Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer
April 11, 2024 updated by: National Cancer Institute (NCI)
A Randomized Phase III Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer
This phase III trial investigates how well nivolumab after combined modality therapy works in treating patients with high risk stage II-IIIB anal cancer.
Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Study Overview
Status
Active, not recruiting
Conditions
Intervention / Treatment
- Biological: Nivolumab
- Procedure: Magnetic Resonance Imaging
- Procedure: Biospecimen Collection
- Procedure: Biopsy
- Procedure: Computed Tomography
- Other: Patient Observation
- Procedure: Colonoscopy
- Procedure: Sigmoidoscopy
- Procedure: Digital Rectal Examination
- Procedure: High Resolution Anoscopy
- Procedure: Proctoscopy
- Procedure: X-Ray Imaging
Detailed Description
PRIMARY OBJECTIVE:
I. To evaluate whether therapy with nivolumab following combined modality therapy (CMT) improves disease-free survival (DFS) compared with observation in patients with high risk anal carcinoma.
SECONDARY OBJECTIVES:
I. To compare nivolumab following combined modality therapy (CMT) with observation in patients with high risk anal carcinoma with regard to:
Ia. Objective response rate (complete [CR] and partial [PR]), stable disease and progression.
Ib. Severe toxicity interval. Ic. Colostomy-free survival. Id. Overall survival. Ie. Toxicity.
OUTLINE: Patients who received standard CMT are randomized to 1 of 2 arms.
ARM A: Patients receive nivolumab intravenously (IV) while on study.
ARM B: Patients undergo observation while on study
Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, computed tomography (CT) scan, magnetic resonance imaging (MRI), biopsy and blood sample collection throughout the study.
Study Type
Interventional
Enrollment (Estimated)
344
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Alberta
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Calgary, Alberta, Canada, T2N 4N2
- Tom Baker Cancer Centre
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British Columbia
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Vancouver, British Columbia, Canada, V5Z 4E6
- BCCA-Vancouver Cancer Centre
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Newfoundland and Labrador
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St. John's, Newfoundland and Labrador, Canada, A1B 3V6
- Doctor H. Bliss Murphy Cancer Centre
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Ontario
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London, Ontario, Canada, N6A 4L6
- London Regional Cancer Program
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Ottawa, Ontario, Canada, K1H 8L6
- Ottawa Hospital and Cancer Center-General Campus
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Sault Ste Marie, Ontario, Canada, P6B 0A8
- Algoma District Cancer Program Sault Area Hospital
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Toronto, Ontario, Canada, M5G 2M9
- University Health Network-Princess Margaret Hospital
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Saskatchewan
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Regina, Saskatchewan, Canada, S4T 7T1
- Allan Blair Cancer Centre
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Saskatoon, Saskatchewan, Canada, S7N 4H4
- Saskatoon Cancer Centre
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Alabama
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Birmingham, Alabama, United States, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, United States, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, United States, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, United States, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, United States, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, United States, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, United States, 99508
- Katmai Oncology Group
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Anchorage, Alaska, United States, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, United States, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, United States, 99701
- Fairbanks Memorial Hospital
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Arizona
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Goodyear, Arizona, United States, 85338
- CTCA at Western Regional Medical Center
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Kingman, Arizona, United States, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, United States, 85054
- Mayo Clinic Hospital in Arizona
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Scottsdale, Arizona, United States, 85259
- Mayo Clinic in Arizona
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Arkansas
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Fort Smith, Arkansas, United States, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, United States, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Jonesboro, Arkansas, United States, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, United States, 72205
- University of Arkansas for Medical Sciences
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California
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Anaheim, California, United States, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, United States, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, United States, 93420
- PCR Oncology
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Arroyo Grande, California, United States, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Auburn, California, United States, 95602
- Sutter Auburn Faith Hospital
-
Auburn, California, United States, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, United States, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, United States, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, United States, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burbank, California, United States, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Burlingame, California, United States, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, United States, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, United States, 94546
- Eden Hospital Medical Center
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Chico, California, United States, 95926
- Enloe Medical Center
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Clovis, California, United States, 93611
- Community Cancer Institute
-
Clovis, California, United States, 93611
- University Oncology Associates
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Davis, California, United States, 95616
- Sutter Davis Hospital
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Dublin, California, United States, 94568
- Kaiser Permanente Dublin
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Fontana, California, United States, 92335
- Kaiser Permanente-Fontana
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Fremont, California, United States, 94538
- Kaiser Permanente-Fremont
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Fremont, California, United States, 94538
- Palo Alto Medical Foundation-Fremont
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Fresno, California, United States, 93720
- Kaiser Permanente-Fresno
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Fresno, California, United States, 93720
- Fresno Cancer Center
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Harbor City, California, United States, 90710
- Kaiser Permanente - Harbor City
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Irvine, California, United States, 92618
- Kaiser Permanente-Irvine
-
La Jolla, California, United States, 92093
- UC San Diego Moores Cancer Center
-
Los Angeles, California, United States, 90033
- USC / Norris Comprehensive Cancer Center
-
Los Angeles, California, United States, 90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles, California, United States, 90034
- Kaiser Permanente West Los Angeles
-
Los Angeles, California, United States, 90033
- Los Angeles General Medical Center
-
Marysville, California, United States, 95901
- Fremont - Rideout Cancer Center
-
Modesto, California, United States, 95355
- Memorial Medical Center
-
Modesto, California, United States, 95356
- Kaiser Permanente-Modesto
-
Mountain View, California, United States, 94040
- Palo Alto Medical Foundation-Camino Division
-
Mountain View, California, United States, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Newport Beach, California, United States, 92663
- USC Norris Oncology/Hematology-Newport Beach
-
Novato, California, United States, 94945
- Sutter Cancer Research Consortium
-
Oakland, California, United States, 94611
- Kaiser Permanente-Oakland
-
Oakland, California, United States, 94611
- Kaiser Permanente Oakland-Broadway
-
Ontario, California, United States, 91761
- Kaiser Permanente-Ontario
-
Orange, California, United States, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, United States, 94304
- Stanford Cancer Institute Palo Alto
-
Palo Alto, California, United States, 94301
- Palo Alto Medical Foundation Health Care
-
Panorama City, California, United States, 91402
- Kaiser Permanente - Panorama City
-
Pasadena, California, United States, 91105
- Keck Medical Center of USC Pasadena
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Rancho Cordova, California, United States, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Rancho Mirage, California, United States, 92270
- Eisenhower Medical Center
-
Redwood City, California, United States, 94063
- Kaiser Permanente-Redwood City
-
Richmond, California, United States, 94801
- Kaiser Permanente-Richmond
-
Riverside, California, United States, 92505
- Kaiser Permanente-Riverside
-
Rohnert Park, California, United States, 94928
- Rohnert Park Cancer Center
-
Roseville, California, United States, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
-
Roseville, California, United States, 95661
- Kaiser Permanente-Roseville
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Roseville, California, United States, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, United States, 95661
- Sutter Roseville Medical Center
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Sacramento, California, United States, 95816
- Sutter Medical Center Sacramento
-
Sacramento, California, United States, 95817
- University of California Davis Comprehensive Cancer Center
-
Sacramento, California, United States, 95814
- Kaiser Permanente Downtown Commons
-
Sacramento, California, United States, 95823
- Kaiser Permanente-South Sacramento
-
Sacramento, California, United States, 95823
- South Sacramento Cancer Center
-
Sacramento, California, United States, 95825
- Kaiser Permanente - Sacramento
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San Diego, California, United States, 92120
