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Nivolumab efter kombineret modalitetsterapi til behandling af patienter med højrisiko trin II-IIIB analcancer

28. maj 2026 opdateret af: National Cancer Institute (NCI)

Et randomiseret fase III-studie af Nivolumab efter kombineret modalitetsterapi (CMT) i højrisiko analcancer

Dette fase III-forsøg undersøger, hvor godt nivolumab efter kombineret modalitetsterapi virker ved behandling af patienter med højrisikostadie II-IIIB analcancer. Immunterapi med monoklonale antistoffer, såsom nivolumab, kan hjælpe kroppens immunsystem med at angribe kræften og kan forstyrre tumorcellernes evne til at vokse og sprede sig.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆR MÅL:

I. At evaluere om behandling med nivolumab efter kombineret modalitetsterapi (CMT) forbedrer sygdomsfri overlevelse (DFS) sammenlignet med observation hos patienter med højrisiko analcarcinom.

SEKUNDÆRE MÅL:

I. At sammenligne nivolumab efter kombineret modalitetsterapi (CMT) med observation hos patienter med højrisiko analcarcinom med hensyn til:

Ia. Objektiv responsrate (komplet [CR] og delvis [PR]), stabil sygdom og progression.

Ib. Alvorligt toksicitetsinterval. Ic. Kolostomifri overlevelse. Id. Samlet overlevelse. Dvs. Toksicitet.

OVERSIGT: Patienter, der modtog standard CMT, randomiseres til 1 ud af 2 arme.

ARM A: Patienter får nivolumab intravenøst (IV) over 30 minutter på dag 1. Behandlingen gentages hver 4. uge i op til 6 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM B: Patienter gennemgår observation i op til 6 måneder.

Efter afslutning af undersøgelsesbehandlingen følges patienterne op efter 6 uger, hver 3. måned i 2 år og derefter hver 6. måned i 3 år.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

