Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women

October 5, 2015 updated by: NSABP Foundation Inc

Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer

RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using raloxifene and tamoxifen may fight breast cancer by blocking the uptake of estrogen by the tumor cells.

PURPOSE: Randomized double-blinded clinical trial to compare the effectiveness of raloxifene with that of tamoxifen in preventing breast cancer in postmenopausal women.

Study Overview

Status

Completed

Conditions

Breast Cancer

Intervention / Treatment

Detailed Description

OBJECTIVES:

Determine whether raloxifene is more or less effective than tamoxifen in significantly reducing the incidence rate of invasive breast cancer in postmenopausal women.
Evaluate the effects of tamoxifen and raloxifene on the incidence of intraductal carcinoma in situ, lobular carcinoma in situ, endometrial cancer, ischemic heart disease, fractures of the hip and spine, or Colles' fractures of the wrist in these participants.
Evaluate the toxic effects of these regimens in these participants.
Determine the effect of these regimens on the quality of life of these participants (at selected centers). (Quality of life evaluation closed to accrual effective 5/31/01.)

OUTLINE: This is a randomized, double-blind study. Participants are stratified by age (35 to 49 vs 50 to 59 vs over 59), race (black vs white vs other), history of lobular carcinoma in situ (yes vs no), prior hysterectomy (yes vs no), and estimated absolute risk of invasive breast cancer within 5 years (using the Gail model)(less than 2.0 vs 2.0-2.9 vs 3.0-4.9 vs 5.0 or greater). Participants are randomized to 1 of 2 arms.

Arm I: Participants receive oral tamoxifen plus placebo daily for 5 years.
Arm II: Participants receive oral raloxifene plus placebo daily for 5 years. Quality of life is assessed (at selected centers) at baseline and at 6, 12, 18, 24, 30, 36, 42, 48, 54, 60, and 72 months. (Quality of life evaluation closed to accrual effective 5/31/01.)

Participants are followed annually after 5 years.

PROJECTED ACCRUAL: Approximately 19,000 participants will be accrued for this study within 5 years.

Study Type

Interventional

Enrollment (Actual)

