Optimization of MRI for Radiation Therapy

Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.

Study Overview

• Status: Recruiting
• Conditions: Cancer Liver; Cancer Brain; Cancer Head &Neck; Cancer Pelvis
• Intervention / Treatment: Procedure: MRI Group

• Study Type: Observational
• Enrollment (Estimated): 432

Contacts and Locations

• Study Contact: Name: Shruti Jolly, MD; Phone Number: 734-936-4300; Email: shrutij@umich.edu

Study Locations

• United States
  • Michigan
    • Ann Arbor, Michigan, United States, 48109
      • Recruiting
      • Univeristy of Michigan
      • Principal Investigator: Shruti Jolly, M.D.

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Participants having a working diagnosis of malignancy in the liver, brain, head and neck, or pelvis, and a plan to treat with radiotherapy.

Description

Inclusion Criteria:

• Patients ≥18 years of age
• A working diagnosis of malignancy in the liver, brain, H&N, or pelvis
• A plan to treat with radiotherapy

Exclusion Criteria:

• Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
MRI group; Patient receives one research MRI prior to radiation treatment.	Procedure: MRI Group; A single research MRI

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Percentage of participants with MRI images suitable for analyses	Patients will be off protocol immediately after the single MRI scan. Comparative treatment planning will occur off-line and will not be used for patient care.	Day One

Collaborators and Investigators

• Sponsor: University of Michigan Rogel Cancer Center
• Investigators: Principal Investigator: Shruti Jolly, MD, University of Michigan

Study record dates

Study Major Dates

• Study Start (Actual): March 14, 2013
• Primary Completion (Estimated): April 1, 2024
• Study Completion (Estimated): April 1, 2024

Study Registration Dates

• First Submitted: December 18, 2013
• First Submitted That Met QC Criteria: January 22, 2014
• First Posted (Estimated): January 24, 2014

Study Record Updates

• Last Update Posted (Actual): December 1, 2023
• Last Update Submitted That Met QC Criteria: November 30, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Keywords: MRI; Cancer
• Other Study ID Numbers: UMCC 2012.113; HUM00068061 (Other Identifier: University of Michigan)