Visual Impairment, Oscillopsia and Multiple Sclerosis

This study consists of two parts. The first part is a survey to examine vision-specific health-related quality of life in a cohort of patients with multiple sclerosis. We test visual impairment like visual acuity, visual field, colour discrimination, contrast sensitivity, eye movement. The aim of this part is to examine the association between responses to the quality of life scale and objective measures of visual impairment.

The second part is an open controlled study, in which we measure motion detection threshold in MS patients with oscillopsia due to pendular nystagmus and in a group of control subjects. The objective of this part is to determine whether patients with pendular nystagmus develop adaptation to oscillopsia using increased threshold of motion detection. We plan to test the effect of visuo-motor rehabilitation on this threshold in patients with oscillopsia due to pendular nystagmus.

Study Overview

• Status: Terminated
• Conditions: Multiple Sclerosis
• Intervention / Treatment: Procedure: visual tests

Detailed Description

In the first part, 100 patients with multiple sclerosis are included. A vision-specific health-related quality of life scale and neuro-ophthalmological tests are administered. The duration of intervention is about 3 hours by patient and one year to finish this part.

In the second part, we include about 40 of 100 MS patients who present an oscillopsia due to pendular nystagmus and a group of 20 control subjects. The patients and subject will perform a motion detection task and the vision-specific health-related quality of life, the intervention lasting 1 hour. Then the patients will be randomized in one group treated by rehabilitation (one 30 mn session per week during 3 months) and the other one without treatment. A motion detection task and the vision-specific health-related quality of life scale will be performed at the end of the treatment for both groups.

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

Study Locations

• France
  • Lyon, France, 69677
    • Caroline Tilikete

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 90 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Patients with established multiple sclerosis

Description

Inclusion Criteria:

• Age 18 to 90
• Patients with established multiple sclerosis
• Visual impairment recovering from MS
• Understanding rules task
• Patient can stay set a long time
• Patient's agreement
• Membership to the Social Security
• No relapsing since three months

Exclusion Criteria:

• Brain damage
• Cognitive or behaviour disorder
• Patients with peripheral vestibular, otologic or ophthalmologic pathology antecedent
• Not stabilized disease (other one than MS)
• Patient under guardianship

Study Plan

How is the study designed?

Collaborators and Investigators

• Sponsor: Hospices Civils de Lyon
• Investigators: Principal Investigator: Caroline Tilikete, MD, Hospices Civils de Lyon

Study record dates

Study Major Dates

• Study Start: April 1, 2007

Study Registration Dates

• First Submitted: July 6, 2007
• First Submitted That Met QC Criteria: July 6, 2007
• First Posted (Estimate): July 9, 2007

Study Record Updates

• Last Update Posted (Estimate): September 30, 2010
• Last Update Submitted That Met QC Criteria: September 29, 2010
• Last Verified: July 1, 2007

More Information

Terms related to this study

• Keywords: nystagmus; oscillopsia; eye movements; Multiples sclerosis; motion detection; retinal slip
• Additional Relevant MeSH Terms: Pathologic Processes; Nervous System Diseases; Immune System Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Eye Diseases; Neurologic Manifestations; Sensation Disorders; Multiple Sclerosis; Sclerosis; Vision, Low; Vision Disorders
• Other Study ID Numbers: 2006.432