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Niwolumab po terapii skojarzonej w leczeniu pacjentów z rakiem odbytu w stadium II-IIIB wysokiego ryzyka

30 października 2026 zaktualizowane przez: National Cancer Institute (NCI)

Randomizowane badanie fazy III niwolumabu po terapii skojarzonej (CMT) w raku odbytu wysokiego ryzyka

This phase III trial investigates how well nivolumab after combined modality therapy works in treating patients with high risk stage II-IIIB anal cancer. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

Przegląd badań

Status

Aktywny, nie rekrutujący

Warunki

Interwencja / Leczenie

Szczegółowy opis

PRIMARY OBJECTIVE:

I. To evaluate whether therapy with nivolumab following combined modality therapy (CMT) improves disease-free survival (DFS) compared with observation in patients with high risk anal carcinoma.

SECONDARY OBJECTIVES:

I. To compare nivolumab following combined modality therapy (CMT) with observation in patients with high risk anal carcinoma with regard to:

Ia. Objective response rate (complete [CR] and partial [PR]), stable disease and progression.

Ib. Severe toxicity interval. Ic. Colostomy-free survival. Id. Overall survival. Ie. Toxicity.

OUTLINE: Patients who received standard CMT are randomized to 1 of 2 arms.

ARM A: Patients receive nivolumab intravenously (IV) while on study.

ARM B: Patients undergo observation while on study

Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, computed tomography (CT) scan, magnetic resonance imaging (MRI), biopsy and blood sample collection throughout the study.

Typ studiów

Interwencyjne

Zapisy (Szacowany)

344

Faza

Faza 3

Kontakty i lokalizacje

Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.

