Nivolumab etter kombinert modalitetsterapi ved behandling av pasienter med høyrisiko stadium II-IIIB analkreft
30. oktober 2026 oppdatert av: National Cancer Institute (NCI)
En randomisert fase III-studie av Nivolumab etter kombinert modalitetsterapi (CMT) ved høyrisiko analkreft
This phase III trial investigates how well nivolumab after combined modality therapy works in treating patients with high risk stage II-IIIB anal cancer. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Studieoversikt
Status
Aktiv, ikke rekrutterende
Forhold
Intervensjon / Behandling
- Fremgangsmåte: Biospecimen Collection
- Fremgangsmåte: Magnetic Resonance Imaging
- Fremgangsmåte: X-Ray Imaging
- Fremgangsmåte: Biopsy Procedure
- Biologisk: Nivolumab
- Fremgangsmåte: Computed Tomography
- Fremgangsmåte: Colonoscopy
- Fremgangsmåte: Digital Rectal Examination
- Fremgangsmåte: High Resolution Anoscopy
- Fremgangsmåte: Proctoscopy
- Fremgangsmåte: Sigmoidoscopy
- Annen: Patient Observation
Detaljert beskrivelse
PRIMARY OBJECTIVE:
I. To evaluate whether therapy with nivolumab following combined modality therapy (CMT) improves disease-free survival (DFS) compared with observation in patients with high risk anal carcinoma.
SECONDARY OBJECTIVES:
I. To compare nivolumab following combined modality therapy (CMT) with observation in patients with high risk anal carcinoma with regard to:
Ia. Objective response rate (complete [CR] and partial [PR]), stable disease and progression.
Ib. Severe toxicity interval. Ic. Colostomy-free survival. Id. Overall survival. Ie. Toxicity.
OUTLINE: Patients who received standard CMT are randomized to 1 of 2 arms.
ARM A: Patients receive nivolumab intravenously (IV) while on study.
ARM B: Patients undergo observation while on study
Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, computed tomography (CT) scan, magnetic resonance imaging (MRI), biopsy and blood sample collection throughout the study.
Studietype
Intervensjonell
Registrering (Antatt)
344
Fase
- Fase 3
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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Alberta
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Calgary, Alberta, Canada, T2N 5G2
- Arthur J E Child Comprehensive Cancer Centre
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British Columbia
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Vancouver, British Columbia, Canada, V5Z 4E6
- BCCA-Vancouver Cancer Centre
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Newfoundland and Labrador
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St. John's, Newfoundland and Labrador, Canada, A1B 3V6
- Doctor H. Bliss Murphy Cancer Centre
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Ontario
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London, Ontario, Canada, N6A 4L6
- London Regional Cancer Program
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Ottawa, Ontario, Canada, K1H 8L6
- Ottawa Hospital and Cancer Center-General Campus
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Sault Ste. Marie, Ontario, Canada, P6B 0A8
- Algoma District Cancer Program Sault Area Hospital
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Toronto, Ontario, Canada, M5G 2M9
- University Health Network-Princess Margaret Hospital
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Saskatchewan
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Regina, Saskatchewan, Canada, S4T 7T1
- Allan Blair Cancer Centre
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Saskatoon, Saskatchewan, Canada, S7N 4H4
- Saskatoon Cancer Centre
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Alabama
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Birmingham, Alabama, Forente stater, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, Forente stater, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Forente stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forente stater, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Forente stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forente stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forente stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forente stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forente stater, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Forente stater, 99701
- Fairbanks Memorial Hospital
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Arizona
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Goodyear, Arizona, Forente stater, 85338
- CTCA at Western Regional Medical Center
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Kingman, Arizona, Forente stater, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Forente stater, 85054
- Mayo Clinic Hospital in Arizona
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Scottsdale, Arizona, Forente stater, 85259
- Mayo Clinic in Arizona
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Arkansas
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Fort Smith, Arkansas, Forente stater, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Forente stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Jonesboro, Arkansas, Forente stater, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, Forente stater, 72205
- University of Arkansas for Medical Sciences
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California
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Anaheim, California, Forente stater, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Forente stater, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Forente stater, 93420
- PCR Oncology
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Arroyo Grande, California, Forente stater, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Auburn, California, Forente stater, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Forente stater, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, Forente stater, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Forente stater, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, Forente stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burbank, California, Forente stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Burlingame, California, Forente stater, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Forente stater, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, Forente stater, 94546
- Eden Hospital Medical Center
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Chico, California, Forente stater, 95926
- Enloe Medical Center
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Clovis, California, Forente stater, 93611
- Community Cancer Institute
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Clovis, California, Forente stater, 93611
- University Oncology Associates
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Davis, California, Forente stater, 95616
- Sutter Davis Hospital
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Dublin, California, Forente stater, 94568
- Kaiser Permanente Dublin
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Fontana, California, Forente stater, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Forente stater, 94538
- Kaiser Permanente-Fremont
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Fremont, California, Forente stater, 94538
- Palo Alto Medical Foundation-Fremont
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Fresno, California, Forente stater, 93720
- Kaiser Permanente-Fresno
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Fresno, California, Forente stater, 93720
- Fresno Cancer Center
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Harbor City, California, Forente stater, 90710
- Kaiser Permanente South Bay
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Irvine, California, Forente stater, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, Forente stater, 92093
- UC San Diego Moores Cancer Center
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Los Angeles, California, Forente stater, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, Forente stater, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Forente stater, 90034
- Kaiser Permanente West Los Angeles
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Los Angeles, California, Forente stater, 90033
- Los Angeles General Medical Center
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Marysville, California, Forente stater, 95901
- Fremont - Rideout Cancer Center
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Modesto, California, Forente stater, 95355
- Memorial Medical Center
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Modesto, California, Forente stater, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, Forente stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Forente stater, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Newport Beach, California, Forente stater, 92663
- USC Norris Oncology/Hematology-Newport Beach
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Novato, California, Forente stater, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Forente stater, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Forente stater, 94611
- Kaiser Permanente Oakland-Broadway
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Ontario, California, Forente stater, 91761
- Kaiser Permanente-Ontario
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Orange, California, Forente stater, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, Forente stater, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Forente stater, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Forente stater, 91402
- Kaiser Permanente - Panorama City
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Pasadena, California, Forente stater, 91105
- Keck Medical Center of USC Pasadena
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Rancho Cordova, California, Forente stater, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Rancho Mirage, California, Forente stater, 92270
- Eisenhower Medical Center
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Redwood City, California, Forente stater, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Forente stater, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Forente stater, 92505
- Kaiser Permanente-Riverside
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Rohnert Park, California, Forente stater, 94928
- Rohnert Park Cancer Center
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Roseville, California, Forente stater, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