344

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 5G2
    - Arthur J E Child Comprehensive Cancer Centre
- British Columbia
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - BCCA-Vancouver Cancer Centre
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Canada, A1B 3V6
    - Doctor H. Bliss Murphy Cancer Centre
- Ontario
  - London, Ontario, Canada, N6A 4L6
    - London Regional Cancer Program
  - Ottawa, Ontario, Canada, K1H 8L6
    - Ottawa Hospital and Cancer Center-General Campus
  - Sault Ste. Marie, Ontario, Canada, P6B 0A8
    - Algoma District Cancer Program Sault Area Hospital
  - Toronto, Ontario, Canada, M5G 2M9
    - University Health Network-Princess Margaret Hospital
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
- Alaska
  - Anchorage, Alaska, Forenede Stater, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forenede Stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forenede Stater, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Goodyear, Arizona, Forenede Stater, 85338
    - CTCA at Western Regional Medical Center
  - Kingman, Arizona, Forenede Stater, 86401
    - Kingman Regional Medical Center
  - Phoenix, Arizona, Forenede Stater, 85054
    - Mayo Clinic Hospital in Arizona
  - Scottsdale, Arizona, Forenede Stater, 85259
    - Mayo Clinic in Arizona
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Mercy Hospital Fort Smith
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
- California
  - Anaheim, California, Forenede Stater, 92806
    - Kaiser Permanente-Anaheim
  - Antioch, California, Forenede Stater, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Arroyo Grande, California, Forenede Stater, 93420
    - PCR Oncology
  - Arroyo Grande, California, Forenede Stater, 93420
    - Mission Hope Medical Oncology - Arroyo Grande
  - Auburn, California, Forenede Stater, 95602
    - Sutter Auburn Faith Hospital
  - Auburn, California, Forenede Stater, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Baldwin Park, California, Forenede Stater, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Forenede Stater, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Mills-Peninsula Medical Center
  - Cameron Park, California, Forenede Stater, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Hospital Medical Center
  - Chico, California, Forenede Stater, 95926
    - Enloe Medical Center
  - Clovis, California, Forenede Stater, 93611
    - Community Cancer Institute
  - Clovis, California, Forenede Stater, 93611
    - University Oncology Associates
  - Davis, California, Forenede Stater, 95616
    - Sutter Davis Hospital
  - Dublin, California, Forenede Stater, 94568
    - Kaiser Permanente Dublin
  - Fontana, California, Forenede Stater, 92335
    - Kaiser Permanente-Fontana
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Palo Alto Medical Foundation-Fremont
  - Fresno, California, Forenede Stater, 93720
    - Kaiser Permanente-Fresno
  - Fresno, California, Forenede Stater, 93720
    - Fresno Cancer Center
  - Harbor City, California, Forenede Stater, 90710
    - Kaiser Permanente South Bay
  - Irvine, California, Forenede Stater, 92618
    - Kaiser Permanente-Irvine
  - La Jolla, California, Forenede Stater, 92093
    - UC San Diego Moores Cancer Center
  - Los Angeles, California, Forenede Stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forenede Stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forenede Stater, 90034
    - Kaiser Permanente West Los Angeles
  - Los Angeles, California, Forenede Stater, 90033
    - Los Angeles General Medical Center
  - Marysville, California, Forenede Stater, 95901
    - Fremont - Rideout Cancer Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forenede Stater, 95356
    - Kaiser Permanente-Modesto
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Newport Beach, California, Forenede Stater, 92663
    - USC Norris Oncology/Hematology-Newport Beach
  - Novato, California, Forenede Stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente Oakland-Broadway
  - Ontario, California, Forenede Stater, 91761
    - Kaiser Permanente-Ontario
  - Orange, California, Forenede Stater, 92868
    - Saint Joseph Hospital - Orange
  - Palo Alto, California, Forenede Stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, Forenede Stater, 91402
    - Kaiser Permanente - Panorama City
  - Pasadena, California, Forenede Stater, 91105
    - Keck Medical Center of USC Pasadena
  - Rancho Cordova, California, Forenede Stater, 95670
    - Kaiser Permanente-Rancho Cordova Cancer Center
  - Rancho Mirage, California, Forenede Stater, 92270
    - Eisenhower Medical Center
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, Forenede Stater, 92505
    - Kaiser Permanente-Riverside
  - Rohnert Park, California, Forenede Stater, 94928
    - Rohnert Park Cancer Center
  - Roseville, California, Forenede Stater, 95678
    - The Permanente Medical Group-Roseville Radiation Oncology
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95814
    - Kaiser Permanente Downtown Commons
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forenede Stater, 95823
    - South Sacramento Cancer Center
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente Sacramento Medical Center
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Forenede Stater, 92108
    - Kaiser Permanente-San Diego Mission
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Forenede Stater, 94110
    - Zuckerberg San Francisco General Hospital
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Marcos, California, Forenede Stater, 92078
    - Kaiser Permanente-San Marcos
  - San Mateo, California, Forenede Stater, 94401
    - Mills Health Center
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser San Rafael-Gallinas
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, Forenede Stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Maria, California, Forenede Stater, 93444
    - Mission Hope Medical Oncology - Santa Maria
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forenede Stater, 95403
    - Sutter Pacific Medical Foundation
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente Cancer Treatment Center
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente-Stockton
  - Sunnyvale, California, Forenede Stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Vacaville, California, Forenede Stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Woodland Hills, California, Forenede Stater, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Forenede Stater, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Forenede Stater, 80920
    - Memorial Hospital North
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forenede Stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forenede Stater, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forenede Stater, 80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver, Colorado, Forenede Stater, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Forenede Stater, 80206
    - National Jewish Health-Main Campus
  - Denver, Colorado, Forenede Stater, 80220
    - Western Surgical Care
  - Denver, Colorado, Forenede Stater, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver, Colorado, Forenede Stater, 80210
    - AdventHealth Porter
  - Durango, Colorado, Forenede Stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forenede Stater, 81301
    - CommonSpirit Cancer Center Mercy
  - Englewood, Colorado, Forenede Stater, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Golden, Colorado, Forenede Stater, 80401
    - Mountain Blue Cancer Care Center
  - Golden, Colorado, Forenede Stater, 80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction, Colorado, Forenede Stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - Banner North Colorado Medical Center
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lafayette, Colorado, Forenede Stater, 80026
    - Good Samaritan Hospital - Cancer Centers of Colorado
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Lakewood, Colorado, Forenede Stater, 80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Littleton, Colorado, Forenede Stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forenede Stater, 80122
    - AdventHealth Littleton
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forenede Stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forenede Stater, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Parker, Colorado, Forenede Stater, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Parker, Colorado, Forenede Stater, 80138
    - AdventHealth Parker
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Forenede Stater, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Forenede Stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Forenede Stater, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, Forenede Stater, 80401
    - Intermountain Health Lutheran Hospital
- Delaware
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Millville, Delaware, Forenede Stater, 19967
    - Beebe South Coastal Health Campus
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forenede Stater, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Forenede Stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Forenede Stater, 20037
    - George Washington University Medical Center
- Florida
  - Altamonte Springs, Florida, Forenede Stater, 32701
    - AdventHealth Altamonte
  - Aventura, Florida, Forenede Stater, 33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Celebration, Florida, Forenede Stater, 34747
    - AdventHealth Celebration
  - Coral Gables, Florida, Forenede Stater, 33146
    - UM Sylvester Comprehensive Cancer Center at Coral Gables
  - Deerfield Beach, Florida, Forenede Stater, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - Broward Health Medical Center
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Forenede Stater, 32610
    - UF Health Cancer Institute - Gainesville
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Forenede Stater, 32224-9980
    - Mayo Clinic in Florida
  - Kissimmee, Florida, Forenede Stater, 34744
    - AdventHealth Kissimmee
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami, Florida, Forenede Stater, 33176
    - UM Sylvester Comprehensive Cancer Center at Kendall
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Orlando
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Medical Group Urology at Orlando
  - Orlando, Florida, Forenede Stater, 32822
    - AdventHealth East Orlando
  - Pembroke Pines, Florida, Forenede Stater, 33028
    - Memorial Hospital West
  - Pensacola, Florida, Forenede Stater, 32504
    - Sacred Heart Hospital
  - Weston, Florida, Forenede Stater, 33331
    - Cleveland Clinic-Weston
  - Winter Park, Florida, Forenede Stater, 32792
    - AdventHealth Winter Park
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forenede Stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forenede Stater, 30303
    - Grady Health System
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Decatur, Georgia, Forenede Stater, 30033
    - Atlanta VA Medical Center
  - Fayetteville, Georgia, Forenede Stater, 30214
    - Piedmont Fayette Hospital
  - Johns Creek, Georgia, Forenede Stater, 30097
    - Emory Johns Creek Hospital
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forenede Stater, 31405
    - Summit Cancer Care-Candler
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell, Idaho, Forenede Stater, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Health - Coeur d'Alene
  - Emmett, Idaho, Forenede Stater, 83617
    - Walter Knox Memorial Hospital
  - Fruitland, Idaho, Forenede Stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Forenede Stater, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, Forenede Stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forenede Stater, 83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Nampa, Idaho, Forenede Stater, 83687
    - Saint Luke's Cancer Institute - Nampa
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls, Idaho, Forenede Stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Burr Ridge, Illinois, Forenede Stater, 60527
    - Loyola Center for Health at Burr Ridge
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Forenede Stater, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Forenede Stater, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forenede Stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush MD Anderson Cancer Center
  - Danville, Illinois, Forenede Stater, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Forenede Stater, 61021
    - Illinois CancerCare-Dixon
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Glenview, Illinois, Forenede Stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Homer Glen, Illinois, Forenede Stater, 60491
    - Loyola Medicine Homer Glen
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest, Illinois, Forenede Stater, 60045
    - Northwestern Medicine Lake Forest Hospital
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forenede Stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - Melrose Park, Illinois, Forenede Stater, 60160
    - Marjorie Weinberg Cancer Center at Loyola-Gottlieb
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - SSM Health Good Samaritan
  - O'Fallon, Illinois, Forenede Stater, 62269
    - Cancer Care Center of O'Fallon
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Springfield Clinic
  - Springfield, Illinois, Forenede Stater, 62781
    - Springfield Memorial Hospital
  - Swansea, Illinois, Forenede Stater, 62226
    - Southwest Illinois Health Services LLP
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - The Carle Foundation Hospital
  - Washington, Illinois, Forenede Stater, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, Forenede Stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Carmel, Indiana, Forenede Stater, 46032
    - IU Health North Hospital
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Forenede Stater, 46290
    - Springmill Medical Center
  - Lafayette, Indiana, Forenede Stater, 47905
    - Franciscan Saint Elizabeth Health - Lafayette East
  - Michigan City, Indiana, Forenede Stater, 46360
    - Woodland Cancer Care Center
  - Mooresville, Indiana, Forenede Stater, 46158
    - Franciscan Health Mooresville
  - New Albany, Indiana, Forenede Stater, 47150
    - Baptist Health Floyd
  - Terre Haute, Indiana, Forenede Stater, 47804
    - Union Hospital
- Iowa
  - Bettendorf, Iowa, Forenede Stater, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Alegent Health Mercy Hospital
  - Creston, Iowa, Forenede Stater, 50801
    - Greater Regional Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50309
    - UI Health Care Mission Cancer and Blood - Des Moines Clinic
  - Des Moines, Iowa, Forenede Stater, 50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - UI Healthcare Mission Cancer and Blood - Fort Dodge
  - Iowa City, Iowa, Forenede Stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - West Des Moines, Iowa, Forenede Stater, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Fairway, Kansas, Forenede Stater, 66205
    - University of Kansas Clinical Research Center
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Forenede Stater, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Forenede Stater, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forenede Stater, 66061
    - The University of Kansas Cancer Center - Olathe
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Mercy Hospital Pittsburg
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Forenede Stater, 66606
    - University of Kansas Health System Saint Francis Campus
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Westwood, Kansas, Forenede Stater, 66205
    - University of Kansas Hospital-Westwood Cancer Center
  - Wichita, Kansas, Forenede Stater, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bardstown, Kentucky, Forenede Stater, 40004
    - Flaget Memorial Hospital
  - Corbin, Kentucky, Forenede Stater, 40701
    - Baptist Health Corbin
  - Corbin, Kentucky, Forenede Stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Lexington, Kentucky, Forenede Stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forenede Stater, 40509
    - Saint Joseph Hospital East
  - Lexington, Kentucky, Forenede Stater, 40503
    - Baptist Health Lexington
  - London, Kentucky, Forenede Stater, 40741
    - Saint Joseph London
  - Louisville, Kentucky, Forenede Stater, 40202
    - The James Graham Brown Cancer Center at University of Louisville
  - Louisville, Kentucky, Forenede Stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forenede Stater, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forenede Stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Madisonville, Kentucky, Forenede Stater, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Paducah, Kentucky, Forenede Stater, 42003
    - Baptist Health Paducah
  - Shepherdsville, Kentucky, Forenede Stater, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forenede Stater, 70808
    - Our Lady of the Lake Physician Group
  - Metairie, Louisiana, Forenede Stater, 70006
    - East Jefferson General Hospital
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Louisiana State University Health Science Center
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Fitchburg, Massachusetts, Forenede Stater, 01420
    - Simonds-Sinon Regional Cancer Center
  - Springfield, Massachusetts, Forenede Stater, 01104
    - Mercy Medical Center
  - Worcester, Massachusetts, Forenede Stater, 01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Rogel Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Bay City, Michigan, Forenede Stater, 48706
    - McLaren Cancer Institute-Bay City
  - Bloomfield, Michigan, Forenede Stater, 48302
    - McLaren Cancer Institute-Bloomfield
  - Brighton, Michigan, Forenede Stater, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton, Michigan, Forenede Stater, 48116
    - University of Michigan - Brighton Center for Specialty Care
  - Brighton, Michigan, Forenede Stater, 48114
    - Trinity Health Medical Center - Brighton
  - Brownstown, Michigan, Forenede Stater, 48183
    - Henry Ford Cancer Institute-Downriver
  - Canton, Michigan, Forenede Stater, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton, Michigan, Forenede Stater, 48188
    - Trinity Health Medical Center - Canton
  - Caro, Michigan, Forenede Stater, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, Forenede Stater, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea, Michigan, Forenede Stater, 48118
    - Chelsea Hospital
  - Clarkston, Michigan, Forenede Stater, 48346
    - McLaren Cancer Institute-Clarkston
  - Clarkston, Michigan, Forenede Stater, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Forenede Stater, 48346
    - Newland Medical Associates-Clarkston
  - Clinton Township, Michigan, Forenede Stater, 48038
    - Henry Ford Macomb Hospital-Clinton Township
  - Dearborn, Michigan, Forenede Stater, 48126
    - Henry Ford Medical Center-Fairlane
  - Dearborn, Michigan, Forenede Stater, 48124