Lokalizacje studiów

Kanada
- Alberta
  - Calgary, Alberta, Kanada, T2N 5G2
    - Arthur J E Child Comprehensive Cancer Centre
- British Columbia
  - Vancouver, British Columbia, Kanada, V5Z 4E6
    - BCCA-Vancouver Cancer Centre
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Kanada, A1B 3V6
    - Doctor H. Bliss Murphy Cancer Centre
- Ontario
  - London, Ontario, Kanada, N6A 4L6
    - London Regional Cancer Program
  - Ottawa, Ontario, Kanada, K1H 8L6
    - Ottawa Hospital and Cancer Center-General Campus
  - Sault Ste. Marie, Ontario, Kanada, P6B 0A8
    - Algoma District Cancer Program Sault Area Hospital
  - Toronto, Ontario, Kanada, M5G 2M9
    - University Health Network-Princess Margaret Hospital
- Saskatchewan
  - Regina, Saskatchewan, Kanada, S4T 7T1
    - Allan Blair Cancer Centre
  - Saskatoon, Saskatchewan, Kanada, S7N 4H4
    - Saskatoon Cancer Centre
Stany Zjednoczone
- Alabama
  - Birmingham, Alabama, Stany Zjednoczone, 35233
    - University of Alabama at Birmingham Cancer Center
- Alaska
  - Anchorage, Alaska, Stany Zjednoczone, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Stany Zjednoczone, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Stany Zjednoczone, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Stany Zjednoczone, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Stany Zjednoczone, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Stany Zjednoczone, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Stany Zjednoczone, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Stany Zjednoczone, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, Stany Zjednoczone, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Goodyear, Arizona, Stany Zjednoczone, 85338
    - CTCA at Western Regional Medical Center
  - Kingman, Arizona, Stany Zjednoczone, 86401
    - Kingman Regional Medical Center
  - Phoenix, Arizona, Stany Zjednoczone, 85054
    - Mayo Clinic Hospital in Arizona
  - Scottsdale, Arizona, Stany Zjednoczone, 85259
    - Mayo Clinic in Arizona
- Arkansas
  - Fort Smith, Arkansas, Stany Zjednoczone, 72903
    - Mercy Hospital Fort Smith
  - Hot Springs, Arkansas, Stany Zjednoczone, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro, Arkansas, Stany Zjednoczone, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
  - Little Rock, Arkansas, Stany Zjednoczone, 72205
    - University of Arkansas for Medical Sciences
- California
  - Anaheim, California, Stany Zjednoczone, 92806
    - Kaiser Permanente-Anaheim
  - Antioch, California, Stany Zjednoczone, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Arroyo Grande, California, Stany Zjednoczone, 93420
    - PCR Oncology
  - Arroyo Grande, California, Stany Zjednoczone, 93420
    - Mission Hope Medical Oncology - Arroyo Grande
  - Auburn, California, Stany Zjednoczone, 95602
    - Sutter Auburn Faith Hospital
  - Auburn, California, Stany Zjednoczone, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Baldwin Park, California, Stany Zjednoczone, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Stany Zjednoczone, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Stany Zjednoczone, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Stany Zjednoczone, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Stany Zjednoczone, 94010
    - Mills-Peninsula Medical Center
  - Cameron Park, California, Stany Zjednoczone, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Castro Valley, California, Stany Zjednoczone, 94546
    - Eden Hospital Medical Center
  - Chico, California, Stany Zjednoczone, 95926
    - Enloe Medical Center
  - Clovis, California, Stany Zjednoczone, 93611
    - Community Cancer Institute
  - Clovis, California, Stany Zjednoczone, 93611
    - University Oncology Associates
  - Davis, California, Stany Zjednoczone, 95616
    - Sutter Davis Hospital
  - Dublin, California, Stany Zjednoczone, 94568
    - Kaiser Permanente Dublin
  - Fontana, California, Stany Zjednoczone, 92335
    - Kaiser Permanente-Fontana
  - Fremont, California, Stany Zjednoczone, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Stany Zjednoczone, 94538
    - Palo Alto Medical Foundation-Fremont
  - Fresno, California, Stany Zjednoczone, 93720
    - Kaiser Permanente-Fresno
  - Fresno, California, Stany Zjednoczone, 93720
    - Fresno Cancer Center
  - Harbor City, California, Stany Zjednoczone, 90710
    - Kaiser Permanente South Bay
  - Irvine, California, Stany Zjednoczone, 92618
    - Kaiser Permanente-Irvine
  - La Jolla, California, Stany Zjednoczone, 92093
    - UC San Diego Moores Cancer Center
  - Los Angeles, California, Stany Zjednoczone, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Stany Zjednoczone, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Stany Zjednoczone, 90034
    - Kaiser Permanente West Los Angeles
  - Los Angeles, California, Stany Zjednoczone, 90033
    - Los Angeles General Medical Center
  - Marysville, California, Stany Zjednoczone, 95901
    - Fremont - Rideout Cancer Center
  - Modesto, California, Stany Zjednoczone, 95355
    - Memorial Medical Center
  - Modesto, California, Stany Zjednoczone, 95356
    - Kaiser Permanente-Modesto
  - Mountain View, California, Stany Zjednoczone, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Stany Zjednoczone, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Newport Beach, California, Stany Zjednoczone, 92663
    - USC Norris Oncology/Hematology-Newport Beach
  - Novato, California, Stany Zjednoczone, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Stany Zjednoczone, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Stany Zjednoczone, 94611
    - Kaiser Permanente Oakland-Broadway
  - Ontario, California, Stany Zjednoczone, 91761
    - Kaiser Permanente-Ontario
  - Orange, California, Stany Zjednoczone, 92868
    - Saint Joseph Hospital - Orange
  - Palo Alto, California, Stany Zjednoczone, 94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto, California, Stany Zjednoczone, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, Stany Zjednoczone, 91402
    - Kaiser Permanente - Panorama City
  - Pasadena, California, Stany Zjednoczone, 91105
    - Keck Medical Center of USC Pasadena
  - Rancho Cordova, California, Stany Zjednoczone, 95670
    - Kaiser Permanente-Rancho Cordova Cancer Center
  - Rancho Mirage, California, Stany Zjednoczone, 92270
    - Eisenhower Medical Center
  - Redwood City, California, Stany Zjednoczone, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Stany Zjednoczone, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, Stany Zjednoczone, 92505
    - Kaiser Permanente-Riverside
  - Rohnert Park, California, Stany Zjednoczone, 94928
    - Rohnert Park Cancer Center
  - Roseville, California, Stany Zjednoczone, 95678
    - The Permanente Medical Group-Roseville Radiation Oncology
  - Roseville, California, Stany Zjednoczone, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Stany Zjednoczone, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Stany Zjednoczone, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Stany Zjednoczone, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Stany Zjednoczone, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Stany Zjednoczone, 95814
    - Kaiser Permanente Downtown Commons
  - Sacramento, California, Stany Zjednoczone, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Stany Zjednoczone, 95823
    - South Sacramento Cancer Center
  - Sacramento, California, Stany Zjednoczone, 95825
    - Kaiser Permanente Sacramento Medical Center
  - San Diego, California, Stany Zjednoczone, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Stany Zjednoczone, 92108
    - Kaiser Permanente-Rio San Diego
  - San Francisco, California, Stany Zjednoczone, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Stany Zjednoczone, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Stany Zjednoczone, 94110
    - Zuckerberg San Francisco General Hospital
  - San Jose, California, Stany Zjednoczone, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Stany Zjednoczone, 94577
    - Kaiser Permanente San Leandro
  - San Marcos, California, Stany Zjednoczone, 92078
    - Kaiser Permanente-San Marcos
  - San Mateo, California, Stany Zjednoczone, 94401
    - Mills Health Center
  - San Rafael, California, Stany Zjednoczone, 94903
    - Kaiser San Rafael-Gallinas
  - San Rafael, California, Stany Zjednoczone, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Stany Zjednoczone, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, Stany Zjednoczone, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Maria, California, Stany Zjednoczone, 93444
    - Mission Hope Medical Oncology - Santa Maria
  - Santa Rosa, California, Stany Zjednoczone, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Stany Zjednoczone, 95403
    - Sutter Pacific Medical Foundation
  - South San Francisco, California, Stany Zjednoczone, 94080
    - Kaiser Permanente Cancer Treatment Center
  - South San Francisco, California, Stany Zjednoczone, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Stany Zjednoczone, 95210
    - Kaiser Permanente-Stockton
  - Sunnyvale, California, Stany Zjednoczone, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Vacaville, California, Stany Zjednoczone, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vallejo, California, Stany Zjednoczone, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Stany Zjednoczone, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Stany Zjednoczone, 94596
    - Kaiser Permanente-Walnut Creek
  - Woodland Hills, California, Stany Zjednoczone, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora, Colorado, Stany Zjednoczone, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Stany Zjednoczone, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Stany Zjednoczone, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, Stany Zjednoczone, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Stany Zjednoczone, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Stany Zjednoczone, 80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs, Colorado, Stany Zjednoczone, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Stany Zjednoczone, 80920
    - Memorial Hospital North
  - Denver, Colorado, Stany Zjednoczone, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Stany Zjednoczone, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Stany Zjednoczone, 80220
    - Rose Medical Center
  - Denver, Colorado, Stany Zjednoczone, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Stany Zjednoczone, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Stany Zjednoczone, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Stany Zjednoczone, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Stany Zjednoczone, 80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver, Colorado, Stany Zjednoczone, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Stany Zjednoczone, 80206
    - National Jewish Health-Main Campus
  - Denver, Colorado, Stany Zjednoczone, 80220
    - Western Surgical Care
  - Denver, Colorado, Stany Zjednoczone, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver, Colorado, Stany Zjednoczone, 80210
    - AdventHealth Porter
  - Durango, Colorado, Stany Zjednoczone, 81301
    - Mercy Medical Center
  - Durango, Colorado, Stany Zjednoczone, 81301
    - CommonSpirit Cancer Center Mercy
  - Englewood, Colorado, Stany Zjednoczone, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Stany Zjednoczone, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Stany Zjednoczone, 80524
    - Poudre Valley Hospital
  - Golden, Colorado, Stany Zjednoczone, 80401
    - Mountain Blue Cancer Care Center
  - Golden, Colorado, Stany Zjednoczone, 80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction, Colorado, Stany Zjednoczone, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Stany Zjednoczone, 80631
    - Banner North Colorado Medical Center
  - Lafayette, Colorado, Stany Zjednoczone, 80026
    - Kaiser Permanente-Rock Creek
  - Lafayette, Colorado, Stany Zjednoczone, 80026
    - Good Samaritan Hospital - Cancer Centers of Colorado
  - Lakewood, Colorado, Stany Zjednoczone, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Lakewood, Colorado, Stany Zjednoczone, 80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Littleton, Colorado, Stany Zjednoczone, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Stany Zjednoczone, 80122
    - AdventHealth Littleton
  - Lone Tree, Colorado, Stany Zjednoczone, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, Stany Zjednoczone, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Stany Zjednoczone, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Stany Zjednoczone, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Stany Zjednoczone, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Stany Zjednoczone, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Parker, Colorado, Stany Zjednoczone, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Parker, Colorado, Stany Zjednoczone, 80138
    - AdventHealth Parker
  - Pueblo, Colorado, Stany Zjednoczone, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Stany Zjednoczone, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Stany Zjednoczone, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Stany Zjednoczone, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, Stany Zjednoczone, 80401
    - Intermountain Health Lutheran Hospital
- Delaware
  - Lewes, Delaware, Stany Zjednoczone, 19958
    - Beebe Medical Center
  - Millville, Delaware, Stany Zjednoczone, 19967
    - Beebe South Coastal Health Campus
  - Newark, Delaware, Stany Zjednoczone, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Stany Zjednoczone, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Stany Zjednoczone, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Stany Zjednoczone, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Stany Zjednoczone, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Stany Zjednoczone, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Stany Zjednoczone, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Stany Zjednoczone, 20037
    - George Washington University Medical Center
- Florida
  - Altamonte Springs, Florida, Stany Zjednoczone, 32701
    - AdventHealth Altamonte
  - Aventura, Florida, Stany Zjednoczone, 33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Celebration, Florida, Stany Zjednoczone, 34747
    - AdventHealth Celebration
  - Coral Gables, Florida, Stany Zjednoczone, 33146
    - UM Sylvester Comprehensive Cancer Center at Coral Gables