19747

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N2
    - Tom Baker Cancer Center - Calgary
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute
- British Columbia
  - Vancouver, British Columbia, Canada, V6T 2B5
    - University Hospital - U.B.C. Site
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- Ontario
  - Kingston, Ontario, Canada, K7L 5P9
    - Familial Oncology Program
  - Mississauga, Ontario, Canada, L5M 2N1
    - Credit Valley Hospital
  - North York, Ontario, Canada, M2E 1K1
    - North York General Hospital, Ontario
  - Ottawa, Ontario, Canada, K1H 1C4
    - Ottawa Regional Cancer Centre
  - Thunder Bay, Ontario, Canada, P7A 7T1
    - Northwestern Ontario Regional Cancer Care
  - Toronto, Ontario, Canada, M5G 2C4
    - Toronto General Hospital
  - Toronto, Ontario, Canada, M4N 3M5
    - Toronto Sunnybrook Regional Cancer Centre
  - Toronto, Ontario, Canada, M5B 1W8
    - St. Michael's Hospital - Toronto
  - Toronto, Ontario, Canada, M5S 1B6
    - Women's College Ambulatory Care Center, Sunnybrook and Women's College Health Science Center
- Quebec
  - Fleurimont, Quebec, Canada, J1H 5N4
    - CHUS-Hopital Fleurimont
  - Greenfield Park, Quebec, Canada, J4V 2H1
    - Hopital Charles LeMoyne
  - Montreal, Quebec, Canada, H3G 1A4
    - Montreal General Hospital
  - Montreal, Quebec, Canada, H3A 1A1
    - Royal Victoria Hospital - Montreal
  - Montreal, Quebec, Canada, H2L-4M1
    - Centre Hospitalier de l'Universite de Montreal
  - Montreal, Quebec, Canada, H3T 1E2
    - Jewish General Hospital - Montreal
  - Montreal, Quebec, Canada, H3G 1L5
    - Ville Marie Breast Center
  - Quebec City, Quebec, Canada, G1S 4L8
    - Hopital du Saint-Sacrement, Quebec
  - Sherbrooke, Quebec, Canada, J1H 5N4
    - Centre Universitaire de Sante de l'Estrie
- Saskatchewan
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Puerto Rico
- - San Juan, Puerto Rico, 00927-5800
    - MBCCOP - San Juan
United States
- Alabama
  - Huntsville, Alabama, United States, 35801
    - Comprehensive Cancer Institute
  - Mobile, Alabama, United States, 36688
    - MBCCOP - Gulf Coast
- Alaska
  - Anchorage, Alaska, United States, 99519-6604
    - Providence Alaska Medical Center
- Arizona
  - Phoenix, Arizona, United States, 85006-2726
    - CCOP - Western Regional, Arizona
  - Scottsdale, Arizona, United States, 85259-5404
    - CCOP - Mayo Clinic Scottsdale Oncology Program
  - Tucson, Arizona, United States, 85724
    - Arizona Cancer Center at University of Arizona Health Sciences Center
- Arkansas
  - Fayetteville, Arkansas, United States, 72703
    - Breast Associates
  - Fort Smith, Arkansas, United States, 72917
    - Surgical Associates
  - Jonesboro, Arkansas, United States, 72401
    - Northeast Arkansas Clinic
  - Little Rock, Arkansas, United States, 72205
    - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
- California
  - Anaheim, California, United States, 92805
    - Kaiser Permanente Medical Center - Anaheim/Orange County
  - Baldwin Park, California, United States, 91706
    - Kaiser Permanente Medical Center - Baldwin Park
  - Bellflower, California, United States, 90706
    - Kaiser Permanente Medical Center - Bellflower
  - Berkeley, California, United States, 94704
    - Alta Bates Comprehensive Cancer Center
  - Burbank, California, United States, 91505
    - Providence Saint Joseph Medical Center - Burbank
  - Burlingame, California, United States, 94010
    - Mills-Peninsula Health Services
  - Chico, California, United States, 95926
    - Enloe Cancer Center at Enloe Medical Center
  - Concord, California, United States, 94524-4110
    - Mount Diablo Medical Center
  - Corona, California, United States, 92882-3400
    - Corona Regional Medical Center
  - Duarte, California, United States, 91010-3000
    - City of Hope Comprehensive Cancer Center
  - Encinitas, California, United States, 92024
    - Scripps Memorial Hospitals-Stevens Cancer Center - Encinitas
  - Fairfield, California, United States, 94533
    - North Bay Cancer Center
  - Fontana, California, United States, 92335
    - Kaiser Permanente Medical Center - Fontana
  - Fullerton, California, United States, 92835
    - Crosson Cancer Center at St. Jude Medical Center
  - Glendale, California, United States, 91204
    - Glendale Memorial Hospital Comprehensive Cancer Center
  - Granada Hills, California, United States, 91344
    - Oncology/Hematology Associates
  - Greenbrae, California, United States, 94904
    - Marin General Hospital Cancer Institute
  - Harbor City, California, United States, 90710
    - Kaiser Permanente Medical Center - Harbor City
  - Hemet, California, United States, 92543
    - Hemet Valley Medical Center
  - La Jolla, California, United States, 92093-0658
    - Rebecca and John Moores UCSD Cancer Center
  - Lancaster, California, United States, 93534
    - Valley Tumor Medical Group
  - Loma Linda, California, United States, 92354
    - Loma Linda University Cancer Institute at Loma Linda University Medical Center
  - Long Beach, California, United States, 90801-1428
    - Todd Cancer Institute at Long Beach Memorial Medical Center
  - Long Beach, California, United States, 90813
    - Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach
  - Los Angeles, California, United States, 90095-1781
    - Jonsson Comprehensive Cancer Center, UCLA
  - Los Angeles, California, United States, 90027
    - Kaiser Permanente Medical Center - Los Angeles
  - Los Angeles, California, United States, 90033-0804
    - USC/Norris Comprehensive Cancer Center and Hospital
  - Los Angeles, California, United States, 90033
    - Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center
  - Los Angeles, California, United States, 90034
    - Kaiser Foundation Hospital - West Los Angeles
  - Los Angeles, California, United States, 90057-1901
    - St. Vincent Medical Center - Los Angeles
  - Mission Viejo, California, United States, 92691
    - Mission Cancer Center at Mission Hospital
  - Modesto, California, United States, 95353
    - Sutter Gould Medical Foundation
  - Northridge, California, United States, 91328
    - Leavey Cancer Center at Northridge Hospital Medical Center
  - Oceanside, California, United States, 92056
    - Breast Health Center
  - Orange, California, United States, 92868
    - Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
  - Orange, California, United States, 92868-3849
    - St. Joseph Hospital Regional Cancer Center - Orange
  - Oxnard, California, United States, 93030
    - Ventura Hematology - Oncology Specialists - Oxnard
  - Palm Springs, California, United States, 92262
    - Comprehensive Cancer Centers of the Desert
  - Palo Alto, California, United States, 95819-5156
    - Palo Alto Medical Foundation
  - Panorama City, California, United States, 91402
    - Kaiser Permanente Medical Group
  - Pasadena, California, United States, 91109-7013
    - Huntington Cancer Center at Huntington Hospital
  - Pomona, California, United States, 91767-3021
    - Wilshire Oncology Medical Group, Incorporated - Pomona
  - Redding, California, United States, 96001
    - North Valley Breast Clinic
  - Riverside, California, United States, 92505
    - Kaiser Permanente Medical Center - Riverside
  - Roseville, California, United States, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, United States, 95819-5156
    - Sutter Breast Cancer Group
  - San Diego, California, United States, 92134-3202
    - Naval Medical Center - San Diego
  - San Diego, California, United States, 92120
    - Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego
  - San Francisco, California, United States, 94143-0128
    - UCSF Comprehensive Cancer Center
  - San Francisco, California, United States, 94118-1618
    - California Pacific Medical Center - California Campus
  - Santa Barbara, California, United States, 93105
    - Cancer Center of Santa Barbara
  - Santa Rosa, California, United States, 95403
    - CCOP - Santa Rosa Memorial Hospital
  - Stanford, California, United States, 94305-5408
    - Stanford Cancer Center at Stanford University Medical Center
  - Torrance, California, United States, 90505
    - Torrance Memorial Medical Center
  - Valencia, California, United States, 91355
    - Santa Clarita Valley Cancer Center - UCLA
  - Vallejo, California, United States, 94589
    - Kaiser Permanente Medical Center - Vallejo
  - Woodland Hills, California, United States, 91365-4084
    - Kaiser Permanente Medical Cener - Woodland Hills
- Colorado
  - Colorado Springs, Colorado, United States, 80933
    - Penrose Cancer Center
  - Denver, Colorado, United States, 80209-5031
    - CCOP - Colorado Cancer Research Program, Incorporated
  - Fort Collins, Colorado, United States, 80524
    - Poudre Valley Hospital
  - Pueblo, Colorado, United States, 81004
    - St. Mary-Corwin Regional Medical Center
- Connecticut
  - Farmington, Connecticut, United States, 06360-7106
    - University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center
  - Hartford, Connecticut, United States, 06105
    - St. Francis Hospital and Medical Center
  - Hartford, Connecticut, United States, 06102-5037
    - Hartford Hospital
  - Manchester, Connecticut, United States, 06040-4188
    - Manchester Memorial Hospital
  - Meriden, Connecticut, United States, 06451
    - Midstate Medical Center
  - New Britain, Connecticut, United States, 06050
    - New Britain General Hospital
