- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01828918
Biomarkers for the Early Diagnosis, Prediction, Prognosis for Colorectal Cancers
Kaohsiung Medical University Hospital
Study Overview
Detailed Description
Colorectal cancer (CRC) is one of the most frequent malignancies and is also the third major cause of cancer-related death in Taiwan, with over 11,000 new cases of CRC were diagnosed and more than 4,400 Taiwanese died from CRC in 2008 (Department of Health). CRC is regarded as the accumulation of acquired genetic and epigenetic changes causing disorders in cell growth, differentiation and apoptosis resulting in transformation of normal colonic epithelium to colon adenocarcinoma.
Recent basic and clinical research on the circulating tumor cells (CTCs) in CRC patients takes potential diagnostics, prognosis, and applications into consideration, especially the molecular detection of CTCs in peripheral blood. Moreover, identification of therapeutic targets on CTCs and real-time monitoring of CTCs in cancer patients undergoing systemic therapy are the most important future clinical applications. The investigators divide the current project into three dimensions to include all the biomarkers related to diagnostic, prognostic and predictive roles for the potential clinical implication. Sub-project 1: prognostic validation and economic evaluation of biochips/biomarkers. Sub-project 2: evaluation of biomarkers for tailored therapy. Sub-project 3: identification and validation of novel biomarkers for early detection. After accomplishment of three sub-projects, a comprehensive network including early diagnostic, prognostic and predictive biomarkers/biochips for high-risk screening, postoperative surveillance, therapeutic strategies of CRC patients will be formed.
Study Type
Enrollment (Anticipated)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
-
-
Kaohsiung, Taiwan, 807
- Recruiting
- Kaohsiung Medical University Hospital
-
Contact:
- Jaw-Yuan Wang, Professor
- Phone Number: 5583 +886-7-3121101
- Email: cy614112@ms14.hinet.net
-
Principal Investigator:
- Jaw-Yuan Wang, Professor
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Age > 18 y/o
- Histological / pathologic and image study proved colorectal cancer
- Patients with adequate tissue for biomarkers analysis
- Patients voluntary sign informed consent
Exclusion Criteria:
- Patients who are not met with either one of items which mentioned above.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: early recurrence
find the postoperative early relapse out
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
postoperative early recurrence
Time Frame: within 12 months postoperation
|
within 12 months postoperation
|
Collaborators and Investigators
Collaborators
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- KMUH-IRB-2012-03-02 (II)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Colorectal Cancers
-
Jules Bordet InstituteCompletedMetastatic Colorectal Cancers | Metastatic Gastric Cancers | Metastatic Oesophageal Cancers | Metastatic Pancreatic Cancers | Metastatic Biliary Cancers | Metastatic Breast CancersBelgium
-
National Cancer Institute (NCI)Active, not recruitingSmall Bowel Cancers | Colorectal CancersUnited States
-
Wang XinyingXijing Hospital; Peking Union Medical College Hospital; Chinese PLA General Hospital and other collaboratorsCompletedPrognosis | Nutrition Assessment | Gastrointestinal Cancers - Stomach | Gastrointestinal Cancers - Colorectal | Survival AnalysisChina
-
Ibrahim Halil SahinGlaxoSmithKlineNot yet recruitingMMR-D/MSI-H Colorectal CancersUnited States
-
The Rogosin InstituteVital Systems Inc.CompletedColorectal CancersUnited States
-
MapKure, LLCRecruitingColorectal Cancer | Pancreatic Ductal Cancer | Advanced or Metastatic RAS Mutant Colorectal and Pancreatic Ductal CancersUnited States
-
Sidney Kimmel Comprehensive Cancer Center at Johns...Merck Sharp & Dohme LLCCompletedMSI Positive Colorectal Cancer | MSI Negative Colorectal Cancer | MSI Positive Non-Colorectal CancersUnited States
-
Agenus Inc.CompletedAdvanced Solid Cancers | Advanced Solid Cancers Refractory to PD-1United States
-
Genomictree, Inc.Severance HospitalCompletedHealthy | Colorectal Cancer | Polyps | Other CancersKorea, Republic of
-
Ann & Robert H Lurie Children's Hospital of ChicagoRecruiting
Clinical Trials on microRNAs
-
Centre Hospitalier Universitaire de Saint EtienneCompleted
-
Regina Elena Cancer InstituteFondazione Policlinico Universitario Agostino Gemelli IRCCS; Weizmann Institute... and other collaboratorsRecruitingLiquid Biopsy | Squamous Cell Carcinoma of the Oropharynx | Lymph Node Metastasis | Carcinomas of Unknown Primary Site | High-risk Human Papillomavirus Infection | Occult Tumor of the Head and Neck AreaItaly
-
Medical University of ViennaActive, not recruitingBone Diseases, Metabolic | Bone | HypophosphatasiaAustria
-
Mansoura UniversityCompletedBladder Cancer | Bladder Disease | Bladder Neoplasm | Micro-RNAEgypt
-
Assistance Publique - Hôpitaux de ParisCompletedHealthy | Crohn Disease | Ulcerative Colitis | Non-IBD ColitisFrance