  - Deerfield Beach, Florida, Stany Zjednoczone, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Fort Lauderdale, Florida, Stany Zjednoczone, 33316
    - Broward Health Medical Center
  - Fort Lauderdale, Florida, Stany Zjednoczone, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Stany Zjednoczone, 32610
    - UF Health Cancer Institute - Gainesville
  - Hollywood, Florida, Stany Zjednoczone, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Stany Zjednoczone, 32224-9980
    - Mayo Clinic in Florida
  - Kissimmee, Florida, Stany Zjednoczone, 34744
    - AdventHealth Kissimmee
  - Miami, Florida, Stany Zjednoczone, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami, Florida, Stany Zjednoczone, 33176
    - UM Sylvester Comprehensive Cancer Center at Kendall
  - Miami Beach, Florida, Stany Zjednoczone, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Stany Zjednoczone, 32803
    - AdventHealth Orlando
  - Orlando, Florida, Stany Zjednoczone, 32803
    - AdventHealth Medical Group Urology at Orlando
  - Orlando, Florida, Stany Zjednoczone, 32822
    - AdventHealth East Orlando
  - Pembroke Pines, Florida, Stany Zjednoczone, 33028
    - Memorial Hospital West
  - Pensacola, Florida, Stany Zjednoczone, 32504
    - Sacred Heart Hospital
  - Weston, Florida, Stany Zjednoczone, 33331
    - Cleveland Clinic-Weston
  - Winter Park, Florida, Stany Zjednoczone, 32792
    - AdventHealth Winter Park
- Georgia
  - Atlanta, Georgia, Stany Zjednoczone, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Stany Zjednoczone, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Stany Zjednoczone, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Stany Zjednoczone, 30303
    - Grady Health System
  - Atlanta, Georgia, Stany Zjednoczone, 30309
    - Piedmont Hospital
  - Decatur, Georgia, Stany Zjednoczone, 30033
    - Atlanta VA Medical Center
  - Fayetteville, Georgia, Stany Zjednoczone, 30214
    - Piedmont Fayette Hospital
  - Johns Creek, Georgia, Stany Zjednoczone, 30097
    - Emory Johns Creek Hospital
  - Savannah, Georgia, Stany Zjednoczone, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Stany Zjednoczone, 31405
    - Summit Cancer Care-Candler
- Hawaii
  - Honolulu, Hawaii, Stany Zjednoczone, 96819
    - Kaiser Permanente Moanalua Medical Center
- Idaho
  - Boise, Idaho, Stany Zjednoczone, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Stany Zjednoczone, 83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell, Idaho, Stany Zjednoczone, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, Stany Zjednoczone, 83814
    - Kootenai Health - Coeur d'Alene
  - Emmett, Idaho, Stany Zjednoczone, 83617
    - Walter Knox Memorial Hospital
  - Fruitland, Idaho, Stany Zjednoczone, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Stany Zjednoczone, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, Stany Zjednoczone, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Stany Zjednoczone, 83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Nampa, Idaho, Stany Zjednoczone, 83687
    - Saint Luke's Cancer Institute - Nampa
  - Post Falls, Idaho, Stany Zjednoczone, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Stany Zjednoczone, 83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls, Idaho, Stany Zjednoczone, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Aurora, Illinois, Stany Zjednoczone, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Stany Zjednoczone, 61704
    - Illinois CancerCare-Bloomington
  - Burr Ridge, Illinois, Stany Zjednoczone, 60527
    - Loyola Center for Health at Burr Ridge
  - Canton, Illinois, Stany Zjednoczone, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Stany Zjednoczone, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Stany Zjednoczone, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Stany Zjednoczone, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Stany Zjednoczone, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Stany Zjednoczone, 60611
    - Northwestern University
  - Chicago, Illinois, Stany Zjednoczone, 60612
    - University of Illinois
  - Chicago, Illinois, Stany Zjednoczone, 60612
    - Rush MD Anderson Cancer Center
  - Danville, Illinois, Stany Zjednoczone, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Stany Zjednoczone, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Stany Zjednoczone, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Stany Zjednoczone, 61021
    - Illinois CancerCare-Dixon
  - Effingham, Illinois, Stany Zjednoczone, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Stany Zjednoczone, 62401
    - Carle Physician Group-Effingham
  - Eureka, Illinois, Stany Zjednoczone, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Stany Zjednoczone, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Stany Zjednoczone, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Stany Zjednoczone, 61401
    - Illinois CancerCare-Galesburg
  - Glenview, Illinois, Stany Zjednoczone, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Highland Park, Illinois, Stany Zjednoczone, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Homer Glen, Illinois, Stany Zjednoczone, 60491
    - Loyola Medicine Homer Glen
  - Kewanee, Illinois, Stany Zjednoczone, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest, Illinois, Stany Zjednoczone, 60045
    - Northwestern Medicine Lake Forest Hospital
  - Macomb, Illinois, Stany Zjednoczone, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Stany Zjednoczone, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Stany Zjednoczone, 60153
    - Loyola University Medical Center
  - Melrose Park, Illinois, Stany Zjednoczone, 60160
    - Marjorie Weinberg Cancer Center at Loyola-Gottlieb
  - Mount Vernon, Illinois, Stany Zjednoczone, 62864
    - SSM Health Good Samaritan
  - O'Fallon, Illinois, Stany Zjednoczone, 62269
    - Cancer Care Center of O'Fallon
  - Ottawa, Illinois, Stany Zjednoczone, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Pekin, Illinois, Stany Zjednoczone, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Stany Zjednoczone, 61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria, Illinois, Stany Zjednoczone, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Stany Zjednoczone, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Stany Zjednoczone, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Stany Zjednoczone, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peru, Illinois, Stany Zjednoczone, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Stany Zjednoczone, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Stany Zjednoczone, 61356
    - Illinois CancerCare-Princeton
  - Springfield, Illinois, Stany Zjednoczone, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Stany Zjednoczone, 62702
    - Springfield Clinic
  - Springfield, Illinois, Stany Zjednoczone, 62781
    - Springfield Memorial Hospital
  - Swansea, Illinois, Stany Zjednoczone, 62226
    - Southwest Illinois Health Services LLP
  - Urbana, Illinois, Stany Zjednoczone, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Stany Zjednoczone, 61801
    - The Carle Foundation Hospital
  - Washington, Illinois, Stany Zjednoczone, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, Stany Zjednoczone, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Carmel, Indiana, Stany Zjednoczone, 46032
    - IU Health North Hospital
  - Indianapolis, Indiana, Stany Zjednoczone, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Stany Zjednoczone, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Stany Zjednoczone, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Stany Zjednoczone, 46290
    - Springmill Medical Center
  - Lafayette, Indiana, Stany Zjednoczone, 47905
    - Franciscan Saint Elizabeth Health - Lafayette East
  - Michigan City, Indiana, Stany Zjednoczone, 46360
    - Woodland Cancer Care Center
  - Mooresville, Indiana, Stany Zjednoczone, 46158
    - Franciscan Health Mooresville
  - New Albany, Indiana, Stany Zjednoczone, 47150
    - Baptist Health Floyd
  - Terre Haute, Indiana, Stany Zjednoczone, 47804
    - Union Hospital
- Iowa
  - Bettendorf, Iowa, Stany Zjednoczone, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Clive, Iowa, Stany Zjednoczone, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Stany Zjednoczone, 50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs, Iowa, Stany Zjednoczone, 51503
    - Alegent Health Mercy Hospital
  - Creston, Iowa, Stany Zjednoczone, 50801
    - Greater Regional Medical Center
  - Des Moines, Iowa, Stany Zjednoczone, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Stany Zjednoczone, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Stany Zjednoczone, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, Stany Zjednoczone, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Stany Zjednoczone, 50309
    - UI Health Care Mission Cancer and Blood - Des Moines Clinic
  - Des Moines, Iowa, Stany Zjednoczone, 50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Fort Dodge, Iowa, Stany Zjednoczone, 50501
    - UI Healthcare Mission Cancer and Blood - Fort Dodge
  - Iowa City, Iowa, Stany Zjednoczone, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - West Des Moines, Iowa, Stany Zjednoczone, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Stany Zjednoczone, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Stany Zjednoczone, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Stany Zjednoczone, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Stany Zjednoczone, 67042
    - Cancer Center of Kansas - El Dorado
  - Fairway, Kansas, Stany Zjednoczone, 66205
    - University of Kansas Clinical Research Center
  - Independence, Kansas, Stany Zjednoczone, 67301
    - Cancer Center of Kansas-Independence
  - Kingman, Kansas, Stany Zjednoczone, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Stany Zjednoczone, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Stany Zjednoczone, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Stany Zjednoczone, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Stany Zjednoczone, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Stany Zjednoczone, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Stany Zjednoczone, 66061
    - The University of Kansas Cancer Center - Olathe
  - Parsons, Kansas, Stany Zjednoczone, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Stany Zjednoczone, 66762
    - Mercy Hospital Pittsburg
  - Pratt, Kansas, Stany Zjednoczone, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Stany Zjednoczone, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Stany Zjednoczone, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Stany Zjednoczone, 66606
    - University of Kansas Health System Saint Francis Campus
  - Wellington, Kansas, Stany Zjednoczone, 67152
    - Cancer Center of Kansas - Wellington
  - Westwood, Kansas, Stany Zjednoczone, 66205
    - University of Kansas Hospital-Westwood Cancer Center
  - Wichita, Kansas, Stany Zjednoczone, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Stany Zjednoczone, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Stany Zjednoczone, 67214
    - Cancer Center of Kansas - Wichita
  - Winfield, Kansas, Stany Zjednoczone, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bardstown, Kentucky, Stany Zjednoczone, 40004
    - CommonSpirit Saint Joseph Hospital - Bardstown
  - Corbin, Kentucky, Stany Zjednoczone, 40701
    - Baptist Health Corbin
  - Corbin, Kentucky, Stany Zjednoczone, 40701
    - Commonwealth Cancer Center-Corbin
  - Lexington, Kentucky, Stany Zjednoczone, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Stany Zjednoczone, 40503
    - Baptist Health Lexington
  - Lexington, Kentucky, Stany Zjednoczone, 40509
    - CommonSpirit Saint Joseph Medical Center - East Lexington
  - London, Kentucky, Stany Zjednoczone, 40741
    - CommonSpirit Saint Joseph Hospital London
  - Louisville, Kentucky, Stany Zjednoczone, 40202
    - The James Graham Brown Cancer Center at University of Louisville
  - Louisville, Kentucky, Stany Zjednoczone, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Stany Zjednoczone, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Stany Zjednoczone, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Stany Zjednoczone, 40215
    - Saints Mary and Elizabeth Hospital
  - Madisonville, Kentucky, Stany Zjednoczone, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Paducah, Kentucky, Stany Zjednoczone, 42003
    - Baptist Health Paducah
  - Shepherdsville, Kentucky, Stany Zjednoczone, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Stany Zjednoczone, 70808
    - Our Lady of the Lake Physician Group
  - Metairie, Louisiana, Stany Zjednoczone, 70006
    - East Jefferson General Hospital
  - New Orleans, Louisiana, Stany Zjednoczone, 70112
    - Louisiana State University Health Science Center
- Maryland
  - Baltimore, Maryland, Stany Zjednoczone, 21204
    - Greater Baltimore Medical Center
- Massachusetts
  - Boston, Massachusetts, Stany Zjednoczone, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Stany Zjednoczone, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Stany Zjednoczone, 02118
    - Boston Medical Center
  - Fitchburg, Massachusetts, Stany Zjednoczone, 01420
    - Simonds-Sinon Regional Cancer Center
  - Springfield, Massachusetts, Stany Zjednoczone, 01104
    - Mercy Medical Center
  - Worcester, Massachusetts, Stany Zjednoczone, 01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Ann Arbor, Michigan, Stany Zjednoczone, 48109
    - University of Michigan Rogel Cancer Center
  - Ann Arbor, Michigan, Stany Zjednoczone, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Stany Zjednoczone, 49017
    - Bronson Battle Creek
  - Bay City, Michigan, Stany Zjednoczone, 48706
    - McLaren Cancer Institute-Bay City
  - Bloomfield, Michigan, Stany Zjednoczone, 48302
    - McLaren Cancer Institute-Bloomfield
  - Brighton, Michigan, Stany Zjednoczone, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton, Michigan, Stany Zjednoczone, 48116
    - University of Michigan - Brighton Center for Specialty Care
  - Brighton, Michigan, Stany Zjednoczone, 48114
    - Trinity Health Medical Center - Brighton
  - Brownstown, Michigan, Stany Zjednoczone, 48183
    - Henry Ford Cancer Institute-Downriver
  - Canton, Michigan, Stany Zjednoczone, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton, Michigan, Stany Zjednoczone, 48188
    - Trinity Health Medical Center - Canton
  - Caro, Michigan, Stany Zjednoczone, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, Stany Zjednoczone, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea, Michigan, Stany Zjednoczone, 48118
