Effects of Peritendinous Corticosteroid Injections, Eccentric Training and Heavy Slow Resistance Training in Patellar Tendinopathy

May 21, 2008 updated by: Bispebjerg Hospital
We will investigate the effect of peritendinous corticosteroid injections, eccentric training and heavy resistance training in male patellar tendinopathy patients. The purpose is to compare the clinical effect of these three treatments in a randomised controlled trial. Also we wish to investigate the treatment mechanisms responsible for the effectiveness of the three treatments.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

3 interventions groups as described above (n=13 in each group) 12 weeks intervention period. Clinical assessments before and after intervention: VAS, VISA, Tendon thickness, Doppler us activity.

Before and after intervention tendon biopsies will be taken and analyzed for crosslinks and fibril diameter. Also tendon mechanical properties will be measured. Tendon and muscle structural properties will be measured with MRI.

Treatment satisfaction will be stated after intervention period.

Study Type

Interventional

Enrollment (Actual)

39

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Denmark
      • Copenhagen, Denmark, 2400
        • Institute of Sports Medicine Copenhagen. Dept 8 1st floor. Bispebjerg Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 55 years (ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Clinical patellar tendinopathy pain.
  • Tendon swelling
  • Hypoechoic
  • Doppler activity in tendon

Exclusion Criteria:

  • Previous knee surgery
  • diabetes
  • arthritis
  • previous steroid injections

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
ACTIVE_COMPARATOR: CORT
Peritendinous corticosteroid injections at 0 and 4 weeks. 12 weeks total
Procedure: peritendinous corticosteroid injections
1 ml of40mg/ml methylprednisolone acetate at 0 and 4 weeks. 2 week observational
EXPERIMENTAL: ECC
12 weeks of eccentric unilateral decline squats
Procedure: eccentric decline squat training
eccentric decline unilateral squats performed twice daily. for 12 weeks
EXPERIMENTAL: HSR
Heavy slow resistance training. 3/week. 12 weeks
Procedure: heavy slow resistance training
Heavy slow resistance training for knee extensors. 3/week. total of 12 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bispebjerg Hospital

Investigators

  • Principal Investigator: Mads Kongsgaard, PhD., MSc., Institute of Sports Medicine, Copenhagen

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2006

Study Completion (ACTUAL)

November 1, 2007

Study Registration Dates

First Submitted

November 27, 2006

First Submitted That Met QC Criteria

November 27, 2006

First Posted (ESTIMATE)

November 28, 2006

Study Record Updates

Last Update Posted (ESTIMATE)

May 22, 2008

Last Update Submitted That Met QC Criteria

May 21, 2008

Last Verified

May 1, 2008

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Patellar tendinopathy

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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