- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00440661
Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis
March 3, 2010 updated by: Laboratoires NEGMA
Exploratory Study of Some Synovial Fluid Inflammation Mediatorsunder Diacerhein in Knee Osteoarthritis Patients. Phase IV Study.
Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis.
The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its effect on other synovial inflammation mediators.
Study Overview
Study Type
Interventional
Enrollment (Anticipated)
96
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Quebec
-
Montreal, Quebec, Canada, H2L1S6
- Rheumatologic Institut of Montreal
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
45 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Painful osteoarthritis
- Hydarthrosis (synovial effusion)
Exclusion Criteria:
- large effusion
- severe pathologies
- anti-osteoarthritic treatments
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Synovial concentration of IL-1
|
Secondary Outcome Measures
Outcome Measure |
---|
WOMAC
|
Synovial concentration of IL-6
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Jean-Pierre RAYNAULD, MD, Institut de Rhumatologie de Montreal
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
March 1, 2007
Primary Completion (Actual)
October 1, 2008
Study Completion (Actual)
October 1, 2008
Study Registration Dates
First Submitted
February 26, 2007
First Submitted That Met QC Criteria
February 26, 2007
First Posted (Estimate)
February 27, 2007
Study Record Updates
Last Update Posted (Estimate)
March 4, 2010
Last Update Submitted That Met QC Criteria
March 3, 2010
Last Verified
October 1, 2007
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- HEC/ART06572N
- 109196
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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