- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00531141
The Optical Coherence Tomography in Age-Related Macular Degeneration Study: The OCT in AMD Study
June 23, 2009 updated by: The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Reproducibility of Retinal Thickness Measurements by Optical Coherence Tomography in Age-Related Macular Degeneration The OCT in AMD Study
The Optical Coherence Tomography (OCT) is a non-contact, non invasive method to examine the retina by providing cross-sectional scans through the retina.
Measurements of the retinal thickness based on automatically set border lines created by threshold algorithm provide information concerning the amount of intraretinal fluid and activity of the lesion.
In this study the reproducibility of retinal thickness measurements in patients suffering from age-related macular degeneration performed by two independent examiners of two examinations of the same day but performed in a time interval of at least two hours should be evaluated.
Using the macular thickness program of stratus OCT, 6 radial lines through the center of the foveal avascular zone are performed, Differences between the first and second measurement will be investigated by a 95% confidence interval, a Bland-Altman plot (with corresponding regression analysis) and a random effect model with time, examiner and diagnosis as fixed factors.
Although threshold algorithm failures and fixation problems are common in age-related macular degeneration evidence of reproducibility and repeatability of maximum retinal thickness is expected.
Study Overview
Study Type
Observational
Enrollment (Anticipated)
200
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Vienna, Austria, A1030
- Ludwig Boltzmann Institute for Retinology and Biomicroscopic Lasersurgery
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
50 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
primary care clinic
Description
Inclusion Criteria:
- Age over 50 years
- Age related macular degeneration
Exclusion Criteria:
- Macular pathologies other than age related macular degeneration (diabetic maculopathy, macular pucker, macular hole,
- Visualization of the macula not possible (dens cataract, vitreous haemorrhage)
- Not consented patients
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
A
examination twice by examiner 1
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OCT performed twice
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B
examination first by examiner 1 thereafter by examiner 2
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OCT performed twice
|
C
examination first by examiner 2 thereafter by examiner 1
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OCT performed twice
|
D
examination performed twice by examiner 2
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OCT performed twice
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Ilse Krebs, MD, Rudolf Foundation Clinic
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
May 1, 2007
Primary Completion (Actual)
June 1, 2008
Study Completion (Actual)
June 1, 2008
Study Registration Dates
First Submitted
September 15, 2007
First Submitted That Met QC Criteria
September 17, 2007
First Posted (Estimate)
September 18, 2007
Study Record Updates
Last Update Posted (Estimate)
June 24, 2009
Last Update Submitted That Met QC Criteria
June 23, 2009
Last Verified
June 1, 2009
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- EK 07-078-VK
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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