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Roseville, California, Forente stater, 95661
- Kaiser Permanente-Roseville
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Roseville, California, Forente stater, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Forente stater, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Forente stater, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Forente stater, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Forente stater, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, Forente stater, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Forente stater, 95823
- South Sacramento Cancer Center
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Sacramento, California, Forente stater, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Forente stater, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Forente stater, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, Forente stater, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Forente stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Francisco, California, Forente stater, 94110
- Zuckerberg San Francisco General Hospital
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San Jose, California, Forente stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Forente stater, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, Forente stater, 92078
- Kaiser Permanente-San Marcos
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San Mateo, California, Forente stater, 94401
- Mills Health Center
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San Rafael, California, Forente stater, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, Forente stater, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Forente stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, Forente stater, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Maria, California, Forente stater, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Forente stater, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Forente stater, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, Forente stater, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, Forente stater, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Forente stater, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, Forente stater, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vacaville, California, Forente stater, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Forente stater, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, Forente stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Forente stater, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Forente stater, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Forente stater, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Forente stater, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Forente stater, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Forente stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, Forente stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forente stater, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Forente stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Forente stater, 80920
- Memorial Hospital North
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Denver, Colorado, Forente stater, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Forente stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forente stater, 80220
- Rose Medical Center
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Denver, Colorado, Forente stater, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Forente stater, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Forente stater, 80204
- Denver Health Medical Center
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Denver, Colorado, Forente stater, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Forente stater, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Forente stater, 80209
- The Women's Imaging Center
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Denver, Colorado, Forente stater, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Forente stater, 80220
- Western Surgical Care
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Denver, Colorado, Forente stater, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Forente stater, 80210
- AdventHealth Porter
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Durango, Colorado, Forente stater, 81301
- Mercy Medical Center
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Durango, Colorado, Forente stater, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, Forente stater, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Forente stater, 80113
- Swedish Medical Center
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Fort Collins, Colorado, Forente stater, 80524
- Poudre Valley Hospital
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Golden, Colorado, Forente stater, 80401
- Mountain Blue Cancer Care Center
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Golden, Colorado, Forente stater, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, Forente stater, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Forente stater, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Forente stater, 80026
- Kaiser Permanente-Rock Creek
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Lafayette, Colorado, Forente stater, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, Forente stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, Forente stater, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, Forente stater, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Forente stater, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Forente stater, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, Forente stater, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Forente stater, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Forente stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forente stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Forente stater, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Forente stater, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, Forente stater, 80138
- AdventHealth Parker
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Pueblo, Colorado, Forente stater, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Forente stater, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Forente stater, 80260
- Rocky Mountain Cancer Centers-Thornton
-
Thornton, Colorado, Forente stater, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Forente stater, 80401
- Intermountain Health Lutheran Hospital
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Delaware
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Lewes, Delaware, Forente stater, 19958
- Beebe Medical Center
-
Millville, Delaware, Forente stater, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Forente stater, 19713
- Helen F Graham Cancer Center
-
Newark, Delaware, Forente stater, 19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark, Delaware, Forente stater, 19713
- Medical Oncology Hematology Consultants PA
-
Newark, Delaware, Forente stater, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Forente stater, 19971
- Beebe Health Campus
-
Seaford, Delaware, Forente stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Forente stater, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, Forente stater, 20037
- George Washington University Medical Center
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Florida
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Altamonte Springs, Florida, Forente stater, 32701
- AdventHealth Altamonte
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Aventura, Florida, Forente stater, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
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Celebration, Florida, Forente stater, 34747
- AdventHealth Celebration
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Coral Gables, Florida, Forente stater, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, Forente stater, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Lauderdale, Florida, Forente stater, 33316
- Broward Health Medical Center
-
Fort Lauderdale, Florida, Forente stater, 33308
- Holy Cross Hospital
-
Gainesville, Florida, Forente stater, 32610
- UF Health Cancer Institute - Gainesville
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Hollywood, Florida, Forente stater, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Jacksonville, Florida, Forente stater, 32224-9980
- Mayo Clinic in Florida
-
Kissimmee, Florida, Forente stater, 34744
- AdventHealth Kissimmee
-
Miami, Florida, Forente stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
-
Miami, Florida, Forente stater, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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Miami Beach, Florida, Forente stater, 33140
- Mount Sinai Medical Center
-
Orlando, Florida, Forente stater, 32803
- AdventHealth Orlando
-
Orlando, Florida, Forente stater, 32803
- AdventHealth Medical Group Urology at Orlando
-
Orlando, Florida, Forente stater, 32822
- AdventHealth East Orlando
-
Pembroke Pines, Florida, Forente stater, 33028
- Memorial Hospital West
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Pensacola, Florida, Forente stater, 32504
- Sacred Heart Hospital
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Weston, Florida, Forente stater, 33331
- Cleveland Clinic-Weston
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Winter Park, Florida, Forente stater, 32792
- AdventHealth Winter Park
-
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Georgia
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Atlanta, Georgia, Forente stater, 30308
- Emory University Hospital Midtown
-
Atlanta, Georgia, Forente stater, 30322
- Emory University Hospital/Winship Cancer Institute
-
Atlanta, Georgia, Forente stater, 30342
- Emory Saint Joseph's Hospital
-
Atlanta, Georgia, Forente stater, 30303
- Grady Health System
-
Atlanta, Georgia, Forente stater, 30309
- Piedmont Hospital
-
Decatur, Georgia, Forente stater, 30033
- Atlanta VA Medical Center
-
Fayetteville, Georgia, Forente stater, 30214
- Piedmont Fayette Hospital
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Johns Creek, Georgia, Forente stater, 30097
- Emory Johns Creek Hospital
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Savannah, Georgia, Forente stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah, Georgia, Forente stater, 31405
