- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00640003
Baclofen Treatment of Ataxia Telangiectasia
December 18, 2017 updated by: Johns Hopkins University
This research is being done to find out if Baclofen, a medicine that is often used for the treatment of abnormal stiffness, might also be useful to treat some of the neurologic problems caused by ataxia telangiectasia (A-T).
The investigators also want to find out if there are better ways to measure the problems of ataxia and abnormal eye movement for future studies of medication in ataxia telangiectasia.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
10
Phase
- Early Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Maryland
-
Baltimore, Maryland, United States, 21287
- Johns Hopkins Hospital
-
Baltimore, Maryland, United States, 21108
- Johns Hopkins Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
12 years and older (Child, Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Teenagers over 12 years old and young adults with A-T may join if they have been evaluated previously in the A-T Clinical Center at Johns Hopkins Hospital and have a measurable abnormality of eye movement.
- Patients who are presently taking Baclofen will be eligible for the study if they are presently receiving the medication under the direction of Dr. Crawford in the ATCC, and are willing to withdraw from the medication for a period of one month prior to the initial screening visit.
- Female patients who are sexually active will be given a standard serum HCG pregnancy test.
- Those who are sexually active will be counseled about necessary precautions against pregnancy during the duration of the trial.
Exclusion Criteria:
- A positive pregnancy test.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: 1
|
Drug given by orally via capsules.
Escalation steps in 4-day intervals.
Step 1: 5mg QAM.
Step 2: 5mg BID.
Step 3: 5mg TID.
Step 4: 10mg QAM, 5mg BID.
Step 5: 10mg BID, 5mg QMid-day.
Step 6: 10mg TID.
Step 6 will last up to 2 weeks.
De-escalation will start from highest dose step and work backwards in 2-day intervals.
Complete drug administration of escalating, staying constant at 10mg TID and de-escalating will be done with both drug and placebo.
Other Names:
placebo drug
|
Experimental: 2
|
Drug given by orally via capsules.
Escalation steps in 4-day intervals.
Step 1: 5mg QAM.
Step 2: 5mg BID.
Step 3: 5mg TID.
Step 4: 10mg QAM, 5mg BID.
Step 5: 10mg BID, 5mg QMid-day.
Step 6: 10mg TID.
Step 6 will last up to 2 weeks.
De-escalation will start from highest dose step and work backwards in 2-day intervals.
Complete drug administration of escalating, staying constant at 10mg TID and de-escalating will be done with both drug and placebo.
Other Names:
placebo drug
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Improvement in the decay constant for velocity storage as assessed by quantitative video examination of eye movement during and after rotation.
Time Frame: 3 months
|
3 months
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Other outcome measures include quantitative measurement of tremor, postural stability and a standard neurologic examination.
Time Frame: 3 months
|
3 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Thomas O Crawford, M.D., Johns Hopkins School of Medicine
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
April 1, 2007
Primary Completion (Actual)
February 1, 2011
Study Completion (Actual)
February 1, 2011
Study Registration Dates
First Submitted
March 14, 2008
First Submitted That Met QC Criteria
March 19, 2008
First Posted (Estimate)
March 20, 2008
Study Record Updates
Last Update Posted (Actual)
December 20, 2017
Last Update Submitted That Met QC Criteria
December 18, 2017
Last Verified
December 1, 2017
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Cardiovascular Diseases
- Vascular Diseases
- Metabolic Diseases
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Immunologic Deficiency Syndromes
- Immune System Diseases
- Neurologic Manifestations
- Genetic Diseases, Inborn
- Dyskinesias
- DNA Repair-Deficiency Disorders
- Neurocutaneous Syndromes
- Cerebellar Diseases
- Primary Immunodeficiency Diseases
- Spinocerebellar Ataxias
- Ataxia
- Telangiectasis
- Cerebellar Ataxia
- Ataxia Telangiectasia
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Peripheral Nervous System Agents
- GABA Agents
- Neuromuscular Agents
- Muscle Relaxants, Central
- GABA Agonists
- GABA-B Receptor Agonists
- Baclofen
Other Study ID Numbers
- NA_00002180
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Ataxia Telangiectasia
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Matrix Biomed, Inc.The University of Texas Health Science Center, HoustonNot yet recruitingAtaxia Telangiectasia | Ataxia Telangiectasia Louis-Bar | Ataxia Telangiectasia in ChildrenUnited States
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Johns Hopkins UniversityTerminatedAtaxia-Telangiectasia (A-T)United States
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NHS TaysideUniversity of DundeeCompletedAtaxia-TelangiectasiaUnited Kingdom
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St. Jude Children's Research HospitalNational Cancer Institute (NCI); Children's Hospital of PhiladelphiaCompletedAtaxia-TelangiectasiaUnited States
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Institute of Child HealthGreat Ormond Street Hospital for Children NHS Foundation TrustCompletedAtaxia Telangiectasia (AT)United Kingdom
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University of PlymouthRecruitingAtaxia Telangiectasia | Ataxia Telangiectasia in ChildrenUnited Kingdom
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The University of QueenslandNational Health and Medical Research Council, AustraliaCompletedAtaxia TelangiectasiaAustralia
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ErydelRecruitingAtaxia TelangiectasiaUnited States, Australia, Belgium, Germany, India, Italy, Poland, Spain, Tunisia
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Acasti Pharma Inc.Active, not recruitingAtaxia TelangiectasiaCanada
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