Motion Correction of Positron Emission Tomography (PET) Data Using Amplitude Gating

February 15, 2016 updated by: M.D. Anderson Cancer Center

Objectives:

Evaluation of an amplitude based gated Positron Emission Tomography (PET) data acquisition system for all GE Discovery Positron Emission Tomography/ Computed Tomography (PET/CT) scanners.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Routine PET/CT scans are taken while patients are breathing normally. The motions made by breathing can reduce the image quality of the scan. Minimizing the effects of this motion by taking the images and processing the scans differently may improve the image quality.

The PET/CT Scan:

If you agree to take part in this study, an elastic belt will be placed around your lower chest/upper abdomen before your routine PET/CT scan. This belt is used to track your breathing motion. This information will be used to help process the scan.

Your PET/CT scan will be performed as usual. During the scan, researchers will focus on your lower chest/upper abdomen (areas that experience breathing motion). Having to focus on this area might extend the scan by up to 10 minutes.

The additional scan time will not increase your radiation exposure since only PET scanning will be performed.

Length of Study:

Your participation on this study will be complete when your scheduled PET/CT scan is complete.

This is an investigational study. The imaging focused on your lower chest/upper abdomen during the scan is investigational.

Up to 26 patients will take part in this study. All will be enrolled at M. D. Anderson.

Study Type

Observational

Enrollment (Actual)

12

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Texas
      • Houston, Texas, United States, 77030
        • UT MD Anderson Cancer Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Individuals over the age of 18 with non-small cell lung cancer (NSCLC) and are scheduled to have a positron emission tomography/computed tomography (PET/CT) scan.

Description

Inclusion Criteria:

  1. Patients with lung or liver lesions measuring 0.5-2cm in diameter will be considered.
  2. Patients that are scheduled to be imaged in the PET/CT suite at the Mays Building will only be considered.

Exclusion Criteria:

  1. Pediatric patients (younger than 18 years) will be excluded.
  2. Patients that cannot tolerate being scanned for an additional 10 minutes with arms above their head will be excluded.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
PET/CT Scan
Procedure: PET/CT Scan
PET/CT scan performed with elastic belt around lower chest/upper abdomen to track breathing motion.
Other Names:
  • Positron Emission Tomography/Computed Tomography
  • Computed Tomography
  • Positron Emission Tomography

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Mean Difference Between Gated + Ungated PET/CT Scans
Time Frame: Scheduled PET/CT scans extended by 10 minutes
Scheduled PET/CT scans extended by 10 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

M.D. Anderson Cancer Center

Collaborators

GE Healthcare

Investigators

  • Principal Investigator: Osama R Mawlawi, PHD, UT MD Anderson Cancer Center

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2009

Primary Completion (Actual)

December 1, 2011

Study Completion (Actual)

December 1, 2011

Study Registration Dates

First Submitted

February 12, 2009

First Submitted That Met QC Criteria

February 12, 2009

First Posted (Estimate)

February 13, 2009

Study Record Updates

Last Update Posted (Estimate)

February 17, 2016

Last Update Submitted That Met QC Criteria

February 15, 2016

Last Verified

January 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2008-0851

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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