Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome

The inflammatory process is involved in the pathogenesis of obesity. Prader-Willi syndrome (PWS) is a genetic model of syndromic obesity. Adiponectin is an adipokine with potent anti-inflammatory properties, and its effect is mediated through adiponectin receptors 1 (adipoR1) and 2 (adipoR2).

Objective of this study is to compare the expression of adipoR1, adipoR2, and adiponectin in peripheral blood mononuclear cells (PBMCs) in PWS children and obese control and to correlate receptor expression with insulin sensitivity and obesity-related parameters.

Study Overview

• Status: Completed
• Conditions: Obesity; Prader-Willi Syndrome

• Study Type: Observational

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 18 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Fourteen children with PWS and control subjects

Description

Inclusion Criteria:

• children with Prader-willi syndrome
• children with simple obesity

Exclusion Criteria:

• subjects with diabetes mellitus (fasting plasma glucose > 126 mg/dL with a 2-h oral glucose tolerance test value of >200 mg/dl)

Study Plan

How is the study designed?

Collaborators and Investigators

• Sponsor: Samsung Medical Center
• Investigators: Principal Investigator: Don-Kyu Jin, M.D., Samsung Medical Center, Sungkyunkwan Uiversity School of Medicine

Study record dates

Study Registration Dates

• First Submitted: November 30, 2008
• First Submitted That Met QC Criteria: December 1, 2008
• First Posted (Estimate): December 2, 2008

Study Record Updates

• Last Update Posted (Estimate): December 2, 2008
• Last Update Submitted That Met QC Criteria: December 1, 2008
• Last Verified: November 1, 2008

More Information

Terms related to this study

• Keywords: Prader-Willi syndrome; adiponectin; adiponectin receptor
• Additional Relevant MeSH Terms: Pathologic Processes; Nervous System Diseases; Neurologic Manifestations; Neurobehavioral Manifestations; Disease; Congenital Abnormalities; Overnutrition; Nutrition Disorders; Genetic Diseases, Inborn; Intellectual Disability; Abnormalities, Multiple; Chromosome Disorders; Obesity; Syndrome; Prader-Willi Syndrome
• Other Study ID Numbers: 2008-10-040