- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02018640
Biomarker Feedback to Motivate Tobacco Cessation in Pregnant ALaska Native Women: Phase 2 (MAW Phase 2)
December 15, 2017 updated by: Christi Patten, Mayo Clinic
Use of tobacco is very high among Alaska Native pregnant women.
The investigators are conducting a three phase study.
The first study is nearly completed and involved measuring biomarkers of tobacco exposure in mothers and infants.
The second phase of the research is a qualitative study to translate the biomarker findings to an intervention.
Study Overview
Status
Completed
Conditions
Detailed Description
Developing effective tobacco cessation interventions during pregnancy for American Indian and Alaska Native people is a national priority and will contribute to the U.S. public health objective of reducing tobacco-related cancer health disparities.
The proposed project builds on our successful partnership with the Alaska Native community and previous work with Alaska Native pregnant women.
We propose to develop and test a novel biomarker feedback intervention relating cotinine levels in the urine of pregnant women with the woman and infant's likely exposure to the tobacco specific nitrosamine and carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) (NNK).
This 5-year project will be conducted in three phases.
In Phase 1 we utilized a non-randomized, clinical observational trial to examine biomarkers of nicotine and carcinogen exposure (urine cotinine and total NNAL [a metabolite of NNK], respectively) among maternal-infant pairs with assessments conducted during pregnancy and at delivery.
In Phase 2, we will obtain qualitative feedback on the findings from Phase 1 through individual interviews conducted with women who use tobacco and a confidant (partner/friend/relative) they have identified to develop the biomarker feedback intervention messages.
Phase 3 will consist of a formative evaluation of the biomarker feedback intervention with pregnant women using a two-group randomized design to assess the intervention's feasibility and acceptability, and the biochemically confirmed abstinence rate at the end of pregnancy.
All phases of the project will be guided by a Community Advisory Committee.
Each phase is an important step to advance our understanding of the potential for biomarker feedback as a strategy to help Alaska Native pregnant women quit tobacco use.
The potential reach of the intervention is significant from a public health perspective as over 600 tobacco users deliver each year at the Alaska Native Medical Center in Anchorage where the proposed project will take place.
Developing effective interventions for tobacco cessation during pregnancy is important to reduce adverse health consequences for the mother and neonate and future risk of tobacco-caused cancers.
Study Type
Observational
Enrollment (Actual)
39
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Alaska
-
Anchorage, Alaska, United States, 99577
- Alaska Native Tribal Health Consortium
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 100 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Alaska Native women and their confidants
Description
Inclusion Criteria:
To be eligible the woman must:
- be Alaska Native
- be aged 18 years of age or older
- provide written informed consent
- have participated in Phase 1 of the research or is currently pregnant (<= 24 weeks gestation)
- have used any tobacco product at least once in the past 7 days (cigarettes or both cigarettes/ST)
To be eligible the confidant (he/she) must:
- be referred by the woman participant
- be aged 18 years of age or older
- provide written informed consent
Exclusion Criteria:
1. does not provide written informed consent
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
receptivity to cancer risk messages
Time Frame: baseline
|
interview of participant reactions to biomarker findings
|
baseline
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
confidant perceptions of cancer risk information
Time Frame: baseline
|
interview of family members, friends, relatives
|
baseline
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
December 1, 2013
Primary Completion (Actual)
August 1, 2015
Study Completion (Actual)
August 1, 2015
Study Registration Dates
First Submitted
December 17, 2013
First Submitted That Met QC Criteria
December 17, 2013
First Posted (Estimate)
December 23, 2013
Study Record Updates
Last Update Posted (Actual)
December 19, 2017
Last Update Submitted That Met QC Criteria
December 15, 2017
Last Verified
December 1, 2017
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 11-001144 Phase 2
- U54CA153605 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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