    - Chelsea Hospital
  - Clarkston, Michigan, Stany Zjednoczone, 48346
    - McLaren Cancer Institute-Clarkston
  - Clarkston, Michigan, Stany Zjednoczone, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Stany Zjednoczone, 48346
    - Newland Medical Associates-Clarkston
  - Clinton Township, Michigan, Stany Zjednoczone, 48038
    - Henry Ford Macomb Hospital-Clinton Township
  - Dearborn, Michigan, Stany Zjednoczone, 48126
    - Henry Ford Medical Center-Fairlane
  - Dearborn, Michigan, Stany Zjednoczone, 48124
    - Corewell Health Dearborn Hospital
  - Detroit, Michigan, Stany Zjednoczone, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Stany Zjednoczone, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Stany Zjednoczone, 48236
    - Henry Ford Health Saint John Hospital
  - East China Township, Michigan, Stany Zjednoczone, 48054
    - Henry Ford River District Hospital
  - Farmington Hills, Michigan, Stany Zjednoczone, 48334
    - Weisberg Cancer Treatment Center
  - Farmington Hills, Michigan, Stany Zjednoczone, 48336
    - Corewell Health Farmington Hills Hospital
  - Flint, Michigan, Stany Zjednoczone, 48532
    - McLaren Cancer Institute-Flint
  - Flint, Michigan, Stany Zjednoczone, 48532
    - Singh and Arora Hematology Oncology PC
  - Flint, Michigan, Stany Zjednoczone, 48503
    - Hurley Medical Center
  - Flint, Michigan, Stany Zjednoczone, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Stany Zjednoczone, 48503
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, Stany Zjednoczone, 48503
    - Cancer Hematology Centers - Flint
  - Grand Rapids, Michigan, Stany Zjednoczone, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Stany Zjednoczone, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grand Rapids, Michigan, Stany Zjednoczone, 49503
    - Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
  - Grosse Pointe, Michigan, Stany Zjednoczone, 48230
    - William Beaumont Hospital-Grosse Pointe
  - Grosse Pointe Woods, Michigan, Stany Zjednoczone, 48236
    - Henry Ford Saint John Hospital - Academic
  - Grosse Pointe Woods, Michigan, Stany Zjednoczone, 48236
    - Henry Ford Saint John Hospital - Breast
  - Grosse Pointe Woods, Michigan, Stany Zjednoczone, 48236
    - Henry Ford Saint John Hospital - Van Elslander
  - Jackson, Michigan, Stany Zjednoczone, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Stany Zjednoczone, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Stany Zjednoczone, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Stany Zjednoczone, 49048
    - Beacon Kalamazoo
  - Lansing, Michigan, Stany Zjednoczone, 48912
    - Mid-Michigan Physicians-Lansing
  - Lansing, Michigan, Stany Zjednoczone, 48910
    - Karmanos Cancer Institute at McLaren Greater Lansing
  - Lansing, Michigan, Stany Zjednoczone, 48912
    - University of Michigan Health - Sparrow Lansing
  - Lapeer, Michigan, Stany Zjednoczone, 48446
    - McLaren Cancer Institute-Lapeer Region
  - Livonia, Michigan, Stany Zjednoczone, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, Stany Zjednoczone, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Stany Zjednoczone, 48044
    - Henry Ford Warren Hospital - Breast Macomb
  - Macomb, Michigan, Stany Zjednoczone, 48044
    - Henry Ford Saint John Hospital - Macomb Medical
  - Marlette, Michigan, Stany Zjednoczone, 48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Mount Clemens, Michigan, Stany Zjednoczone, 48043
    - McLaren Cancer Institute-Macomb
  - Mount Pleasant, Michigan, Stany Zjednoczone, 48858
    - McLaren Cancer Institute-Central Michigan
  - Muskegon, Michigan, Stany Zjednoczone, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Stany Zjednoczone, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores, Michigan, Stany Zjednoczone, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Novi, Michigan, Stany Zjednoczone, 48377
    - Henry Ford Medical Center-Columbus
  - Novi, Michigan, Stany Zjednoczone, 48374
    - Henry Ford Health Providence Novi Hospital
  - Petoskey, Michigan, Stany Zjednoczone, 49770
    - McLaren Cancer Institute-Northern Michigan
  - Pontiac, Michigan, Stany Zjednoczone, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Stany Zjednoczone, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac, Michigan, Stany Zjednoczone, 48341
    - Michigan Healthcare Professionals Pontiac
  - Pontiac, Michigan, Stany Zjednoczone, 48341
    - Trinity Health IHA Medical Group-Alice Gustafson Center
  - Port Huron, Michigan, Stany Zjednoczone, 48060
    - McLaren-Port Huron
  - Reed City, Michigan, Stany Zjednoczone, 49677
    - Corewell Health Reed City Hospital
  - Rochester Hills, Michigan, Stany Zjednoczone, 48309
    - Henry Ford Rochester Hospital
  - Roseville, Michigan, Stany Zjednoczone, 48066
    - Michigan Cancer Specialists
  - Royal Oak, Michigan, Stany Zjednoczone, 48073
    - Cancer Care Associates PC
  - Royal Oak, Michigan, Stany Zjednoczone, 48073
    - Comprehensive Medical Center PLLC
  - Royal Oak, Michigan, Stany Zjednoczone, 48073
    - Oakland Medical Group
  - Royal Oak, Michigan, Stany Zjednoczone, 48067
    - Oakland Colon Rectal Associates
  - Royal Oak, Michigan, Stany Zjednoczone, 48073
    - Hematology Oncology Consultants PC-Royal Oak
  - Royal Oak, Michigan, Stany Zjednoczone, 48073
    - Corewell Health William Beaumont University Hospital
  - Saginaw, Michigan, Stany Zjednoczone, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saginaw, Michigan, Stany Zjednoczone, 48604
    - Covenant HealthCare Mackinaw
  - Saginaw, Michigan, Stany Zjednoczone, 48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph, Michigan, Stany Zjednoczone, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Stany Zjednoczone, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Shelby, Michigan, Stany Zjednoczone, 48315
    - Henry Ford Macomb Health Center - Shelby Township
  - Southfield, Michigan, Stany Zjednoczone, 48075
    - Henry Ford Health Providence Southfield Hospital
  - Sterling Heights, Michigan, Stany Zjednoczone, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Sterling Heights, Michigan, Stany Zjednoczone, 48312
    - Premier Hematology Oncology Care
  - Sterling Heights, Michigan, Stany Zjednoczone, 48314
    - Mitchell Folbe MD PC
  - Tawas City, Michigan, Stany Zjednoczone, 48764
    - MyMichigan Medical Center Tawas
  - Traverse City, Michigan, Stany Zjednoczone, 49684
    - Munson Medical Center
  - Troy, Michigan, Stany Zjednoczone, 48084
    - Michigan Institute of Urology-Town Center
  - Troy, Michigan, Stany Zjednoczone, 48085
    - Claudia BR Herke MD PC
  - Troy, Michigan, Stany Zjednoczone, 48098
    - Hematology Oncology Consultants PC-Troy
  - Troy, Michigan, Stany Zjednoczone, 48085
    - Corewell Health Beaumont Troy Hospital
  - Warren, Michigan, Stany Zjednoczone, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Stany Zjednoczone, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Stany Zjednoczone, 48093
    - Henry Ford Madison Heights Hospital - Breast
  - Warren, Michigan, Stany Zjednoczone, 48093
    - Henry Ford Health Warren Hospital
  - Warren, Michigan, Stany Zjednoczone, 48093
    - Henry Ford Warren Hospital - GLCMS
  - West Bloomfield, Michigan, Stany Zjednoczone, 48322
    - Henry Ford West Bloomfield Hospital
  - West Branch, Michigan, Stany Zjednoczone, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, Stany Zjednoczone, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, Stany Zjednoczone, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Stany Zjednoczone, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Aitkin, Minnesota, Stany Zjednoczone, 56431
    - Riverwood Healthcare Center
  - Bemidji, Minnesota, Stany Zjednoczone, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Stany Zjednoczone, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Stany Zjednoczone, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Stany Zjednoczone, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, Stany Zjednoczone, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, Stany Zjednoczone, 55433
    - Mercy Hospital
  - Deer River, Minnesota, Stany Zjednoczone, 56636
    - Essentia Health - Deer River Clinic
  - Detroit Lakes, Minnesota, Stany Zjednoczone, 56501
    - Essentia Health Saint Mary's - Detroit Lakes Clinic
  - Duluth, Minnesota, Stany Zjednoczone, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Stany Zjednoczone, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Stany Zjednoczone, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Stany Zjednoczone, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Stany Zjednoczone, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fosston, Minnesota, Stany Zjednoczone, 56542
    - Essentia Health - Fosston
  - Fridley, Minnesota, Stany Zjednoczone, 55432
    - Unity Hospital
  - Hibbing, Minnesota, Stany Zjednoczone, 55746
    - Essentia Health Hibbing Clinic
  - Maple Grove, Minnesota, Stany Zjednoczone, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Stany Zjednoczone, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Stany Zjednoczone, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Stany Zjednoczone, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Stany Zjednoczone, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Stany Zjednoczone, 55454
    - Health Partners Inc
  - Monticello, Minnesota, Stany Zjednoczone, 55362
    - Monticello Cancer Center
  - New Ulm, Minnesota, Stany Zjednoczone, 56073
    - New Ulm Medical Center
  - Park Rapids, Minnesota, Stany Zjednoczone, 56470
    - Essentia Health - Park Rapids
  - Princeton, Minnesota, Stany Zjednoczone, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, Stany Zjednoczone, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Stany Zjednoczone, 55905
    - Mayo Clinic in Rochester
  - Saint Louis Park, Minnesota, Stany Zjednoczone, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Stany Zjednoczone, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Stany Zjednoczone, 55102
    - United Hospital
  - Sandstone, Minnesota, Stany Zjednoczone, 55072
    - Essentia Health Sandstone
  - Shakopee, Minnesota, Stany Zjednoczone, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Stany Zjednoczone, 55082
    - Lakeview Hospital
  - Thief River Falls, Minnesota, Stany Zjednoczone, 56701
    - Sanford Thief River Falls Medical Center
  - Virginia, Minnesota, Stany Zjednoczone, 55792
    - Essentia Health Virginia Clinic
  - Waconia, Minnesota, Stany Zjednoczone, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Stany Zjednoczone, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Stany Zjednoczone, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Worthington, Minnesota, Stany Zjednoczone, 56187
    - Sanford Cancer Center Worthington
  - Wyoming, Minnesota, Stany Zjednoczone, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Grenada, Mississippi, Stany Zjednoczone, 38901
    - Baptist Cancer Center-Grenada
  - New Albany, Mississippi, Stany Zjednoczone, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Stany Zjednoczone, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Southhaven, Mississippi, Stany Zjednoczone, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Stany Zjednoczone, 63011
    - Mercy Oncology and Hematology - Clayton-Clarkson
  - Bonne Terre, Missouri, Stany Zjednoczone, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Stany Zjednoczone, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Stany Zjednoczone, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Stany Zjednoczone, 63703
    - Mercy Cancer Center - Cape Girardeau
  - Chesterfield, Missouri, Stany Zjednoczone, 63017
    - Saint Luke's Hospital
  - City of Saint Peters, Missouri, Stany Zjednoczone, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Creve Coeur, Missouri, Stany Zjednoczone, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Stany Zjednoczone, 63640
    - Parkland Health Center - Farmington
  - Jefferson City, Missouri, Stany Zjednoczone, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Stany Zjednoczone, 64804
    - Freeman Health System
  - Joplin, Missouri, Stany Zjednoczone, 64804
    - Mercy Hospital Joplin
  - Rolla, Missouri, Stany Zjednoczone, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, Stany Zjednoczone, 65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph, Missouri, Stany Zjednoczone, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Stany Zjednoczone, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Stany Zjednoczone, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Stany Zjednoczone, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Stany Zjednoczone, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Stany Zjednoczone, 63129
    - Siteman Cancer Center-South County
  - St Louis, Missouri, Stany Zjednoczone, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Stany Zjednoczone, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Stany Zjednoczone, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Stany Zjednoczone, 63128
    - Mercy Hospital South
  - Sullivan, Missouri, Stany Zjednoczone, 63080
    - Missouri Baptist Sullivan Hospital
  - Washington, Missouri, Stany Zjednoczone, 63090
    - Mercy Hospital Washington
- Montana
  - Anaconda, Montana, Stany Zjednoczone, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Stany Zjednoczone, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Stany Zjednoczone, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Stany Zjednoczone, 59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman, Montana, Stany Zjednoczone, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, Stany Zjednoczone, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Stany Zjednoczone, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Stany Zjednoczone, 59405
    - Benefis Sletten Cancer Institute
  - Helena, Montana, Stany Zjednoczone, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Stany Zjednoczone, 59901
    - Logan Health Medical Center
  - Missoula, Montana, Stany Zjednoczone, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Stany Zjednoczone, 59804
    - Community Medical Center
- Nebraska
  - Grand Island, Nebraska, Stany Zjednoczone, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, Stany Zjednoczone, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, Stany Zjednoczone, 68845
    - Fred and Pamela Buffett Cancer Center - Kearney
  - Lincoln, Nebraska, Stany Zjednoczone, 68510
    - Saint Elizabeth Regional Medical Center