  - New Haven, Connecticut, United States, 06520-8028
    - Yale Comprehensive Cancer Center
  - New Haven, Connecticut, United States, 06511
    - Hospital of St. Raphael
  - New London, Connecticut, United States, 06320
    - Lawrence and Memorial Hospital
  - Norwich,, Connecticut, United States, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Stamford, Connecticut, United States, 06902
    - Hematology Oncology, P.C.
  - Torrington, Connecticut, United States, 06790
    - Northwestern Connecticut Oncology-Hematology Associates
  - Williamantic, Connecticut, United States, 06226
    - Windham Community Memorial Hospital
- Delaware
  - Lewes, Delaware, United States, 19958
    - Beebe Medical Center
  - Seaford, Delaware, United States, 19973
    - Nanticoke Memorial Hospital
  - Wilmington, Delaware, United States, 19899
    - CCOP - Christiana Care Health Services
- District of Columbia
  - Washington, District of Columbia, United States, 20010
    - Washington Hospital Center
  - Washington, District of Columbia, United States, 20007
    - Lombardi Cancer Center at Georgetown University Medical Center
  - Washington, District of Columbia, United States, 20017
    - Providence Hospital
- Florida
  - Atlantis, Florida, United States, 33462
    - JFK Medical Center
  - Jacksonville, Florida, United States, 32224
    - Mayo Clinic - Jacksonville
  - Jacksonville, Florida, United States, 32203
    - St. Vincent's Medical Center
  - Jacksonville, Florida, United States, 32207
    - Baptist Regional Cancer Institute - Jacksonville
  - Jupiter, Florida, United States, 33458
    - Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  - Lakeland, Florida, United States, 33804-5000
    - Watson Clinic
  - Lakeland, Florida, United States, 33804
    - Lakeland Regional Cancer Center at Lakeland Regional Medical Center
  - Miami, Florida, United States, 33136
    - University of Miami Sylvester Cancer Center
  - Miami Beach, Florida, United States, 33140
    - CCOP - Mount Sinai Medical Center
  - Orlando, Florida, United States, 32806
    - MD Anderson Cancer Center Orlando
  - Orlando, Florida, United States, 32803-1273
    - Florida Hospital Medical Center
  - Pensacola, Florida, United States, 32514-6088
    - West Florida Regional Medical Center
  - Plantation, Florida, United States, 33324
    - Cancer Research Network Inc.
  - Stuart, Florida, United States, 34996
    - Clinical Research Center of South Florida
  - Tampa, Florida, United States, 33612-9497
    - H. Lee Moffitt Cancer Center and Research Institute
  - West Palm Beach, Florida, United States, 33401
    - Palm Beach Cancer Institute
- Georgia
  - Atlanta, Georgia, United States, 30342-1701
    - CCOP - Atlanta Regional
  - Augusta, Georgia, United States, 30912
    - Medical College of Georgia
  - Savannah, Georgia, United States, 31403-3089
    - Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
  - Savannah, Georgia, United States, 31405-6013
    - Cancer Care and Research Pavilion at St. Joseph's/Candler
- Hawaii
  - Honolulu, Hawaii, United States, 96813
    - MBCCOP - Hawaii
- Idaho
  - Coeur d'Alene, Idaho, United States, 83814
    - North Idaho Cancer Center
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - Northwest Community Hospital
  - Aurora, Illinois, United States, 60504-4206
    - Rush Copley Medical Center
  - Chicago, Illinois, United States, 60612-7323
    - MBCCOP - University of Illinois at Chicago
  - Chicago, Illinois, United States, 60637-1470
    - University of Chicago Cancer Research Center
  - Chicago, Illinois, United States, 60611
    - Northwestern Memorial Hospital
  - Chicago, Illinois, United States, 60611-3013
    - Robert H. Lurie Comprehensive Cancer Center at Northwestern University
  - Chicago, Illinois, United States, 60657
    - Creticos Cancer Center at Advocate Illinois Masonic Medical Center
  - Chicago, Illinois, United States, 60612
    - Rush Cancer Institute at Rush University Medical Center
  - Chicago, Illinois, United States, 60612-9985
    - John H. Stroger, Jr. Hospital of Cook County
  - Chicago, Illinois, United States, 60631
    - Resurrection Medical Center
  - Chicago, Illinois, United States, 60634
    - Our Lady of the Resurrection Medical Center
  - Decatur, Illinois, United States, 62526
    - CCOP - Central Illinois
  - Elgin, Illinois, United States, 60120-2198
    - Sherman Hospital
  - Evanston, Illinois, United States, 60201
    - CCOP - Evanston
  - Evanston, Illinois, United States, 60202
    - St. Francis Hospital
  - Harvey, Illinois, United States, 60426
    - Ingalls Memorial Hospital
  - Hazel Crest, Illinois, United States, 60429
    - Advocate South Suburban Hospital
  - Highland Park, Illinois, United States, 60035-2497
    - Evanston Northwestern Health Care - Highland Park Hospital
  - Hinsdale, Illinois, United States, 60521
    - Hinsdale Hematology Oncology Associates
  - Joliet, Illinois, United States, 60435
    - Joliet Oncology Hematology Associates, Limited - Joliet
  - Maywood, Illinois, United States, 60153
    - Cardinal Bernardin Cancer Center at Loyola University Medical Center
  - Naperville, Illinois, United States, 60540-7499
    - Edward Hospital Cancer Center
  - Normal, Illinois, United States, 61761
    - Mid-Illinois Hematology-Oncology Associates
  - Oak Lawn, Illinois, United States, 60453
    - Advocate Christ Medical Center
  - Olympia Fields, Illinois, United States, 60461
    - Saint James Hospital and Health Centers Comprehensive Cancer Institute
  - Park Ridge, Illinois, United States, 60068
    - Lutheran General Cancer Care Center
  - Peoria, Illinois, United States, 61602
    - CCOP - Illinois Oncology Research Association
  - Rock Island, Illinois, United States, 61201
    - Trinity Medical Center - West
  - Rockford, Illinois, United States, 61108
    - Saint Anthony Medical Center
  - Rockford, Illinois, United States, 61104-2315
    - Swedish-American Regional Cancer Center
  - Rockford, Illinois, United States, 61103
    - Rockford Clinic
  - Skokie, Illinois, United States, 60076
    - Edward H. Kaplan MD and Associates
  - Springfield, Illinois, United States, 62781
    - Memorial Medical Center
  - Springfield, Illinois, United States, 62769
    - St. John's Hospital
  - Urbana, Illinois, United States, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Goshen, Indiana, United States, 46526
    - Center for Cancer Care at Goshen Health System
  - Indianapolis, Indiana, United States, 46260
    - St. Vincent Hospital and Health Care Center
  - Indianapolis, Indiana, United States, 46202
    - Indiana Community Cancer Care, Incorporated
  - Indianapolis, Indiana, United States, 46206-1367
    - Methodist Cancer Center at Methodist Hospital
  - Indianapolis, Indiana, United States, 46256
    - Indiana Regional Cancer Center
  - Lafayette, Indiana, United States, 47904
    - Oncology Institute of Greater Lafayette
  - Michigan City, Indiana, United States, 46360
    - Saint Anthony Memorial Health Centers
  - Muncie, Indiana, United States, 47303-3499
    - Ball Memorial Hospital Cancer Center
  - Munster, Indiana, United States, 46321
    - Community Hospital
  - South Bend, Indiana, United States, 46601
    - CCOP - Northern Indiana CR Consortium
- Iowa
  - Ames, Iowa, United States, 50010
    - McFarland Clinic, P.C.
  - Cedar Rapids, Iowa, United States, 52403-1206
    - CCOP - Cedar Rapids Oncology Project
  - Clinton, Iowa, United States, 52732-5031
    - Medical Associates
  - Council Bluffs, Iowa, United States, 51503
    - Jennie Edmundson Memorial Hospital
  - Davenport, Iowa, United States, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, United States, 50309-1016
    - CCOP - Iowa Oncology Research Association
  - Dubuque, Iowa, United States, 52001
    - Wendt Regional Cancer Center of Finley Hospital
  - Iowa City, Iowa, United States, 52242-1009
    - Holden Comprehensive Cancer Center at University of Iowa
  - Mason City, Iowa, United States, 50401
    - Mercy Cancer Center at Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, United States, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, United States, 51101-1733
    - Siouxland Hematology-Oncology
  - Waterloo, Iowa, United States, 50701
    - Cedar Valley Medical Specialists, P.C.
- Kansas
  - Kansas City, Kansas, United States, 66160-7357
    - Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
  - Wichita, Kansas, United States, 67214-3882
    - CCOP - Wichita
- Kentucky
  - Ashland, Kentucky, United States, 41101
    - King's Daughters Medical Center
  - Edgewood, Kentucky, United States, 41017
    - St. Elizabeth Medical Center
  - Frankfort, Kentucky, United States, 40601
    - HCA Kings Daughters Memorial Hospital
  - Lexington, Kentucky, United States, 40503
    - Central Baptist Hospital
  - Lexington, Kentucky, United States, 40536-0093
    - Markey Cancer Center at University of Kentucky Chandler Medical Center
  - Louisville, Kentucky, United States, 40207
    - Baptist Hospital East - Louisville
  - Louisville, Kentucky, United States, 40202
    - James Graham Brown Cancer Center at University of Louisville
  - Louisville, Kentucky, United States, 40202-5070
    - Norton Healthcare Cancer Center
- Louisiana
  - Baton Rouge, Louisiana, United States, 70809
    - Ochsner Clinic of Baton Rouge
  - Baton Rouge, Louisiana, United States, 70821-2511
    - Baton Rouge General Medical Center
  - Houma, Louisiana, United States, 70360