    - Corewell Health Dearborn Hospital
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forenede Stater, 48236
    - Henry Ford Health Saint John Hospital
  - East China Township, Michigan, Forenede Stater, 48054
    - Henry Ford River District Hospital
  - Farmington Hills, Michigan, Forenede Stater, 48334
    - Weisberg Cancer Treatment Center
  - Farmington Hills, Michigan, Forenede Stater, 48336
    - Corewell Health Farmington Hills Hospital
  - Flint, Michigan, Forenede Stater, 48532
    - McLaren Cancer Institute-Flint
  - Flint, Michigan, Forenede Stater, 48532
    - Singh and Arora Hematology Oncology PC
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, Forenede Stater, 48503
    - Cancer Hematology Centers - Flint
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
  - Grosse Pointe, Michigan, Forenede Stater, 48230
    - William Beaumont Hospital-Grosse Pointe
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Henry Ford Saint John Hospital - Academic
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Henry Ford Saint John Hospital - Breast
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Henry Ford Saint John Hospital - Van Elslander
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49048
    - Beacon Kalamazoo
  - Lansing, Michigan, Forenede Stater, 48912
    - Mid-Michigan Physicians-Lansing
  - Lansing, Michigan, Forenede Stater, 48910
    - Karmanos Cancer Institute at McLaren Greater Lansing
  - Lansing, Michigan, Forenede Stater, 48912
    - University of Michigan Health - Sparrow Lansing
  - Lapeer, Michigan, Forenede Stater, 48446
    - McLaren Cancer Institute-Lapeer Region
  - Livonia, Michigan, Forenede Stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Forenede Stater, 48044
    - Henry Ford Warren Hospital - Breast Macomb
  - Macomb, Michigan, Forenede Stater, 48044
    - Henry Ford Saint John Hospital - Macomb Medical
  - Marlette, Michigan, Forenede Stater, 48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Mount Clemens, Michigan, Forenede Stater, 48043
    - McLaren Cancer Institute-Macomb
  - Mount Pleasant, Michigan, Forenede Stater, 48858
    - McLaren Cancer Institute-Central Michigan
  - Muskegon, Michigan, Forenede Stater, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Forenede Stater, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores, Michigan, Forenede Stater, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Novi, Michigan, Forenede Stater, 48377
    - Henry Ford Medical Center-Columbus
  - Novi, Michigan, Forenede Stater, 48374
    - Henry Ford Health Providence Novi Hospital
  - Petoskey, Michigan, Forenede Stater, 49770
    - McLaren Cancer Institute-Northern Michigan
  - Pontiac, Michigan, Forenede Stater, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Forenede Stater, 48341
    - Newland Medical Associates-Pontiac
  - Pontiac, Michigan, Forenede Stater, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac, Michigan, Forenede Stater, 48341
    - Michigan Healthcare Professionals Pontiac
  - Port Huron, Michigan, Forenede Stater, 48060
    - McLaren-Port Huron
  - Reed City, Michigan, Forenede Stater, 49677
    - Corewell Health Reed City Hospital
  - Rochester Hills, Michigan, Forenede Stater, 48309
    - Henry Ford Rochester Hospital
  - Roseville, Michigan, Forenede Stater, 48066
    - Michigan Cancer Specialists
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Cancer Care Associates PC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Comprehensive Medical Center PLLC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Oakland Medical Group
  - Royal Oak, Michigan, Forenede Stater, 48067
    - Oakland Colon Rectal Associates
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Hematology Oncology Consultants PC-Royal Oak
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Corewell Health William Beaumont University Hospital
  - Saginaw, Michigan, Forenede Stater, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saginaw, Michigan, Forenede Stater, 48604
    - Covenant HealthCare Mackinaw
  - Saginaw, Michigan, Forenede Stater, 48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Shelby, Michigan, Forenede Stater, 48315
    - Henry Ford Macomb Health Center - Shelby Township
  - Southfield, Michigan, Forenede Stater, 48075
    - Henry Ford Health Providence Southfield Hospital
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Premier Hematology Oncology Care
  - Sterling Heights, Michigan, Forenede Stater, 48314
    - Mitchell Folbe MD PC
  - Tawas City, Michigan, Forenede Stater, 48764
    - MyMichigan Medical Center Tawas
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forenede Stater, 48084
    - Michigan Institute of Urology-Town Center
  - Troy, Michigan, Forenede Stater, 48085
    - Claudia BR Herke MD PC
  - Troy, Michigan, Forenede Stater, 48098
    - Hematology Oncology Consultants PC-Troy
  - Troy, Michigan, Forenede Stater, 48085
    - Corewell Health Beaumont Troy Hospital
  - Warren, Michigan, Forenede Stater, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Forenede Stater, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Forenede Stater, 48093
    - Henry Ford Madison Heights Hospital - Breast
  - Warren, Michigan, Forenede Stater, 48093
    - Henry Ford Health Warren Hospital
  - Warren, Michigan, Forenede Stater, 48093
    - Henry Ford Warren Hospital - GLCMS
  - West Bloomfield, Michigan, Forenede Stater, 48322
    - Henry Ford West Bloomfield Hospital
  - West Branch, Michigan, Forenede Stater, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, Forenede Stater, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Forenede Stater, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Aitkin, Minnesota, Forenede Stater, 56431
    - Riverwood Healthcare Center
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, Forenede Stater, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Deer River, Minnesota, Forenede Stater, 56636
    - Essentia Health - Deer River Clinic
  - Detroit Lakes, Minnesota, Forenede Stater, 56501
    - Essentia Health Saint Mary's - Detroit Lakes Clinic
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fosston, Minnesota, Forenede Stater, 56542
    - Essentia Health - Fosston
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hibbing, Minnesota, Forenede Stater, 55746
    - Essentia Health Hibbing Clinic
  - Maple Grove, Minnesota, Forenede Stater, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55454
    - Health Partners Inc
  - Monticello, Minnesota, Forenede Stater, 55362
    - Monticello Cancer Center
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Park Rapids, Minnesota, Forenede Stater, 56470
    - Essentia Health - Park Rapids
  - Princeton, Minnesota, Forenede Stater, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic in Rochester
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Sandstone, Minnesota, Forenede Stater, 55072
    - Essentia Health Sandstone
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Thief River Falls, Minnesota, Forenede Stater, 56701
    - Sanford Thief River Falls Medical Center
  - Virginia, Minnesota, Forenede Stater, 55792
    - Essentia Health Virginia Clinic
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Worthington, Minnesota, Forenede Stater, 56187
    - Sanford Cancer Center Worthington
  - Wyoming, Minnesota, Forenede Stater, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Grenada, Mississippi, Forenede Stater, 38901
    - Baptist Cancer Center-Grenada
  - New Albany, Mississippi, Forenede Stater, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Forenede Stater, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Southhaven, Mississippi, Forenede Stater, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Forenede Stater, 63011
    - Mercy Oncology and Hematology - Clayton-Clarkson
  - Bonne Terre, Missouri, Forenede Stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forenede Stater, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Mercy Cancer Center - Cape Girardeau
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - City of Saint Peters, Missouri, Forenede Stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Creve Coeur, Missouri, Forenede Stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Forenede Stater, 63640
    - Parkland Health Center - Farmington
  - Jefferson City, Missouri, Forenede Stater, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Rolla, Missouri, Forenede Stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, Forenede Stater, 65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Forenede Stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forenede Stater, 63129
    - Siteman Cancer Center-South County
  - St Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forenede Stater, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital South
  - Sullivan, Missouri, Forenede Stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forenede Stater, 63127
    - BJC Outpatient Center at Sunset Hills
  - Washington, Missouri, Forenede Stater, 63090
    - Mercy Hospital Washington
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Sletten Cancer Institute
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Logan Health Medical Center
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Center
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, Forenede Stater, 68845
    - Fred and Pamela Buffett Cancer Center - Kearney
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Saint Elizabeth Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Hematology and Oncology Consultants PC
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, Forenede Stater, 89074
    - Urology Specialists of Nevada - Green Valley
  - Henderson, Nevada, Forenede Stater, 89074
    - Oncology Las Vegas - Henderson
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forenede Stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Forenede Stater, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forenede Stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forenede Stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, Forenede Stater, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Forenede Stater, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Urology Specialists of Nevada - Southwest
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89183
    - OptumCare Cancer Care at Fort Apache
  - Pahrump, Nevada, Forenede Stater, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89509
    - Radiation Oncology Associates
- New Hampshire
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
- New Jersey
  - Basking Ridge, New Jersey, Forenede Stater, 07920
    - Memorial Sloan Kettering Basking Ridge
  - Middletown, New Jersey, Forenede Stater, 07748
    - Memorial Sloan Kettering Monmouth
  - Montvale, New Jersey, Forenede Stater, 07645
    - Memorial Sloan Kettering Bergen
  - Moorestown, New Jersey, Forenede Stater, 08057
    - Virtua Samson Cancer Center
  - Morristown, New Jersey, Forenede Stater, 07960
    - Morristown Medical Center
  - Mount Holly, New Jersey, Forenede Stater, 08060
    - Virtua Memorial
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Teaneck, New Jersey, Forenede Stater, 07666
    - Holy Name Hospital
  - Voorhees Township, New Jersey, Forenede Stater, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - Lovelace Medical Center-Saint Joseph Square
  - Albuquerque, New Mexico, Forenede Stater, 87109
    - Lovelace Radiation Oncology
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87110
    - Presbyterian Kaseman Hospital
  - Rio Rancho, New Mexico, Forenede Stater, 87124
    - Presbyterian Rust Medical Center/Jorgensen Cancer Center
- New York
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Commack, New York, Forenede Stater, 11725
    - Memorial Sloan Kettering Commack
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - Harrison, New York, Forenede Stater, 10604
    - Memorial Sloan Kettering Westchester
  - New York, New York, Forenede Stater, 10065
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Forenede Stater, 10019
    - Mount Sinai West
  - New York, New York, Forenede Stater, 10029
    - Mount Sinai Hospital
  - New York, New York, Forenede Stater, 10075
    - Lenox Hill Hospital
  - New York, New York, Forenede Stater, 10065
    - Manhattan Eye Ear and Throat Hospital
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Forenede Stater, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Uniondale, New York, Forenede Stater, 11553
    - Memorial Sloan Kettering Nassau
- North Carolina
  - Albemarle, North Carolina, Forenede Stater, 28002
    - Atrium Health Stanly/LCI-Albemarle
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forenede Stater, 28210
    - Atrium Health Pineville/LCI-Pineville
  - Charlotte, North Carolina, Forenede Stater, 28262
    - Atrium Health University City/LCI-University
  - Charlotte, North Carolina, Forenede Stater, 28211
    - Levine Cancer Institute-SouthPark
  - Charlotte, North Carolina, Forenede Stater, 28277
    - Levine Cancer Institute-Ballantyne
  - Clemmons, North Carolina, Forenede Stater, 27012
    - Wake Forest University at Clemmons
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Concord, North Carolina, Forenede Stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Elkin, North Carolina, Forenede Stater, 28521
    - Wake Forest University at Elkin
  - Gastonia, North Carolina, Forenede Stater, 28054
    - Levine Cancer Institute-Gaston
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Onslow Memorial Hospital
  - Kenansville, North Carolina, Forenede Stater, 28349
    - ECU Health Oncology Kenansville
  - Kinston, North Carolina, Forenede Stater, 28501
    - ECU Health Oncology Kinston
  - Lexington, North Carolina, Forenede Stater, 27292
    - Wake Forest University at Lexington
  - Lincolnton, North Carolina, Forenede Stater, 28092
    - Atrium Health Lincoln/LCI-Lincolnton
  - Monroe, North Carolina, Forenede Stater, 28112
    - Atrium Health Union/LCI-Union
  - Mount Airy, North Carolina, Forenede Stater, 27030
    - Wake Forest University at Mount Airy
  - Raleigh, North Carolina, Forenede Stater, 27607
    - Rex Hematology Oncology Associates-Blue Ridge
  - Raleigh, North Carolina, Forenede Stater, 27607
    - UNC Health Cancer Care Raleigh
  - Raleigh, North Carolina, Forenede Stater, 27614
    - UNC Health Cancer Care Wakefield
  - Richlands, North Carolina, Forenede Stater, 28574
    - ECU Health Oncology Richlands
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Wake Forest University Health Sciences
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Sanford South University Medical Center
  - Jamestown, North Dakota, Forenede Stater, 58401
    - Essentia Health - Jamestown Clinic
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Beachwood, Ohio, Forenede Stater, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Belpre, Ohio, Forenede Stater, 45714
    - Strecker Cancer Center-Belpre
  - Chardon, Ohio, Forenede Stater, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forenede Stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forenede Stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Forenede Stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Dublin, Ohio, Forenede Stater, 43016
    - Dublin Methodist Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Mercy Cancer Center-Elyria
  - Grove City, Ohio, Forenede Stater, 43123
    - Mount Carmel Grove City Hospital
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Mansfield, Ohio, Forenede Stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Forenede Stater, 43302
    - OhioHealth Marion General Hospital
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - UH Seidman Cancer Center at Landerbrook Health Center
  - Mentor, Ohio, Forenede Stater, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights, Ohio, Forenede Stater, 44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Newark Radiation Oncology
  - Parma, Ohio, Forenede Stater, 44129
    - University Hospitals Parma Medical Center
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Ravenna, Ohio, Forenede Stater, 44266
    - University Hospitals Portage Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Wadsworth, Ohio, Forenede Stater, 44281
    - University Hospitals Sharon Health Center
  - West Chester, Ohio, Forenede Stater, 45069
    - University of Cincinnati Cancer Center-West Chester
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Forenede Stater, 44145
    - UH Seidman Cancer Center at Saint John Medical Center
  - Westlake, Ohio, Forenede Stater, 44145
    - UHHS-Westlake Medical Center
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
- Oregon
  - Baker City, Oregon, Forenede Stater, 97814
    - Saint Alphonsus Cancer Care Center-Baker City
  - Bend, Oregon, Forenede Stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forenede Stater, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Forenede Stater, 97420
    - Bay Area Hospital
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Ontario, Oregon, Forenede Stater, 97914
    - Saint Alphonsus Cancer Care Center-Ontario
  - Portland, Oregon, Forenede Stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Northwest
  - Redmond, Oregon, Forenede Stater, 97756
    - Saint Charles Health System-Redmond
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Jefferson Abington Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Beaver, Pennsylvania, Forenede Stater, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Forenede Stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Collegeville, Pennsylvania, Forenede Stater, 19426
    - Main Line Health Center-Collegeville
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Pocono Medical Center
  - Exton, Pennsylvania, Forenede Stater, 19341
    - Main Line Health Center-Exton
  - Greensburg, Pennsylvania, Forenede Stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Harrisburg, Pennsylvania, Forenede Stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Harrisburg, Pennsylvania, Forenede Stater, 17101
    - UPMC Pinnacle Harrisburg
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Lehigh Valley Hospital-Hazleton
  - Johnstown, Pennsylvania, Forenede Stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lewisburg, Pennsylvania, Forenede Stater, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - McKeesport, Pennsylvania, Forenede Stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Moon Township, Pennsylvania, Forenede Stater, 15108
    - UPMC Hillman Cancer Center in Coraopolis
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - Temple University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Pennsylvania Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - UPMC-Shadyside Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Forenede Stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pottsville, Pennsylvania, Forenede Stater, 17901
    - Geisinger Cancer Services-Pottsville
  - Seneca, Pennsylvania, Forenede Stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - UPMC Uniontown Hospital Radiation Oncology