  - Omaha, Nebraska, Stany Zjednoczone, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Stany Zjednoczone, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Stany Zjednoczone, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Stany Zjednoczone, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Stany Zjednoczone, 68122
    - Hematology and Oncology Consultants PC
  - Papillion, Nebraska, Stany Zjednoczone, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, Stany Zjednoczone, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Stany Zjednoczone, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Stany Zjednoczone, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Stany Zjednoczone, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Stany Zjednoczone, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Stany Zjednoczone, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, Stany Zjednoczone, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, Stany Zjednoczone, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, Stany Zjednoczone, 89074
    - Urology Specialists of Nevada - Green Valley
  - Henderson, Nevada, Stany Zjednoczone, 89074
    - Oncology Las Vegas - Henderson
  - Las Vegas, Nevada, Stany Zjednoczone, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Stany Zjednoczone, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Stany Zjednoczone, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Stany Zjednoczone, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Stany Zjednoczone, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Stany Zjednoczone, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Stany Zjednoczone, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, Stany Zjednoczone, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Stany Zjednoczone, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Stany Zjednoczone, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Stany Zjednoczone, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Stany Zjednoczone, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Stany Zjednoczone, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Stany Zjednoczone, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Stany Zjednoczone, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Stany Zjednoczone, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Stany Zjednoczone, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, Stany Zjednoczone, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Stany Zjednoczone, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, Stany Zjednoczone, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, Stany Zjednoczone, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, Stany Zjednoczone, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, Stany Zjednoczone, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Stany Zjednoczone, 89113
    - Urology Specialists of Nevada - Southwest
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas, Nevada, Stany Zjednoczone, 89183
    - OptumCare Cancer Care at Fort Apache
  - Pahrump, Nevada, Stany Zjednoczone, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Stany Zjednoczone, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Stany Zjednoczone, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Stany Zjednoczone, 89509
    - Radiation Oncology Associates
- New Hampshire
  - Lebanon, New Hampshire, Stany Zjednoczone, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
- New Jersey
  - Basking Ridge, New Jersey, Stany Zjednoczone, 07920
    - Memorial Sloan Kettering Basking Ridge
  - Middletown, New Jersey, Stany Zjednoczone, 07748
    - Memorial Sloan Kettering Monmouth
  - Montvale, New Jersey, Stany Zjednoczone, 07645
    - Memorial Sloan Kettering Bergen
  - Moorestown, New Jersey, Stany Zjednoczone, 08057
    - Virtua Samson Cancer Center
  - Morristown, New Jersey, Stany Zjednoczone, 07960
    - Morristown Medical Center
  - Mount Holly, New Jersey, Stany Zjednoczone, 08060
    - Virtua Memorial
  - New Brunswick, New Jersey, Stany Zjednoczone, 08903
    - Rutgers Cancer Institute of New Jersey
  - Summit, New Jersey, Stany Zjednoczone, 07902
    - Overlook Hospital
  - Teaneck, New Jersey, Stany Zjednoczone, 07666
    - Holy Name Hospital
  - Voorhees Township, New Jersey, Stany Zjednoczone, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Stany Zjednoczone, 87102
    - Lovelace Medical Center-Saint Joseph Square
  - Albuquerque, New Mexico, Stany Zjednoczone, 87109
    - Lovelace Radiation Oncology
  - Albuquerque, New Mexico, Stany Zjednoczone, 87106
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Stany Zjednoczone, 87110
    - Presbyterian Kaseman Hospital
  - Rio Rancho, New Mexico, Stany Zjednoczone, 87124
    - Presbyterian Rust Medical Center/Jorgensen Cancer Center
- New York
  - Buffalo, New York, Stany Zjednoczone, 14263
    - Roswell Park Cancer Institute
  - Commack, New York, Stany Zjednoczone, 11725
    - Memorial Sloan Kettering Commack
  - Glens Falls, New York, Stany Zjednoczone, 12801
    - Glens Falls Hospital
  - Harrison, New York, Stany Zjednoczone, 10604
    - Memorial Sloan Kettering Westchester
  - New York, New York, Stany Zjednoczone, 10065
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Stany Zjednoczone, 10019
    - Mount Sinai West
  - New York, New York, Stany Zjednoczone, 10029
    - Mount Sinai Hospital
  - New York, New York, Stany Zjednoczone, 10075
    - Lenox Hill Hospital
  - New York, New York, Stany Zjednoczone, 10065
    - Manhattan Eye Ear and Throat Hospital
  - The Bronx, New York, Stany Zjednoczone, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Stany Zjednoczone, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Stany Zjednoczone, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Uniondale, New York, Stany Zjednoczone, 11553
    - Memorial Sloan Kettering Nassau
- North Carolina
  - Albemarle, North Carolina, Stany Zjednoczone, 28002
    - Atrium Health Stanly/LCI-Albemarle
  - Chapel Hill, North Carolina, Stany Zjednoczone, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Stany Zjednoczone, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Stany Zjednoczone, 28210
    - Atrium Health Pineville/LCI-Pineville
  - Charlotte, North Carolina, Stany Zjednoczone, 28262
    - Atrium Health University City/LCI-University
  - Charlotte, North Carolina, Stany Zjednoczone, 28211
    - Levine Cancer Institute-SouthPark
  - Charlotte, North Carolina, Stany Zjednoczone, 28277
    - Levine Cancer Institute-Ballantyne
  - Clemmons, North Carolina, Stany Zjednoczone, 27012
    - Wake Forest University at Clemmons
  - Clinton, North Carolina, Stany Zjednoczone, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Concord, North Carolina, Stany Zjednoczone, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Elkin, North Carolina, Stany Zjednoczone, 28521
    - Wake Forest University at Elkin
  - Gastonia, North Carolina, Stany Zjednoczone, 28054
    - Levine Cancer Institute-Gaston
  - Goldsboro, North Carolina, Stany Zjednoczone, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Stany Zjednoczone, 27534
    - Wayne Memorial Hospital
  - Hendersonville, North Carolina, Stany Zjednoczone, 28791
    - Margaret R Pardee Memorial Hospital
  - Jacksonville, North Carolina, Stany Zjednoczone, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville, North Carolina, Stany Zjednoczone, 28546
    - Onslow Memorial Hospital
  - Kenansville, North Carolina, Stany Zjednoczone, 28349
    - ECU Health Oncology Kenansville
  - Kinston, North Carolina, Stany Zjednoczone, 28501
    - ECU Health Oncology Kinston
  - Lexington, North Carolina, Stany Zjednoczone, 27292
    - Wake Forest University at Lexington
  - Lincolnton, North Carolina, Stany Zjednoczone, 28092
    - Atrium Health Lincoln/LCI-Lincolnton
  - Monroe, North Carolina, Stany Zjednoczone, 28112
    - Atrium Health Union/LCI-Union
  - Mount Airy, North Carolina, Stany Zjednoczone, 27030
    - Wake Forest University at Mount Airy
  - Raleigh, North Carolina, Stany Zjednoczone, 27607
    - Rex Hematology Oncology Associates-Blue Ridge
  - Raleigh, North Carolina, Stany Zjednoczone, 27607
    - UNC Health Cancer Care Raleigh
  - Raleigh, North Carolina, Stany Zjednoczone, 27614
    - UNC Health Cancer Care Wakefield
  - Richlands, North Carolina, Stany Zjednoczone, 28574
    - ECU Health Oncology Richlands
  - Winston-Salem, North Carolina, Stany Zjednoczone, 27157
    - Wake Forest University Health Sciences
- North Dakota
  - Bismarck, North Dakota, Stany Zjednoczone, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Stany Zjednoczone, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Stany Zjednoczone, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Stany Zjednoczone, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Stany Zjednoczone, 58103
    - Sanford South University Medical Center
  - Jamestown, North Dakota, Stany Zjednoczone, 58401
    - Essentia Health - Jamestown Clinic
  - Minot, North Dakota, Stany Zjednoczone, 58701
    - Trinity Cancer Care Center
- Ohio
  - Beachwood, Ohio, Stany Zjednoczone, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Belpre, Ohio, Stany Zjednoczone, 45714
    - Strecker Cancer Center-Belpre
  - Chardon, Ohio, Stany Zjednoczone, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, Stany Zjednoczone, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Stany Zjednoczone, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cincinnati, Ohio, Stany Zjednoczone, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Stany Zjednoczone, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Stany Zjednoczone, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Stany Zjednoczone, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Stany Zjednoczone, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Stany Zjednoczone, 44109
    - MetroHealth Medical Center
  - Columbus, Ohio, Stany Zjednoczone, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Stany Zjednoczone, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Stany Zjednoczone, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Stany Zjednoczone, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Stany Zjednoczone, 43228
    - Doctors Hospital
  - Columbus, Ohio, Stany Zjednoczone, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Stany Zjednoczone, 43215
    - Grant Medical Center
  - Columbus, Ohio, Stany Zjednoczone, 43222
    - Mount Carmel Health Center West
  - Delaware, Ohio, Stany Zjednoczone, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Stany Zjednoczone, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Stany Zjednoczone, 43015
    - Grady Memorial Hospital
  - Dublin, Ohio, Stany Zjednoczone, 43016
    - Dublin Methodist Hospital
  - Elyria, Ohio, Stany Zjednoczone, 44035
    - Mercy Cancer Center-Elyria
  - Grove City, Ohio, Stany Zjednoczone, 43123
    - Mount Carmel Grove City Hospital
  - Lancaster, Ohio, Stany Zjednoczone, 43130
    - Fairfield Medical Center
  - Mansfield, Ohio, Stany Zjednoczone, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Stany Zjednoczone, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Stany Zjednoczone, 43302
    - OhioHealth Marion General Hospital
  - Mayfield Heights, Ohio, Stany Zjednoczone, 44124
    - UH Seidman Cancer Center at Landerbrook Health Center
  - Mentor, Ohio, Stany Zjednoczone, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights, Ohio, Stany Zjednoczone, 44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Mount Vernon, Ohio, Stany Zjednoczone, 43050
    - Knox Community Hospital
  - Newark, Ohio, Stany Zjednoczone, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Stany Zjednoczone, 43055
    - Newark Radiation Oncology
  - Parma, Ohio, Stany Zjednoczone, 44129
    - University Hospitals Parma Medical Center
  - Portsmouth, Ohio, Stany Zjednoczone, 45662
    - Southern Ohio Medical Center
  - Ravenna, Ohio, Stany Zjednoczone, 44266
    - University Hospitals Portage Medical Center
  - Sandusky, Ohio, Stany Zjednoczone, 44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Wadsworth, Ohio, Stany Zjednoczone, 44281
    - University Hospitals Sharon Health Center
  - West Chester, Ohio, Stany Zjednoczone, 45069
    - University of Cincinnati Cancer Center-West Chester
  - Westerville, Ohio, Stany Zjednoczone, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Stany Zjednoczone, 44145
    - UH Seidman Cancer Center at Saint John Medical Center
  - Westlake, Ohio, Stany Zjednoczone, 44145
    - UHHS-Westlake Medical Center
  - Zanesville, Ohio, Stany Zjednoczone, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Stany Zjednoczone, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Stany Zjednoczone, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Stany Zjednoczone, 73120
    - Mercy Hospital Oklahoma City
  - Tulsa, Oklahoma, Stany Zjednoczone, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
- Oregon
  - Baker City, Oregon, Stany Zjednoczone, 97814
    - Saint Alphonsus Cancer Care Center-Baker City
  - Bend, Oregon, Stany Zjednoczone, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Stany Zjednoczone, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Stany Zjednoczone, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Stany Zjednoczone, 97420
    - Bay Area Hospital
  - Newberg, Oregon, Stany Zjednoczone, 97132
    - Providence Newberg Medical Center
  - Ontario, Oregon, Stany Zjednoczone, 97914
    - Saint Alphonsus Cancer Care Center-Ontario
  - Portland, Oregon, Stany Zjednoczone, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Stany Zjednoczone, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Stany Zjednoczone, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Stany Zjednoczone, 97227
    - Kaiser Permanente Northwest
  - Redmond, Oregon, Stany Zjednoczone, 97756
    - Saint Charles Health System-Redmond
- Pennsylvania
  - Abington, Pennsylvania, Stany Zjednoczone, 19001
    - Jefferson Abington Hospital
  - Allentown, Pennsylvania, Stany Zjednoczone, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Beaver, Pennsylvania, Stany Zjednoczone, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem, Pennsylvania, Stany Zjednoczone, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bethlehem, Pennsylvania, Stany Zjednoczone, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Bryn Mawr, Pennsylvania, Stany Zjednoczone, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Stany Zjednoczone, 19317
    - Christiana Care Health System-Concord Health Center
  - Collegeville, Pennsylvania, Stany Zjednoczone, 19426