    - Cancer Care Specialists
  - New Orleans, Louisiana, United States, 70121
    - CCOP - Ochsner
  - New Orleans, Louisiana, United States, 70112
    - MBCCOP - LSU Health Sciences Center
  - New Orleans, Louisiana, United States, 70112
    - Tulane Cancer Center at Tulane University Hospital and Clinic
  - Shreveport, Louisiana, United States, 71101
    - Cancer Treatment Center at Christus Schumpert St. Mary Place
- Maine
  - Bangor, Maine, United States, 04401
    - Eastern Maine Medical Center
  - Sanford, Maine, United States, 04073
    - Goodall Hospital
  - Scarborough, Maine, United States, 04074
    - Maine Center for Cancer Medicine and Blood Disorders - Scarborough
- Maryland
  - Annapolis, Maryland, United States, 21401
    - Anne Arundel Medical Center
  - Baltimore, Maryland, United States, 21231-2410
    - Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  - Baltimore, Maryland, United States, 21204
    - Greater Baltimore Medical Center and Cancer Center
  - Baltimore, Maryland, United States, 21201
    - Greenebaum Cancer Center at University of Maryland Medical Center
  - Baltimore, Maryland, United States, 21237
    - Franklin Square Hospital Center
  - Bethesda, Maryland, United States, 20814
    - Suburban Hospital
  - Frederick, Maryland, United States, 21701
    - Frederick Memorial Hospital Regional Cancer Therapy Center
- Massachusetts
  - Boston, Massachusetts, United States, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, United States, 02115
    - Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
  - Boston, Massachusetts, United States, 02114
    - Massachusetts General Hospital Cancer Center
  - Boston, Massachusetts, United States, 02118
    - Cancer Research Center at Boston Medical Center
  - Boston, Massachusetts, United States, 02215
    - Harvard Vanguard Medical Associates - Kenmore
  - Burlington, Massachusetts, United States, 01805
    - Lahey Clinic Medical Center - Burlington
  - Fall River, Massachusetts, United States, 02721
    - Saint Anne's Hospital
  - Norfolk, Massachusetts, United States, 02062
    - Caritas Norwood Hospital
  - Peabody, Massachusetts, United States, 01960
    - NSMC Cancer Center
  - Pittsfield, Massachusetts, United States, 01201
    - Berkshire Physicians and Surgeons, P.C.
  - Plymouth, Massachusetts, United States, 02360
    - Jordan Hospital Club Cancer Center
  - Springfield, Massachusetts, United States, 01199
    - Baystate Regional Cancer Program at Baystate Medical Center
  - Worcester, Massachusetts, United States, 01655
    - University of Massachusetts Memorial Medical Center - University Campus
- Michigan
  - Adrian, Michigan, United States, 49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor, Michigan, United States, 48109-0752
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, United States, 48106
    - CCOP - Michigan Cancer Research Consortium
  - Battle Creek, Michigan, United States, 49016
    - Battle Creek Health System
  - Bay City, Michigan, United States, 48708
    - Bay Diagnostic Center for Women
  - Coldwater, Michigan, United States, 49036
    - Community Health Center of Branch County
  - Dearborn, Michigan, United States, 48123-2500
    - Oakwood Hospital and Medical Center
  - Detroit, Michigan, United States, 48202
    - Josephine Ford Cancer Center at Henry Ford Hospital
  - Detroit, Michigan, United States, 48201-1379
    - Barbara Ann Karmanos Cancer Institute
  - Detroit, Michigan, United States, 48236
    - St. John Hospital and Medical Center
  - Flint, Michigan, United States, 48503
    - Hurley Medical Center
  - Flint, Michigan, United States, 48532
    - Flint Hematology Oncology
  - Grand Blanc, Michigan, United States, 48439-8066
    - Genesys Regional Medical Center
  - Grand Rapids, Michigan, United States, 49503
    - CCOP - Grand Rapids
  - Holland, Michigan, United States, 49423
    - Holland Community Hospital
  - Jackson, Michigan, United States, 49201
    - Center for Hematology/Oncology
  - Kalamazoo, Michigan, United States, 49007-3731
    - CCOP - Kalamazoo
  - Lansing, Michigan, United States, 48912
    - Michigan State University Department of Surgery
  - Lapeer, Michigan, United States, 48446
    - Lapeer Regional Hospital
  - Marquette, Michigan, United States, 49855
    - Marquette General Hospital
  - Monroe, Michigan, United States, 48161-0067
    - Mercy Memorial Hospital, Corporation
  - Mount Clemens, Michigan, United States, 48043
    - Community Cancer Care Specialist
  - Owosso, Michigan, United States, 48867
    - Memorial Healthcare
  - Port Huron, Michigan, United States, 48060
    - Blue Water Oncology PC, Port Huron
  - Royal Oak, Michigan, United States, 48073-6769
    - CCOP - Beaumont
  - Saginaw, Michigan, United States, 48601
    - Saint Mary's Seton Cancer Institute
  - Southfield, Michigan, United States, 48075-9975
    - Providence Cancer Institute at Providence Hospital
  - Traverse City, Michigan, United States, 49684
    - Munson Medical Center
  - Warren, Michigan, United States, 48093-3494
    - St. John Macomb Hospital
- Minnesota
  - Duluth, Minnesota, United States, 55805
    - CCOP - Duluth
  - Duluth, Minnesota, United States, 55805
    - St. Luke's Medical Clinic
  - Minneapolis, Minnesota, United States, 55455
    - University of Minnesota
  - Minneapolis, Minnesota, United States, 55415
    - Hennepin County Medical Center - Minneapolis
  - Minneapolis, Minnesota, United States, 55407
    - Minnesota Cooperative Group Program
  - Rochester, Minnesota, United States, 55905
    - Mayo Clinic Cancer Center
  - Saint Louis Park, Minnesota, United States, 55416
    - CCOP - Metro-Minnesota
  - Willmar, Minnesota, United States, 56201
    - Rice Memorial Hospital
- Mississippi
  - Biloxi, Mississippi, United States, 39530-4239
    - Coast Oncology/Hematology, P.L.L.C.
  - Cleveland, Mississippi, United States, 38732
    - Mid Delta Family Practice
  - Hattiesburg, Mississippi, United States, 39401
    - Hattiesburg Clinic, P.A.
  - Jackson, Mississippi, United States, 39202
    - Jackson Oncology Associates, PLLC
  - Keesler AFB, Mississippi, United States, 39534-2576
    - Keesler Medical Center - Keesler Air Force Base
  - Tupelo, Mississippi, United States, 38801
    - North Mississippi Hematology and Oncology Associates, Limited
- Missouri
  - Chesterfield, Missouri, United States, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, United States, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Joplin, Missouri, United States, 64804
    - St. John's Regional Medical Center
  - Joplin, Missouri, United States, 64803-2644
    - Freeman Cancer Institute at Freeman Health System
  - Kansas City, Missouri, United States, 64131
    - CCOP - Kansas City
  - Rolla, Missouri, United States, 65401
    - Phelps County Regional Medical Center
  - Saint Louis, Missouri, United States, 63110
    - Siteman Cancer Center
  - Saint Louis, Missouri, United States, 63131
    - Missouri Baptist Cancer Center
  - Saint Louis, Missouri, United States, 63141
    - CCOP - St. Louis-Cape Girardeau
  - Saint Louis, Missouri, United States, 63109
    - Midwest Hematology Oncology Group, Inc.
  - Springfield, Missouri, United States, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, United States, 65807
    - CCOP - Cancer Research for the Ozarks
  - St. Charles, Missouri, United States, 63301
    - Missouri Cancer Care, P.C. - St. Charles
  - West Plains, Missouri, United States, 65775
    - Ozarks Medical Center
- Montana
  - Billings, Montana, United States, 59101
    - CCOP - Montana Cancer Consortium
  - Great Falls, Montana, United States, 59405
    - Montana Cancer Institute - Benefis Healthcare
  - Kalispell, Montana, United States, 59901
    - Kalispell Regional Medical Center
- Nebraska
  - Grand Island, Nebraska, United States, 68802
    - Saint Francis Medical Center
  - Kearney, Nebraska, United States, 68848-1990
    - Cancer Center at the Good Samaritan Health Systems
  - Lincoln, Nebraska, United States, 68510-4844
    - Cancer Resource Center - Lincoln
  - Omaha, Nebraska, United States, 68131-2197
    - Creighton University Medical Center
  - Omaha, Nebraska, United States, 68114
    - Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
  - Omaha, Nebraska, United States, 68124
    - Bergan Mercy Medical Center
  - Omaha, Nebraska, United States, 68122
    - Alegent Health - Immanuel Medical Center
- Nevada
  - Las Vegas, Nevada, United States, 89106
    - CCOP - Southern Nevada Cancer Research Foundation
- New Hampshire
  - Hooksett, New Hampshire, United States, 03106
    - New Hampshire Oncology-Hematology, PA - Hooksett
  - Nashua, New Hampshire, United States, 03061
    - Southern New Hampshire Medical Center
- New Jersey
  - Camden, New Jersey, United States, 08103
    - Cooper Cancer Institute
  - Englewood, New Jersey, United States, 07631
    - Englewood Hospital and Medical Center
  - Flemington, New Jersey, United States, 08822
    - Hunterdon Regional Cancer Center
  - Hackensack, New Jersey, United States, 07601
    - CCOP - Northern New Jersey
  - Livingston, New Jersey, United States, 07039
    - St. Barnabas Medical Center
  - Long Branch, New Jersey, United States, 07740-6395
    - Monmouth Medical Center
  - Millville, New Jersey, United States, 08332
    - South Jersey Regional Cancer Center
  - Mount Holly, New Jersey, United States, 08060
    - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital
  - New Brunswick, New Jersey, United States, 08903
    - Cancer Institute Of New Jersey
  - Newark, New Jersey, United States, 07112
    - Newark Beth Israel Medical Center
  - Phillipsburg, New Jersey, United States, 08865
    - Warren Hospital
  - Pomona, New Jersey, United States, 08240
    - Atlantic City Medical Center
  - Red Bank, New Jersey, United States, 07701
    - Booker Cancer Center at Riverview Medical Center
  - Ridgewood, New Jersey, United States, 07450
    - Valley Hospital
  - Somerville, New Jersey, United States, 08876
    - Somerset Medical Center
  - Toms River, New Jersey, United States, 08755
    - Community Medical Center
  - Trenton, New Jersey, United States, 08607
    - Capital Health System at Mercer
  - Woodbury, New Jersey, United States, 08096
    - Underwood Memorial Hospital
- New Mexico
  - Albuquerque, New Mexico, United States, 87131
    - University of New Mexico Cancer Research and Treatment Center
  - Albuquerque, New Mexico, United States, 87102
    - Hematology-Oncology Associates, PC
  - Albuquerque, New Mexico, United States, 87108
    - Lovelace Medical Center at Lovelace Sandia Health System
  - Albuquerque, New Mexico, United States, 87109
    - New Mexico Oncology-Hematology Consultants, Limited
  - Santa Fe, New Mexico, United States, 87505-7670
    - New Mexico Cancer Care Associates
- New York
  - Albany, New York, United States, 12208
    - New York Oncology Hematology, P.C. - Albany Regional Cancer Center
  - Bronx, New York, United States, 10461
    - Albert Einstein Clinical Cancer Center
  - Bronx, New York, United States, 10466
    - Comprehensive Cancer Center at Our Lady of Mercy Medical Center
  - Buffalo, New York, United States, 14263-0001
    - Roswell Park Cancer Institute
  - Cooperstown, New York, United States, 13326-1394
    - Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
  - Glens Falls, New York, United States, 12801
    - Charles R. Wood Foundation Cancer Center at Glens Falls Hospital
  - Jamaica, New York, United States, 11432
    - Queens Cancer Center of Queens Hospital
  - Latham, New York, United States, 12110-0610
    - New York Oncology Hematology, P.C. - Latham
  - Manhasset, New York, United States, 11030
    - CCOP - North Shore University Hospital
  - New York, New York, United States, 10021
    - Memorial Sloan-Kettering Cancer Center
  - New York, New York, United States, 10016
    - NYU School of Medicine's Kaplan Comprehensive Cancer Center
  - New York, New York, United States, 10032
    - Herbert Irving Comprehensive Cancer Center at Columbia University
  - New York, New York, United States, 10011
    - Saint Vincent Catholic Medical Center of New York
  - Poughkeepsie, New York, United States, 12601
    - Vassar Brothers Medical Center
  - Poughkeepsie, New York, United States, 12601
    - St. Francis Hospital and Health Centers
  - Rochester, New York, United States, 14642
    - James P. Wilmot Cancer Center at University of Rochester Medical Center
  - Rochester, New York, United States, 14607
    - Genesee Surgical Associates
  - Rochester, New York, United States, 14620
    - Gynecologic Oncology Associates
  - Stony Brook, New York, United States, 11794-8174
    - University Hospital - Stony Brook
  - Syracuse, New York, United States, 13217
    - CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
  - Syracuse, New York, United States, 13210
    - University Hospital at State University of New York - Upstate Medical University
- North Carolina
  - Asheville, North Carolina, United States, 28801
    - Mission Hospitals
  - Chapel Hill, North Carolina, United States, 27599-7295
    - Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
  - Charlotte, North Carolina, United States, 28232-2861
    - Blumenthal Cancer Center at Carolinas Medical Center
  - Charlotte, North Carolina, United States, 28233-3549
    - Presbyterian Healthcare
  - Durham, North Carolina, United States, 27710
    - Duke Comprehensive Cancer Center
  - Fayetteville, North Carolina, United States, 28302-2000
    - Cape Fear Valley Health System
  - Gastonia, North Carolina, United States, 28054
    - Gaston Hematology and Oncology
  - Goldsboro, North Carolina, United States, 27534
    - Southeastern Medical Oncology Center
  - Greensboro, North Carolina, United States, 27403-1199
    - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
  - Greenville, North Carolina, United States, 27858-4354
    - Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina
  - Hendersonville, North Carolina, United States, 28791
    - Pardee Memorial Hospital
  - High Point, North Carolina, United States, 27262
    - Cornerstone Surgery
  - Raleigh, North Carolina, United States, 27607
    - Raleigh Hematology/Oncology Associates, P.A. - Rex Cancer Center
  - Statesville, North Carolina, United States, 28687-1828
    - Cancer Center at Iredell Memorial Hospital
  - Wilmington, North Carolina, United States, 28402-9000
    - New Hanover Regional Medical Center
  - Winston-Salem, North Carolina, United States, 27104-4241
    - CCOP - Southeast Cancer Control Consortium
  - Winston-Salem, North Carolina, United States, 27157-1082
    - Comprehensive Cancer Center at Wake Forest University
  - Winston-Salem, North Carolina, United States, 27103
    - Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, United States, 58501
    - Quain & Ramstad Clinic
  - Fargo, North Dakota, United States, 58122
    - CCOP - Merit Care Hospital
- Ohio
  - Akron, Ohio, United States, 44302
    - Akron General Medical Center
  - Canton, Ohio, United States, 44708
    - Mercy Medical Center
  - Canton, Ohio, United States, 44710
    - Aultman Hospital Cancer Center at Aultman Health Foundation
  - Cincinnati, Ohio, United States, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, United States, 45219
    - Cancer Center at Christ Hospital
  - Cincinnati, Ohio, United States, 45267-0502
    - Charles M. Barrett Cancer Center at University Hospital
  - Cleveland, Ohio, United States, 44195
    - Cleveland Clinic Taussig Cancer Center
  - Cleveland, Ohio, United States, 44106-5065
    - Ireland Cancer Center
  - Cleveland, Ohio, United States, 44111
    - Fairview Hospital
  - Cleveland, Ohio, United States, 44120
    - Kaiser Permanente
  - Columbus, Ohio, United States, 43210-1240
    - Arthur G. James Cancer Hospital - Ohio State University
  - Columbus, Ohio, United States, 43206
    - CCOP - Columbus
  - Findlay, Ohio, United States, 45840
    - Blanchard Valley Medical Associates
  - Fremont, Ohio, United States, 43420
    - Fremont Memorial Hospital
  - Independence, Ohio, United States, 44131
    - Cleveland Clinic Cancer Center
  - Kettering, Ohio, United States, 45429
    - CCOP - Dayton
  - Lima, Ohio, United States, 45804
    - Lima Memorial Hospital
  - Maumee, Ohio, United States, 43537
    - St. Luke's Hospital
  - Parma, Ohio, United States, 44129
    - Parma Community General Hospital
  - Sandusky, Ohio, United States, 44870
    - Firelands Regional Medical Center
  - Sylvania, Ohio, United States, 43560
    - Flower Hospital - ProMedica Health System
  - Toledo, Ohio, United States, 43608
    - St. Vincent Mercy Medical Center
  - Toledo, Ohio, United States, 43606
    - Toledo Hospital
  - Toledo, Ohio, United States, 43623
    - CCOP - Toledo Community Hospital
  - Toledo, Ohio, United States, 43614-0008
    - Medical College of Ohio Cancer Institute
  - Toledo, Ohio, United States, 43616
    - St. Charles Hospital
  - Toledo, Ohio, United States, 43623
    - Toledo Clinic, Incorporated
  - Warrensville Heights, Ohio, United States, 44122
    - Cleveland Clinic Health System STAR BCPT
  - Wauseon, Ohio, United States, 43567
    - Fulton County Health Center
- Oklahoma
  - Muskogee, Oklahoma, United States, 74401
    - Muskogee Regional Medical Center
  - Oklahoma City, Oklahoma, United States, 73101
    - Frank C. Love Cancer Institute at St. Anthony Hospital
  - Oklahoma City, Oklahoma, United States, 73109
    - Central Oklahoma Cancer Center at INTEGRIS Southwest Medical Center
  - Oklahoma City, Oklahoma, United States, 73120
    - Mercy Health Center
  - Oklahoma City, Oklahoma, United States, 73190
    - Oklahoma University Medical Center at University of Oklahoma Health Sciences Center
  - Tulsa, Oklahoma, United States, 74136
    - CCOP - Oklahoma
  - Tulsa, Oklahoma, United States, 74104
    - St. John Health System
- Oregon
  - Bend, Oregon, United States, 97701
    - St. Charles Medical Center
  - Portland, Oregon, United States, 97201-3098
    - Cancer Institute at Oregon Health and Science University
  - Portland, Oregon, United States, 97213
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, United States, 97227-1098
    - Kaiser Permanente Center for Health Research
- Pennsylvania
  - Abington, Pennsylvania, United States, 19001
    - Abington Memorial Hospital
  - Allentown, Pennsylvania, United States, 18102
    - Sacred Heart Hospital
  - Allentown, Pennsylvania, United States, 18103
    - John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
  - Altoona, Pennsylvania, United States, 16602
    - Bon Secours-Holy Family Health System
  - Bethlehem, Pennsylvania, United States, 18015
    - St. Luke's Hospital Cancer Center
  - Bryn Mawr, Pennsylvania, United States, 19010
    - Bryn Mawr Hospital
  - Danville, Pennsylvania, United States, 17822-2001
    - Geisinger Medical Center