- Kaiser Permanente-San Diego Zion
-
San Diego, California, United States, 92108
- Kaiser Permanente-San Diego Mission
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San Francisco, California, United States, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, United States, 94115
- California Pacific Medical Center-Pacific Campus
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San Francisco, California, United States, 94110
- Zuckerberg San Francisco General Hospital
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San Jose, California, United States, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, United States, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, United States, 92078
- Kaiser Permanente-San Marcos
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San Mateo, California, United States, 94401
- Mills Health Center
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San Rafael, California, United States, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, United States, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, United States, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, United States, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Maria, California, United States, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, United States, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, United States, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, United States, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, United States, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, United States, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, United States, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vacaville, California, United States, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vacaville, California, United States, 95687
- Sutter Cancer Centers Radiation Oncology Services-Vacaville
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Vallejo, California, United States, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, United States, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, United States, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, United States, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, United States, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, United States, 80012
- The Medical Center of Aurora
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Aurora, Colorado, United States, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, United States, 80301
- Boulder Community Hospital
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Boulder, Colorado, United States, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, United States, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, United States, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, United States, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, United States, 80920
- Memorial Hospital North
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Denver, Colorado, United States, 80210
- Porter Adventist Hospital
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Denver, Colorado, United States, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, United States, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, United States, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, United States, 80220
- Rose Medical Center
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Denver, Colorado, United States, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, United States, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, United States, 80204
- Denver Health Medical Center
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Denver, Colorado, United States, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, United States, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, United States, 80209
- The Women's Imaging Center
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Denver, Colorado, United States, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, United States, 80220
- Western Surgical Care
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Durango, Colorado, United States, 81301
- Mercy Medical Center
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Durango, Colorado, United States, 81301
- Southwest Oncology PC
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Englewood, Colorado, United States, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, United States, 80113
- Swedish Medical Center
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Fort Collins, Colorado, United States, 80524
- Poudre Valley Hospital
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Golden, Colorado, United States, 80401
- Mountain Blue Cancer Care Center
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Golden, Colorado, United States, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, United States, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, United States, 80631
- North Colorado Medical Center
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Lafayette, Colorado, United States, 80026
- Good Samaritan Medical Center
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Lafayette, Colorado, United States, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, United States, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, United States, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, United States, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, United States, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, United States, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, United States, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, United States, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, United States, 80501
- Longmont United Hospital
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Longmont, Colorado, United States, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, United States, 80539
- McKee Medical Center
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Parker, Colorado, United States, 80138
- Parker Adventist Hospital
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Parker, Colorado, United States, 80138
- Rocky Mountain Cancer Centers-Parker
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Pueblo, Colorado, United States, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, United States, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, United States, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, United States, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, United States, 80033
- SCL Health Lutheran Medical Center
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Delaware
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Frankford, Delaware, United States, 19945
- Beebe South Coastal Health Campus
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Lewes, Delaware, United States, 19958
- Beebe Medical Center
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Newark, Delaware, United States, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, United States, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, United States, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, United States, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, United States, 19971
- Beebe Health Campus
-
Seaford, Delaware, United States, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, United States, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington, District of Columbia, United States, 20037
- George Washington University Medical Center
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Florida
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Altamonte Springs, Florida, United States, 32701
- AdventHealth Altamonte
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Aventura, Florida, United States, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
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Celebration, Florida, United States, 34747
- AdventHealth Celebration
-
Coral Gables, Florida, United States, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, United States, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Lauderdale, Florida, United States, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, United States, 33308
- Holy Cross Hospital
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Gainesville, Florida, United States, 32610
- University of Florida Health Science Center - Gainesville
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Hollywood, Florida, United States, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Jacksonville, Florida, United States, 32224-9980
- Mayo Clinic in Florida
-
Kissimmee, Florida, United States, 34744
- AdventHealth Kissimmee
-
Miami, Florida, United States, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, United States, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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Miami Beach, Florida, United States, 33140
- Mount Sinai Medical Center
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Orlando, Florida, United States, 32803
- AdventHealth Orlando
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Orlando, Florida, United States, 32803
- AdventHealth Medical Group Urology at Orlando
-
Orlando, Florida, United States, 32822
- AdventHealth East Orlando
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Pembroke Pines, Florida, United States, 33028
- Memorial Hospital West
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Pensacola, Florida, United States, 32504
- Sacred Heart Hospital
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Weston, Florida, United States, 33331
- Cleveland Clinic-Weston
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Winter Park, Florida, United States, 32792
- AdventHealth Winter Park
-
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Georgia
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Atlanta, Georgia, United States, 30308
- Emory University Hospital Midtown
-
Atlanta, Georgia, United States, 30322
- Emory University Hospital/Winship Cancer Institute
-
Atlanta, Georgia, United States, 30342
- Emory Saint Joseph's Hospital
-
Atlanta, Georgia, United States, 30303
- Grady Health System
-
Atlanta, Georgia, United States, 30309
- Piedmont Hospital
-
Decatur, Georgia, United States, 30033
- Atlanta VA Medical Center
-
Fayetteville, Georgia, United States, 30214
- Piedmont Fayette Hospital
-
Johns Creek, Georgia, United States, 30097
- Emory Johns Creek Hospital
-
Savannah, Georgia, United States, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah, Georgia, United States, 31405
- Summit Cancer Care-Candler
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Hawaii
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Honolulu, Hawaii, United States, 96819