    - Main Line Health Center-Collegeville
  - Danville, Pennsylvania, Stany Zjednoczone, 17822
    - Geisinger Medical Center
  - East Stroudsburg, Pennsylvania, Stany Zjednoczone, 18301
    - Pocono Medical Center
  - Exton, Pennsylvania, Stany Zjednoczone, 19341
    - Main Line Health Center-Exton
  - Greensburg, Pennsylvania, Stany Zjednoczone, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Harrisburg, Pennsylvania, Stany Zjednoczone, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Harrisburg, Pennsylvania, Stany Zjednoczone, 17101
    - UPMC Pinnacle Harrisburg
  - Hazleton, Pennsylvania, Stany Zjednoczone, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hazleton, Pennsylvania, Stany Zjednoczone, 18201
    - Lehigh Valley Hospital-Hazleton
  - Johnstown, Pennsylvania, Stany Zjednoczone, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lewisburg, Pennsylvania, Stany Zjednoczone, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Stany Zjednoczone, 17044
    - Lewistown Hospital
  - McKeesport, Pennsylvania, Stany Zjednoczone, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Media, Pennsylvania, Stany Zjednoczone, 19063
    - Riddle Memorial Hospital
  - Moon Township, Pennsylvania, Stany Zjednoczone, 15108
    - UPMC Hillman Cancer Center in Coraopolis
  - Paoli, Pennsylvania, Stany Zjednoczone, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19140
    - Temple University Hospital
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19107
    - Pennsylvania Hospital
  - Pittsburgh, Pennsylvania, Stany Zjednoczone, 15232
    - UPMC Hillman Cancer Center
  - Pittsburgh, Pennsylvania, Stany Zjednoczone, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Stany Zjednoczone, 15232
    - UPMC-Shadyside Hospital
  - Pittsburgh, Pennsylvania, Stany Zjednoczone, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Stany Zjednoczone, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Stany Zjednoczone, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pottsville, Pennsylvania, Stany Zjednoczone, 17901
    - Geisinger Cancer Services-Pottsville
  - Seneca, Pennsylvania, Stany Zjednoczone, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Stany Zjednoczone, 16801
    - Geisinger Medical Group
  - Uniontown, Pennsylvania, Stany Zjednoczone, 15401
    - UPMC Uniontown Hospital Radiation Oncology
  - Washington, Pennsylvania, Stany Zjednoczone, 15301
    - UPMC Washington Hospital Radiation Oncology
  - West Reading, Pennsylvania, Stany Zjednoczone, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Stany Zjednoczone, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Willow Grove, Pennsylvania, Stany Zjednoczone, 19090
    - Asplundh Cancer Pavilion
  - Wynnewood, Pennsylvania, Stany Zjednoczone, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Stany Zjednoczone, 17408
    - UPMC Memorial
- South Carolina
  - Boiling Springs, South Carolina, Stany Zjednoczone, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Clinton, South Carolina, Stany Zjednoczone, 29325
    - Prisma Health Cancer Institute - Laurens
  - Easley, South Carolina, Stany Zjednoczone, 29640
    - Prisma Health Cancer Institute - Easley
  - Gaffney, South Carolina, Stany Zjednoczone, 29341
    - Gibbs Cancer Center-Gaffney
  - Georgetown, South Carolina, Stany Zjednoczone, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenville, South Carolina, Stany Zjednoczone, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Stany Zjednoczone, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Stany Zjednoczone, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Stany Zjednoczone, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greer, South Carolina, Stany Zjednoczone, 29650
    - Prisma Health Cancer Institute - Greer
  - Greer, South Carolina, Stany Zjednoczone, 29651
    - Gibbs Cancer Center-Pelham
  - Rock Hill, South Carolina, Stany Zjednoczone, 29732
    - Levine Cancer Institute-Rock Hill
  - Rock Hill, South Carolina, Stany Zjednoczone, 29730
    - Rock Hill Radiation Therapy Center
  - Seneca, South Carolina, Stany Zjednoczone, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, Stany Zjednoczone, 29303
    - Spartanburg Medical Center
  - Union, South Carolina, Stany Zjednoczone, 29379
    - SMC Center for Hematology Oncology Union
- South Dakota
  - Sioux Falls, South Dakota, Stany Zjednoczone, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Stany Zjednoczone, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Chattanooga, Tennessee, Stany Zjednoczone, 37404
    - Memorial Hospital
  - Collierville, Tennessee, Stany Zjednoczone, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Franklin, Tennessee, Stany Zjednoczone, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Hixson, Tennessee, Stany Zjednoczone, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Memphis, Tennessee, Stany Zjednoczone, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Nashville, Tennessee, Stany Zjednoczone, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Stany Zjednoczone, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
  - Ooltewah, Tennessee, Stany Zjednoczone, 37363
    - Memorial GYN Plus
- Texas
  - Bryan, Texas, Stany Zjednoczone, 77802
    - Saint Joseph Regional Cancer Center
  - Dallas, Texas, Stany Zjednoczone, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Stany Zjednoczone, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Fort Worth, Texas, Stany Zjednoczone, 76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Houston, Texas, Stany Zjednoczone, 77030
    - UT MD Anderson Cancer Center
  - Richardson, Texas, Stany Zjednoczone, 75080
    - UT Southwestern Clinical Center at Richardson/Plano
- Utah
  - American Fork, Utah, Stany Zjednoczone, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Stany Zjednoczone, 84720
    - Sandra L Maxwell Cancer Center
  - Farmington, Utah, Stany Zjednoczone, 84025
    - Farmington Health Center
  - Logan, Utah, Stany Zjednoczone, 84321
    - Logan Regional Hospital
  - Murray, Utah, Stany Zjednoczone, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Stany Zjednoczone, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Stany Zjednoczone, 84604
    - Utah Valley Regional Medical Center
  - Riverton, Utah, Stany Zjednoczone, 84065
    - Riverton Hospital
  - Salt Lake City, Utah, Stany Zjednoczone, 84112
    - Huntsman Cancer Institute/University of Utah
  - Salt Lake City, Utah, Stany Zjednoczone, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Stany Zjednoczone, 84143
    - LDS Hospital
  - Salt Lake City, Utah, Stany Zjednoczone, 84106
    - University of Utah Sugarhouse Health Center
  - St. George, Utah, Stany Zjednoczone, 84770
    - Saint George Regional Medical Center
- Vermont
  - Berlin Corners, Vermont, Stany Zjednoczone, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, Stany Zjednoczone, 05401
    - University of Vermont Medical Center
  - Burlington, Vermont, Stany Zjednoczone, 05405
    - University of Vermont and State Agricultural College
  - Saint Johnsbury, Vermont, Stany Zjednoczone, 05819
    - Dartmouth Cancer Center - North
- Virginia
  - Martinsville, Virginia, Stany Zjednoczone, 24112
    - Sovah Health Martinsville
  - Richmond, Virginia, Stany Zjednoczone, 23298
    - VCU Massey Comprehensive Cancer Center
  - South Hill, Virginia, Stany Zjednoczone, 23970
    - VCU Community Memorial Health Center
- Washington
  - Aberdeen, Washington, Stany Zjednoczone, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, Stany Zjednoczone, 98001
    - MultiCare Auburn Medical Center
  - Bellevue, Washington, Stany Zjednoczone, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Stany Zjednoczone, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Burien, Washington, Stany Zjednoczone, 98166
    - Saint Anne Hospital
  - Centralia, Washington, Stany Zjednoczone, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Stany Zjednoczone, 98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw, Washington, Stany Zjednoczone, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Stany Zjednoczone, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Stany Zjednoczone, 98003
    - Saint Francis Hospital
  - Gig Harbor, Washington, Stany Zjednoczone, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Stany Zjednoczone, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Stany Zjednoczone, 99336
    - Kadlec Clinic Hematology and Oncology
  - Lacey, Washington, Stany Zjednoczone, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Stany Zjednoczone, 98499
    - Saint Clare Hospital
  - Longview, Washington, Stany Zjednoczone, 98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend, Washington, Stany Zjednoczone, 98368
    - Jefferson Healthcare
  - Poulsbo, Washington, Stany Zjednoczone, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Stany Zjednoczone, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Stany Zjednoczone, 98055
    - Valley Medical Center
  - Seattle, Washington, Stany Zjednoczone, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Stany Zjednoczone, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Stany Zjednoczone, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Stany Zjednoczone, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Stany Zjednoczone, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Stany Zjednoczone, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Seattle, Washington, Stany Zjednoczone, 98109
    - Fred Hutchinson Cancer Center
  - Sedro-Woolley, Washington, Stany Zjednoczone, 98284
    - PeaceHealth United General Medical Center
  - Shelton, Washington, Stany Zjednoczone, 98584
    - Providence Regional Cancer System-Shelton
  - Silverdale, Washington, Stany Zjednoczone, 98383
    - Saint Joseph Medical Center Hematology and Oncology - Silverdale
  - Spokane, Washington, Stany Zjednoczone, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane, Washington, Stany Zjednoczone, 99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Spokane Valley, Washington, Stany Zjednoczone, 99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma, Washington, Stany Zjednoczone, 98405
    - Mary Bridge Children's Hospital and Health Center
  - Tacoma, Washington, Stany Zjednoczone, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Stany Zjednoczone, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Stany Zjednoczone, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Stany Zjednoczone, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Stany Zjednoczone, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yelm, Washington, Stany Zjednoczone, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Bridgeport, West Virginia, Stany Zjednoczone, 26330
    - United Hospital Center
  - Charleston, West Virginia, Stany Zjednoczone, 25304
    - Vandalia Health/CAMC Institute for Academic Medicine
  - Martinsburg, West Virginia, Stany Zjednoczone, 25401
    - WVUH-Berkely Medical Center
  - Morgantown, West Virginia, Stany Zjednoczone, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Stany Zjednoczone, 26101
    - Camden Clark Medical Center
- Wisconsin
  - Appleton, Wisconsin, Stany Zjednoczone, 54911
    - ThedaCare Regional Cancer Center
  - Ashland, Wisconsin, Stany Zjednoczone, 54806
    - Duluth Clinic Ashland
  - Ashland, Wisconsin, Stany Zjednoczone, 54806
    - Northwest Wisconsin Cancer Center
  - Burlington, Wisconsin, Stany Zjednoczone, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Eau Claire, Wisconsin, Stany Zjednoczone, 54701
    - Marshfield Medical Center-EC Cancer Center
  - Eau Claire, Wisconsin, Stany Zjednoczone, 54701
    - HSHS Sacred Heart Hospital
  - Fond du Lac, Wisconsin, Stany Zjednoczone, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Stany Zjednoczone, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Stany Zjednoczone, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Stany Zjednoczone, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Stany Zjednoczone, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Stany Zjednoczone, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Stany Zjednoczone, 54301
    - Bellin Memorial Hospital
  - Johnson Creek, Wisconsin, Stany Zjednoczone, 53038
    - University of Wisconsin Carbone Cancer Center - Johnson Creek
  - Kenosha, Wisconsin, Stany Zjednoczone, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Stany Zjednoczone, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Stany Zjednoczone, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Marinette, Wisconsin, Stany Zjednoczone, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marshfield, Wisconsin, Stany Zjednoczone, 54449
    - Marshfield Medical Center-Marshfield
  - Milwaukee, Wisconsin, Stany Zjednoczone, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Stany Zjednoczone, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Stany Zjednoczone, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Stany Zjednoczone, 54548
    - Marshfield Medical Center - Minocqua
  - Mukwonago, Wisconsin, Stany Zjednoczone, 53149
    - ProHealth D N Greenwald Center
  - New Richmond, Wisconsin, Stany Zjednoczone, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Stany Zjednoczone, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oshkosh, Wisconsin, Stany Zjednoczone, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Stany Zjednoczone, 53406
    - Aurora Cancer Care-Racine
  - Rice Lake, Wisconsin, Stany Zjednoczone, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Stany Zjednoczone, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point, Wisconsin, Stany Zjednoczone, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Sturgeon Bay, Wisconsin, Stany Zjednoczone, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Stany Zjednoczone, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Stany Zjednoczone, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Stany Zjednoczone, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Stany Zjednoczone, 53188
    - ProHealth Waukesha Memorial Hospital
  - Wausau, Wisconsin, Stany Zjednoczone, 54401
    - Marshfield Clinic-Wausau Center
  - Wauwatosa, Wisconsin, Stany Zjednoczone, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Stany Zjednoczone, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Stany Zjednoczone, 54476
    - Marshfield Medical Center - Weston
- Wyoming
  - Cheyenne, Wyoming, Stany Zjednoczone, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Stany Zjednoczone, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Stany Zjednoczone, 82801
    - Welch Cancer Center

Kryteria uczestnictwa

Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.

Kryteria kwalifikacji

Wiek uprawniający do nauki

18 lat i starsze (Dorosły, Starszy dorosły)

Akceptuje zdrowych ochotników

Nie

Płeć kwalifikująca się do nauki

Wszystko

Opis

Inclusion Criteria:

REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Age >= 18 years
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have histologically proven stage IIB (T3N0M0 only), IIIA (T2N1M0), IIIB (T4N0M0), or IIIC (T3N1M0, T4N1M0) invasive squamous cell carcinoma of the anus or anorectum, according to the American Joint Committee on Cancer (AJCC) 8th edition; this may include tumors of non-keratinizing histology such as basaloid, transitional cell, or cloacogenic histology; individuals with squamous cell carcinoma of the anal margin are eligible if there is evidence of extension of the primary tumor into the anal canal
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have hemoglobin levels of > 9 g/dL (within 2 weeks prior to registration)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient must have a platelet count of > 100,000/mm^3 (within 2 weeks prior to registration)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient's absolute neutrophil count (ANC) level must be > 1500/mm^3 (within 2 weeks prior to registration)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Serum creatinine must be =< 1.5 X upper limit of normal (ULN) (within 2 weeks prior to registration)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Total bilirubin must be < 2 X ULN (within 2 weeks prior to registration)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =< 2.5 X institutional upper limit of normal (within 2 weeks prior to registration)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Albumin >= 3.0 g/dL (within 2 weeks prior to registration)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients known to be human immunodeficiency virus (HIV)+ are permitted; patients with CD4 > 200 and serum HIV viral load of < 200 copies/mm^3 are eligible, and in addition:
- Participants must be purified protein derivative (PPD) negative; alternatively, the QuantiFERON-tuberculosis (TB) Gold In-Tube (QFT-GIT) assay (Cellestis Limited, Carnegie, Australia) can be used; an individual is considered positive for M. tuberculosis infection if the IFN-gamma response to TB antigens is above the test cut-off (after subtracting the background IFN-gamma response in the negative control); the result must be obtained within 20 weeks prior to enrollment; PPD positive (or Quantiferon assay positive) participants are permitted if prophylaxis has been completed prior to enrollment
- No history of acquired immune deficiency syndrome (AIDS)-related complications within past year other than a history of low CD4+ T-cell count > 200/mm^3 prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to chemoradiotherapy and should not be used as an exclusion criterion if low
- Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the anal cancer
- Participants MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications when clinically indicated, and should be under the care of a physician experienced in HIV management; participants will be eligible regardless of antiretroviral medication (including no antiretroviral medication) provided there is no intention to initiate therapy or the regimen has been stable for at least 4 weeks with no intention to change the regimen within 12 weeks following enrollment
- Patient must have =< grade 2 diarrhea (participants with grade 1 diarrhea are eligible provided stool for ova/parasites and stool cryptosporidium studies are negative;
- NOTE: HIV testing is not required for eligibility
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: For patients registering prior to start of chemoradiotherapy, baseline scans must have been completed within 4 weeks prior to registration
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Women of child bearing potential and sexually active males must use accepted and effective method(s) of contraception and/or abstain from sexual intercourse while on protocol treatment and for at least 5 months after the last dose of nivolumab (for female patients) and for at least 7 months after the last dose of nivolumab (for male patients)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Any surgery must have been completed >= 4 weeks prior to starting study treatment
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoclonal antibody)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No patients with immunodeficiency or receiving systemic steroid therapy equivalent to > 10 mg prednisone per day or any other form of immunosuppressive therapy within 7 days prior to Step 1 registration; topical corticosteroid or occasional inhaled corticosteroids are allowed
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No live vaccines within 30 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowed
- NOTE: no live vaccines may be administered while participating in the trial
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Previously irradiated patients (Arm S) must have received radiation per National Comprehensive Cancer Network guidelines; radiation therapy delivered on protocol (Arm T) will be reviewed
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients will be registered within 63 days following completion of standard chemoradiation for anal cancer; standard chemoradiation therapy is as defined
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have histologically proven stage IIB (T3N0M0 only), IIIA (T2N1M0), IIIB (T4N0M0), or IIIC (T3N1M0, T4N1M0) invasive squamous cell carcinoma of the anus or anorectum, according to the AJCC 8th edition; this may include tumors of non-keratinizing histology such as basaloid, transitional cell, or cloacogenic histology; individuals with squamous cell carcinoma of the anal margin are eligible if there is evidence of extension of the primary tumor into the anal canal
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have received at least 54 gray (Gy) of radiation to the PTVp (primary) and 45 Gy to PTVn (elective nodal region) for the treatment of the anal cancer
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have ECOG performance status of 0-2
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have hemoglobin levels of > 10 g/dL (within 2 weeks prior to registration)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must have a platelet count of > 100,000/mm^3 (within 2 weeks prior to registration)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient's ANC level must be > 1500/mm^3 (within 2 weeks prior to registration)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Serum creatinine must be =< 1.5 X ULN (within 2 weeks prior to registration)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Total bilirubin must be < 2 X ULN (within 2 weeks prior to registration)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: AST (SGOT)/ALT (SGPT) =< 2.5 X institutional upper limit of normal (within 2 weeks prior to registration)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Albumin >= 3.0 g/dL (within 2 weeks prior to registration)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients known to be human immunodeficiency virus (HIV)+ are permitted; patients with CD4 > 200 and serum HIV viral load of < 200 copies/mm^3 are eligible; in addition:
- Participants must be PPD negative; alternatively, the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay (Cellestis Limited, Carnegie, Australia) can be used; an individual is considered positive for M. tuberculosis infection if the IFN-gamma response to TB antigens is above the test cut-off (after subtracting the background IFN-gamma response in the negative control); the result must be obtained within 20 weeks prior to enrollment; PPD positive (or Quantiferon assay positive) participants are permitted if prophylaxis has been completed prior to enrollment; NOTE: If patient completed chemoradiation on Step 1, PPD testing does not need to be performed again
- No history of AIDS-related complications within past year other than a history of low CD4+ T-cell count > 200/mm^3 prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to chemoradiotherapy should not be used as an exclusion criterion if low
- Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the anal cancer
- Participants MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications when clinically indicated, and should be under the care of a physician experienced in HIV management; participants will be eligible regardless of antiretroviral medication (including no antiretroviral medication) provided there is no intention to initiate therapy or the regimen has been stable for at least 4 weeks with no intention to change the regimen within 12 weeks following enrollment
- Patient must have =< grade 2 diarrhea (participants with grade 1 diarrhea are eligible provided stool for ova/parasites and stool cryptosporidium studies are negative)
- NOTE: HIV testing is not required for eligibility
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Scans done within 4 weeks of randomization to Step 2
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must have recovered from all toxicities associated with chemoradiotherapy for anal cancer, to grade =< 1 with the exception of alopecia
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Women of child bearing potential and sexually active males must use accepted and effective method(s) of contraception and/or abstain from sexual intercourse while on protocol treatment and for at least 5 months after the last dose of nivolumab (for female patients) and for at least 7 months after the last dose of nivolumab (for male patients)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoclonal antibody)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No patients with immunodeficiency or receiving systemic steroid therapy equivalent to > 10 mg prednisone per day or any other form of immunosuppressive therapy within 7 days prior to the first dose of study medication; topical corticosteroid or occasional inhaled corticosteroids are allowed
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No live vaccines within 30 days prior to the first dose of trial treatment and while participating in the trial; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowed

Exclusion Criteria:

REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: For patients registering to Arm T, patients must not have received prior chemoradiotherapy for anal cancer
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients with an allogenic bone marrow/stem, cell or solid organ transplant are excluded
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Women MUST NOT be pregnant or breast-feeding due to the potential teratogenic harm or abortifacient effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used; all patients must also not expect to conceive or father children from study registration and throughout their time on study treatment; for female patients this must continue until at least 5 months after the last dose of nivolumab and for male patients until at least 7 months after the last dose of nivolumab; all females of child bearing potential must have a serum or urine pregnancy test to rule out pregnancy within 2 weeks prior to registration; a female of childbearing potential is any woman, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients will be excluded if they have a T1 or M1, and T2N0 cancer
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must not have had prior potentially curative surgery (abdominal, peritoneal resection) for carcinoma of the anus
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Participants may not be receiving any other standard anti-cancer therapy or experimental agent concurrently with the study drugs
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Individuals with a history of a different malignancy are ineligible except if they have been disease-free for at least 2 years and are deemed by the investigator to be at low risk for recurrence; individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient must not have active autoimmune disease in the past 2 years
- NOTE: This does not include patients with autoimmune disease controlled by medication, such as hypothyroidism; this eligibility includes only patients with endocrine disease controlled by hormone replacement, e.g. hypothyroid, adrenal insufficiency, or diabetes mellitus (DM)
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients with an allogenic bone marrow/stem, cell or solid organ transplant are excluded
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Women MUST NOT be pregnant or breast-feeding due to the potential teratogenic harm or abortifacient effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used; all patients must also not expect to conceive or father children from study registration and throughout their time on study treatment; for female patients this must continue until at least 5 months after the last dose of nivolumab and for male patients until at least 7 months after the last dose of nivolumab; all females of child bearing potential must have a serum or urine pregnancy test to rule out pregnancy within 2 weeks prior to registration; a female of childbearing potential is any woman, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have had prior potentially curative surgery (abdominal, peritoneal resection) for carcinoma of the anus
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Participants may not be receiving any other standard anti-cancer therapy or experimental agent concurrently with the study drugs
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Individuals with a history of a different malignancy are ineligible except if they have been disease-free for at least 2 years and are deemed by the investigator to be at low risk for recurrence; individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must not have active autoimmune disease that has required systemic treatment in past 2 years
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab

Plan studiów

Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.

Jak projektuje się badanie?

Szczegóły projektu

Główny cel: Leczenie
Przydział: Randomizowane
Model interwencyjny: Przydział równoległy
Maskowanie: Brak (otwarta etykieta)

Liczba ramion

Broń i interwencje

Grupa uczestników / Arm	Interwencja / Leczenie
Eksperymentalny: Arm A (nivolumab) Patients receive nivolumab while on study. Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study.	Procedura: Biospecimen Collection Undergo blood sample collection Inne nazwy: Pobieranie próbek biologicznych Zebrano próbki biologiczne Kolekcja próbek Procedura: Magnetic Resonance Imaging Undergo MRI Inne nazwy: MRI Rezonans magnetyczny Skanowanie rezonansu magnetycznego Obrazowanie medyczne, rezonans magnetyczny / jądrowy rezonans magnetyczny PAN Obrazowanie MR Obrazowanie NMR NMRI Obrazowanie magnetycznego rezonansu jądrowego Obrazowanie metodą rezonansu magnetycznego (MRI) sMRI Rezonans magnetyczny (zabieg) Strukturalny MRI Procedura: X-Ray Imaging Undergo chest x-ray Inne nazwy: Konwencjonalne promieniowanie rentgenowskie Radiologia diagnostyczna Obrazowanie medyczne, rentgen Obrazowanie radiograficzne Radiografia RG Statyczne promieniowanie rentgenowskie Rentgenowskie Zwykłe zdjęcia rentgenowskie Procedura obrazowania radiograficznego (zabieg) Procedura: Biopsy Procedure Undergo biopsy Inne nazwy: Bx TYP_BIOPSY Biopsja Biologiczny: Nivolumab Given IV Inne nazwy: BMS-936558 MDX-1106 NIWO ONO-4538 Opdivo CMAB819 Niwolumab biopodobny CMAB819 MDX 1106 MDX1106 BMS 936558 ABP 206 Niwolumab Biopodobny ABP 206 BCD-263 Niwolumab Biopodobny BCD-263 BMS936558 ONO 4538 ONO4538 Procedura: Computed Tomography Undergo CT scan Inne nazwy: Tomografia komputerowa KOT Skanowanie CAT Tomografia komputerowa osiowa Komputerowa tomografia osiowa tomografia Komputerowa tomografia osiowa (zabieg) Tomografia komputerowa (CT). Diagnostyczny skan CAT Diagnostyczny typ usługi skanowania CAT Procedura: Colonoscopy Undergo colonoscopy Procedura: Digital Rectal Examination Undergo digital rectal examination Inne nazwy: DRE Procedura: High Resolution Anoscopy Undergo anoscopy Inne nazwy: HRA Procedura: Proctoscopy Undergo proctoscopy Procedura: Sigmoidoscopy Undergo sigmoidoscopy Inne nazwy: Proktosigmoidoskopia
Inny: Arm B (clinical observation) Patients undergo observation while on study. Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study.	Procedura: Biospecimen Collection Undergo blood sample collection Inne nazwy: Pobieranie próbek biologicznych Zebrano próbki biologiczne Kolekcja próbek Procedura: Magnetic Resonance Imaging Undergo MRI Inne nazwy: MRI Rezonans magnetyczny Skanowanie rezonansu magnetycznego Obrazowanie medyczne, rezonans magnetyczny / jądrowy rezonans magnetyczny PAN Obrazowanie MR Obrazowanie NMR NMRI Obrazowanie magnetycznego rezonansu jądrowego Obrazowanie metodą rezonansu magnetycznego (MRI) sMRI Rezonans magnetyczny (zabieg) Strukturalny MRI Procedura: X-Ray Imaging Undergo chest x-ray Inne nazwy: Konwencjonalne promieniowanie rentgenowskie Radiologia diagnostyczna Obrazowanie medyczne, rentgen Obrazowanie radiograficzne Radiografia RG Statyczne promieniowanie rentgenowskie Rentgenowskie Zwykłe zdjęcia rentgenowskie Procedura obrazowania radiograficznego (zabieg) Procedura: Computed Tomography Undergo CT scan Inne nazwy: Tomografia komputerowa KOT Skanowanie CAT Tomografia komputerowa osiowa Komputerowa tomografia osiowa tomografia Komputerowa tomografia osiowa (zabieg) Tomografia komputerowa (CT). Diagnostyczny skan CAT Diagnostyczny typ usługi skanowania CAT Procedura: Colonoscopy Undergo colonoscopy Procedura: Digital Rectal Examination Undergo digital rectal examination Inne nazwy: DRE Procedura: High Resolution Anoscopy Undergo anoscopy Inne nazwy: HRA Procedura: Proctoscopy Undergo proctoscopy Procedura: Sigmoidoscopy Undergo sigmoidoscopy Inne nazwy: Proktosigmoidoskopia Inny: Patient Observation Undergo observation Inne nazwy: Obserwacja Aktywny nadzór odroczona terapia oczekujące zarządzanie Czujne czekanie

Grupa uczestników / Arm

Interwencja / Leczenie

Eksperymentalny: Arm A (nivolumab)

Patients receive nivolumab while on study. Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study.

