An Oral Dose-Ranging Finding Study in Patients With HIV Disease, CDC Classification Groups IIB, III, and IV-C2

To establish the relationship between the oral dose of zidovudine (AZT) and its hematologic toxicity. AZT has preliminarily been shown to decrease significant events and death in a group of AIDS / Pneumocystis carinii pneumonia (PCP) and AIDS related complex (ARC) patients followed at this time for a limited period. If these data withstand further follow-up, it appears that AZT is a potential antiretroviral agent that may have application in the use of all stages of HIV disease. At this time the optimal dose that will not cause significant toxicity is not known. If this drug has widespread application, it becomes imperative to further study both the dose and the toxicity. Patients with documented HIV viremia and who are well will be evaluated in a dose-escalating protocol for toxicity, persistent viremia, evidence of improvement of immune dysfunction, and the development of further manifestation of HIV disease. Drug levels will be monitored and correlated with the toxicity and viremia.

Study Overview

• Status: Completed
• Conditions: HIV Infections
• Intervention / Treatment: Drug: Zidovudine

• Study Type: Interventional
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • North Carolina
    • Research Triangle Park, North Carolina, United States, 27709
      • Glaxo Wellcome Inc

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria

Patients must have HIV reactivity.

• Patients must belong to one of the following three groups according to the CDC classification:
• IIB - including only those patients with autoimmune thrombocytopenia (platelet count = or < 100000 platelets/mm3).
• OR Lymphopenia (lymphocyte count = or < 1000 cells/mm3).
• OR Helper cell lymphopenia (helper cells < the mean of normals).
• OR CDC classification III or IV-C2.
• Patients with = or < involuntary 10 percent weight loss in the last 6 months.
• ECOG performance status 0 or 1.
• Weigh 70 kg + or - 15 kg in order to standardize the g/kg dosing.
• Positive antibody for HIV by an ELISA test kit. If the ELISA is negative, then eligibility will be confirmed by second confirmatory test, i.e., immunoblot.

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

• AIDS or the CDC classification stage IV except stage IV-C2.
• HIV antibody negative by immunoblot.
• Persistent fevers of > 38.5 degrees C.
• Persistent diarrhea undiagnosed > 1 month.
• Involuntary weight loss of > 10 percent in the 6 months prior to study entry.
• ECOG performance status of 2, 3, or 4.
• Class IV-C2 with prior history of:
• Multidermal herpes zoster.
• Oral candidiasis on more than one occasion.
• Tuberculosis.

Concurrent Medication:

Excluded:

• Other antiretroviral agents.
• Active immunomodulating agents.
• Any other experimental therapy.
• Drugs which cause anemia or neutropenia.
• Drugs which are glucuronidated and may interfere with the metabolism of AZT, i.e., acetaminophen > 5 days.
• Acyclovir systemically administered > 5 days.
• Any other experimental agents.

Patients with the following are excluded:

• AIDS or the CDC classification stage IV except stage IV-C2.
• HIV antibody negative by immunoblot.
• Persistent fevers of > 38.5 degrees C.
• Persistent diarrhea undiagnosed > 1 month.
• Involuntary weight loss of > 10 percent in the 6 months prior to study entry.
• ECOG performance status of 2, 3, or 4.
• Class IV-C2 with prior history of:
• Multidermal herpes zoster.
• Oral candidiasis on more than one occasion.
• Tuberculosis.

Prior Medication:

Excluded within 3 months of study entry:

• Other antiretroviral agents. Active immunomodulating agents.
• Excluded within 2 weeks of study entry:
• Drugs which cause anemia or neutropenia.
• Drugs which are glucuronidated and may interfere with the metabolism of zidovudine (AZT), i.e., acetaminophen > 5 days.
• Acyclovir systemically administered > 5 days.
• Any other experimental agents.

Known active drug abuse.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment

Collaborators and Investigators

• Sponsor: Glaxo Wellcome

Study record dates

Study Registration Dates

• First Submitted: November 2, 1999
• First Submitted That Met QC Criteria: August 30, 2001
• First Posted (Estimate): August 31, 2001

Study Record Updates

• Last Update Posted (Estimate): June 24, 2005
• Last Update Submitted That Met QC Criteria: June 23, 2005
• Last Verified: February 1, 1995

More Information

Terms related to this study

• Keywords: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Zidovudine; Dose-Response Relationship, Drug
• Additional Relevant MeSH Terms: RNA Virus Infections; Virus Diseases; Infections; Blood-Borne Infections; Communicable Diseases; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; Immunologic Deficiency Syndromes; Immune System Diseases; Slow Virus Diseases; HIV Infections; Acquired Immunodeficiency Syndrome; Molecular Mechanisms of Pharmacological Action; Anti-Infective Agents; Antiviral Agents; Reverse Transcriptase Inhibitors; Nucleic Acid Synthesis Inhibitors; Enzyme Inhibitors; Anti-HIV Agents; Anti-Retroviral Agents; Antimetabolites; Zidovudine
• Other Study ID Numbers: 014C; 013