- Kaiser Permanente Moanalua Medical Center
-
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Idaho
-
Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, United States, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, United States, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene, Idaho, United States, 83814
- Kootenai Health - Coeur d'Alene
-
Emmett, Idaho, United States, 83617
- Walter Knox Memorial Hospital
-
Fruitland, Idaho, United States, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, United States, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, United States, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, United States, 83686
- Saint Luke's Cancer Institute - Nampa
-
Nampa, Idaho, United States, 83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Post Falls, Idaho, United States, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, United States, 83864
- Kootenai Cancer Clinic
-
Twin Falls, Idaho, United States, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, United States, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
-
Burr Ridge, Illinois, United States, 60527
- Loyola Center for Health at Burr Ridge
-
Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, United States, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, United States, 62918
- SIH Cancer Institute
-
Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, United States, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, United States, 60611
- Northwestern University
-
Chicago, Illinois, United States, 60612
- Rush University Medical Center
-
Chicago, Illinois, United States, 60612
- University of Illinois
-
Danville, Illinois, United States, 61832
- Carle at The Riverfront
-
Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, United States, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Dixon, Illinois, United States, 61021
- Illinois CancerCare-Dixon
-
Effingham, Illinois, United States, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, United States, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
-
Evanston, Illinois, United States, 60201
- NorthShore University HealthSystem-Evanston Hospital
-
Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
-
Glenview, Illinois, United States, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
-
Highland Park, Illinois, United States, 60035
- NorthShore University HealthSystem-Highland Park Hospital
-
Homer Glen, Illinois, United States, 60491
- Loyola Medicine Homer Glen
-
Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest, Illinois, United States, 60045
- Northwestern Medicine Lake Forest Hospital
-
Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, United States, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, United States, 60153
- Loyola University Medical Center
-
Melrose Park, Illinois, United States, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
-
Mount Vernon, Illinois, United States, 62864
- Good Samaritan Regional Health Center
-
O'Fallon, Illinois, United States, 62269
- Cancer Care Center of O'Fallon
-
Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, United States, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
-
Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, United States, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, United States, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, United States, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
-
Springfield, Illinois, United States, 62781
- Memorial Medical Center
-
Springfield, Illinois, United States, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, United States, 62702
- Springfield Clinic
-
Swansea, Illinois, United States, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, United States, 61801
- Carle Cancer Center
-
Urbana, Illinois, United States, 61801
- The Carle Foundation Hospital
-
Washington, Illinois, United States, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, United States, 60560
- Rush-Copley Healthcare Center
-
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Indiana
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Carmel, Indiana, United States, 46032
- IU Health North Hospital
-
Indianapolis, Indiana, United States, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, United States, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Indianapolis, Indiana, United States, 46202
- Sidney and Lois Eskenazi Hospital
-
Indianapolis, Indiana, United States, 46290
- Springmill Medical Center
-
Lafayette, Indiana, United States, 47905
- Franciscan Saint Elizabeth Health - Lafayette East
-
Michigan City, Indiana, United States, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, United States, 46158
- Franciscan Health Mooresville
-
New Albany, Indiana, United States, 47150
- Baptist Health Floyd
-
Terre Haute, Indiana, United States, 47804
- Union Hospital
-
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Iowa
-
Bettendorf, Iowa, United States, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, United States, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, United States, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, United States, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, United States, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, United States, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, United States, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, United States, 50314
- Mission Cancer and Blood - Laurel
-
Des Moines, Iowa, United States, 50316
- Iowa Lutheran Hospital
-
Fort Dodge, Iowa, United States, 50501
- Trinity Regional Medical Center
-
Iowa City, Iowa, United States, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
West Des Moines, Iowa, United States, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, United States, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, United States, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, United States, 67042
- Cancer Center of Kansas - El Dorado
-
Fairway, Kansas, United States, 66205
- University of Kansas Clinical Research Center
-
Independence, Kansas, United States, 67301
- Cancer Center of Kansas-Independence
-
Kingman, Kansas, United States, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, United States, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, United States, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, United States, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, United States, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, United States, 66061
- Olathe Health Cancer Center
-
Parsons, Kansas, United States, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, United States, 66762
- Ascension Via Christi - Pittsburg
-
Pratt, Kansas, United States, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, United States, 67401
- Salina Regional Health Center
-
Salina, Kansas, United States, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, United States, 66606
- University of Kansas Health System Saint Francis Campus
-
Wellington, Kansas, United States, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, United States, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, United States, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Wichita
-
Winfield, Kansas, United States, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, United States, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, United States, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, United States, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, United States, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, United States, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, United States, 40503
- Baptist Health Lexington
-
London, Kentucky, United States, 40741
- Saint Joseph London
-
Louisville, Kentucky, United States, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, United States, 40202
- Jewish Hospital
-
Louisville, Kentucky, United States, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, United States, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, United States, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, United States, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, United States, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, United States, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, United States, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, United States, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, United States, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, United States, 70809
- Our Lady of the Lake Physicians Group - Medical Oncology
-
Metairie, Louisiana, United States, 70006
- East Jefferson General Hospital
-
New Orleans, Louisiana, United States, 70112
- Louisiana State University Health Science Center
-
-
Maryland
-
Baltimore, Maryland, United States, 21204
- Greater Baltimore Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, United States, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, United States, 02118
- Boston Medical Center
-
Fitchburg, Massachusetts, United States, 01420
- Simonds-Sinon Regional Cancer Center
-
Springfield, Massachusetts, United States, 01104
- Mercy Medical Center
-
Worcester, Massachusetts, United States, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48109
- University of Michigan Comprehensive Cancer Center
-
Ann Arbor, Michigan, United States, 48106
- Saint Joseph Mercy Hospital
-
Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
-
Bay City, Michigan, United States, 48706
- McLaren Cancer Institute-Bay City
-
Bloomfield, Michigan, United States, 48302
- McLaren Cancer Institute-Bloomfield
-
Brighton, Michigan, United States, 48114
- Saint Joseph Mercy Brighton
-
Brighton, Michigan, United States, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, United States, 48116
- University of Michigan - Brighton Center for Specialty Care
-
Brownstown, Michigan, United States, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, United States, 48188
- Saint Joseph Mercy Canton
-
Canton, Michigan, United States, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Caro, Michigan, United States, 48723
- Caro Cancer Center
-
Chelsea, Michigan, United States, 48118
- Saint Joseph Mercy Chelsea
-
Chelsea, Michigan, United States, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Clarkston, Michigan, United States, 48346
- McLaren Cancer Institute-Clarkston
-
Clarkston, Michigan, United States, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, United States, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, United States, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, United States, 48124
- Beaumont Hospital - Dearborn
-
Dearborn, Michigan, United States, 48126
- Henry Ford Medical Center-Fairlane
-