  - Darby, Pennsylvania, United States, 19023
    - Mercy Fitzgerald Hospital
  - Doylestown, Pennsylvania, United States, 18901
    - Doylestown Hospital
  - Drexel Hill, Pennsylvania, United States, 19026
    - Delaware County Memorial Hospital
  - Easton, Pennsylvania, United States, 18042
    - Easton Hospital
  - Ephrata, Pennsylvania, United States, 17522-1002
    - Ephrata Community Hopital
  - Erie, Pennsylvania, United States, 16505
    - Regional Cancer Center - Erie
  - Harrisburg, Pennsylvania, United States, 17105-8700
    - Pinnacle Health Regional Cancer Center at Pinnacle Health System
  - Havertown, Pennsylvania, United States, 19083
    - Mercy Community Hospital
  - Hershey, Pennsylvania, United States, 17033-0850
    - Penn State Cancer Institute at Milton S. Hershey Medical Center
  - Lancaster, Pennsylvania, United States, 17604-3555
    - Lancaster General Hospital
  - Langhorne, Pennsylvania, United States, 19047
    - Saint Mary Regional Cancer Center
  - Media, Pennsylvania, United States, 19063
    - Riddle Memorial Hospital
  - Paoli, Pennsylvania, United States, 19301-1792
    - Cancer Center at Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, United States, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, United States, 19141
    - Albert Einstein Cancer Center
  - Philadelphia, Pennsylvania, United States, 19143
    - Mercy Hospital of Philadelphia
  - Philadelphia, Pennsylvania, United States, 19107-5541
    - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
  - Philadelphia, Pennsylvania, United States, 19104-4283
    - Abramson Cancer Center at University of Pennsylvania Medical Center
  - Philadelphia, Pennsylvania, United States, 19107
    - Pennsylvania Oncology Hematology Associates
  - Philadelphia, Pennsylvania, United States, 19114
    - Frankford Hospital
  - Philadelphia, Pennsylvania, United States, 19118
    - Chestnut Hill Healthcare
  - Philadelphia, Pennsylvania, United States, 19140
    - Fox Chase - Temple Cancer Center
  - Pittsburgh, Pennsylvania, United States, 15212-4772
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, United States, 15213-3489
    - Hillman Cancer Center at University of Pittsburgh Cancer Institute
  - Pottstown, Pennsylvania, United States, 19464
    - Pottstown Memorial Regional Cancer Center
  - Reading, Pennsylvania, United States, 19612-6052
    - Reading Hospital and Medical Center
  - Sellersville, Pennsylvania, United States, 18960
    - Grand View Hospital
  - Upland, Pennsylvania, United States, 19013
    - Crozer-Chester Medical Center
  - West Chester, Pennsylvania, United States, 19380
    - Chester County Hospital
  - Wynnewood, Pennsylvania, United States, 19096
    - Lankenau Cancer Center at Lankenau Hospital
  - York, Pennsylvania, United States, 17403
    - Wellspan Health - York Cancer Center
- Rhode Island
  - Providence, Rhode Island, United States, 02903
    - Rhode Island Hospital
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - AnMed Health
  - Charleston, South Carolina, United States, 29425
    - Hollings Cancer Center at Medical University of South Carolina
  - Charleston, South Carolina, United States, 29401
    - Roper St. Francis Healthcare - Roper Hospital
  - Columbia, South Carolina, United States, 29203
    - Palmetto Richland Memorial Hospital
  - Florence, South Carolina, United States, 29501
    - McLeod Regional Medical Center
  - Greenville, South Carolina, United States, 29601
    - Cancer Centers of the Carolinas - Eastside
  - Spartanburg, South Carolina, United States, 29303
    - CCOP - Upstate Carolina
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, United States, 57104
    - CCOP - Sioux Community Cancer Consortium
- Tennessee
  - Kingsport, Tennessee, United States, 37662
    - Wellmont Holston Valley Hospital and Medical Center
  - Knoxville, Tennessee, United States, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, United States, 37920-2911
    - U.T. Cancer Institute at University of Tennessee Medical Center
  - Memphis, Tennessee, United States, 38117
    - Baptist Cancer Institute - Memphis at Baptist Memorial Hospital - Memphis
  - Nashville, Tennessee, United States, 37208-3599
    - MBCCOP - Meharry Medical College - Nashville
  - Nashville, Tennessee, United States, 37232-6838
    - Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center
- Texas
  - Abilene, Texas, United States, 79601-2316
    - Hendrick Cancer Center
  - Amarillo, Texas, United States, 79106
    - Harrington Cancer Center
  - Beaumont, Texas, United States, 77701
    - Julie and Ben Rogers Cancer Center
  - Dallas, Texas, United States, 75231
    - Presbyterian Hospital of Dallas
  - Dallas, Texas, United States, 75235-9154
    - Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
  - Dallas, Texas, United States, 75246
    - Charles A. Sammons Cancer Center
  - Dallas, Texas, United States, 75265-5999
    - Methodist Dallas Medical Center
  - El Paso, Texas, United States, 79902
    - Providence Memorial Hospital
  - Fort Worth, Texas, United States, 76104
    - Harris Methodist Fort Worth
  - Houston, Texas, United States, 77030
    - Baylor College of Medicine
  - Houston, Texas, United States, 77030-4009
    - University of Texas - MD Anderson Cancer Center
  - Houston, Texas, United States, 77030
    - Texas Cancer Institute at St. Luke's Episcopal Hospital
  - Irving, Texas, United States, 75061
    - Baylor Medical Center at Garland
  - Lackland Air Force Base, Texas, United States, 78236-5300
    - Wilford Hall Medical Center
  - Laredo, Texas, United States, 78041
    - Sanchez Cancer Center
  - Lubbock, Texas, United States, 79410-1894
    - Joe Arrington Cancer Research and Treatment Center
  - Lubbock, Texas, United States, 79415
    - Southwest Cancer and Research Center at University Medical Center
  - Lufkin, Texas, United States, 75902
    - Memorial Health System of East Texas
  - Richardson, Texas, United States, 75080
    - Baylor/Richardson Cancer Center
  - San Antonio, Texas, United States, 78284-7811
    - University of Texas Health Science Center at San Antonio
  - Temple, Texas, United States, 76508
    - CCOP - Scott and White Hospital
  - Tyler, Texas, United States, 75708
    - University of Texas Health Center at Tyler
- Utah
  - Salt Lake City, Utah, United States, 84112
    - Huntsman Cancer Institute
- Vermont
  - Bennington, Vermont, United States, 05201
    - Green Mountain Oncology Group
  - Bennington, Vermont, United States, 05201
    - Southwestern Vermont Regional Cancer Center
  - Berlin, Vermont, United States, 05602
    - Mountainview Medical
  - Burlington, Vermont, United States, 05401-3498
    - Vermont Cancer Center at University of Vermont
  - Rutland, Vermont, United States, 05701
    - Community Cancer Center at Rutland Regional Medical Center
- Virginia
  - Charlottesville, Virginia, United States, 22901
    - Martha Jefferson Hospital
  - Danville, Virginia, United States, 24541
    - Cancer Center of the Piedmont, Inc.
  - Danville, Virginia, United States, 24541
    - Danville Hematology and Oncology, Incorporated
  - Newport News, Virginia, United States, 23606
    - Virginia Oncology Associates - Newport News
  - Richmond, Virginia, United States, 23298-0037
    - MBCCOP - Massey Cancer Center
  - Richmond, Virginia, United States, 23229
    - Henrico Doctors' Hospital - Parham Campus
  - Roanoke, Virginia, United States, 24014
    - Oncology and Hematology Associates of Southwest Virginia, Inc.
- Washington
  - Bellingham, Washington, United States, 98225
    - St. Joseph Hospital Community Cancer Center
  - Bremerton, Washington, United States, 98310
    - Olympic Hematology and Oncology
  - Everett, Washington, United States, 98258-0000
    - Flynn Cancer Center at Providence Everett Medical Center - Pacific Campus
  - Seattle, Washington, United States, 98101
    - CCOP - Virginia Mason Research Center
  - Seattle, Washington, United States, 98109-1024
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, United States, 98104
    - Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  - Spokane, Washington, United States, 99207
    - Cancer Care Northwest - Spokane North
  - Spokane, Washington, United States, 99220
    - Rockwood Clinic P.S.
  - Tacoma, Washington, United States, 98405-0986
    - CCOP - Northwest
  - Yakima, Washington, United States, 89802
    - Yakima Regional Cancer Care Center
- West Virginia
  - Charleston, West Virginia, United States, 25304-1297
    - David Lee Cancer Center at Charleston Area Medical Center
  - Parkersburg, West Virginia, United States, 26102
    - Camden-Clark Memorial Hospital
- Wisconsin
  - La Crosse, Wisconsin, United States, 54601
    - Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
  - Madison, Wisconsin, United States, 53792-6164
    - University of Wisconsin Comprehensive Cancer Center
  - Marshfield, Wisconsin, United States, 54449
    - CCOP - Marshfield Clinic Research Foundation
  - Milwaukee, Wisconsin, United States, 53226
    - Medical College of Wisconsin Cancer Center
  - Milwaukee, Wisconsin, United States, 53201-0342
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, United States, 53215
    - Oncology Alliance, S.C.
  - Waukesha, Wisconsin, United States, 53188
    - Waukesha Memorial Hospital Regional Cancer Center
  - Wausau, Wisconsin, United States, 54401
    - UW Cancer Center Wausau Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

