Pre-eclampsia and Biochemical Markers (PET)

Correlation Between Complications of Pre-eclampsia and Detection of Novel Biochemical Markers

In view of both endothelial injury in pre-eclampsia, high blood pressure and kidney impairment characteristics, a recent study demonstrated that the serum levels of NGAL increased at the end of the second trimester in women who subsequently developed pre-eclampsia compared to the control group.

This correlates well with the endothelial damage that occurs during pre-eclampsia and thus NGAL can be considered as a promising marker in predicting both early and late onset pre-eclampsia. It may be required to combine one or more biomarker with NGAL to increase the precision, and sensitivity for detection of risk and reliability of using biomarkers for pre-eclampsia.

Study Overview

• Status: Completed
• Conditions: Detection of Preeclampsia Complications

• Study Type: Observational
• Enrollment (Actual): 90

Contacts and Locations

Study Locations

• Egypt
  • Cairo
    • Assiut, Cairo, Egypt, 002
      • Ahmed Abbas

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 40 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Probability Sample

Study Population

Pregnant women after 20 weeks

Description

Inclusion Criteria:

• Age 20-40 years.
• Gestational age >20 weeks.

Exclusion Criteria:

• Patients with preexisting renal disease,hypertension, diabetes mellitus, gestational hypertension.
• Patients Refuse to participate in the study
• Patients already have complicated preeclampsia.

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort
Eclampsia; pregnant women with eclampsia will be diagnosed by the occurrence of seizures on top of preeclampsia.
severe preeclampsia; pregnant women with severe preeclampsia will be diagnosed according to blood pressure ≥160/110 mmHg with proteinuria detection by boiling method +3,+4.
healthy; matched normotensive pregnant women.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
The level of circulating NGAL	24 hours

Collaborators and Investigators

• Sponsor: Assiut University

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2016
• Primary Completion (Actual): December 1, 2016
• Study Completion (Actual): May 1, 2017

Study Registration Dates

• First Submitted: January 22, 2016
• First Submitted That Met QC Criteria: January 25, 2016
• First Posted (Estimate): January 28, 2016

Study Record Updates

• Last Update Posted (Actual): June 9, 2017
• Last Update Submitted That Met QC Criteria: June 8, 2017
• Last Verified: June 1, 2017

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pregnancy Complications; Hypertension, Pregnancy-Induced; Eclampsia; Pre-Eclampsia
• Other Study ID Numbers: PET

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES