Likely Use of PrEP for African American YMSM

Factors Affecting the Likely Use of PrEP for African American Young Men Who Have Sex With Men

HIV Pre-Exposure Prophylaxis (PrEP), in the form of the anti-retroviral pill Truvada©, has been approved by the FDA as a method for reducing HIV transmission rates in the population, particularly young men who have sex with men (YMSM). This study will use a qualitative design to interview 20-30, HIV-negative, 16-24 year old African American YMSM to: 1) identify and understand African American YMSM's, aged 16-24, cognitive and emotional processes in response to using PrEP to reduce their risk for HIV and 2) identify what factors (sociocultural, individual, experiences in health care, socioeconomic) influence African American YMSM's likely use of PrEP as a coping strategy for HIV prevention. Demographic information will be collected and analyzed using Statistical Analysis Software version 9.3. Individual interviews will be audio recorded and transcribed by a vetted transcription service for analysis. This is minimal risk to participants.

Study Overview

• Status: Completed
• Conditions: HIV
• Intervention / Treatment: Other: No intervention used

Detailed Description

This study will use an exploratory, naturalistic qualitative design where participants will be interviewed to collect data on their emotional and cognitive processes (illness representation) in response to the threat of a potential HIV infection, and what factors (social, cultural, individual characteristics, and experiences in health care) influence their likely use of PrEP. The sample for this study will include 20 to 30 African American YMSM, aged 16-24, residing in Durham, Wake, and Orange counties of North Carolina.

The in-depth interview guide and the 26-item descriptive survey PrEP Knowledge, Sexual History, and Demographic Instrument were developed for this study using a combination of the concepts from the adapted Common Sense Model of Illness Representation (CSM) and questions adapted from the Adolescent Trial Network's (ATN) 082 study's questionnaire. Participants will be asked questions relating to African American YMSM's likely use of HIV Pre-Exposure Prophylaxis (PrEP) as an HIV risk-reduction strategy. Once informed consent is obtained, the interview will commence and study participants will be individually interviewed to discuss what factors influence their likely use of PrEP. Each participant will complete the descriptive survey and the one-on-one interview.

• Study Type: Observational
• Enrollment (Actual): 25

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 24 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

• Sampling Method: Non-Probability Sample

Study Population

20 to 30 African American young men who have sex with men, aged 16-24

Description

Inclusion Criteria:

• between the ages of 16-24
• self-identify as African-American, Black, or mixed race including African American or Black
• have been assigned male sex at birth
• self-identify as gay, bisexual, or queer, or self-identify as a heterosexual male who has had a past voluntary sexual experience with another man or currently has sexual desires for men
• report being uninfected with HIV
• be mentally capable of providing informed consent
• be able to speak and read English
• not currently using PrEP for HIV.

Exclusion Criteria:

• HIV-infected men are excluded because this study is focused on the prevention of HIV transmission
• Men who were not assigned male sex at birth are excluded from this study, because transgender men face very different and distinct issues with access to care compared to YMSM
• Men who are currently using PrEP are excluded from this study because this study is exploring the barriers and facilitators to use of PrEP in African American YMSM aged 16-24. Men who are currently using PrEP may have a different illness representation compared to men who are not using PrEP.

Study Plan

How is the study designed?

Design Details

• Observational Models: Ecologic or Community
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
African American YMSM	Other: No intervention used

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Factors that influence African American YMSM's likely use of PrEP	During patient interview, approximately 1.5 hours
Cognitive processes in response to using PrEP to reduce risk for HIV	During patient interview, approximately 1.5 hours
Emotional processes in response to using PrEP to reduce risk for HIV	During patient interview, approximately 1.5 hours

Collaborators and Investigators

• Sponsor: Duke University

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2016
• Primary Completion (Actual): December 29, 2016
• Study Completion (Actual): December 29, 2016

Study Registration Dates

• First Submitted: May 25, 2016
• First Submitted That Met QC Criteria: June 20, 2016
• First Posted (Estimate): June 22, 2016

Study Record Updates

• Last Update Posted (Actual): April 14, 2017
• Last Update Submitted That Met QC Criteria: April 12, 2017
• Last Verified: April 1, 2017

More Information

Terms related to this study

• Keywords: PrEP; HIV Prevention; African American YMSM; HIV Pre-Exposure Prophylaxis; Common Sense Model; Healthcare
• Other Study ID Numbers: Pro00070892

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No