  - Washington, Pennsylvania, Forenede Stater, 15301
    - UPMC Washington Hospital Radiation Oncology
  - West Reading, Pennsylvania, Forenede Stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Willow Grove, Pennsylvania, Forenede Stater, 19090
    - Asplundh Cancer Pavilion
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forenede Stater, 17408
    - UPMC Memorial
- South Carolina
  - Boiling Springs, South Carolina, Forenede Stater, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Clinton, South Carolina, Forenede Stater, 29325
    - Prisma Health Cancer Institute - Laurens
  - Easley, South Carolina, Forenede Stater, 29640
    - Prisma Health Cancer Institute - Easley
  - Gaffney, South Carolina, Forenede Stater, 29341
    - Gibbs Cancer Center-Gaffney
  - Georgetown, South Carolina, Forenede Stater, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Forenede Stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greer, South Carolina, Forenede Stater, 29650
    - Prisma Health Cancer Institute - Greer
  - Greer, South Carolina, Forenede Stater, 29651
    - Gibbs Cancer Center-Pelham
  - Rock Hill, South Carolina, Forenede Stater, 29732
    - Levine Cancer Institute-Rock Hill
  - Rock Hill, South Carolina, Forenede Stater, 29730
    - Rock Hill Radiation Therapy Center
  - Seneca, South Carolina, Forenede Stater, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
  - Union, South Carolina, Forenede Stater, 29379
    - SMC Center for Hematology Oncology Union
- South Dakota
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Chattanooga, Tennessee, Forenede Stater, 37404
    - Memorial Hospital
  - Collierville, Tennessee, Forenede Stater, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Franklin, Tennessee, Forenede Stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Hixson, Tennessee, Forenede Stater, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
  - Ooltewah, Tennessee, Forenede Stater, 37363
    - Memorial GYN Plus
- Texas
  - Bryan, Texas, Forenede Stater, 77802
    - Saint Joseph Regional Cancer Center
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Fort Worth, Texas, Forenede Stater, 76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Houston, Texas, Forenede Stater, 77030
    - M D Anderson Cancer Center
  - Richardson, Texas, Forenede Stater, 75080
    - UT Southwestern Clinical Center at Richardson/Plano
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L Maxwell Cancer Center
  - Farmington, Utah, Forenede Stater, 84025
    - Farmington Health Center
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center
  - Riverton, Utah, Forenede Stater, 84065
    - Riverton Hospital
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute/University of Utah
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
  - Salt Lake City, Utah, Forenede Stater, 84106
    - University of Utah Sugarhouse Health Center
  - St. George, Utah, Forenede Stater, 84770
    - Saint George Regional Medical Center
- Vermont
  - Berlin Corners, Vermont, Forenede Stater, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, Forenede Stater, 05401
    - University of Vermont Medical Center
  - Burlington, Vermont, Forenede Stater, 05405
    - University of Vermont and State Agricultural College
  - Saint Johnsbury, Vermont, Forenede Stater, 05819
    - Dartmouth Cancer Center - North
- Virginia
  - Martinsville, Virginia, Forenede Stater, 24112
    - Sovah Health Martinsville
  - Richmond, Virginia, Forenede Stater, 23298
    - VCU Massey Comprehensive Cancer Center
  - South Hill, Virginia, Forenede Stater, 23970
    - VCU Community Memorial Health Center
- Washington
  - Aberdeen, Washington, Forenede Stater, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, Forenede Stater, 98001
    - MultiCare Auburn Medical Center
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Burien, Washington, Forenede Stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forenede Stater, 98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw, Washington, Forenede Stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Gig Harbor, Washington, Forenede Stater, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Lacey, Washington, Forenede Stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forenede Stater, 98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend, Washington, Forenede Stater, 98368
    - Jefferson Healthcare
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Forenede Stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forenede Stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forenede Stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Forenede Stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Forenede Stater, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Seattle, Washington, Forenede Stater, 98109
    - Fred Hutchinson Cancer Center
  - Sedro-Woolley, Washington, Forenede Stater, 98284
    - PeaceHealth United General Medical Center
  - Shelton, Washington, Forenede Stater, 98584
    - Providence Regional Cancer System-Shelton
  - Silverdale, Washington, Forenede Stater, 98383
    - Saint Joseph Medical Center Hematology and Oncology - Silverdale
  - Spokane, Washington, Forenede Stater, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane, Washington, Forenede Stater, 99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Spokane Valley, Washington, Forenede Stater, 99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma, Washington, Forenede Stater, 98405
    - Mary Bridge Children's Hospital and Health Center
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yelm, Washington, Forenede Stater, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Bridgeport, West Virginia, Forenede Stater, 26330
    - United Hospital Center
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston Division
  - Martinsburg, West Virginia, Forenede Stater, 25401
    - WVUH-Berkely Medical Center
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Forenede Stater, 26101
    - Camden Clark Medical Center
- Wisconsin
  - Appleton, Wisconsin, Forenede Stater, 54911
    - ThedaCare Regional Cancer Center
  - Ashland, Wisconsin, Forenede Stater, 54806
    - Duluth Clinic Ashland
  - Ashland, Wisconsin, Forenede Stater, 54806
    - Northwest Wisconsin Cancer Center
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Medical Center-EC Cancer Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - HSHS Sacred Heart Hospital
  - Fond du Lac, Wisconsin, Forenede Stater, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Bellin Memorial Hospital
  - Johnson Creek, Wisconsin, Forenede Stater, 53038
    - University of Wisconsin Carbone Cancer Center - Johnson Creek
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Milwaukee, Wisconsin, Forenede Stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Medical Center - Minocqua
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - ProHealth D N Greenwald Center
  - New Richmond, Wisconsin, Forenede Stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Medical Center - Weston
- Wyoming
  - Cheyenne, Wyoming, Forenede Stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forenede Stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Patienter skal have histologisk bevist stadium IIB (kun T3N0M0), IIIA (T2N1M0), IIIB (T4N0M0) eller IIIC (T3N1M0, T4N1M0) invasivt planocellulært cellekarcinom i anus eller anus. Joint Committee on Cancer (AJCC) 8. udgave; dette kan omfatte tumorer af ikke-keratiniserende histologi, såsom basaloid-, overgangscelle- eller kloakogen histologi; personer med pladecellekarcinom i analmarginen er kvalificerede, hvis der er tegn på forlængelse af den primære tumor ind i analkanalen
REGISTRERING TIL TRIN 1 KVALIFIKATIONSKRITERIER: Patienter skal have Eastern Cooperative Oncology Group (ECOG) præstationsstatus på 0-2
REGISTRERING TIL TRIN 1 KVALIFICERINGSKRITERIER: Patienter skal have hæmoglobinniveauer på > 9 g/dL (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 1 KVALIFICERINGSKRITERIER: Patienten skal have et trombocyttal på > 100.000/mm^3 (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 1 KVALIFICERINGSKRITERIER: Patientens absolutte neutrofiltal (ANC) niveau skal være > 1500/mm^3 (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Serumkreatinin skal være =< 1,5 X øvre normalgrænse (ULN) (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Total bilirubin skal være < 2 X ULN (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Aspartataminotransferase (AST) (serum glutaminsyre oxaloeddikesyre transaminase [SGOT])/alanin aminotransferase (ALT) (serum glutamin pyrodrueus transaminase [SGPT]) =< 2,5 X institutionel øvre grænse for normal 2 uger til registrering)
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Albumin >= 3,0 g/dL (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Patienter, der vides at være humant immundefektvirus (HIV)+, er tilladt; patienter med CD4 > 200 og serum HIV viral belastning på < 200 kopier/mm^3 er kvalificerede, og desuden:
- Deltagerne skal være oprensede proteinderivater (PPD) negative; alternativt kan QuantiFERON-tuberculosis (TB) Gold In-Tube (QFT-GIT) assayet (Cellestis Limited, Carnegie, Australien) anvendes; et individ anses for positivt for M. tuberculosis-infektion, hvis IFN-gamma-responset på TB-antigener er over testgrænsen (efter at have trukket baggrunds-IFN-gamma-responset fra den negative kontrol); resultatet skal opnås inden for 20 uger før tilmelding; PPD-positive (eller Quantiferon assay-positive) deltagere er tilladt, hvis profylakse er afsluttet før tilmelding
- Ingen historie med erhvervet immundefektsyndrom (AIDS)-relaterede komplikationer inden for det seneste år bortset fra en historie med lavt CD4+ T-celletal > 200/mm^3 før påbegyndelse af antiretroviral kombinationsbehandling; på studiet er CD4+ T-celletallet muligvis ikke informativt på grund af kemoradioterapi og bør ikke bruges som et eksklusionskriterium, hvis det er lavt
- Patienten skal være rask på baggrund af HIV-sygdom med høj sandsynlighed for næsten normal levetid, hvis det ikke var for analkræft
- Deltagerne SKAL modtage passende pleje og behandling for HIV-infektion, herunder antiretroviral medicin, når det er klinisk indiceret, og bør være under pleje af en læge med erfaring i HIV-håndtering; deltagere vil være berettigede uanset antiretroviral medicin (inklusive ingen antiretroviral medicin), forudsat at der ikke er nogen hensigt om at påbegynde behandling, eller at kuren har været stabil i mindst 4 uger uden intention om at ændre regimet inden for 12 uger efter tilmelding
- Patienten skal have =< grad 2 diarré (deltagere med grad 1 diarré er berettiget forudsat afføring for æg/parasitter og afføring cryptosporidium undersøgelser er negative;
- BEMÆRK: HIV-test er ikke påkrævet for berettigelse
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: For patienter, der registrerer sig før start af kemoradioterapi, skal baseline-scanninger være gennemført inden for 4 uger før registrering
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Kvinder i den fødedygtige alder og seksuelt aktive mænd skal bruge accepterede og effektive præventionsmetoder og/eller afholde sig fra samleje under protokolbehandling og i mindst 5 måneder efter den sidste dosis nivolumab (til kvindelige patienter) og i mindst 7 måneder efter den sidste dosis nivolumab (til mandlige patienter)
REGISTRERING TIL TRIN 1 KVALIFICERINGSKRITERIER: Enhver operation skal være gennemført >= 4 uger før start af undersøgelsesbehandling
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Ingen ukontrolleret interkurrent sygdom, herunder, men ikke begrænset til, igangværende eller aktiv infektion, symptomatisk kongestiv hjertesvigt, ustabil angina pectoris, hjertearytmi eller psykiatrisk sygdom/sociale situationer, der ville begrænse overholdelse af undersøgelseskrav
REGISTRERING TIL TRIN 1 KVALIFIKATIONSKRITERIER: Ingen forudgående behandling med en immun checkpoint-hæmmer (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoklonalt antistof)
REGISTRERING TIL TRIN 1 KVALIFICERINGSKRITERIER: Ingen patienter med immundefekt eller får systemisk steroidbehandling svarende til > 10 mg prednison pr. dag eller nogen anden form for immunsuppressiv terapi inden for 7 dage før trin 1 registrering; topiske kortikosteroider eller lejlighedsvis inhalerede kortikosteroider er tilladt
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Ingen levende vacciner inden for 30 dage før registrering; eksempler på levende vacciner omfatter, men er ikke begrænset til, følgende: mæslinger, fåresyge, røde hunde, skoldkopper, gul feber, rabies, BCG og tyfus (oral) vaccine; sæsonbestemte influenzavacciner til injektion er generelt dræbte virusvacciner og er tilladt; dog er intranasale influenzavacciner (f.eks. Flu-Mist) levende svækkede vacciner og er ikke tilladt
- BEMÆRK: der må ikke administreres levende vacciner, mens du deltager i forsøget
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Tidligere bestrålede patienter (arm S) skal have modtaget stråling i henhold til retningslinjerne fra National Comprehensive Cancer Network; strålebehandling leveret efter protokol (arm T) vil blive gennemgået
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienter vil blive registreret inden for 63 dage efter afslutning af standard kemoradiation for anal cancer; standard kemoradiationsterapi er som defineret
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienter skal have histologisk dokumenteret stadium IIB (kun T3N0M0), IIIA (T2N1M0), IIIB (T4N0M0) eller IIIC (T3N1M0, T4N1M0) invasivt planocellulært cellekarcinom i anus eller anorJCC. 8. udgave; dette kan omfatte tumorer af ikke-keratiniserende histologi, såsom basaloid-, overgangscelle- eller kloakogen histologi; personer med pladecellekarcinom i analmarginen er kvalificerede, hvis der er tegn på forlængelse af den primære tumor ind i analkanalen
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Patienter skal have modtaget mindst 54 grå (Gy) stråling til PTVp (primær) og 45 Gy til PTVn (elektiv nodalregion) til behandling af analcancer
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienter skal have ECOG præstationsstatus på 0-2
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienter skal have hæmoglobinniveauer på > 10 g/dL (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienten skal have et trombocyttal på > 100.000/mm^3 (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patientens ANC-niveau skal være > 1500/mm^3 (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Serumkreatinin skal være =< 1,5 X ULN (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Total bilirubin skal være < 2 X ULN (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: AST (SGOT)/ALT (SGPT) =< 2,5 X institutionel øvre grænse for normal (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Albumin >= 3,0 g/dL (inden for 2 uger før registrering)
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Patienter, der vides at være humant immundefekt virus (HIV)+ patienter med CD4 > 200 og serum HIV viral belastning på < 200 kopier/mm^3 er kvalificerede; ud over:
- Deltagere skal være PPD-negative; alternativt kan QuantiFERON-TB Gold In-Tube (QFT-GIT) assayet (Cellestis Limited, Carnegie, Australien) anvendes; et individ anses for positivt for M. tuberculosis-infektion, hvis IFN-gamma-responset på TB-antigener er over testgrænsen (efter at have trukket baggrunds-IFN-gamma-responset fra den negative kontrol); resultatet skal opnås inden for 20 uger før tilmelding; PPD-positive (eller Quantiferon assay-positive) deltagere er tilladt, hvis profylakse er afsluttet før tilmelding; BEMÆRK: Hvis patienten fuldførte kemoradiation på trin 1, skal PPD-testning ikke udføres igen
- Ingen historie med AIDS-relaterede komplikationer inden for det seneste år bortset fra en historie med lavt CD4+ T-celletal > 200/mm^3 før påbegyndelse af antiretroviral kombinationsbehandling; i studiet bør CD4+-T-celletallet muligvis ikke være informativt på grund af kemoradioterapi bør ikke bruges som et eksklusionskriterium, hvis det er lavt
- Patienten skal være rask på baggrund af HIV-sygdom med høj sandsynlighed for næsten normal levetid, hvis det ikke var for analkræft
- Deltagerne SKAL modtage passende pleje og behandling for HIV-infektion, herunder antiretroviral medicin, når det er klinisk indiceret, og bør være under pleje af en læge med erfaring i HIV-håndtering; deltagere vil være berettigede uanset antiretroviral medicin (inklusive ingen antiretroviral medicin), forudsat at der ikke er nogen hensigt om at påbegynde behandling, eller at kuren har været stabil i mindst 4 uger uden intention om at ændre regimet inden for 12 uger efter tilmelding
- Patienten skal have =< grad 2 diarré (deltagere med grad 1 diarré er berettiget, forudsat afføring for æg/parasitter og afføring cryptosporidium undersøgelser er negative)
- BEMÆRK: HIV-test er ikke påkrævet for berettigelse
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Scanninger udført inden for 4 uger efter randomisering til trin 2
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienten skal være kommet sig fra alle toksiciteter forbundet med kemoradioterapi for analcancer, til grad =< 1 med undtagelse af alopeci
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Kvinder i den fødedygtige alder og seksuelt aktive mænd skal bruge accepterede og effektive præventionsmetoder og/eller afholde sig fra samleje under protokolbehandling og i mindst 5 måneder efter den sidste dosis nivolumab (til kvindelige patienter) og i mindst 7 måneder efter den sidste dosis nivolumab (til mandlige patienter)
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Ingen ukontrolleret interkurrent sygdom, herunder, men ikke begrænset til igangværende eller aktiv infektion, symptomatisk kongestiv hjertesvigt, ustabil angina pectoris, hjertearytmi eller psykiatrisk sygdom/sociale situationer, der ville begrænse overholdelse af undersøgelseskrav
REGISTRERING TIL TRIN 2 KVALIFIKATIONSKRITERIER: Ingen forudgående behandling med en immun checkpoint-hæmmer (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoklonalt antistof)
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Ingen patienter med immundefekt eller får systemisk steroidbehandling svarende til > 10 mg prednison pr. dag eller nogen anden form for immunsuppressiv terapi inden for 7 dage før den første dosis af undersøgelsesmedicin; topiske kortikosteroider eller lejlighedsvis inhalerede kortikosteroider er tilladt
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Ingen levende vacciner inden for 30 dage før den første dosis af forsøgsbehandling og under deltagelse i forsøget; eksempler på levende vacciner omfatter, men er ikke begrænset til, følgende: mæslinger, fåresyge, røde hunde, skoldkopper, gul feber, rabies, BCG og tyfus (oral) vaccine; sæsonbestemte influenzavacciner til injektion er generelt dræbte virusvacciner og er tilladt; dog er intranasale influenzavacciner (f.eks. Flu-Mist) levende svækkede vacciner og er ikke tilladt

