, PaCO2, HCO3) at 12, 24 and 48 hours; |
at 12, 24, 48 hours after start of respiratory support
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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