Procedura: Biospecimen Collection

Undergo blood sample collection

Inne nazwy:

Pobieranie próbek biologicznych
Zebrano próbki biologiczne
Kolekcja próbek

Procedura: Magnetic Resonance Imaging

Undergo MRI

Inne nazwy:

MRI
Rezonans magnetyczny
Skanowanie rezonansu magnetycznego
Obrazowanie medyczne, rezonans magnetyczny / jądrowy rezonans magnetyczny
PAN
Obrazowanie MR
Obrazowanie NMR
NMRI
Obrazowanie magnetycznego rezonansu jądrowego
Obrazowanie metodą rezonansu magnetycznego (MRI)
sMRI
Rezonans magnetyczny (zabieg)
Strukturalny MRI

Procedura: X-Ray Imaging

Undergo chest x-ray

Inne nazwy:

Konwencjonalne promieniowanie rentgenowskie
Radiologia diagnostyczna
Obrazowanie medyczne, rentgen
Obrazowanie radiograficzne
Radiografia
RG
Statyczne promieniowanie rentgenowskie
Rentgenowskie
Zwykłe zdjęcia rentgenowskie
Procedura obrazowania radiograficznego (zabieg)

Procedura: Biopsy Procedure

Undergo biopsy

Inne nazwy:

Bx
TYP_BIOPSY
Biopsja

Biologiczny: Nivolumab

Given IV

Inne nazwy:

BMS-936558
MDX-1106
NIWO
ONO-4538
Opdivo
CMAB819
Niwolumab biopodobny CMAB819
MDX 1106
MDX1106
BMS 936558
ABP 206
Niwolumab Biopodobny ABP 206
BCD-263
Niwolumab Biopodobny BCD-263
BMS936558
ONO 4538
ONO4538

Procedura: Computed Tomography

Undergo CT scan

Inne nazwy:

Tomografia komputerowa
KOT
Skanowanie CAT
Tomografia komputerowa osiowa
Komputerowa tomografia osiowa
tomografia
Komputerowa tomografia osiowa (zabieg)
Tomografia komputerowa (CT).
Diagnostyczny skan CAT
Diagnostyczny typ usługi skanowania CAT

Procedura: Colonoscopy

Undergo colonoscopy

Procedura: Digital Rectal Examination

Undergo digital rectal examination

Inne nazwy:

Procedura: High Resolution Anoscopy

Undergo anoscopy

Inne nazwy:

Procedura: Proctoscopy

Undergo proctoscopy

Procedura: Sigmoidoscopy

Undergo sigmoidoscopy

Inne nazwy:

Proktosigmoidoskopia

Inny: Arm B (clinical observation)

Patients undergo observation while on study. Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study.

Procedura: Biospecimen Collection

Undergo blood sample collection

Inne nazwy:

Pobieranie próbek biologicznych
Zebrano próbki biologiczne
Kolekcja próbek

Procedura: Magnetic Resonance Imaging

Undergo MRI

Inne nazwy:

MRI
Rezonans magnetyczny
Skanowanie rezonansu magnetycznego
Obrazowanie medyczne, rezonans magnetyczny / jądrowy rezonans magnetyczny
PAN
Obrazowanie MR
Obrazowanie NMR
NMRI
Obrazowanie magnetycznego rezonansu jądrowego
Obrazowanie metodą rezonansu magnetycznego (MRI)
sMRI
Rezonans magnetyczny (zabieg)
Strukturalny MRI

Procedura: X-Ray Imaging

Undergo chest x-ray

Inne nazwy:

Konwencjonalne promieniowanie rentgenowskie
Radiologia diagnostyczna
Obrazowanie medyczne, rentgen
Obrazowanie radiograficzne
Radiografia
RG
Statyczne promieniowanie rentgenowskie
Rentgenowskie
Zwykłe zdjęcia rentgenowskie
Procedura obrazowania radiograficznego (zabieg)

Procedura: Computed Tomography

Undergo CT scan

Inne nazwy:

Tomografia komputerowa
KOT
Skanowanie CAT
Tomografia komputerowa osiowa
Komputerowa tomografia osiowa
tomografia
Komputerowa tomografia osiowa (zabieg)
Tomografia komputerowa (CT).
Diagnostyczny skan CAT
Diagnostyczny typ usługi skanowania CAT

Procedura: Colonoscopy

Undergo colonoscopy

Procedura: Digital Rectal Examination

Undergo digital rectal examination

Inne nazwy:

Procedura: High Resolution Anoscopy

Undergo anoscopy

Inne nazwy:

Procedura: Proctoscopy

Undergo proctoscopy

Procedura: Sigmoidoscopy

Undergo sigmoidoscopy

Inne nazwy:

Proktosigmoidoskopia

Inny: Patient Observation

Undergo observation

Inne nazwy:

Obserwacja
Aktywny nadzór
odroczona terapia
oczekujące zarządzanie
Czujne czekanie

Co mierzy badanie?

Podstawowe miary wyniku

Miara wyniku	Opis środka	Ramy czasowe
Disease free survival Ramy czasowe: Up to 7 years	Will be defined as the occurrence of progression of local disease, distant metastases, second primary or death from the date of randomization.	Up to 7 years

Miary wyników drugorzędnych

Miara wyniku	Opis środka	Ramy czasowe
Ogólne przetrwanie Ramy czasowe: Do 7 lat		Do 7 lat
Objective response rate Ramy czasowe: Up to 7 years	Will be defined by complete and partial response.	Up to 7 years
Severe toxicity interval Ramy czasowe: The time between randomization and the occurrence of late severe side effects (up to 7 years)	The following late side effects are considered as severe: any anal/rectal damage (ulcer, fistula, or perforation), rectal stenosis that required colostomy, skin ulceration, and severe fibrosis. This parameter estimates the probability of being free of late side effects for patients under loco-regional control.	The time between randomization and the occurrence of late severe side effects (up to 7 years)
Colostomy-free survival Ramy czasowe: Up to 7 years		Up to 7 years
Incidence of toxicities Ramy czasowe: Up to 7 years	Will be assessed by National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0.	Up to 7 years

Współpracownicy i badacze

Tutaj znajdziesz osoby i organizacje zaangażowane w to badanie.

Sponsor

National Cancer Institute (NCI)

Współpracownicy

Canadian Cancer Trials Group

Śledczy

Główny śledczy: Lakshmi Rajdev, ECOG-ACRIN Cancer Research Group

Daty zapisu na studia

Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.

Główne daty studiów

Rozpoczęcie studiów (Rzeczywisty)

5 lipca 2018

Zakończenie podstawowe (Szacowany)

31 grudnia 2027

Ukończenie studiów (Szacowany)

31 grudnia 2027

Daty rejestracji na studia

Pierwszy przesłany

28 lipca 2017

Pierwszy przesłany, który spełnia kryteria kontroli jakości

28 lipca 2017

Pierwszy wysłany (Rzeczywisty)

31 lipca 2017

Aktualizacje rekordów badań

Ostatnia wysłana aktualizacja (Rzeczywisty)

2 listopada 2026

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

30 października 2026

Ostatnia weryfikacja

1 października 2026

Więcej informacji

Terminy związane z tym badaniem

Dodatkowe istotne warunki MeSH

Inne numery identyfikacyjne badania

NCI-2017-01347
U10CA180820 (Grant/umowa NIH USA)
NCI-2017-01347 (Identyfikator rejestru: CTRP (Clinical Trial Reporting Program))
EA2165 (Inny identyfikator: CTEP)
EA2165 (Inny identyfikator: ECOG-ACRIN Cancer Research Group)

Informacje o lekach i urządzeniach, dokumenty badawcze

Bada produkt leczniczy regulowany przez amerykańską FDA

Tak

Bada produkt urządzenia regulowany przez amerykańską FDA

Nie

Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .

Niwolumab po terapii skojarzonej w leczeniu pacjentów z rakiem odbytu w stadium II-IIIB wysokiego ryzyka

Randomizowane badanie fazy III niwolumabu po terapii skojarzonej (CMT) w raku odbytu wysokiego ryzyka

Przegląd badań

Status

Warunki

Interwencja / Leczenie

Szczegółowy opis

Typ studiów

Zapisy (Szacowany)

Faza

Kontakty i lokalizacje

Lokalizacje studiów

Kryteria uczestnictwa

Kryteria kwalifikacji

Wiek uprawniający do nauki

Akceptuje zdrowych ochotników

Płeć kwalifikująca się do nauki

Opis

Plan studiów

Jak projektuje się badanie?

Szczegóły projektu

Liczba ramion

Broń i interwencje

Grupa uczestników / Arm

Interwencja / Leczenie

Co mierzy badanie?

Podstawowe miary wyniku

Miara wyniku

Opis środka

Ramy czasowe

Miary wyników drugorzędnych

Miara wyniku

Opis środka

Ramy czasowe

Współpracownicy i badacze

Sponsor

Współpracownicy

Śledczy

Daty zapisu na studia

Główne daty studiów

Rozpoczęcie studiów (Rzeczywisty)

Zakończenie podstawowe (Szacowany)

Ukończenie studiów (Szacowany)

Daty rejestracji na studia

Pierwszy przesłany

Pierwszy przesłany, który spełnia kryteria kontroli jakości

Pierwszy wysłany (Rzeczywisty)

Aktualizacje rekordów badań

Ostatnia wysłana aktualizacja (Rzeczywisty)

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

Ostatnia weryfikacja

Więcej informacji

Terminy związane z tym badaniem

Dodatkowe istotne warunki MeSH

Inne numery identyfikacyjne badania

Informacje o lekach i urządzeniach, dokumenty badawcze

Bada produkt leczniczy regulowany przez amerykańską FDA

Bada produkt urządzenia regulowany przez amerykańską FDA