- Summit Cancer Care-Candler
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Hawaii
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Honolulu, Hawaii, Forente stater, 96819
- Kaiser Permanente Moanalua Medical Center
-
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Idaho
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Boise, Idaho, Forente stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise, Idaho, Forente stater, 83712
- Saint Luke's Cancer Institute - Boise
-
Caldwell, Idaho, Forente stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene, Idaho, Forente stater, 83814
- Kootenai Health - Coeur d'Alene
-
Emmett, Idaho, Forente stater, 83617
- Walter Knox Memorial Hospital
-
Fruitland, Idaho, Forente stater, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, Forente stater, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, Forente stater, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Forente stater, 83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Nampa, Idaho, Forente stater, 83687
- Saint Luke's Cancer Institute - Nampa
-
Post Falls, Idaho, Forente stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, Forente stater, 83864
- Kootenai Clinic Cancer Services - Sandpoint
-
Twin Falls, Idaho, Forente stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
-
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Illinois
-
Aurora, Illinois, Forente stater, 60504
- Rush-Copley Medical Center
-
Bloomington, Illinois, Forente stater, 61704
- Illinois CancerCare-Bloomington
-
Burr Ridge, Illinois, Forente stater, 60527
- Loyola Center for Health at Burr Ridge
-
Canton, Illinois, Forente stater, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, Forente stater, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, Forente stater, 62918
- SIH Cancer Institute
-
Carthage, Illinois, Forente stater, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, Forente stater, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, Forente stater, 60611
- Northwestern University
-
Chicago, Illinois, Forente stater, 60612
- University of Illinois
-
Chicago, Illinois, Forente stater, 60612
- Rush MD Anderson Cancer Center
-
Danville, Illinois, Forente stater, 61832
- Carle at The Riverfront
-
Decatur, Illinois, Forente stater, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Forente stater, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Dixon, Illinois, Forente stater, 61021
- Illinois CancerCare-Dixon
-
Effingham, Illinois, Forente stater, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Forente stater, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, Forente stater, 61530
- Illinois CancerCare-Eureka
-
Evanston, Illinois, Forente stater, 60201
- NorthShore University HealthSystem-Evanston Hospital
-
Galesburg, Illinois, Forente stater, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Forente stater, 61401
- Illinois CancerCare-Galesburg
-
Glenview, Illinois, Forente stater, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
-
Highland Park, Illinois, Forente stater, 60035
- NorthShore University HealthSystem-Highland Park Hospital
-
Homer Glen, Illinois, Forente stater, 60491
- Loyola Medicine Homer Glen
-
Kewanee, Illinois, Forente stater, 61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest, Illinois, Forente stater, 60045
- Northwestern Medicine Lake Forest Hospital
-
Macomb, Illinois, Forente stater, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Forente stater, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, Forente stater, 60153
- Loyola University Medical Center
-
Melrose Park, Illinois, Forente stater, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
-
Mount Vernon, Illinois, Forente stater, 62864
- SSM Health Good Samaritan
-
O'Fallon, Illinois, Forente stater, 62269
- Cancer Care Center of O'Fallon
-
Ottawa, Illinois, Forente stater, 61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin, Illinois, Forente stater, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Forente stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, Forente stater, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forente stater, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Forente stater, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Forente stater, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Forente stater, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Forente stater, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Forente stater, 61356
- Illinois CancerCare-Princeton
-
Springfield, Illinois, Forente stater, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Forente stater, 62702
- Springfield Clinic
-
Springfield, Illinois, Forente stater, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Forente stater, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Forente stater, 61801
- Carle Cancer Center
-
Urbana, Illinois, Forente stater, 61801
- The Carle Foundation Hospital
-
Washington, Illinois, Forente stater, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, Forente stater, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Carmel, Indiana, Forente stater, 46032
- IU Health North Hospital
-
Indianapolis, Indiana, Forente stater, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Forente stater, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Indianapolis, Indiana, Forente stater, 46202
- Sidney and Lois Eskenazi Hospital
-
Indianapolis, Indiana, Forente stater, 46290
- Springmill Medical Center
-
Lafayette, Indiana, Forente stater, 47905
- Franciscan Saint Elizabeth Health - Lafayette East
-
Michigan City, Indiana, Forente stater, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, Forente stater, 46158
- Franciscan Health Mooresville
-
New Albany, Indiana, Forente stater, 47150
- Baptist Health Floyd
-
Terre Haute, Indiana, Forente stater, 47804
- Union Hospital
-
-
Iowa
-
Bettendorf, Iowa, Forente stater, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Clive, Iowa, Forente stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forente stater, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Forente stater, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Forente stater, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Forente stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forente stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forente stater, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Forente stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forente stater, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Forente stater, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Forente stater, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Iowa City, Iowa, Forente stater, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
West Des Moines, Iowa, Forente stater, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Forente stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Forente stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forente stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forente stater, 67042
- Cancer Center of Kansas - El Dorado
-
Fairway, Kansas, Forente stater, 66205
- University of Kansas Clinical Research Center
-
Independence, Kansas, Forente stater, 67301
- Cancer Center of Kansas-Independence
-
Kingman, Kansas, Forente stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forente stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forente stater, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Forente stater, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Forente stater, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Forente stater, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, Forente stater, 66061
- The University of Kansas Cancer Center - Olathe
-
Parsons, Kansas, Forente stater, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Forente stater, 66762
- Mercy Hospital Pittsburg
-
Pratt, Kansas, Forente stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forente stater, 67401
- Salina Regional Health Center
-
Salina, Kansas, Forente stater, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Forente stater, 66606
- University of Kansas Health System Saint Francis Campus
-
Wellington, Kansas, Forente stater, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, Forente stater, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Forente stater, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Forente stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forente stater, 67214
- Cancer Center of Kansas - Wichita
-
Winfield, Kansas, Forente stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, Forente stater, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Forente stater, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, Forente stater, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Forente stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forente stater, 40503
- Baptist Health Lexington
-
Lexington, Kentucky, Forente stater, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Forente stater, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Forente stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forente stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forente stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forente stater, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Forente stater, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Forente stater, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Forente stater, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, Forente stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forente stater, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Forente stater, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Forente stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forente stater, 70808
- Our Lady of the Lake Physician Group
-
Metairie, Louisiana, Forente stater, 70006
- East Jefferson General Hospital
-
New Orleans, Louisiana, Forente stater, 70112
- Louisiana State University Health Science Center
-
-
Maryland
-
Baltimore, Maryland, Forente stater, 21204
- Greater Baltimore Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, Forente stater, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Forente stater, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Forente stater, 02118
- Boston Medical Center
-
Fitchburg, Massachusetts, Forente stater, 01420
- Simonds-Sinon Regional Cancer Center