Ekskluderingskriterier:

REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: For patienter, der registrerer sig til Arm T, må patienter ikke have modtaget forudgående kemoradioterapi for analcancer
REGISTRERING TIL TRIN 1 KVALIFICERINGSKRITERIER: Patienter med en allogen knoglemarvs-/stam-, celle- eller fast organtransplantation er udelukket
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Kvinder MÅ IKKE være gravide eller ammende på grund af den potentielle teratogene skade eller abortfremkaldende virkning på et ufødt foster og mulig risiko for uønskede hændelser hos ammende spædbørn med de anvendte behandlingsregimer; alle patienter må heller ikke forvente at blive gravide eller få børn fra undersøgelsesregistrering og gennem hele deres tid på undersøgelsesbehandling; for kvindelige patienter skal dette fortsætte indtil mindst 5 måneder efter den sidste dosis nivolumab og for mandlige patienter indtil mindst 7 måneder efter den sidste dosis nivolumab; alle kvinder i den fødedygtige alder skal have en serum- eller uringraviditetstest for at udelukke graviditet inden for 2 uger før registrering; en kvinde i den fødedygtige alder er enhver kvinde, uanset seksuel orientering eller om de har gennemgået tubal ligering, som opfylder følgende kriterier: 1) har opnået menarche på et tidspunkt, 2) ikke har gennemgået en hysterektomi eller bilateral ooforektomi, eller 3) ikke har været naturligt postmenopausal (amenoré efter kræftbehandling udelukker ikke den fødedygtige alder) i mindst 24 på hinanden følgende måneder (dvs. har haft menstruation på noget tidspunkt i de foregående 24 på hinanden følgende måneder)
REGISTRERING TIL TRIN 1 KVALIFIKATIONSKRITERIER: Patienter vil blive udelukket, hvis de har en T1- eller M1- og T2N0-kræft
REGISTRERING TIL TRIN 1 KVALIFICERINGSKRITERIER: Patienter må ikke have haft tidligere potentielt helbredende kirurgi (abdominal, peritoneal resektion) for carcinom i anus
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Deltagerne modtager muligvis ikke nogen anden standard anti-cancerterapi eller eksperimentelt middel samtidig med undersøgelsesmedicinen
REGISTRERING TIL TRIN 1 BERETNINGSKRITERIER: Personer med en historie med en anden malignitet er ikke kvalificerede, undtagen hvis de har været sygdomsfrie i mindst 2 år og af investigator anses for at have lav risiko for tilbagefald; personer med følgende kræftformer er berettigede, hvis de er diagnosticeret og behandlet inden for de seneste 5 år: livmoderhalskræft in situ og basalcelle- eller pladecellekarcinom i huden
REGISTRERING TIL TRIN 1 KVALIFIKATIONSKRITERIER: Patienten må ikke have aktiv autoimmun sygdom inden for de seneste 2 år
- BEMÆRK: Dette inkluderer ikke patienter med autoimmun sygdom kontrolleret af medicin, såsom hypothyroidisme; denne berettigelse omfatter kun patienter med endokrin sygdom kontrolleret af hormonsubstitution, f.eks. hypothyreoidea, binyrebarkinsufficiens eller diabetes mellitus (DM)
REGISTRERING TIL TRIN 1 KVALIFICERINGSKRITERIER: Patienter må ikke have kendt interstitiel lungesygdom, der er symptomatisk eller kan interferere med påvisning eller håndtering af formodet lægemiddelrelateret lungetoksicitet
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienter med en allogen knoglemarvs-/stam-, celle- eller solid organtransplantation er udelukket
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Kvinder MÅ IKKE være gravide eller ammende på grund af den potentielle teratogene skade eller abortfremkaldende virkning på et ufødt foster og mulig risiko for uønskede hændelser hos ammende spædbørn med de anvendte behandlingsregimer; alle patienter må heller ikke forvente at blive gravide eller få børn fra undersøgelsesregistrering og gennem hele deres tid på undersøgelsesbehandling; for kvindelige patienter skal dette fortsætte indtil mindst 5 måneder efter den sidste dosis nivolumab og for mandlige patienter indtil mindst 7 måneder efter den sidste dosis nivolumab; alle kvinder i den fødedygtige alder skal have en serum- eller uringraviditetstest for at udelukke graviditet inden for 2 uger før registrering; en kvinde i den fødedygtige alder er enhver kvinde, uanset seksuel orientering eller om de har gennemgået tubal ligering, som opfylder følgende kriterier: 1) har opnået menarche på et tidspunkt, 2) ikke har gennemgået en hysterektomi eller bilateral ooforektomi, eller 3) ikke har været naturligt postmenopausal (amenoré efter kræftbehandling udelukker ikke den fødedygtige alder) i mindst 24 på hinanden følgende måneder (dvs. har haft menstruation på noget tidspunkt i de foregående 24 på hinanden følgende måneder)
REGISTRERING TIL TRIN 2 KVALIFIKATIONSKRITERIER: Patienter må ikke have haft tidligere potentielt helbredende kirurgi (abdominal, peritoneal resektion) for carcinom i anus
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Deltagerne modtager muligvis ikke nogen anden standard anti-cancerterapi eller eksperimentelt middel samtidig med undersøgelsesmedicinen
REGISTRERING TIL TRIN 2 BERETNINGSKRITERIER: Personer med en historie med en anden malignitet er ikke berettigede, undtagen hvis de har været sygdomsfrie i mindst 2 år og af investigator anses for at have lav risiko for gentagelse; personer med følgende kræftformer er berettigede, hvis de er diagnosticeret og behandlet inden for de seneste 5 år: livmoderhalskræft in situ og basalcelle- eller pladecellekarcinom i huden
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienten må ikke have aktiv autoimmun sygdom, der har krævet systemisk behandling i de sidste 2 år
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienter må ikke have kendt interstitiel lungesygdom, der er symptomatisk eller kan interferere med påvisning eller håndtering af formodet lægemiddelrelateret lungetoksicitet
REGISTRERING TIL TRIN 2 KVALIFICERINGSKRITERIER: Patienter må ikke have en historie med allergiske reaktioner, der tilskrives forbindelser med lignende kemisk eller biologisk sammensætning som nivolumab