35 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

Female

Description

DISEASE CHARACTERISTICS:

Postmenopausal women at increased risk for developing invasive breast cancer, who meet one of the following criteria:
- At least 12 months since spontaneous menstrual bleeding
- Prior documented hysterectomy and bilateral salpingo-oophorectomy
- At least 55 years of age with prior hysterectomy with or without oophorectomy
- Age 35 to 54 with a prior hysterectomy without oophorectomy OR with a status of ovaries unknown with documented follicle-stimulating hormone level demonstrating elevation in postmenopausal range
Histologically confirmed lobular carcinoma in situ treated by local excision only OR a minimum projected 5 year probability of invasive breast cancer of at least 1.66%, using Breast Cancer Risk Assessment Profile
No clinical evidence of malignancy on physical exam within the past 180 days
No evidence of suspicious or malignant disease on bilateral mammogram within the past year
No bilateral or unilateral prophylactic mastectomy
No prior invasive breast cancer or intraductal carcinoma in situ
Hormone receptor status:
- Not specified

PATIENT CHARACTERISTICS:

Age:

35 and over

Sex:

Female

Menopausal status:

See Disease Characteristics

Performance status:

No restricted normal activity for a significant portion of each day

Life expectancy:

At least 10 years

Hematopoietic:

Granulocyte count at least 1,500/mm^3
Complete blood count and differential normal
Platelet count normal

Hepatic:

SGOT or SGPT normal
Bilirubin normal
Alkaline phosphatase normal

Renal:

Creatinine normal

Cardiovascular:

No cerebral vascular accident, transient ischemic attack, atrial fibrillation, or uncontrolled hypertension
No deep vein thrombosis

Pulmonary:

No pulmonary embolus

Other:

No other prior malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
No concurrent nonmalignant disease that would preclude administration of tamoxifen or raloxifene
No clinical depression, psychiatric condition, or addictive disorder
No uncontrolled diabetes

PRIOR CONCURRENT THERAPY:

Biologic therapy:

Not specified

Chemotherapy:

Not specified

Endocrine therapy:

At least 3 months since prior estrogen or progesterone replacement therapy, oral contraceptives, androgens, luteinizing hormone-releasing hormone analogs, prolactin inhibitors, or antiandrogens
At least 3 months since prior tamoxifen, raloxifene, or other selective estrogen-receptor modulators of less than 3 months duration
Concurrent Estring allowed

Radiotherapy:

No prior breast radiotherapy

Surgery:

See Disease Characteristics

Other:

No prior systemic adjuvant therapy for breast cancer
No other participation in a cancer prevention or osteoporosis prevention study involving pharmacologic intervention(s)
- NSABP-P-1 patients who received placebo are eligible
No concurrent warfarin or cholestyramine
Concurrent calcitonin or nonhormonal medication (e.g., cholecalciferol, fluoride, or bisphosphonates) allowed

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Group 1 Tamoxifen and placebo	Drug: Tamoxifen 20 mg/day plus placebo for 5 years
Experimental: Group 2 Raloxifene and Placebo	Drug: Raloxifene 60 mg/day plus placebo for 5 years

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of invasive breast cancer; superiority of one of the therapies. Time Frame: Time from randomization to the occurance of invasive breast cancer.	Determine which of the following is true: compared to tamoxifen, raloxifene significantly reduces the incidence rate of invasive breast cancer; compared to raloxifene, tamoxifen significantly reduces the incidence rate of invasive breast cancer; or the statistical superiority of one of the treatments cannot be demonstrated and the choice of therapy should be based on benefit/risk considerations.	Time from randomization to the occurance of invasive breast cancer.

Secondary Outcome Measures

Outcome Measure	Time Frame
Effect of the study therapies on the incidence of intraductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). Time Frame: Time from randomization to the occurance of DCIS or LCIS.	Time from randomization to the occurance of DCIS or LCIS.
Effect of the study therapies on the incidence of endometrial cancer. Time Frame: Time from randomization to the occurance of endometrial cancer.	Time from randomization to the occurance of endometrial cancer.
Effect of the study therapies on the incidence of ischemic heart disease. Time Frame: Time from randomization to the occurance of ischimic heart disease.	Time from randomization to the occurance of ischimic heart disease.
Effect of the study therapies on the incidence of fractures of the hip, spine, or Colles' fractures of the wrist. Time Frame: Time from randomization to the occurance of fractures of the hip, spine, or Colles' fractures of the wrist.	Time from randomization to the occurance of fractures of the hip, spine, or Colles' fractures of the wrist.
Effect of the study therapies on the toxicity and side effects of each therapy. Time Frame: Incidences of protocol defined toxicities and side effects.	Incidences of protocol defined toxicities and side effects.
Effect of the study therapies on participants' quality of life. Time Frame: pre-entry, every 6 months for 5 years, and then annual after 5 years following randomization.	pre-entry, every 6 months for 5 years, and then annual after 5 years following randomization.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

NSABP Foundation Inc

Collaborators

National Cancer Institute (NCI)

Eli Lilly and Company

AstraZeneca

Investigators

Study Chair: Norman Wolmark, MD, NSABP Foundation Inc

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Goetz MP, Schaid DJ, Wickerham DL, Safgren S, Mushiroda T, Kubo M, Batzler A, Costantino JP, Vogel VG, Paik S, Carlson EE, Flockhart DA, Wolmark N, Nakamura Y, Weinshilboum RM, Ingle JN, Ames MM. Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials. Clin Cancer Res. 2011 Nov 1;17(21):6944-51. doi: 10.1158/1078-0432.CCR-11-0860. Epub 2011 Aug 31. Erratum In: Clin Cancer Res. 2012 Jun 15;18(12):3491.
Cronin WM, Cecchini RS, Wickerham DL, et al.: Factors associated with participant adherence in the NSABP Study of Tamoxifen and Raloxifene (STAR). [Abstract] J Clin Oncol 26 (Suppl 15): A-6518, 2008.
Land SR, Ritter MW, Costantino JP, Julian TB, Cronin WM, Haile SR, Wolmark N, Ganz PA. Compliance with patient-reported outcomes in multicenter clinical trials: methodologic and practical approaches. J Clin Oncol. 2007 Nov 10;25(32):5113-20. doi: 10.1200/JCO.2007.12.1749.
Gradishar WJ, Cella D. Selective estrogen receptor modulators and prevention of invasive breast cancer. JAMA. 2006 Jun 21;295(23):2784-6. doi: 10.1001/jama.295.23.jed60037. Epub 2006 Jun 5. No abstract available.
Vogel VG. The NSABP Study of Tamoxifen and Raloxifene (STAR) trial. Expert Rev Anticancer Ther. 2009 Jan;9(1):51-60. doi: 10.1586/14737140.9.1.51. Erratum In: Expert Rev Anticancer Ther. 2009 Mar;9(3):388.
Wickerham DL, Costantino JP, Vogel VG, Cronin WM, Cecchini RS, Ford LG, Wolmark N. The use of tamoxifen and raloxifene for the prevention of breast cancer. Recent Results Cancer Res. 2009;181:113-9. doi: 10.1007/978-3-540-69297-3_12.
Ganz PA, Land SR, Wickerham DL, et al.: The Study of Tamoxifen and Raloxifene (STAR): Change in patient-reported outcomes (PROs) after the end of treatment. [Abstract] J Clin Oncol 25 (Suppl 18): A-1506, 2007.
Ganz PA, Land SR, Wickerham DL, et al.: The study of tamoxifen and raloxifene (STAR): first report of patient-reported outcomes (PROs) from the NSABP P-2 breast cancer prevention study. [Abstract] J Clin Oncol 24 (Suppl 18): A-LBA561, 2006.
Land SR, Wickerham DL, Costantino JP, Ritter MW, Vogel VG, Lee M, Pajon ER, Wade JL 3rd, Dakhil S, Lockhart JB Jr, Wolmark N, Ganz PA. Patient-reported symptoms and quality of life during treatment with tamoxifen or raloxifene for breast cancer prevention: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA. 2006 Jun 21;295(23):2742-51. doi: 10.1001/jama.295.23.joc60075. Epub 2006 Jun 5. Erratum In: JAMA. 2007 Sep 5;298(9):973.
Vogel VG, Costantino JP, Wickerham DL, et al.: The effects of tamoxifen versus raloxifene on the risk of developing noninvasive breast cancer in the NSABP study of tamoxifen and raloxifene (STAR) P-2 trial. [Abstract] Breast Cancer Res Treat 100 (Suppl 1): A-33, S16, 2006.
Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, Bevers TB, Fehrenbacher L, Pajon ER Jr, Wade JL 3rd, Robidoux A, Margolese RG, James J, Lippman SM, Runowicz CD, Ganz PA, Reis SE, McCaskill-Stevens W, Ford LG, Jordan VC, Wolmark N; National Surgical Adjuvant Breast and Bowel Project (NSABP). Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA. 2006 Jun 21;295(23):2727-41. doi: 10.1001/jama.295.23.joc60074. Epub 2006 Jun 5. Erratum In: JAMA. 2006 Dec 27;296(24):2926. JAMA. 2007 Sep 5;298(9):973.
McCaskill-Stevens W, Wilson JW, Cook ED, Edwards CL, Gibson RV, McElwain DL, Figueroa-Moseley CD, Paskett ED, Roberson NL, Wickerham DL, Wolmark N. National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene trial: advancing the science of recruitment and breast cancer risk assessment in minority communities. Clin Trials. 2013 Apr;10(2):280-91. doi: 10.1177/1740774512470315. Epub 2013 Jan 18.
Cecchini RS, Costantino JP, Cauley JA, Cronin WM, Wickerham DL, Land SR, Weissfeld JL, Wolmark N. Body mass index and the risk for developing invasive breast cancer among high-risk women in NSABP P-1 and STAR breast cancer prevention trials. Cancer Prev Res (Phila). 2012 Apr;5(4):583-92. doi: 10.1158/1940-6207.CAPR-11-0482. Epub 2012 Feb 7.
Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, Bevers TB, Fehrenbacher L, Pajon ER, Wade JL 3rd, Robidoux A, Margolese RG, James J, Runowicz CD, Ganz PA, Reis SE, McCaskill-Stevens W, Ford LG, Jordan VC, Wolmark N; National Surgical Adjuvant Breast and Bowel Project. Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing breast cancer. Cancer Prev Res (Phila). 2010 Jun;3(6):696-706. doi: 10.1158/1940-6207.CAPR-10-0076. Epub 2010 Apr 19.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 1999