-
Springfield, Massachusetts, Forente stater, 01104
- Mercy Medical Center
-
Worcester, Massachusetts, Forente stater, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Forente stater, 48109
- University of Michigan Rogel Cancer Center
-
Ann Arbor, Michigan, Forente stater, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Forente stater, 49017
- Bronson Battle Creek
-
Bay City, Michigan, Forente stater, 48706
- McLaren Cancer Institute-Bay City
-
Bloomfield, Michigan, Forente stater, 48302
- McLaren Cancer Institute-Bloomfield
-
Brighton, Michigan, Forente stater, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Forente stater, 48116
- University of Michigan - Brighton Center for Specialty Care
-
Brighton, Michigan, Forente stater, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Forente stater, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Forente stater, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Forente stater, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Forente stater, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Forente stater, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Forente stater, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Forente stater, 48346
- McLaren Cancer Institute-Clarkston
-
Clarkston, Michigan, Forente stater, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Forente stater, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, Forente stater, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Forente stater, 48126
- Henry Ford Medical Center-Fairlane
-
Dearborn, Michigan, Forente stater, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Forente stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forente stater, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Forente stater, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Forente stater, 48054
- Henry Ford River District Hospital
-
Farmington Hills, Michigan, Forente stater, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Forente stater, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Forente stater, 48532
- McLaren Cancer Institute-Flint
-
Flint, Michigan, Forente stater, 48532
- Singh and Arora Hematology Oncology PC
-
Flint, Michigan, Forente stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forente stater, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Forente stater, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Forente stater, 48503
- Cancer Hematology Centers - Flint
-
Grand Rapids, Michigan, Forente stater, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Forente stater, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Forente stater, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe, Michigan, Forente stater, 48230
- William Beaumont Hospital-Grosse Pointe
-
Grosse Pointe Woods, Michigan, Forente stater, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Forente stater, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Forente stater, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, Forente stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forente stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forente stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forente stater, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, Forente stater, 48912
- Mid-Michigan Physicians-Lansing
-
Lansing, Michigan, Forente stater, 48910
- Karmanos Cancer Institute at McLaren Greater Lansing
-
Lansing, Michigan, Forente stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Lapeer, Michigan, Forente stater, 48446
- McLaren Cancer Institute-Lapeer Region
-
Livonia, Michigan, Forente stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Forente stater, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Forente stater, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Forente stater, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Forente stater, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Mount Clemens, Michigan, Forente stater, 48043
- McLaren Cancer Institute-Macomb
-
Mount Pleasant, Michigan, Forente stater, 48858
- McLaren Cancer Institute-Central Michigan
-
Muskegon, Michigan, Forente stater, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Forente stater, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Forente stater, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, Forente stater, 48377
- Henry Ford Medical Center-Columbus
-
Novi, Michigan, Forente stater, 48374
- Henry Ford Health Providence Novi Hospital
-
Petoskey, Michigan, Forente stater, 49770
- McLaren Cancer Institute-Northern Michigan
-
Pontiac, Michigan, Forente stater, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Forente stater, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Forente stater, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, Forente stater, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Port Huron, Michigan, Forente stater, 48060
- McLaren-Port Huron
-
Reed City, Michigan, Forente stater, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, Forente stater, 48309
- Henry Ford Rochester Hospital
-
Roseville, Michigan, Forente stater, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, Forente stater, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Forente stater, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Forente stater, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Forente stater, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Forente stater, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Forente stater, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Forente stater, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Forente stater, 48604
- Covenant HealthCare Mackinaw
-
Saginaw, Michigan, Forente stater, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Forente stater, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Forente stater, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Shelby, Michigan, Forente stater, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Southfield, Michigan, Forente stater, 48075
- Henry Ford Health Providence Southfield Hospital
-
Sterling Heights, Michigan, Forente stater, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Sterling Heights, Michigan, Forente stater, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, Forente stater, 48314
- Mitchell Folbe MD PC
-
Tawas City, Michigan, Forente stater, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, Forente stater, 49684
- Munson Medical Center
-
Troy, Michigan, Forente stater, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Forente stater, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, Forente stater, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Forente stater, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Forente stater, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Forente stater, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Forente stater, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Forente stater, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Forente stater, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Bloomfield, Michigan, Forente stater, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, Forente stater, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Forente stater, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Forente stater, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Forente stater, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Forente stater, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, Forente stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forente stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forente stater, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Forente stater, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Forente stater, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Forente stater, 55433
- Mercy Hospital
-
Deer River, Minnesota, Forente stater, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Forente stater, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forente stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forente stater, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Forente stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Forente stater, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Forente stater, 55432
- Unity Hospital
-
Hibbing, Minnesota, Forente stater, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, Forente stater, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Forente stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forente stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forente stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forente stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forente stater, 55454
- Health Partners Inc
-
Monticello, Minnesota, Forente stater, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Forente stater, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Forente stater, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Forente stater, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Forente stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forente stater, 55905
- Mayo Clinic in Rochester
-
Saint Louis Park, Minnesota, Forente stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forente stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forente stater, 55102
- United Hospital
-
Sandstone, Minnesota, Forente stater, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Forente stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forente stater, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Forente stater, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Forente stater, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Forente stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forente stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forente stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Forente stater, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Forente stater, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Grenada, Mississippi, Forente stater, 38901
- Baptist Cancer Center-Grenada
-
New Albany, Mississippi, Forente stater, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Forente stater, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, Forente stater, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Forente stater, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bonne Terre, Missouri, Forente stater, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Forente stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forente stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forente stater, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Forente stater, 63017