Detroit, Michigan, United States, 48202
- Henry Ford Hospital
-
Detroit, Michigan, United States, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, United States, 48236
- Ascension Saint John Hospital
-
East China Township, Michigan, United States, 48054
- Great Lakes Cancer Management Specialists-Doctors Park
-
Farmington Hills, Michigan, United States, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, United States, 48336
- Beaumont Hospital - Farmington Hills
-
Flint, Michigan, United States, 48532
- McLaren Cancer Institute-Flint
-
Flint, Michigan, United States, 48532
- Singh and Arora Hematology Oncology PC
-
Flint, Michigan, United States, 48503
- Hurley Medical Center
-
Flint, Michigan, United States, 48503
- Genesee Cancer and Blood Disease Treatment Center
-
Flint, Michigan, United States, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, United States, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, United States, 49503
- Helen DeVos Children's Hospital at Spectrum Health
-
Grand Rapids, Michigan, United States, 49503
- Trinity Health Grand Rapids Hospital
-
Grosse Pointe, Michigan, United States, 48230
- William Beaumont Hospital-Grosse Pointe
-
Grosse Pointe Woods, Michigan, United States, 48236
- Academic Hematology Oncology Specialists
-
Grosse Pointe Woods, Michigan, United States, 48236
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
-
Grosse Pointe Woods, Michigan, United States, 48236
- Michigan Breast Specialists-Grosse Pointe Woods
-
Jackson, Michigan, United States, 49201
- Allegiance Health
-
Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, United States, 49048
- Borgess Medical Center
-
Lansing, Michigan, United States, 48912
- Mid-Michigan Physicians-Lansing
-
Lansing, Michigan, United States, 48910
- Karmanos Cancer Institute at McLaren Greater Lansing
-
Lansing, Michigan, United States, 48912
- University of Michigan Health - Sparrow Lansing
-
Lapeer, Michigan, United States, 48446
- McLaren Cancer Institute-Lapeer Region
-
Livonia, Michigan, United States, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, United States, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, United States, 48044
- Great Lakes Cancer Management Specialists-Macomb Medical Campus
-
Macomb, Michigan, United States, 48044
- Michigan Breast Specialists-Macomb Township
-
Marlette, Michigan, United States, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Mount Clemens, Michigan, United States, 48043
- McLaren Cancer Institute-Macomb
-
Mount Pleasant, Michigan, United States, 48858
- McLaren Cancer Institute-Central Michigan
-
Muskegon, Michigan, United States, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, United States, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, United States, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, United States, 48374
- Ascension Providence Hospitals - Novi
-
Novi, Michigan, United States, 48377
- Henry Ford Medical Center-Columbus
-
Petoskey, Michigan, United States, 49770
- McLaren Cancer Institute-Northern Michigan
-
Pontiac, Michigan, United States, 48341
- Saint Joseph Mercy Oakland
-
Pontiac, Michigan, United States, 48341
- 21st Century Oncology-Pontiac
-
Pontiac, Michigan, United States, 48341
- Hope Cancer Center
-
Pontiac, Michigan, United States, 48341
- Newland Medical Associates-Pontiac
-
Port Huron, Michigan, United States, 48060
- McLaren-Port Huron
-
Reed City, Michigan, United States, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, United States, 48309
- Great Lakes Cancer Management Specialists-Rochester Hills
-
Roseville, Michigan, United States, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, United States, 48073
- William Beaumont Hospital-Royal Oak
-
Royal Oak, Michigan, United States, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, United States, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, United States, 48073
- Hematology Oncology Consultants PC
-
Royal Oak, Michigan, United States, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, United States, 48067
- Oakland Colon Rectal Associates
-
Saginaw, Michigan, United States, 48601
- Ascension Saint Mary's Hospital
-
Saginaw, Michigan, United States, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, United States, 48604
- Covenant HealthCare Mackinaw
-
Saint Joseph, Michigan, United States, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, United States, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Shelby, Michigan, United States, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Southfield, Michigan, United States, 48075
- Ascension Providence Hospitals - Southfield
-
Sterling Heights, Michigan, United States, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Sterling Heights, Michigan, United States, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, United States, 48314
- Mitchell Folbe MD PC
-
Tawas City, Michigan, United States, 48764
- Ascension Saint Joseph Hospital
-
Traverse City, Michigan, United States, 49684
- Munson Medical Center
-
Troy, Michigan, United States, 48085
- William Beaumont Hospital - Troy
-
Troy, Michigan, United States, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, United States, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, United States, 48098
- Hematology Oncology Consultants PC-Troy
-
Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
-
Warren, Michigan, United States, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, United States, 48093
- Great Lakes Cancer Management Specialists-Macomb Professional Building
-
Warren, Michigan, United States, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, United States, 48093
- Michigan Breast Specialists-Warren
-
West Bloomfield, Michigan, United States, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, United States, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, United States, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, United States, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, United States, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, United States, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, United States, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, United States, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, United States, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, United States, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Deer River, Minnesota, United States, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, United States, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, United States, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, United States, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, United States, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, United States, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, United States, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, United States, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hibbing, Minnesota, United States, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, United States, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, United States, 55454
- Health Partners Inc
-
Monticello, Minnesota, United States, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, United States, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, United States, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, United States, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, United States, 55905
- Mayo Clinic in Rochester
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, United States, 55101
- Regions Hospital
-
Saint Paul, Minnesota, United States, 55102
- United Hospital
-
Sandstone, Minnesota, United States, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, United States, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, United States, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, United States, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, United States, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, United States, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Grenada, Mississippi, United States, 38901
- Baptist Cancer Center-Grenada
-
New Albany, Mississippi, United States, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, United States, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, United States, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, United States, 63011
- Saint Louis Cancer and Breast Institute-Ballwin
-
Bonne Terre, Missouri, United States, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, United States, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Southeast Cancer Center
-
Chesterfield, Missouri, United States, 63017
- Saint Luke's Hospital
-
Creve Coeur, Missouri, United States, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, United States, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, United States, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, United States, 64804
- Freeman Health System
-
Joplin, Missouri, United States, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, United States, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, United States, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, United States, 64506
- Heartland Regional Medical Center
-
Saint Louis, Missouri, United States, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, United States, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, United States, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, United States, 63128
- Mercy Hospital South
-
Saint Louis, Missouri, United States, 63129
- Siteman Cancer Center-South County
-
Saint Louis, Missouri, United States, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Peters, Missouri, United States, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Sainte Genevieve, Missouri, United States, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, United States, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, United States, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, United States, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, United States, 63127
- BJC Outpatient Center at Sunset Hills
-
Washington, Missouri, United States, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, United States, 59711
- Community Hospital of Anaconda
-
Billings, Montana, United States, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, United States, 59101
- Saint Vincent Healthcare
-
Billings, Montana, United States, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, United States, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, United States, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Helena, Montana, United States, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, United States, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, United States, 59804