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Arm A (nivolumab) Patienter får nivolumab under undersøgelsen. Patienterne gennemgår sigmoidoskopi, koloskopi eller anoskopi, proktoskopi eller digital rektalundersøgelse, røntgen, CT-scanning, MRI, biopsi og blodprøvetagning under hele undersøgelsen.	Biologisk: Nivolumab Givet IV Andre navne: BMS-936558 MDX-1106 NIVO ONO-4538 Opdivo CMAB819 Nivolumab Biosimilar CMAB819 MDX 1106 MDX1106 BMS 936558 ABP 206 Nivolumab Biosimilar ABP 206 BCD-263 Nivolumab Biosimilar BCD-263 BMS936558 ONO 4538 ONO4538 Procedure: MR scanning Gennemgå MR Andre navne: MR Magnetisk resonans Magnetisk resonansbilledscanning Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans HR MR billeddannelse MR-scanning NMR billeddannelse NMRI Kernemagnetisk resonansbilleddannelse Magnetisk resonansbilleddannelse (MRI) sMRI Magnetisk resonansbilleddannelse (procedure) MRI'er Strukturel MR Procedure: Bioprøvesamling Gennemgå blodprøvetagning Andre navne: Biologisk prøvesamling Bioprøve indsamlet Prøvesamling Prøvekollektion Procedure: Computertomografi Gennemgå CT-scanning Andre navne: CT KAT CAT-scanning Beregnet aksial tomografi Computerstyret aksial tomografi Computerstyret tomografi CT-scanning tomografi Computerstyret aksial tomografi (procedure) Computerstyret tomografi (CT) scanning Diagnostisk CAT -scanning Diagnostic CAT Scan Service Type Procedure: Koloskopi Gennemgå koloskopi Procedure: Sigmoidoskopi Gennemgå sigmoidoskopi Andre navne: Proctosigmoidoskopi Procedure: Digital rektal undersøgelse Gennemgå digital rektal undersøgelse Andre navne: DRE Procedure: Høj opløsning anoskopi Gennemgå anoskopi Andre navne: HRA Procedure: Proktoskopi Gennemgå proktoskopi Procedure: Røntgenbilleder Får foretaget røntgen af thorax Andre navne: Konventionel røntgen Diagnostisk radiologi Medicinsk billeddannelse, røntgen Radiografisk billeddannelse Radiografi RG Statisk røntgen Røntgen Almindelige film røntgenbilleder Radiografisk billeddannelsesprocedure (procedure) Procedure: Biopsi -procedure Gennemgå biopsi Andre navne: Bx BIOPSY_TYPE Biopsi
Andet: Arm B (klinisk observation) Patienter gennemgår observation under undersøgelsen. Patienterne gennemgår sigmoidoskopi, koloskopi eller anoskopi, proktoskopi eller digital rektalundersøgelse, røntgen, CT-scanning, MRI, biopsi og blodprøvetagning under hele undersøgelsen.	Procedure: MR scanning Gennemgå MR Andre navne: MR Magnetisk resonans Magnetisk resonansbilledscanning Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans HR MR billeddannelse MR-scanning NMR billeddannelse NMRI Kernemagnetisk resonansbilleddannelse Magnetisk resonansbilleddannelse (MRI) sMRI Magnetisk resonansbilleddannelse (procedure) MRI'er Strukturel MR Procedure: Bioprøvesamling Gennemgå blodprøvetagning Andre navne: Biologisk prøvesamling Bioprøve indsamlet Prøvesamling Prøvekollektion Procedure: Computertomografi Gennemgå CT-scanning Andre navne: CT KAT CAT-scanning Beregnet aksial tomografi Computerstyret aksial tomografi Computerstyret tomografi CT-scanning tomografi Computerstyret aksial tomografi (procedure) Computerstyret tomografi (CT) scanning Diagnostisk CAT -scanning Diagnostic CAT Scan Service Type Andet: Patientobservation Gennemgå observation Andre navne: Observation Aktiv overvågning udskudt terapi forventningsfuld ledelse Vagtende venter Procedure: Koloskopi Gennemgå koloskopi Procedure: Sigmoidoskopi Gennemgå sigmoidoskopi Andre navne: Proctosigmoidoskopi Procedure: Digital rektal undersøgelse Gennemgå digital rektal undersøgelse Andre navne: DRE Procedure: Høj opløsning anoskopi Gennemgå anoskopi Andre navne: HRA Procedure: Proktoskopi Gennemgå proktoskopi Procedure: Røntgenbilleder Får foretaget røntgen af thorax Andre navne: Konventionel røntgen Diagnostisk radiologi Medicinsk billeddannelse, røntgen Radiografisk billeddannelse Radiografi RG Statisk røntgen Røntgen Almindelige film røntgenbilleder Radiografisk billeddannelsesprocedure (procedure)