- Saint Luke's Hospital
-
City of Saint Peters, Missouri, Forente stater, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Creve Coeur, Missouri, Forente stater, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Forente stater, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Forente stater, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Forente stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forente stater, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, Forente stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Forente stater, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Forente stater, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Forente stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forente stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forente stater, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Forente stater, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Forente stater, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Forente stater, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Forente stater, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Forente stater, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Forente stater, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Forente stater, 63080
- Missouri Baptist Sullivan Hospital
-
Washington, Missouri, Forente stater, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Forente stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forente stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forente stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forente stater, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Forente stater, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Forente stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forente stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forente stater, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Forente stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forente stater, 59901
- Logan Health Medical Center
-
Missoula, Montana, Forente stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forente stater, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Forente stater, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Forente stater, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Forente stater, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Forente stater, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Forente stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forente stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forente stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forente stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forente stater, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Forente stater, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Forente stater, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Forente stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forente stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forente stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forente stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forente stater, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Forente stater, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Forente stater, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Forente stater, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Forente stater, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Forente stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forente stater, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Forente stater, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Forente stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forente stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forente stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forente stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forente stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forente stater, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Forente stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forente stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forente stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forente stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forente stater, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Forente stater, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Forente stater, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Forente stater, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Forente stater, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Forente stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forente stater, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Forente stater, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Forente stater, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Forente stater, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Forente stater, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Forente stater, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Forente stater, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Forente stater, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Forente stater, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Forente stater, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Forente stater, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Forente stater, 89169
- University Cancer Center
-
Las Vegas, Nevada, Forente stater, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Forente stater, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Forente stater, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Forente stater, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Forente stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forente stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forente stater, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon, New Hampshire, Forente stater, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Basking Ridge, New Jersey, Forente stater, 07920
- Memorial Sloan Kettering Basking Ridge
-
Middletown, New Jersey, Forente stater, 07748
- Memorial Sloan Kettering Monmouth
-
Montvale, New Jersey, Forente stater, 07645
- Memorial Sloan Kettering Bergen
-
Moorestown, New Jersey, Forente stater, 08057
- Virtua Samson Cancer Center
-
Morristown, New Jersey, Forente stater, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, Forente stater, 08060
- Virtua Memorial
-
New Brunswick, New Jersey, Forente stater, 08903
- Rutgers Cancer Institute of New Jersey
-
Summit, New Jersey, Forente stater, 07902
- Overlook Hospital
-
Teaneck, New Jersey, Forente stater, 07666
- Holy Name Hospital
-
Voorhees Township, New Jersey, Forente stater, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, Forente stater, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, Forente stater, 87109
- Lovelace Radiation Oncology
-
Albuquerque, New Mexico, Forente stater, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forente stater, 87110
- Presbyterian Kaseman Hospital
-
Rio Rancho, New Mexico, Forente stater, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
-
New York
-
Buffalo, New York, Forente stater, 14263
- Roswell Park Cancer Institute
-
Commack, New York, Forente stater, 11725
- Memorial Sloan Kettering Commack
-
Glens Falls, New York, Forente stater, 12801
- Glens Falls Hospital
-
Harrison, New York, Forente stater, 10604
- Memorial Sloan Kettering Westchester
-
New York, New York, Forente stater, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Forente stater, 10019
- Mount Sinai West
-
New York, New York, Forente stater, 10029
- Mount Sinai Hospital
-
New York, New York, Forente stater, 10075
- Lenox Hill Hospital
-
New York, New York, Forente stater, 10065
- Manhattan Eye Ear and Throat Hospital
-
The Bronx, New York, Forente stater, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Forente stater, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Forente stater, 10461
- Montefiore Medical Center-Weiler Hospital
-
Uniondale, New York, Forente stater, 11553
- Memorial Sloan Kettering Nassau
-
-
North Carolina
-
Albemarle, North Carolina, Forente stater, 28002
- Atrium Health Stanly/LCI-Albemarle
-
Chapel Hill, North Carolina, Forente stater, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Forente stater, 28203
- Carolinas Medical Center/Levine Cancer Institute
-
Charlotte, North Carolina, Forente stater, 28210
- Atrium Health Pineville/LCI-Pineville
-
Charlotte, North Carolina, Forente stater, 28262
- Atrium Health University City/LCI-University
-
Charlotte, North Carolina, Forente stater, 28211
- Levine Cancer Institute-SouthPark
-
Charlotte, North Carolina, Forente stater, 28277
- Levine Cancer Institute-Ballantyne
-
Clemmons, North Carolina, Forente stater, 27012
- Wake Forest University at Clemmons
-
Clinton, North Carolina, Forente stater, 28328
- Southeastern Medical Oncology Center-Clinton
-
Concord, North Carolina, Forente stater, 28025
- Atrium Health Cabarrus/LCI-Concord
-
Elkin, North Carolina, Forente stater, 28521
- Wake Forest University at Elkin
-
Gastonia, North Carolina, Forente stater, 28054
- Levine Cancer Institute-Gaston
-
Goldsboro, North Carolina, Forente stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Forente stater, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, Forente stater, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, Forente stater, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, Forente stater, 28546
- Onslow Memorial Hospital
-
Kenansville, North Carolina, Forente stater, 28349
- ECU Health Oncology Kenansville
-
Kinston, North Carolina, Forente stater, 28501
- ECU Health Oncology Kinston
-
Lexington, North Carolina, Forente stater, 27292
- Wake Forest University at Lexington
-
Lincolnton, North Carolina, Forente stater, 28092
- Atrium Health Lincoln/LCI-Lincolnton
-
Monroe, North Carolina, Forente stater, 28112
- Atrium Health Union/LCI-Union
-
Mount Airy, North Carolina, Forente stater, 27030
- Wake Forest University at Mount Airy
-
Raleigh, North Carolina, Forente stater, 27607
- Rex Hematology Oncology Associates-Blue Ridge