- Community Medical Hospital
-
Missoula, Montana, United States, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Grand Island, Nebraska, United States, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, United States, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, United States, 68845
- Heartland Hematology and Oncology
-
Lincoln, Nebraska, United States, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, United States, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, United States, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, United States, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, United States, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, United States, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, United States, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, United States, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, United States, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, United States, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, United States, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, United States, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, United States, 89074
- GenesisCare USA - Henderson
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, United States, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, United States, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, United States, 89074
- Urology Specialists of Nevada - Green Valley
-
Las Vegas, Nevada, United States, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, United States, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, United States, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, United States, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, United States, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, United States, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, United States, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, United States, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, United States, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, United States, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, United States, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, United States, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, United States, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, United States, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, United States, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, United States, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, United States, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, United States, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, United States, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, United States, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, United States, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, United States, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, United States, 89102
- Desert West Surgery
-
Las Vegas, Nevada, United States, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, United States, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, United States, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, United States, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, United States, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, United States, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, United States, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89169
- University Cancer Center
-
Las Vegas, Nevada, United States, 89113
- Urology Specialists of Nevada - Southwest
-
Pahrump, Nevada, United States, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, United States, 89502
- Renown Regional Medical Center
-
Reno, Nevada, United States, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, United States, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon, New Hampshire, United States, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Basking Ridge, New Jersey, United States, 07920
- Memorial Sloan Kettering Basking Ridge
-
Middletown, New Jersey, United States, 07748
- Memorial Sloan Kettering Monmouth
-
Montvale, New Jersey, United States, 07645
- Memorial Sloan Kettering Bergen
-
Moorestown, New Jersey, United States, 08057
- Virtua Samson Cancer Center
-
Morristown, New Jersey, United States, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, United States, 08060
- Virtua Memorial
-
New Brunswick, New Jersey, United States, 08903
- Rutgers Cancer Institute of New Jersey
-
Summit, New Jersey, United States, 07902
- Overlook Hospital
-
Teaneck, New Jersey, United States, 07666
- Holy Name Hospital
-
Voorhees, New Jersey, United States, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, United States, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, United States, 87109
- Lovelace Radiation Oncology
-
Albuquerque, New Mexico, United States, 87110
- Presbyterian Kaseman Hospital
-
Rio Rancho, New Mexico, United States, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
-
New York
-
Bronx, New York, United States, 10461
- Montefiore Medical Center-Einstein Campus
-
Bronx, New York, United States, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, United States, 10461
- Montefiore Medical Center-Weiler Hospital
-
Buffalo, New York, United States, 14263
- Roswell Park Cancer Institute
-
Commack, New York, United States, 11725
- Memorial Sloan Kettering Commack
-
Glens Falls, New York, United States, 12801
- Glens Falls Hospital
-
Harrison, New York, United States, 10604
- Memorial Sloan Kettering Westchester
-
New York, New York, United States, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, United States, 10019
- Mount Sinai West
-
New York, New York, United States, 10029
- Mount Sinai Hospital
-
New York, New York, United States, 10021
- Lenox Hill Hospital
-
New York, New York, United States, 10065
- Manhattan Eye Ear and Throat Hospital
-
Uniondale, New York, United States, 11553
- Memorial Sloan Kettering Nassau
-
-
North Carolina
-
Albemarle, North Carolina, United States, 28002
- Atrium Health Stanly/LCI-Albemarle
-
Chapel Hill, North Carolina, United States, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, United States, 28203
- Carolinas Medical Center/Levine Cancer Institute
-
Charlotte, North Carolina, United States, 28210
- Atrium Health Pineville/LCI-Pineville
-
Charlotte, North Carolina, United States, 28262
- Atrium Health University City/LCI-University
-
Charlotte, North Carolina, United States, 28211
- Levine Cancer Institute-SouthPark
-
Charlotte, North Carolina, United States, 28277
- Levine Cancer Institute-Ballantyne
-
Clemmons, North Carolina, United States, 27012
- Wake Forest University at Clemmons
-
Clinton, North Carolina, United States, 28328
- Southeastern Medical Oncology Center-Clinton
-
Concord, North Carolina, United States, 28025
- Atrium Health Cabarrus/LCI-Concord
-
Elkin, North Carolina, United States, 28521
- Wake Forest University at Elkin
-
Gastonia, North Carolina, United States, 28054
- Levine Cancer Institute-Gaston
-
Goldsboro, North Carolina, United States, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, United States, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, United States, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, United States, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, United States, 28546
- Onslow Memorial Hospital
-
Kenansville, North Carolina, United States, 28349
- Vidant Oncology-Kenansville
-
Kinston, North Carolina, United States, 28501
- Vidant Oncology-Kinston
-
Lexington, North Carolina, United States, 27292
- Wake Forest University at Lexington
-
Lincolnton, North Carolina, United States, 28092
- Atrium Health Lincoln/LCI-Lincolnton
-
Monroe, North Carolina, United States, 28112
- Atrium Health Union/LCI-Union
-
Mount Airy, North Carolina, United States, 27030
- Wake Forest University at Mount Airy
-
Raleigh, North Carolina, United States, 27607
- UNC Rex Healthcare
-
Raleigh, North Carolina, United States, 27614
- UNC Rex Cancer Center of Wakefield
-
Raleigh, North Carolina, United States, 27607
- Rex Hematology Oncology Associates-Blue Ridge
-
Richlands, North Carolina, United States, 28574
- Vidant Oncology-Richlands
-
Winston-Salem, North Carolina, United States, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, United States, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, United States, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, United States, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, United States, 58103
- Sanford South University Medical Center
-
Jamestown, North Dakota, United States, 58401
- Essentia Health - Jamestown Clinic
-
Minot, North Dakota, United States, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Beachwood, Ohio, United States, 44122
- UHHS-Chagrin Highlands Medical Center
-
Belpre, Ohio, United States, 45714
- Strecker Cancer Center-Belpre
-
Chardon, Ohio, United States, 44024
- Geauga Hospital
-
Chillicothe, Ohio, United States, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, United States, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, United States, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, United States, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, United States, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, United States, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, United States, 44106
- Case Western Reserve University
-
Cleveland, Ohio, United States, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, United States, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, United States, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, United States, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, United States, 43228
- Doctors Hospital
-
Columbus, Ohio, United States, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, United States, 43215
- Grant Medical Center
-
Columbus, Ohio, United States, 43222
- Mount Carmel Health Center West
-
Delaware, Ohio, United States, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, United States, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, United States, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, United States, 43016
- Dublin Methodist Hospital
-
Elyria, Ohio, United States, 44035
- Mercy Cancer Center-Elyria
-
Grove City, Ohio, United States, 43123
- Mount Carmel Grove City Hospital
-
Lancaster, Ohio, United States, 43130
- Fairfield Medical Center
-
Mansfield, Ohio, United States, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, United States, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, United States, 43302
- OhioHealth Marion General Hospital
-
