Cardiac Water and Fluoromethane Cardiac PET

Comparison of Cardiac Perfusion by O15-water and F17-fluoromethane PET

In this study we are looking at the blood flow to the heart using two different chemical tags or tracers that give off a low level of radiation. The tracers used in this study are called O15-water and F17-fluoromethane. These tracers mix with the blood and will move through the body. The researchers will use positron emission tomography (PET scans)to track the tracers as they moe through the heart and chest.

Study Overview

• Status: Completed
• Conditions: Healthy Volunteers
• Intervention / Treatment: Procedure: Cardiac PET imaging- rest and pharmacological stress

• Study Type: Interventional
• Enrollment: 10
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Wisconsin
    • Madison, Wisconsin, United States, 53792
      • University of Wisconsin

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• 1. Age 18 to 40 years old 2. Willing to provide written informed consent

Exclusion Criteria:

• 1. A history of CAD 2. A history of active bronchospasm or asthma on theophylline bronchodilators 3. A history of any cardiac risk factors including: HTN, Diabetes, Hyperlipidemia, Smoking, and premature CAD in immediate family member 4. A history of liver disease or other significant disease 5. Females who are pregnant or lactating

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: Non-Randomized
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
-- implement myocardial perfusion quantification for O15-labeled water at rest and with pharmacologic stress,	assess at time of PET scan
-- determine the biodistribution of fluoromethane in the thorax to see if it is usable for a cardiac perfusion tracer,	assess at time of PET Scan

Secondary Outcome Measures

Outcome Measure	Time Frame
--develop initial methods for quantification of myocardial perfusion if applicable for labeled fluoromethane.	assess at time of PET scan

Collaborators and Investigators

• Sponsor: University of Wisconsin, Madison
• Investigators: Principal Investigator: Charles K Stone, MD, Univeristy of Wisconsin

Study record dates

Study Major Dates

• Study Start: January 1, 2004
• Primary Completion (Actual): March 1, 2004
• Study Completion (Actual): March 1, 2004

Study Registration Dates

• First Submitted: September 12, 2005
• First Submitted That Met QC Criteria: September 13, 2005
• First Posted (Estimate): September 20, 2005

Study Record Updates

• Last Update Posted (Estimate): August 29, 2012
• Last Update Submitted That Met QC Criteria: August 28, 2012
• Last Verified: August 1, 2012

More Information

Terms related to this study

• Keywords: Cardiac PET imaging; Radiopharmaceutical tracers
• Other Study ID Numbers: 2003-241