Deltagergruppe / Arm

Intervention / Behandling

Eksperimentel: Arm A (nivolumab)

Patienter får nivolumab under undersøgelsen. Patienterne gennemgår sigmoidoskopi, koloskopi eller anoskopi, proktoskopi eller digital rektalundersøgelse, røntgen, CT-scanning, MRI, biopsi og blodprøvetagning under hele undersøgelsen.

Biologisk: Nivolumab

Givet IV

Andre navne:

BMS-936558
MDX-1106
NIVO
ONO-4538
Opdivo
CMAB819
Nivolumab Biosimilar CMAB819
MDX 1106
MDX1106
BMS 936558
ABP 206
Nivolumab Biosimilar ABP 206
BCD-263
Nivolumab Biosimilar BCD-263
BMS936558
ONO 4538
ONO4538

Procedure: MR scanning

Gennemgå MR

Andre navne:

MR
Magnetisk resonans
Magnetisk resonansbilledscanning
Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
HR
MR billeddannelse
MR-scanning
NMR billeddannelse
NMRI
Kernemagnetisk resonansbilleddannelse
Magnetisk resonansbilleddannelse (MRI)
sMRI
Magnetisk resonansbilleddannelse (procedure)
MRI'er
Strukturel MR

Procedure: Bioprøvesamling

Gennemgå blodprøvetagning

Andre navne:

Biologisk prøvesamling
Bioprøve indsamlet
Prøvesamling
Prøvekollektion

Procedure: Computertomografi

Gennemgå CT-scanning

Andre navne:

CT
KAT
CAT-scanning
Beregnet aksial tomografi
Computerstyret aksial tomografi
Computerstyret tomografi
CT-scanning
tomografi
Computerstyret aksial tomografi (procedure)
Computerstyret tomografi (CT) scanning
Diagnostisk CAT -scanning
Diagnostic CAT Scan Service Type

Procedure: Koloskopi

Gennemgå koloskopi

Procedure: Sigmoidoskopi

Gennemgå sigmoidoskopi

Andre navne:

Proctosigmoidoskopi

Procedure: Digital rektal undersøgelse

Gennemgå digital rektal undersøgelse

Andre navne:

Procedure: Høj opløsning anoskopi

Gennemgå anoskopi

Andre navne:

Procedure: Proktoskopi

Gennemgå proktoskopi

Procedure: Røntgenbilleder

Får foretaget røntgen af thorax

Andre navne:

Konventionel røntgen
Diagnostisk radiologi
Medicinsk billeddannelse, røntgen
Radiografisk billeddannelse
Radiografi
RG
Statisk røntgen
Røntgen
Almindelige film røntgenbilleder
Radiografisk billeddannelsesprocedure (procedure)

Procedure: Biopsi -procedure

Gennemgå biopsi

Andre navne:

Bx
BIOPSY_TYPE
Biopsi

Andet: Arm B (klinisk observation)

Patienter gennemgår observation under undersøgelsen. Patienterne gennemgår sigmoidoskopi, koloskopi eller anoskopi, proktoskopi eller digital rektalundersøgelse, røntgen, CT-scanning, MRI, biopsi og blodprøvetagning under hele undersøgelsen.

Procedure: MR scanning

Gennemgå MR

Andre navne:

MR
Magnetisk resonans
Magnetisk resonansbilledscanning
Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
HR
MR billeddannelse
MR-scanning
NMR billeddannelse
NMRI
Kernemagnetisk resonansbilleddannelse
Magnetisk resonansbilleddannelse (MRI)
sMRI
Magnetisk resonansbilleddannelse (procedure)
MRI'er
Strukturel MR

Procedure: Bioprøvesamling

Gennemgå blodprøvetagning

Andre navne:

Biologisk prøvesamling
Bioprøve indsamlet
Prøvesamling
Prøvekollektion

Procedure: Computertomografi

Gennemgå CT-scanning

Andre navne:

CT
KAT
CAT-scanning
Beregnet aksial tomografi
Computerstyret aksial tomografi
Computerstyret tomografi
CT-scanning
tomografi
Computerstyret aksial tomografi (procedure)
Computerstyret tomografi (CT) scanning
Diagnostisk CAT -scanning
Diagnostic CAT Scan Service Type

Andet: Patientobservation

Gennemgå observation

Andre navne:

Observation
Aktiv overvågning
udskudt terapi
forventningsfuld ledelse
Vagtende venter

Procedure: Koloskopi

Gennemgå koloskopi

Procedure: Sigmoidoskopi

Gennemgå sigmoidoskopi

Andre navne:

Proctosigmoidoskopi

Procedure: Digital rektal undersøgelse

Gennemgå digital rektal undersøgelse

Andre navne:

Procedure: Høj opløsning anoskopi

Gennemgå anoskopi

Andre navne:

Procedure: Proktoskopi

Gennemgå proktoskopi

Procedure: Røntgenbilleder

Får foretaget røntgen af thorax

Andre navne:

Konventionel røntgen
Diagnostisk radiologi
Medicinsk billeddannelse, røntgen
Radiografisk billeddannelse
Radiografi
RG
Statisk røntgen
Røntgen
Almindelige film røntgenbilleder
Radiografisk billeddannelsesprocedure (procedure)