Mayfield Heights, Ohio, United States, 44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor, Ohio, United States, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, United States, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, United States, 43050
- Knox Community Hospital
-
Newark, Ohio, United States, 43055
- Licking Memorial Hospital
-
Newark, Ohio, United States, 43055
- Newark Radiation Oncology
-
Parma, Ohio, United States, 44129
- University Hospitals Parma Medical Center
-
Portsmouth, Ohio, United States, 45662
- Southern Ohio Medical Center
-
Ravenna, Ohio, United States, 44266
- University Hospitals Portage Medical Center
-
Sandusky, Ohio, United States, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Wadsworth, Ohio, United States, 44281
- University Hospitals Sharon Health Center
-
West Chester, Ohio, United States, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, United States, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, United States, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Westlake, Ohio, United States, 44145
- UHHS-Westlake Medical Center
-
Zanesville, Ohio, United States, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, United States, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, United States, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, United States, 97814
- Saint Alphonsus Medical Center-Baker City
-
Bend, Oregon, United States, 97701
- Saint Charles Health System
-
Clackamas, Oregon, United States, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, United States, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, United States, 97420
- Bay Area Hospital
-
Newberg, Oregon, United States, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, United States, 97914
- Saint Alphonsus Medical Center-Ontario
-
Portland, Oregon, United States, 97239
- Oregon Health and Science University
-
Portland, Oregon, United States, 97213
- Providence Portland Medical Center
-
Portland, Oregon, United States, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, United States, 97227
- Kaiser Permanente Northwest
-
Redmond, Oregon, United States, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Abington, Pennsylvania, United States, 19001
- Jefferson Abington Hospital
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Beaver, Pennsylvania, United States, 15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, United States, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, United States, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, United States, 19317
- Christiana Care Health System-Concord Health Center
-
Collegeville, Pennsylvania, United States, 19426
- Main Line Health Center-Collegeville
-
Danville, Pennsylvania, United States, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, United States, 18301
- Pocono Medical Center
-
Exton, Pennsylvania, United States, 19341
- Main Line Health Center-Exton
-
Greensburg, Pennsylvania, United States, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Harrisburg, Pennsylvania, United States, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Harrisburg, Pennsylvania, United States, 17101
- UPMC Pinnacle Harrisburg
-
Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, United States, 18201
- Lehigh Valley Hospital-Hazleton
-
Johnstown, Pennsylvania, United States, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, United States, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, United States, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, United States, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Media, Pennsylvania, United States, 19063
- Riddle Memorial Hospital
-
Moon, Pennsylvania, United States, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Paoli, Pennsylvania, United States, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, United States, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, United States, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, United States, 19114
- Jefferson Torresdale Hospital
-
Philadelphia, Pennsylvania, United States, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, United States, 19140
- Temple University Hospital
-
Philadelphia, Pennsylvania, United States, 19107
- Pennsylvania Hospital
-
Pittsburgh, Pennsylvania, United States, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, United States, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, United States, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, United States, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, United States, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, United States, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, United States, 17901
- Geisinger Cancer Services-Pottsville
-
Seneca, Pennsylvania, United States, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, United States, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, United States, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Reading, Pennsylvania, United States, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Willow Grove, Pennsylvania, United States, 19090
- Asplundh Cancer Pavilion
-
Wynnewood, Pennsylvania, United States, 19096
- Lankenau Medical Center
-
York, Pennsylvania, United States, 17408
- UPMC Memorial
-
-
South Carolina
-
Boiling Springs, South Carolina, United States, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Clinton, South Carolina, United States, 29325
- Prisma Health Cancer Institute - Laurens
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, United States, 29341
- Gibbs Cancer Center-Gaffney
-
Georgetown, South Carolina, United States, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, United States, 29651
- Gibbs Cancer Center-Pelham
-
Rock Hill, South Carolina, United States, 29732
- Levine Cancer Institute-Rock Hill
-
Rock Hill, South Carolina, United States, 29730
- Rock Hill Radiation Therapy Center
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, United States, 29303
- Spartanburg Medical Center
-
Union, South Carolina, United States, 29379
- MGC Hematology Oncology-Union
-
-
South Dakota
-
Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, United States, 37404
- Memorial Hospital
-
Collierville, Tennessee, United States, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Franklin, Tennessee, United States, 37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Hixson, Tennessee, United States, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Memphis, Tennessee, United States, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Nashville, Tennessee, United States, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, United States, 37204
- Vanderbilt Breast Center at One Hundred Oaks
-
Ooltewah, Tennessee, United States, 37363
- Memorial GYN Plus
-
-
Texas
-
Bryan, Texas, United States, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, United States, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, United States, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, United States, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Houston, Texas, United States, 77030
- M D Anderson Cancer Center
-
Richardson, Texas, United States, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork, Utah, United States, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, United States, 84720
- Sandra L Maxwell Cancer Center
-
Farmington, Utah, United States, 84025
- Farmington Health Center
-
Logan, Utah, United States, 84321
- Logan Regional Hospital
-
Murray, Utah, United States, 84107
- Intermountain Medical Center
-
Ogden, Utah, United States, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, United States, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, United States, 84065
- Riverton Hospital
-
Saint George, Utah, United States, 84770
- Saint George Regional Medical Center
-
Salt Lake City, Utah, United States, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, United States, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, United States, 84143
- LDS Hospital
-
Salt Lake City, Utah, United States, 84106
- University of Utah Sugarhouse Health Center
-
-
Vermont
-
Berlin, Vermont, United States, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, United States, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, United States, 05405
- University of Vermont and State Agricultural College
-
Saint Johnsbury, Vermont, United States, 05819
- Norris Cotton Cancer Center-North
-
-
Virginia
-
Martinsville, Virginia, United States, 24115
- Sovah Health Martinsville
-
Richmond, Virginia, United States, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
South Hill, Virginia, United States, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, United States, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, United States, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, United States, 98004
- Overlake Medical Center
-
Bellingham, Washington, United States, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, United States, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Bremerton, Washington, United States, 98310
- Harrison Medical Center
-
Burien, Washington, United States, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, United States, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, United States, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, United States, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, United States, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, United States, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, United States, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, United States, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, United States, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, United States, 98499
- Saint Clare Hospital
-
Longview, Washington, United States, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, United States, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, United States, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, United States, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, United States, 98055
- Valley Medical Center
-
Seattle, Washington, United States, 98109
- Fred Hutchinson Cancer Research Center
-
Seattle, Washington, United States, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, United States, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, United States, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, United States, 98109
- FHCC South Lake Union
-
Seattle, Washington, United States, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, United States, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, United States, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, United States, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, United States, 98584
- Providence Regional Cancer System-Shelton