Primary Completion (Actual)

December 1, 2005

Study Completion (Actual)

August 1, 2012

Study Registration Dates

First Submitted

November 1, 1999

First Submitted That Met QC Criteria

January 26, 2003

First Posted (Estimate)

January 27, 2003

Study Record Updates

Last Update Posted (Estimate)

October 6, 2015

Last Update Submitted That Met QC Criteria

October 5, 2015

Last Verified

October 1, 2015

More Information

Terms related to this study

Keywords

breast cancer

Additional Relevant MeSH Terms

Other Study ID Numbers

NSABP P-2
CDR0000067081

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Breast Cancer

Northwestern University
Eisai Inc.

Unknown

Carboplatin and Eribulin Mesylate in Triple Negative Breast Cancer Patients

Male Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Triple-negative Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer | HER2-negative...

United States
University of Southern California
National Cancer Institute (NCI)

Withdrawn

Azacitidine in Treating Patients With Triple Negative Stage I-IV Invasive Breast Cancer That Can Be Removed By Surgery

Stage IV Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Triple-negative Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer
Oncoliq US Inc

Recruiting

Validation of the Oncoliq Test for the Early Detection of Breast Cancer.

Breast Cancer Female | Breast Cancer Detection | Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Breast Cancer With Low to Intermediate HER2 Expression | Breast Cancer - Female | Breast Cancer (Early Breast Cancer) | Breast Cancer - Ductal Carcinoma in Situ (DCIS) | Breast Cancer - Infiltrating...

Argentina
University of California, Irvine
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Carboplatin+Nab-paclitaxel, Plus Trastuzumab (HER2+) or Bevacizumab (HER2-) in the Neoadjuvant Setting

Breast Cancer | HER2-positive Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer | HER2-negative Breast Cancer

United States
University of Washington
National Cancer Institute (NCI)

Completed

Doxorubicin Hydrochloride, Cyclophosphamide, and Filgrastim Followed By Paclitaxel Albumin-Stabilized Nanoparticle Formulation With or Without Trastuzumab in Treating Patients With Breast Cancer Previously Treated With Surgery

HER2-positive Breast Cancer | Stage IV Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor-positive Breast Cancer

United States
Joseph Baar, MD, PhD

Completed

MUC1 Vaccine for Triple-negative Breast Cancer

Breast Cancer | Stage I Breast Cancer | Inflammatory Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Triple-negative Breast Cancer | Stage IIIC Breast Cancer

United States
Case Comprehensive Cancer Center
National Institute on Minority Health and Health Disparities (NIMHD)

Completed

Attitudes, Beliefs, and Preferences of Older Stage I-III Breast Cancer Survivors Towards Physical Activity

Cancer Survivor | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIA Breast Cancer | Stage IIB Breast Cancer | Stage IIIC Breast Cancer

United States
University of Washington
National Cancer Institute (NCI)

Completed

Sunitinib Malate, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide Before Surgery in Treating Patients With Stage IIB-IIIC Breast Cancer

Inflammatory Breast Cancer | Male Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer

United States
University of Maryland, Baltimore
Syndax Pharmaceuticals

Terminated

Entinostat and Anastrozole in Treating Postmenopausal Women With TNBC That Can Be Removed by Surgery (0927GCC)

Stage I Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Triple-negative Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer | HER2-negative Breast Cancer

United States
National Cancer Institute (NCI)

Completed

Saracatinib in Treating Patients With Metastatic or Locally Advanced Breast Cancer That Cannot Be Removed By Surgery

Male Breast Cancer | Stage IV Breast Cancer | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer

United States

Clinical Trials on Tamoxifen

Karolinska Institutet
Region Stockholm; The Sjöberg Foundation; Swedish Cancer Society; The Swedish Breast... and other collaborators

Not yet recruiting

The POWER Trial: Personalised Dose Optimisation With Adjuvant Tamoxifen Therapy in Breast cancER (POWER)

Breast Cancer | Adjuvant Drug Therapy

Sweden
Ente Ospedaliero Ospedali Galliera
European Institute of Oncology; Fundacao Champalimaud

Completed

Long-term Follow-up of the TAM-01 Study and Pooled Analysis of Low-dose Tamoxifen Studies in Non-invasive or Microinvasive Breast Neoplasms (Babytam long)

Breast Cancer Invasive

Italy
Azienda Ospedaliera Universitaria Integrata Verona

Not yet recruiting

Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. (TMX)

Cystic Fibrosis - Complete

Italy
Uruk University

Completed

Effect of Metformin on Endometrial Thickness in Postmenopausal Breast Cancer Patients Receiving Tamoxifen

Breast Cancer | Endometrial Hyperplasia and Endometrial Cancers

Iraq
European Institute of Oncology
Istituto Oncologico Veneto IRCCS; Ente Ospedaliero Ospedali Galliera; Istituto...

Active, not recruiting

Low Dose TamOxifen and LifestylE Changes for bReast cANcer prevenTion (TOLERANT)

Ductal Carcinoma in Situ | RAD51C Gene Mutation | RAD51D Gene Mutation | PALB2 Gene Mutation | Lobular Carcinoma in Situ | ATM Gene Mutation | CDH1 Gene Mutation | CHEK2 Gene Mutation | BRCA Mutation

Italy
Sana'a University
Al-Thawra Modern General Hospital

Active, not recruiting

Letrozole vs. Clomiphene Citrate Plus Tamoxifen for Ovulation Induction and Pregnancy Outcomes. (LET-CC-TAM)

Infertility Drugs | Infertility Involuntary

Yemen
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

External Mastalgia-oil Versus Oral Tamoxifen in Premenopausal Women with Severe Mastalgia

Mastalgia

China
Northwestern University
National Cancer Institute (NCI)

Completed

4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in Situ

Estrogen Receptor-positive Breast Cancer | Ductal Breast Carcinoma in Situ

United States
University of Nebraska

Recruiting

Chemoprevention With Tamoxifen in Pre-Invasive Pancreas Mucinous Cystic Neoplasms Not Undergoing Immediate Resection (MCN_Tam)

Pancreatic Cyst | Pancreatic Mucinous Cystic Neoplasm

United States
The Methodist Hospital Research Institute
Millennium Pharmaceuticals, Inc.

Completed

TAK-228 Plus Tamoxifen in Patients With ER-Positive, HER2-negative Breast Cancer (ANETT)

Estrogen Receptor Positive Breast Cancer

United States

Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women