-
Raleigh, North Carolina, Forente stater, 27607
- UNC Health Cancer Care Raleigh
-
Raleigh, North Carolina, Forente stater, 27614
- UNC Health Cancer Care Wakefield
-
Richlands, North Carolina, Forente stater, 28574
- ECU Health Oncology Richlands
-
Winston-Salem, North Carolina, Forente stater, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, Forente stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forente stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Forente stater, 58103
- Sanford South University Medical Center
-
Jamestown, North Dakota, Forente stater, 58401
- Essentia Health - Jamestown Clinic
-
Minot, North Dakota, Forente stater, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Beachwood, Ohio, Forente stater, 44122
- UHHS-Chagrin Highlands Medical Center
-
Belpre, Ohio, Forente stater, 45714
- Strecker Cancer Center-Belpre
-
Chardon, Ohio, Forente stater, 44024
- Geauga Hospital
-
Chillicothe, Ohio, Forente stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forente stater, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Forente stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forente stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forente stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forente stater, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Forente stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forente stater, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Forente stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forente stater, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Forente stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forente stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forente stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forente stater, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Forente stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forente stater, 43222
- Mount Carmel Health Center West
-
Delaware, Ohio, Forente stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forente stater, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, Forente stater, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Forente stater, 43016
- Dublin Methodist Hospital
-
Elyria, Ohio, Forente stater, 44035
- Mercy Cancer Center-Elyria
-
Grove City, Ohio, Forente stater, 43123
- Mount Carmel Grove City Hospital
-
Lancaster, Ohio, Forente stater, 43130
- Fairfield Medical Center
-
Mansfield, Ohio, Forente stater, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Forente stater, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Forente stater, 43302
- OhioHealth Marion General Hospital
-
Mayfield Heights, Ohio, Forente stater, 44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor, Ohio, Forente stater, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Forente stater, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, Forente stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forente stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forente stater, 43055
- Newark Radiation Oncology
-
Parma, Ohio, Forente stater, 44129
- University Hospitals Parma Medical Center
-
Portsmouth, Ohio, Forente stater, 45662
- Southern Ohio Medical Center
-
Ravenna, Ohio, Forente stater, 44266
- University Hospitals Portage Medical Center
-
Sandusky, Ohio, Forente stater, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Wadsworth, Ohio, Forente stater, 44281
- University Hospitals Sharon Health Center
-
West Chester, Ohio, Forente stater, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Forente stater, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, Forente stater, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Westlake, Ohio, Forente stater, 44145
- UHHS-Westlake Medical Center
-
Zanesville, Ohio, Forente stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forente stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forente stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forente stater, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Forente stater, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Forente stater, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Forente stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forente stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forente stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forente stater, 97420
- Bay Area Hospital
-
Newberg, Oregon, Forente stater, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Forente stater, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Portland, Oregon, Forente stater, 97239
- Oregon Health and Science University
-
Portland, Oregon, Forente stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forente stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forente stater, 97227
- Kaiser Permanente Northwest
-
Redmond, Oregon, Forente stater, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Abington, Pennsylvania, Forente stater, 19001
- Jefferson Abington Hospital
-
Allentown, Pennsylvania, Forente stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Beaver, Pennsylvania, Forente stater, 15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem, Pennsylvania, Forente stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, Forente stater, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, Forente stater, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, Forente stater, 19317
- Christiana Care Health System-Concord Health Center
-
Collegeville, Pennsylvania, Forente stater, 19426
- Main Line Health Center-Collegeville
-
Danville, Pennsylvania, Forente stater, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Forente stater, 18301
- Pocono Medical Center
-
Exton, Pennsylvania, Forente stater, 19341
- Main Line Health Center-Exton
-
Greensburg, Pennsylvania, Forente stater, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Harrisburg, Pennsylvania, Forente stater, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Harrisburg, Pennsylvania, Forente stater, 17101
- UPMC Pinnacle Harrisburg
-
Hazleton, Pennsylvania, Forente stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Forente stater, 18201
- Lehigh Valley Hospital-Hazleton
-
Johnstown, Pennsylvania, Forente stater, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Forente stater, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Forente stater, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, Forente stater, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Media, Pennsylvania, Forente stater, 19063
- Riddle Memorial Hospital
-
Moon Township, Pennsylvania, Forente stater, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Paoli, Pennsylvania, Forente stater, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Forente stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19114
- Jefferson Torresdale Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, Forente stater, 19140
- Temple University Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19107
- Pennsylvania Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15232
- UPMC Hillman Cancer Center
-
Pittsburgh, Pennsylvania, Forente stater, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Forente stater, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Forente stater, 17901
- Geisinger Cancer Services-Pottsville
-
Seneca, Pennsylvania, Forente stater, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, Forente stater, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, Forente stater, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, Forente stater, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Reading, Pennsylvania, Forente stater, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Forente stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Willow Grove, Pennsylvania, Forente stater, 19090
- Asplundh Cancer Pavilion
-
Wynnewood, Pennsylvania, Forente stater, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Forente stater, 17408
- UPMC Memorial
-
-
South Carolina
-
Boiling Springs, South Carolina, Forente stater, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Clinton, South Carolina, Forente stater, 29325
- Prisma Health Cancer Institute - Laurens
-
Easley, South Carolina, Forente stater, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, Forente stater, 29341
- Gibbs Cancer Center-Gaffney
-
Georgetown, South Carolina, Forente stater, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forente stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, Forente stater, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Forente stater, 29651
- Gibbs Cancer Center-Pelham
-
Rock Hill, South Carolina, Forente stater, 29732
- Levine Cancer Institute-Rock Hill
-
Rock Hill, South Carolina, Forente stater, 29730
- Rock Hill Radiation Therapy Center
-
Seneca, South Carolina, Forente stater, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Forente stater, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Forente stater, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Sioux Falls, South Dakota, Forente stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forente stater, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Forente stater, 37404
- Memorial Hospital
-
Collierville, Tennessee, Forente stater, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Franklin, Tennessee, Forente stater, 37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Hixson, Tennessee, Forente stater, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Memphis, Tennessee, Forente stater, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Nashville, Tennessee, Forente stater, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, Forente stater, 37204
- Vanderbilt Breast Center at One Hundred Oaks
-
Ooltewah, Tennessee, Forente stater, 37363
- Memorial GYN Plus
-
-
Texas
-
Bryan, Texas, Forente stater, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Forente stater, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Forente stater, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, Forente stater, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Houston, Texas, Forente stater, 77030
- UT MD Anderson Cancer Center
-
Richardson, Texas, Forente stater, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork, Utah, Forente stater, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Forente stater, 84720
- Sandra L Maxwell Cancer Center
-
Farmington, Utah, Forente stater, 84025
- Farmington Health Center
-
Logan, Utah, Forente stater, 84321