-
Spokane, Washington, United States, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, United States, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, United States, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, United States, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, United States, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, United States, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, United States, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, United States, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, United States, 99362
- Providence Saint Mary Regional Cancer Center
-
Yelm, Washington, United States, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Bridgeport, West Virginia, United States, 26330
- United Hospital Center
-
Charleston, West Virginia, United States, 25304
- West Virginia University Charleston Division
-
Martinsburg, West Virginia, United States, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, United States, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, United States, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Appleton, Wisconsin, United States, 54911
- ThedaCare Regional Cancer Center
-
Ashland, Wisconsin, United States, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, United States, 54806
- Northwest Wisconsin Cancer Center
-
Burlington, Wisconsin, United States, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire, Wisconsin, United States, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, United States, 54701
- HSHS Sacred Heart Hospital
-
Fond Du Lac, Wisconsin, United States, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, United States, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, United States, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, United States, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, United States, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, United States, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, United States, 54301
- Bellin Memorial Hospital
-
Johnson Creek, Wisconsin, United States, 53038
- UW Cancer Center Johnson Creek
-
Kenosha, Wisconsin, United States, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, United States, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, United States, 53792
- University of Wisconsin Carbone Cancer Center
-
Marinette, Wisconsin, United States, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, United States, 54449
- Marshfield Medical Center-Marshfield
-
Milwaukee, Wisconsin, United States, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, United States, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, United States, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, United States, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, United States, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, United States, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, United States, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, United States, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, United States, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, United States, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, United States, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, United States, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, United States, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, United States, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, United States, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, United States, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, United States, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, United States, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, United States, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, United States, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, United States, 54476
- Marshfield Medical Center - Weston
-
-
Wyoming
-
Cheyenne, Wyoming, United States, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, United States, 82414
- Billings Clinic-Cody
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Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Age >= 18 years
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have histologically proven stage IIB (T3N0M0 only), IIIA (T2N1M0), IIIB (T4N0M0), or IIIC (T3N1M0, T4N1M0) invasive squamous cell carcinoma of the anus or anorectum, according to the American Joint Committee on Cancer (AJCC) 8th edition; this may include tumors of non-keratinizing histology such as basaloid, transitional cell, or cloacogenic histology; individuals with squamous cell carcinoma of the anal margin are eligible if there is evidence of extension of the primary tumor into the anal canal
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have hemoglobin levels of > 9 g/dL (within 2 weeks prior to registration)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient must have a platelet count of > 100,000/mm^3 (within 2 weeks prior to registration)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient's absolute neutrophil count (ANC) level must be > 1500/mm^3 (within 2 weeks prior to registration)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Serum creatinine must be =< 1.5 X upper limit of normal (ULN) (within 2 weeks prior to registration)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Total bilirubin must be < 2 X ULN (within 2 weeks prior to registration)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =< 2.5 X institutional upper limit of normal (within 2 weeks prior to registration)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Albumin >= 3.0 g/dL (within 2 weeks prior to registration)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients known to be human immunodeficiency virus (HIV)+ are permitted; patients with CD4 > 200 and serum HIV viral load of < 200 copies/mm^3 are eligible, and in addition:
- Participants must be purified protein derivative (PPD) negative; alternatively, the QuantiFERON-tuberculosis (TB) Gold In-Tube (QFT-GIT) assay (Cellestis Limited, Carnegie, Australia) can be used; an individual is considered positive for M. tuberculosis infection if the IFN-gamma response to TB antigens is above the test cut-off (after subtracting the background IFN-gamma response in the negative control); the result must be obtained within 20 weeks prior to enrollment; PPD positive (or Quantiferon assay positive) participants are permitted if prophylaxis has been completed prior to enrollment
- No history of acquired immune deficiency syndrome (AIDS)-related complications within past year other than a history of low CD4+ T-cell count > 200/mm^3 prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to chemoradiotherapy and should not be used as an exclusion criterion if low
- Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the anal cancer
- Participants MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications when clinically indicated, and should be under the care of a physician experienced in HIV management; participants will be eligible regardless of antiretroviral medication (including no antiretroviral medication) provided there is no intention to initiate therapy or the regimen has been stable for at least 4 weeks with no intention to change the regimen within 12 weeks following enrollment
- Patient must have =< grade 2 diarrhea (participants with grade 1 diarrhea are eligible provided stool for ova/parasites and stool cryptosporidium studies are negative;
- NOTE: HIV testing is not required for eligibility
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: For patients registering prior to start of chemoradiotherapy, baseline scans must have been completed within 4 weeks prior to registration
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Women of child bearing potential and sexually active males must use accepted and effective method(s) of contraception and/or abstain from sexual intercourse while on protocol treatment and for at least 5 months after the last dose of nivolumab (for female patients) and for at least 7 months after the last dose of nivolumab (for male patients)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Any surgery must have been completed >= 4 weeks prior to starting study treatment
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoclonal antibody)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No patients with immunodeficiency or receiving systemic steroid therapy equivalent to > 10 mg prednisone per day or any other form of immunosuppressive therapy within 7 days prior to Step 1 registration; topical corticosteroid or occasional inhaled corticosteroids are allowed
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No live vaccines within 30 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowed
- NOTE: no live vaccines may be administered while participating in the trial
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Previously irradiated patients (Arm S) must have received radiation per National Comprehensive Cancer Network guidelines; radiation therapy delivered on protocol (Arm T) will be reviewed
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients will be registered within 63 days following completion of standard chemoradiation for anal cancer; standard chemoradiation therapy is as defined
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have histologically proven stage IIB (T3N0M0 only), IIIA (T2N1M0), IIIB (T4N0M0), or IIIC (T3N1M0, T4N1M0) invasive squamous cell carcinoma of the anus or anorectum, according to the AJCC 8th edition; this may include tumors of non-keratinizing histology such as basaloid, transitional cell, or cloacogenic histology; individuals with squamous cell carcinoma of the anal margin are eligible if there is evidence of extension of the primary tumor into the anal canal
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have received at least 54 gray (Gy) of radiation to the PTVp (primary) and 45 Gy to PTVn (elective nodal region) for the treatment of the anal cancer
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have ECOG performance status of 0-2
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have hemoglobin levels of > 10 g/dL (within 2 weeks prior to registration)
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must have a platelet count of > 100,000/mm^3 (within 2 weeks prior to registration)
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient's ANC level must be > 1500/mm^3 (within 2 weeks prior to registration)
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Serum creatinine must be =< 1.5 X ULN (within 2 weeks prior to registration)
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Total bilirubin must be < 2 X ULN (within 2 weeks prior to registration)
