Cardiovascular Evaluation Before Renal Transplantation

Cardiovascular Diagnostic Before Renal Transplantation: a Prospective Study to Assess Cardiovascular Morbidity Before Renal Transplantation and to Improve Standard Diagnostic Procedures.

Due to rising importance of cardiovascular disease before and after renal transplantation we have changed our standard diagnostic procedure and perform stress echocardiography and myocardial scintigraphy. We would like to monitor these results and the outcome of our patients.

Study Overview

• Status: Unknown
• Conditions: Coronary Artery Disease; Chronic Kidney Disease
• Intervention / Treatment: Other: diagnostic procedure

Detailed Description

Chronic kidney disease is a well-known risk factor for cardiovascular disease. Patients waiting for a renal transplantation usually undergo an extensive diagnostic procedure to avoid complications after transplantation such as neoplasia or inflammation. In the past years, cardiovascular complications before and after renal transplantation have gained more attention. We therefore have changed our standard diagnostic procedure before renal transplantation and perform stress echocardiography and myocardial scintigraphy. Thus we would like to evaluate our new standard diagnostic procedure and observe the results of these diagnostic procedures as well as their impact on clinical outcome.

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

• Study Contact: Name: Barbara Suwelack, MD; Phone Number: 00492518347540; Email: barbara.suwelack@ukmuenster.de
• Study Contact Backup: Name: Viola Malyar, MD; Phone Number: 00492518347540; Email: viola.malyar@ukmuenster.de

Study Locations

• Germany
  • Muenster, Germany, 48149
    • Recruiting
    • Department of Internal Medicine D, University Hospital Muenster
    • Contact: Barbara Suwelack, MD; Phone Number: 00492518347540; Email: barbara.suwelack@ukmuenster.de
    • Contact: Viola Malyar, MD; Phone Number: 00492518347540; Email: viola.malyar@ukmuenster.de

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All patients with endstage renal disease which are awaiting their ergsitration to our transplantation programm since July 2009 until July 2010.

Description

Inclusion Criteria:

• endstage renal disease
• preparing for renal transplantation

Exclusion Criteria:

• children (< 18 years)
• women who are pregnant or nursing
• patients who are also awaiting heart transplantation or have already a heart transplant
• severe mental illness

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
before renal transplantation; Patients with CKD IV° to V° who are actually registering for a renal transplantation in our department.	Other: diagnostic procedure; Cardiovascular diagnostic standard procedure before renal transplantation using stress echocardiography and stress myocardial scintigraphy.; Other Names: diagnostic standard procedure

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
cardiovascular morbidity	one year

Collaborators and Investigators

• Sponsor: University Hospital Muenster
• Investigators: Principal Investigator: Barbara Suwelack, MD, University Hospital Muenster; Study Chair: Hermann Pavenstädt, MD, University Hospital Muenster; Study Chair: Holger Reinecke, MD, University Hospital Muenster; Study Chair: Otmar Schober, MD, PhD, University Hospital Muenster

Study record dates

Study Major Dates

• Study Start: December 1, 2009
• Primary Completion (Anticipated): June 1, 2010
• Study Completion (Anticipated): September 1, 2010

Study Registration Dates

• First Submitted: February 5, 2010
• First Submitted That Met QC Criteria: February 5, 2010
• First Posted (Estimate): February 8, 2010

Study Record Updates

• Last Update Posted (Estimate): February 8, 2010
• Last Update Submitted That Met QC Criteria: February 5, 2010
• Last Verified: January 1, 2010

More Information

Terms related to this study

• Keywords: renal transplantation; cardiovascular morbidity; evaluation before renal transplantation
• Additional Relevant MeSH Terms: Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Urologic Diseases; Renal Insufficiency; Coronary Disease; Coronary Artery Disease; Kidney Diseases; Renal Insufficiency, Chronic
• Other Study ID Numbers: KVDiagnostikpratransplantation; HerzundNierenMünster (Registry Identifier: clinical trials registry.)