- Logan Regional Hospital
-
Murray, Utah, Forente stater, 84107
- Intermountain Medical Center
-
Ogden, Utah, Forente stater, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Forente stater, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Forente stater, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Forente stater, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Forente stater, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Forente stater, 84143
- LDS Hospital
-
Salt Lake City, Utah, Forente stater, 84106
- University of Utah Sugarhouse Health Center
-
St. George, Utah, Forente stater, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Berlin Corners, Vermont, Forente stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forente stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forente stater, 05405
- University of Vermont and State Agricultural College
-
Saint Johnsbury, Vermont, Forente stater, 05819
- Dartmouth Cancer Center - North
-
-
Virginia
-
Martinsville, Virginia, Forente stater, 24112
- Sovah Health Martinsville
-
Richmond, Virginia, Forente stater, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Forente stater, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, Forente stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Forente stater, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, Forente stater, 98004
- Overlake Medical Center
-
Bellingham, Washington, Forente stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Forente stater, 98166
- Saint Anne Hospital
-
Centralia, Washington, Forente stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forente stater, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Forente stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forente stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forente stater, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Forente stater, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Forente stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forente stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Forente stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forente stater, 98499
- Saint Clare Hospital
-
Longview, Washington, Forente stater, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, Forente stater, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Forente stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Forente stater, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, Forente stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forente stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forente stater, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forente stater, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Forente stater, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Forente stater, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Forente stater, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Seattle, Washington, Forente stater, 98109
- Fred Hutchinson Cancer Center
-
Sedro-Woolley, Washington, Forente stater, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Forente stater, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Forente stater, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Forente stater, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Forente stater, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Forente stater, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Forente stater, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Forente stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forente stater, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Forente stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Forente stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forente stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yelm, Washington, Forente stater, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Bridgeport, West Virginia, Forente stater, 26330
- United Hospital Center
-
Charleston, West Virginia, Forente stater, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
Martinsburg, West Virginia, Forente stater, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, Forente stater, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, Forente stater, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Appleton, Wisconsin, Forente stater, 54911
- ThedaCare Regional Cancer Center
-
Ashland, Wisconsin, Forente stater, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Forente stater, 54806
- Northwest Wisconsin Cancer Center
-
Burlington, Wisconsin, Forente stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire, Wisconsin, Forente stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Forente stater, 54701
- HSHS Sacred Heart Hospital
-
Fond du Lac, Wisconsin, Forente stater, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Forente stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forente stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forente stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forente stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forente stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Forente stater, 54301
- Bellin Memorial Hospital
-
Johnson Creek, Wisconsin, Forente stater, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, Forente stater, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Forente stater, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Forente stater, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Marinette, Wisconsin, Forente stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Forente stater, 54449
- Marshfield Medical Center-Marshfield
-
Milwaukee, Wisconsin, Forente stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forente stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forente stater, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Forente stater, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Forente stater, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Forente stater, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Forente stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, Forente stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forente stater, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, Forente stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forente stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Forente stater, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, Forente stater, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Forente stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forente stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forente stater, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Forente stater, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Forente stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forente stater, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Forente stater, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Forente stater, 54476
- Marshfield Medical Center - Weston
-
-
Wyoming
-
Cheyenne, Wyoming, Forente stater, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Forente stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forente stater, 82801
- Welch Cancer Center
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år og eldre (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
Inclusion Criteria:
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Age >= 18 years
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have histologically proven stage IIB (T3N0M0 only), IIIA (T2N1M0), IIIB (T4N0M0), or IIIC (T3N1M0, T4N1M0) invasive squamous cell carcinoma of the anus or anorectum, according to the American Joint Committee on Cancer (AJCC) 8th edition; this may include tumors of non-keratinizing histology such as basaloid, transitional cell, or cloacogenic histology; individuals with squamous cell carcinoma of the anal margin are eligible if there is evidence of extension of the primary tumor into the anal canal
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have hemoglobin levels of > 9 g/dL (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient must have a platelet count of > 100,000/mm^3 (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient's absolute neutrophil count (ANC) level must be > 1500/mm^3 (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Serum creatinine must be =< 1.5 X upper limit of normal (ULN) (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Total bilirubin must be < 2 X ULN (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =< 2.5 X institutional upper limit of normal (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Albumin >= 3.0 g/dL (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients known to be human immunodeficiency virus (HIV)+ are permitted; patients with CD4 > 200 and serum HIV viral load of < 200 copies/mm^3 are eligible, and in addition:
- Participants must be purified protein derivative (PPD) negative; alternatively, the QuantiFERON-tuberculosis (TB) Gold In-Tube (QFT-GIT) assay (Cellestis Limited, Carnegie, Australia) can be used; an individual is considered positive for M. tuberculosis infection if the IFN-gamma response to TB antigens is above the test cut-off (after subtracting the background IFN-gamma response in the negative control); the result must be obtained within 20 weeks prior to enrollment; PPD positive (or Quantiferon assay positive) participants are permitted if prophylaxis has been completed prior to enrollment
- No history of acquired immune deficiency syndrome (AIDS)-related complications within past year other than a history of low CD4+ T-cell count > 200/mm^3 prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to chemoradiotherapy and should not be used as an exclusion criterion if low
- Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the anal cancer
- Participants MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications when clinically indicated, and should be under the care of a physician experienced in HIV management; participants will be eligible regardless of antiretroviral medication (including no antiretroviral medication) provided there is no intention to initiate therapy or the regimen has been stable for at least 4 weeks with no intention to change the regimen within 12 weeks following enrollment
- Patient must have =< grade 2 diarrhea (participants with grade 1 diarrhea are eligible provided stool for ova/parasites and stool cryptosporidium studies are negative;
