MMP-9 Monitoring Particulate Cerebral Embolisation (MMP9MPCE)
April 8, 2014 updated by: Peking Union Medical College Hospital
Dynamic Changes of MMP9 Concentration Cross Carotid Endarterectomy Monitoring Particulate Cerebral Embolisation
- In carotid endarterectomy(CEA) surgery, the dynamic changes of plasma MMP9 concentration cross CEA will be identified.
- And the part of patients suffered particulate cerebral embolic injury, their MMP9 level will increase in the early stage after CEA.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Observational
Enrollment (Actual)
48
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Beijing
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Beijing, Beijing, China, 100730
- vascular surgery department of PUMCH
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
40 years to 90 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
patients under CEA in the PUMCH
Description
Inclusion Criteria:
-All patients enrolled had at least ≥70% unilateral or bilateral stenosis of Internal -Carotid Artery， or those who had a <70% stenosis but obvious cerebral ischema symptoms had been existed.
Exclusion Criteria:
- Exclusion criteria included poor temporal window
- Refused to cooperate with us
- Nonatheromatous such as takayasu arteritis and fibromuscular dysplasia.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
carotid endarterectomy (CEA)
CEA patients with vein blood collection
|
5 ml peripheral vein blood samples were collected from each patient admitted to our study at the following time-points：Pre-operative（morning of surgery），just before declamping，30mins after declamping and post-operative（12h）.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
|---|---|
|
postoperative ischemic stroke
Time Frame: 7 days after surgery
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7 days after surgery
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
|---|---|
|
postoperative elevation of plasma MMP9
Time Frame: perioperative phage
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perioperative phage
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2012
Primary Completion (Actual)
October 1, 2013
Study Completion (Actual)
November 1, 2013
Study Registration Dates
First Submitted
April 7, 2014
First Submitted That Met QC Criteria
April 8, 2014
First Posted (Estimate)
April 9, 2014
Study Record Updates
Last Update Posted (Estimate)
April 9, 2014
Last Update Submitted That Met QC Criteria
April 8, 2014
Last Verified
September 1, 2013
More Information
Terms related to this study
Other Study ID Numbers
- PUMCH-0321
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.