Psychodynamic Therapy for Treating Panic Disorder

Randomized Controlled Trial of Psychodynamic Psychotherapy vs. Applied Relaxation for Panic Disorder

This study will determine the effectiveness of a manualized form of brief psychodynamic psychotherapy in comparison with applied relaxation training in treating adults with panic disorder.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This is a randomized controlled trial of a manualized form of brief psychodynamic psychotherapy in comparison with applied relaxation training, a less active form of treatment in other studies, for adults with primary Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) panic disorder.

Forty nine patients who have signed written consent who have primary DSM-IV panic disorder have been entered into the study. Randomization has been stratified by presence of major depression and use of psychoactive, anti-panic medications. Medications, if present, have been held constant. All patients have received 24 sessions of either psychodynamic psychotherapy, or applied relaxation training for panic disorder. This study is currently closed for recruitment, although final follow-up assessments have yet to be completed.

Study Type

Interventional

Enrollment (Actual)

49

Phase

  • Phase 2
  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

    • New York
      • New York City, New York, United States, 10021
        • Weill Medical College

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 55 years (ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • 18-55 years old
  • Primary DSM-IV panic disorder with or without agoraphobia
  • Severity 5/8 minimum on the Anxiety Disorders Interview Schedule

Exclusion Criteria:

  • Psychosis
  • Unstable medication dosage
  • Unwilling to discontinue ongoing psychotherapy
  • Organic mental syndrome
  • Substance use or abuse

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 1 PFPP
Panic Focused Psychodynamic Psychotherapy
Psychoanalytic Psychotherapy for panic disorder
Other Names:
  • Psychodynamic psychotherapy
Active Comparator: 2 ART
Applied Relaxation Training
Applied Relaxation Training
Other Names:
  • Behavioral Therapy
  • Applied Relaxation Training

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
PDSS (panic disorder severity scale)
Time Frame: termination, 2, 4, 6, 12 month f/u
termination, 2, 4, 6, 12 month f/u

Secondary Outcome Measures

Outcome Measure
Time Frame
SDS (Sheehan disability scale)
Time Frame: termination, 2, 4, 6, 12 month f/u
termination, 2, 4, 6, 12 month f/u
HARS (Hamilton anxiety rating scale)
Time Frame: termination, 2, 4, 6, 12 month f/u
termination, 2, 4, 6, 12 month f/u
HDRS (Hamilton depression rating scale)
Time Frame: termination, 2, 4, 6, 12 month f/u
termination, 2, 4, 6, 12 month f/u

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Principal Investigator: Barbara Milrod, M.D., Weill Medical College

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2000

Primary Completion (Actual)

January 1, 2005

Study Completion (Actual)

July 1, 2005

Study Registration Dates

First Submitted

August 5, 2005

First Submitted That Met QC Criteria

August 5, 2005

First Posted (Estimate)

August 9, 2005

Study Record Updates

Last Update Posted (Estimate)

June 27, 2013

Last Update Submitted That Met QC Criteria

June 26, 2013

Last Verified

June 1, 2013

More Information

Terms related to this study

Other Study ID Numbers

  • K23MH001849 (U.S. NIH Grant/Contract)
  • DSIR AT-CD

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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