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: AST (SGOT)/ALT (SGPT) =< 2.5 X institutional upper limit of normal (within 2 weeks prior to registration)
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Albumin >= 3.0 g/dL (within 2 weeks prior to registration)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients known to be human immunodeficiency virus (HIV)+ patients with CD4 > 200 and serum HIV viral load of < 200 copies/mm^3 are eligible; in addition:
- Participants must be PPD negative; alternatively, the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay (Cellestis Limited, Carnegie, Australia) can be used; an individual is considered positive for M. tuberculosis infection if the IFN-gamma response to TB antigens is above the test cut-off (after subtracting the background IFN-gamma response in the negative control); the result must be obtained within 20 weeks prior to enrollment; PPD positive (or Quantiferon assay positive) participants are permitted if prophylaxis has been completed prior to enrollment; NOTE: If patient completed chemoradiation on Step 1, PPD testing does not need to be performed again
- No history of AIDS-related complications within past year other than a history of low CD4+ T-cell count > 200/mm^3 prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to chemoradiotherapy should not be used as an exclusion criterion if low
- Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the anal cancer
- Participants MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications when clinically indicated, and should be under the care of a physician experienced in HIV management; participants will be eligible regardless of antiretroviral medication (including no antiretroviral medication) provided there is no intention to initiate therapy or the regimen has been stable for at least 4 weeks with no intention to change the regimen within 12 weeks following enrollment
- Patient must have =< grade 2 diarrhea (participants with grade 1 diarrhea are eligible provided stool for ova/parasites and stool cryptosporidium studies are negative)
- NOTE: HIV testing is not required for eligibility
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Scans done within 4 weeks of randomization to Step 2
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must have recovered from all toxicities associated with chemoradiotherapy for anal cancer, to grade =< 1 with the exception of alopecia
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Women of child bearing potential and sexually active males must use accepted and effective method(s) of contraception and/or abstain from sexual intercourse while on protocol treatment and for at least 5 months after the last dose of nivolumab (for female patients) and for at least 7 months after the last dose of nivolumab (for male patients)
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoclonal antibody)
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No patients with immunodeficiency or receiving systemic steroid therapy equivalent to > 10 mg prednisone per day or any other form of immunosuppressive therapy within 7 days prior to the first dose of study medication; topical corticosteroid or occasional inhaled corticosteroids are allowed
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No live vaccines within 30 days prior to the first dose of trial treatment and while participating in the trial; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowed
Exclusion Criteria:
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: For patients registering to Arm T, patients must not have received prior chemoradiotherapy for anal cancer
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients with an allogenic bone marrow/stem, cell or solid organ transplant are excluded
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Women MUST NOT be pregnant or breast-feeding due to the potential teratogenic harm or abortifacient effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used; all patients must also not expect to conceive or father children from study registration and throughout their time on study treatment; for female patients this must continue until at least 5 months after the last dose of nivolumab and for male patients until at least 7 months after the last dose of nivolumab; all females of child bearing potential must have a serum or urine pregnancy test to rule out pregnancy within 2 weeks prior to registration; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients will be excluded if they have a T1 or M1, and T2N0 cancer
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must not have had prior potentially curative surgery (abdominal, peritoneal resection) for carcinoma of the anus
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Participants may not be receiving any other standard anti-cancer therapy or experimental agent concurrently with the study drugs
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Individuals with a history of a different malignancy are ineligible except if they have been disease-free for at least 2 years and are deemed by the investigator to be at low risk for recurrence; individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient must not have active autoimmune disease in the past 2 years
- NOTE: This does not include patients with autoimmune disease controlled by medication, such as hypothyroidism; this eligibility includes only patients with endocrine disease controlled by hormone replacement, e.g. hypothyroid, adrenal insufficiency, or diabetes mellitus (DM)
- REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients with an allogenic bone marrow/stem, cell or solid organ transplant are excluded
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Women MUST NOT be pregnant or breast-feeding due to the potential teratogenic harm or abortifacient effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used; all patients must also not expect to conceive or father children from study registration and throughout their time on study treatment; for female patients this must continue until at least 5 months after the last dose of nivolumab and for male patients until at least 7 months after the last dose of nivolumab; all females of child bearing potential must have a serum or urine pregnancy test to rule out pregnancy within 2 weeks prior to registration; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have had prior potentially curative surgery (abdominal, peritoneal resection) for carcinoma of the anus
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Participants may not be receiving any other standard anti-cancer therapy or experimental agent concurrently with the study drugs
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Individuals with a history of a different malignancy are ineligible except if they have been disease-free for at least 2 years and are deemed by the investigator to be at low risk for recurrence; individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must not have active autoimmune disease that has required systemic treatment in past 2 years
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
- REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: Arm A (nivolumab)
Patients receive nivolumab while on study.
Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study.
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Given IV
Other Names:
Undergo MRI
Other Names:
Undergo blood sample collection
Other Names:
Undergo biopsy
Other Names:
Undergo CT scan
Other Names:
Undergo colonoscopy
Undergo sigmoidoscopy
Other Names:
Undergo digital rectal examination
Other Names:
Undergo anoscopy
Other Names:
Undergo proctoscopy
Undergo chest x-ray
Other Names:
|
|
Other: Arm B (clinical observation)
Patients undergo observation while on study.
Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study.
|
Undergo MRI
Other Names:
Undergo blood sample collection
Other Names:
Undergo CT scan
Other Names:
Undergo observation
Other Names:
Undergo colonoscopy
Undergo sigmoidoscopy
Other Names:
Undergo digital rectal examination
Other Names:
Undergo anoscopy
Other Names:
Undergo proctoscopy
Undergo chest x-ray
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Disease free survival
Time Frame: Up to 5 years
|
Will be defined as the occurrence of progression of local disease, distant metastases, second primary or death from the date of randomization.
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Up to 5 years
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Overall survival
Time Frame: Up to 5 years
|
Up to 5 years
|
|
|
Objective response rate
Time Frame: Up to 5 years
|
Will be defined by complete and partial response.
|
Up to 5 years
|
|
Severe toxicity interval
Time Frame: The time between randomization and the occurrence of late severe side effects (up to 5 years)
|
The following late side effects are considered as severe: any anal/rectal damage (ulcer, fistula, or perforation), rectal stenosis that required colostomy, skin ulceration, and severe fibrosis.
This parameter estimates the probability of being free of late side effects for patients under loco-regional control.
|
The time between randomization and the occurrence of late severe side effects (up to 5 years)
|
|
Colostomy-free survival
Time Frame: Up to 5 years
|
Up to 5 years
|
|
|
Incidence of toxicities
Time Frame: Up to 5 years
|
Will be assessed by National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0.
|
Up to 5 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Lakshmi Rajdev, ECOG-ACRIN Cancer Research Group
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 5, 2018
Primary Completion (Estimated)
December 31, 2025
Study Completion (Estimated)
December 31, 2025
Study Registration Dates
First Submitted
July 28, 2017
First Submitted That Met QC Criteria
July 28, 2017
First Posted (Actual)
July 31, 2017
Study Record Updates
Last Update Posted (Actual)
April 12, 2024
Last Update Submitted That Met QC Criteria
April 11, 2024
Last Verified
April 1, 2024
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Digestive System Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Gastrointestinal Neoplasms
- Digestive System Neoplasms
- Gastrointestinal Diseases
- Intestinal Diseases
- Intestinal Neoplasms
- Rectal Diseases
- Colorectal Neoplasms
- Neoplasms, Squamous Cell
- Rectal Neoplasms
- Anus Diseases
- Carcinoma
- Carcinoma, Squamous Cell
- Anus Neoplasms
- Molecular Mechanisms of Pharmacological Action
- Antineoplastic Agents
- Antineoplastic Agents, Immunological
- Immune Checkpoint Inhibitors
- Nivolumab
Other Study ID Numbers
- NCI-2017-01347 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180820 (U.S. NIH Grant/Contract)
- EA2165 (Other Identifier: CTEP)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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