Application of MR-PET in Colorectal Cancer

This study will explore the potential value in proper therapeutic decision and clinical outcome prediction by using integrated MR-PET system and advanced MR techniques in patients with colorectal cancer.

Study Overview

• Status: Unknown
• Conditions: Colorectal Cancer
• Intervention / Treatment: Device: The imaging biomarkers determined by MR-PET

Detailed Description

This research expect that the image techniques and experience in this cancer group may be valuable and helpful for others. With advantage of MR-PET in better soft tissue delineation/functional information and less radiation dose than PET-CT, the ultimate goal in both research and clinical application is to establish new diagnostic standard and management guideline by MR-PET, which can further improve clinical outcome and disease prognosis in patients colorectal cancer.

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan
    • Recruiting
    • National Taiwan University Hospital
    • Contact: Ting-Fang Shih, MD; Phone Number: 65568 +886-2-23123456; Email: ttfshih@ntu.edu.tw

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 90 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

This is a prospective cohort study. Patients with 50 newly diagnosed colorectal cancers and 50 patients with suspicious recurrent colorectal cancers will be enrolled.

Description

Inclusion Criteria:

1. Group 1: Patients with newly diagnosed colorectal cancers
2. Group 2: Patients with suspicious recurrent colorectal cancers

Exclusion Criteria:

1. Age <20 or >90 years old
2. Contraindication for MRI: claustrophobia or MR non-compatible devices
3. Contraindication for MR contrast medium: severe adverse reaction or impaired renal function (Cre > 2.0)
4. History of other malignancy
5. Prior arthroplasty of hip (may cause artifacts on MRI)
6. Pregnancy

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
The recurrence rate at 1 year after surgery	1 year

Secondary Outcome Measures

Outcome Measure	Time Frame
The overall survival at 1 year after surgery	1 year

Collaborators and Investigators

• Sponsor: National Taiwan University Hospital
• Investigators: Principal Investigator: Ting-Fang Shih, M.D., Department of Medical Imaging, National Taiwan University Hospital.

Study record dates

Study Major Dates

• Study Start: July 1, 2014
• Primary Completion (Anticipated): December 1, 2017
• Study Completion (Anticipated): May 1, 2018

Study Registration Dates

• First Submitted: September 10, 2015
• First Submitted That Met QC Criteria: September 16, 2015
• First Posted (Estimate): September 17, 2015

Study Record Updates

• Last Update Posted (Actual): May 16, 2017
• Last Update Submitted That Met QC Criteria: May 14, 2017
• Last Verified: May 1, 2017

More Information

Terms related to this study

• Keywords: Application of MR-PET
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colorectal Neoplasms
• Other Study ID Numbers: 201403082MIND