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Sygdomsfri overlevelse Tidsramme: Op til 5 år	Vil blive defineret som forekomsten af progression af lokal sygdom, fjernmetastaser, anden primær eller død fra randomiseringsdatoen.	Op til 5 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Samlet overlevelse Tidsramme: Op til 5 år		Op til 5 år
Objektiv svarprocent Tidsramme: Op til 5 år	Vil blive defineret ved fuldstændig og delvis respons.	Op til 5 år
Alvorligt toksicitetsinterval Tidsramme: Tiden mellem randomisering og forekomsten af sene alvorlige bivirkninger (op til 5 år)	Følgende sene bivirkninger anses for at være alvorlige: enhver anal/rektal skade (sår, fistel eller perforation), rektal stenose, der krævede kolostomi, hudsår og alvorlig fibrose. Denne parameter estimerer sandsynligheden for at være fri for sene bivirkninger for patienter under lokoregional kontrol.	Tiden mellem randomisering og forekomsten af sene alvorlige bivirkninger (op til 5 år)
Kolostomifri overlevelse Tidsramme: Op til 5 år		Op til 5 år
Forekomst af toksiciteter Tidsramme: Op til 5 år	Vil blive vurderet af National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0.	Op til 5 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Samarbejdspartnere

Canadian Cancer Trials Group

Efterforskere

Ledende efterforsker: Lakshmi Rajdev, ECOG-ACRIN Cancer Research Group

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

5. juli 2018

Primær færdiggørelse (Anslået)

31. december 2027

Studieafslutning (Anslået)

31. december 2027

Datoer for studieregistrering

Først indsendt

28. juli 2017

Først indsendt, der opfyldte QC-kriterier

28. juli 2017

Først opslået (Faktiske)

31. juli 2017

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

29. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

28. maj 2026

Sidst verificeret

1. marts 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

NCI-2017-01347 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
U10CA180820 (U.S. NIH-bevilling/kontrakt)
EA2165 (Anden identifikator: CTEP)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Anal basaloid karcinom

ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Lavere dosis kemoradiation i behandling af patienter med tidligt stadie af anal kræft, DECREASE-undersøgelsen

Anal basaloid karcinom | Anal Canal Cloacogenic Carcinom | Anal kanal planocellulært karcinom | Anal margin planocellulært karcinom | Stadie I Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

Forenede Stater
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

EA2176: Fase 3 klinisk forsøg med Carboplatin og Paclitaxel +/- Nivolumab hos patienter med metastatisk analcancer

Anal basaloid karcinom | Anal Canal Cloacogenic Carcinom | Metastatisk anal planocellulært karcinom | Tilbagevendende anal planocellulært karcinom | Stage III anal cancer AJCC v8 | Stadie IV analkræft AJCC v8 | Uoperabelt anal planocellulært karcinom

Forenede Stater
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Cisplatin og Fluorouracil sammenlignet med Carboplatin og Paclitaxel til behandling af patienter med inoperabel lokalt tilbagevendende eller metastatisk analcancer (InterAACT)

Anal planocellulært karcinom | Anal basaloid karcinom | Anal Canal Cloacogenic Carcinom | Metastatisk analkanalcarcinom | Tilbagevendende analkanalcarcinom | Stadie IIIB Anal Canal Cancer | Stadie IV Anal Canal Cancer

Forenede Stater
Cairo University

Rekruttering

IFOC Sammenlignet Med LIFT ved Høj Anal Fistel: Et Pilot RCT

Høj anal fistel | Anal fistelkirurgi

Egypten
Xiangya Hospital of Central South University

Ikke rekrutterer endnu

Effekt og sikkerhed af Camrelizumab plus Rivoceranib og lokal terapi for hepatocellulært karcinom med lunge metastaser (CAPLocal): En multicentrisk, enkelt-armet, prospektiv kohortestudie

Hepatecellular carcinoma
National Cancer Institute (NCI)

Afsluttet

Cisplatin og gemcitabinhydrochlorid med eller uden berzosertib til behandling af patienter med metastatisk urothelial cancer

Metastatisk blæreurothelial karcinom | Metastatisk Ureter Urothelial Carcinoma | Stadie IV Blære Urothelial Carcinoma AJCC v7 | Metastatisk nyrebækken og Ureter Urothelial Carcinoma

Forenede Stater
Tyra Biosciences, Inc

Rekruttering

Fase 2A/B Effektivitet og Sikkerhed af Dabogratinib hos Deltagere med Lavgrads Øvre Urinvejskarcinom (SURF303)

Low Grade Upper Tract Urothelial Carcinoma

Forenede Stater
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Afsluttet

LET-IMPT og standardkemoterapi til behandling af patienter med nyligt diagnosticeret trin I-III analkanalpladecellekræft

Stage III anal cancer AJCC v8 | Anal kanal planocellulært karcinom | Stadie IIB Anal Cancer AJCC v8 | Stadie IIIA anal cancer AJCC v8 | Stadie IIIB anal cancer AJCC v8 | Stadie IIIC anal cancer AJCC v8 | Stadie I Anal Cancer AJCC v8 | Stadie II anal kræft AJCC v8 | Stage IIA Anal Cancer AJCC v8

Forenede Stater
The Cleveland Clinic
Bard Ltd

Afsluttet

Sammenlignende undersøgelse mellem to fækale styringssystemer

Anal erosion

Forenede Stater
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Forsøger at finde den korrekte behandlingslængde med immunkontrolpunktterapi (IMAGINE)

Metastatisk blæreurothelial karcinom | Metastatisk nyrebækken Urothelial Carcinom | Metastatisk Ureter Urothelial Carcinoma | Metastatisk Urethral Urothelial Carcinoma | Metastatisk Urothelial Carcinom | Lokalt avanceret blæreurothelial karcinom | Lokalt avanceret nyrebækken Urothelial Carcinoma | Lokalt... og andre forhold

Forenede Stater

Kliniske forsøg med Nivolumab

Universitair Ziekenhuis Brussel

Rekruttering

Et klinisk forsøg på kombineret (neo-)adjuverende intravenøs plus intrakraniel administration af Ipilimumab og Nivolumab ved tilbagevendende glioblastom (NEO-GLITIPNI)

Tilbagevendende glioblastom

Belgien
Brown University
Bristol-Myers Squibb; The Miriam Hospital; Rhode Island Hospital; Women and...

Afsluttet

BrUOG 355: Nivolumab til skræddersyet strålebehandling med samtidig cisplatin til behandling af patienter med livmoderhalskræft

Livmoderhalskræft

Forenede Stater
Baptist Health South Florida
Bristol-Myers Squibb; NovoCure Ltd.

Afsluttet

Forsøg med kombinations-TTF(Optune), Nivolumab Plus/Minus Ipilimumab for recidiverende glioblastom

Tilbagevendende glioblastom

Forenede Stater
Blokhin's Russian Cancer Research Center

Tilmelding efter invitation

Fase II åben-label et-centers klinisk undersøgelse af effektiviteten og sikkerheden af lavdosis immunoterapi i behandlingen af patienter med metastatisk og lokalt fremskreden kolorektal og mavekraft med mikrosatellit ustabil fænotype (MSI)/mangel på mismatch-reparationssystemet (dMMR) (NIVO402025)

Mavekræft | Kolorektal cancer

Rusland
Bristol-Myers Squibb

Aktiv, ikke rekrutterende

En undersøgelse for at evaluere, om deltagere med melanom foretrækker subkutan vs intravenøs administration af Nivolumab og Nivolumab + Relatlimab fastdosiskombinationer

Melanom

Spanien, Grækenland, Italien, Forenede Stater, Chile
National Health Research Institutes, Taiwan
National Taiwan University Hospital; Mackay Memorial Hospital; China Medical... og andre samarbejdspartnere

Afsluttet

Nivolumab Plus Ipilimumab som neoadjuverende terapi for hepatocellulært karcinom (HCC)

Hepatocellulært karcinom (HCC)

Taiwan
HUYABIO International, LLC.
Bristol-Myers Squibb

Aktiv, ikke rekrutterende

Undersøgelse, der sammenligner undersøgelsesmedicin HBI-8000 kombineret med Nivolumab vs. Nivolumab hos patienter med avanceret melanom

Uoperabelt eller metastatisk melanom | Progressiv hjernemetastase

New Zealand, Spanien, Forenede Stater, Belgien, Frankrig, Tyskland, Singapore, Australien, Japan, Sydafrika, Italien, Brasilien, Tjekkiet, Østrig, Det Forenede Kongerige, Sydkorea, Puerto Rico
National Research Center for Hematology, Russia

Rekruttering

Pet-tilpasset førstelinjeterapi med nivolumab til avanceret Hodgkin-lymfom (FINISH-HL)

Hodgkins sygdom | Hodgkin lymfom | Avanceret Hodgkin-lymfom

Rusland
Dan Zandberg
Array BioPharma

Aktiv, ikke rekrutterende

Undersøgelse af ARRY-614 Plus enten Nivolumab eller Nivolumab+Ipilimumab

Melanom | Nyrecellekarcinom | Solid tumor | Ikke-småcellet lungekræft | Planocellulært karcinom i hoved og hals

Forenede Stater
Michael B. Atkins, MD
Bristol-Myers Squibb; Hoosier Cancer Research Network

Afsluttet

Undersøgelse af frontlinjeterapi med Nivolumab og salvage Nivolumab + Ipilimumab hos patienter med avanceret nyrecellekarcinom

Avanceret nyrecellekarcinom

Forenede Stater

Nivolumab efter kombineret modalitetsterapi til behandling af patienter med højrisiko trin II-IIIB analcancer

Et randomiseret fase III-studie af Nivolumab efter kombineret modalitetsterapi (CMT) i højrisiko analcancer

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Anslået)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Anslået)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

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