Glucose and Lipid Metabolism in Adolescents

Glucose and Lipid Metabolism in Adolescents

Sponsors

Lead sponsor: National Institutes of Health (NIH)

Source Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Brief Summary

A 12 wk aerobic exercise program will reduce visceral, hepatic and intramyocellular fat accumulation and improve insulin sensitivity and glucose metabolism in obese sedentary Hispanic adolescents.

Detailed Description

Lean and Obese post pubertal adolescents perform an aerobic exercise program 30 minx4/week at a heart rate corresponding to at least 70% of that obtained at VO2 peak. The exercise program is preceded and followed by a 7 d diet delivered by the metabolic research kitchen (identical on both study occasions); metabolic studies (identical on both study occasions) including 24h calorimetry, measurements of glucose and lipid metabolism and insulin sensitivity and secretion using compounds labelled with stable i.e. non radioactive isotopes and gas chromatography-mass spectrometry.Fat mass and lean body mass are measured by DXA and visceral/subcutaneous, hepatic and intramyocellular fat by MRI/MRS. Since we want to specifically determine the effects of exercise, there is no intent of weight loss. The subjects are weighed twice a week to assure weight stability.

Overall Status Unknown status
Start Date February 2004
Completion Date December 2011
Primary Completion Date December 2011
Study Type Observational
Primary Outcome
Measure Time Frame
Fat distribution, insulin sensitivity, glucose production, gluconeogenesis, glycogenolysis In response to a 12 wk exercise program.
Secondary Outcome
Measure Time Frame
Lipolysis, blood lipids, adiponectin, leptin and CRP In response to a 12 wk exercise program
Enrollment 42
Condition
Intervention

Intervention type: Behavioral

Intervention name: Exercise

Description: 12 wk aerobic or/ resistance exercise program

Arm group label: Adolescents

Eligibility

Sampling method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- Healthy

- No medication

- Sedentary

- No first degree relative with diabetes,

- Hispanic

- BMI >30 or <25 kg/m2.

Exclusion Criteria:

- Any medication including birth control pills

- Performing more than >45 min of moderate to light physical activity/week

- Chronic illness

Gender: All

Minimum age: 13 Years

Maximum age: 17 Years

Healthy volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Agneta L Sunehag, M.D., Ph.D Principal Investigator Baylor College of Medicine
Overall Contact

Last name: Agneta L Sunehag, M.D., Ph.D.

Phone: 713 798 6725

Email: [email protected]

Location
facility status contact investigator Baylor College of Medicine Agneta L Sunehag, M.D., Ph.D 713-798-6725 [email protected] Agneta L Sunehag, M.D., Ph.D Principal Investigator
Location Countries

United States

Verification Date

October 2009

Responsible Party

Name title: Agneta L Sunehag M.D., Ph.D.

Organization: Baylor College of Medicine, Houston TX

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Arm group label: Adolescents

Description: Post pubertal, sedentary lean and obese Hispanic adolescents

Study Design Info

Observational model: Cohort

Time perspective: Prospective

Source: ClinicalTrials.gov