- NOTE: HIV testing is not required for eligibility
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: For patients registering prior to start of chemoradiotherapy, baseline scans must have been completed within 4 weeks prior to registration
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Women of child bearing potential and sexually active males must use accepted and effective method(s) of contraception and/or abstain from sexual intercourse while on protocol treatment and for at least 5 months after the last dose of nivolumab (for female patients) and for at least 7 months after the last dose of nivolumab (for male patients)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Any surgery must have been completed >= 4 weeks prior to starting study treatment
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoclonal antibody)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No patients with immunodeficiency or receiving systemic steroid therapy equivalent to > 10 mg prednisone per day or any other form of immunosuppressive therapy within 7 days prior to Step 1 registration; topical corticosteroid or occasional inhaled corticosteroids are allowed
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No live vaccines within 30 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowed
- NOTE: no live vaccines may be administered while participating in the trial
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Previously irradiated patients (Arm S) must have received radiation per National Comprehensive Cancer Network guidelines; radiation therapy delivered on protocol (Arm T) will be reviewed
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients will be registered within 63 days following completion of standard chemoradiation for anal cancer; standard chemoradiation therapy is as defined
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have histologically proven stage IIB (T3N0M0 only), IIIA (T2N1M0), IIIB (T4N0M0), or IIIC (T3N1M0, T4N1M0) invasive squamous cell carcinoma of the anus or anorectum, according to the AJCC 8th edition; this may include tumors of non-keratinizing histology such as basaloid, transitional cell, or cloacogenic histology; individuals with squamous cell carcinoma of the anal margin are eligible if there is evidence of extension of the primary tumor into the anal canal
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have received at least 54 gray (Gy) of radiation to the PTVp (primary) and 45 Gy to PTVn (elective nodal region) for the treatment of the anal cancer
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have ECOG performance status of 0-2
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have hemoglobin levels of > 10 g/dL (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must have a platelet count of > 100,000/mm^3 (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient's ANC level must be > 1500/mm^3 (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Serum creatinine must be =< 1.5 X ULN (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Total bilirubin must be < 2 X ULN (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: AST (SGOT)/ALT (SGPT) =< 2.5 X institutional upper limit of normal (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Albumin >= 3.0 g/dL (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients known to be human immunodeficiency virus (HIV)+ are permitted; patients with CD4 > 200 and serum HIV viral load of < 200 copies/mm^3 are eligible; in addition:
- Participants must be PPD negative; alternatively, the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay (Cellestis Limited, Carnegie, Australia) can be used; an individual is considered positive for M. tuberculosis infection if the IFN-gamma response to TB antigens is above the test cut-off (after subtracting the background IFN-gamma response in the negative control); the result must be obtained within 20 weeks prior to enrollment; PPD positive (or Quantiferon assay positive) participants are permitted if prophylaxis has been completed prior to enrollment; NOTE: If patient completed chemoradiation on Step 1, PPD testing does not need to be performed again
- No history of AIDS-related complications within past year other than a history of low CD4+ T-cell count > 200/mm^3 prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to chemoradiotherapy should not be used as an exclusion criterion if low
- Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the anal cancer
- Participants MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications when clinically indicated, and should be under the care of a physician experienced in HIV management; participants will be eligible regardless of antiretroviral medication (including no antiretroviral medication) provided there is no intention to initiate therapy or the regimen has been stable for at least 4 weeks with no intention to change the regimen within 12 weeks following enrollment
- Patient must have =< grade 2 diarrhea (participants with grade 1 diarrhea are eligible provided stool for ova/parasites and stool cryptosporidium studies are negative)
- NOTE: HIV testing is not required for eligibility
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Scans done within 4 weeks of randomization to Step 2
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must have recovered from all toxicities associated with chemoradiotherapy for anal cancer, to grade =< 1 with the exception of alopecia
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Women of child bearing potential and sexually active males must use accepted and effective method(s) of contraception and/or abstain from sexual intercourse while on protocol treatment and for at least 5 months after the last dose of nivolumab (for female patients) and for at least 7 months after the last dose of nivolumab (for male patients)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoclonal antibody)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No patients with immunodeficiency or receiving systemic steroid therapy equivalent to > 10 mg prednisone per day or any other form of immunosuppressive therapy within 7 days prior to the first dose of study medication; topical corticosteroid or occasional inhaled corticosteroids are allowed
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No live vaccines within 30 days prior to the first dose of trial treatment and while participating in the trial; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowed
Exclusion Criteria:
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: For patients registering to Arm T, patients must not have received prior chemoradiotherapy for anal cancer
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients with an allogenic bone marrow/stem, cell or solid organ transplant are excluded
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Women MUST NOT be pregnant or breast-feeding due to the potential teratogenic harm or abortifacient effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used; all patients must also not expect to conceive or father children from study registration and throughout their time on study treatment; for female patients this must continue until at least 5 months after the last dose of nivolumab and for male patients until at least 7 months after the last dose of nivolumab; all females of child bearing potential must have a serum or urine pregnancy test to rule out pregnancy within 2 weeks prior to registration; a female of childbearing potential is any woman, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients will be excluded if they have a T1 or M1, and T2N0 cancer
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must not have had prior potentially curative surgery (abdominal, peritoneal resection) for carcinoma of the anus
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Participants may not be receiving any other standard anti-cancer therapy or experimental agent concurrently with the study drugs
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Individuals with a history of a different malignancy are ineligible except if they have been disease-free for at least 2 years and are deemed by the investigator to be at low risk for recurrence; individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient must not have active autoimmune disease in the past 2 years
- NOTE: This does not include patients with autoimmune disease controlled by medication, such as hypothyroidism; this eligibility includes only patients with endocrine disease controlled by hormone replacement, e.g. hypothyroid, adrenal insufficiency, or diabetes mellitus (DM)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients with an allogenic bone marrow/stem, cell or solid organ transplant are excluded
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Women MUST NOT be pregnant or breast-feeding due to the potential teratogenic harm or abortifacient effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used; all patients must also not expect to conceive or father children from study registration and throughout their time on study treatment; for female patients this must continue until at least 5 months after the last dose of nivolumab and for male patients until at least 7 months after the last dose of nivolumab; all females of child bearing potential must have a serum or urine pregnancy test to rule out pregnancy within 2 weeks prior to registration; a female of childbearing potential is any woman, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have had prior potentially curative surgery (abdominal, peritoneal resection) for carcinoma of the anus
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Participants may not be receiving any other standard anti-cancer therapy or experimental agent concurrently with the study drugs
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Individuals with a history of a different malignancy are ineligible except if they have been disease-free for at least 2 years and are deemed by the investigator to be at low risk for recurrence; individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must not have active autoimmune disease that has required systemic treatment in past 2 years
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Arm A (nivolumab)
Patients receive nivolumab while on study. Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study. |
Undergo blood sample collection
Andre navn:
Undergo MRI
Andre navn:
Undergo chest x-ray
Andre navn:
Undergo biopsy
Andre navn:
Given IV
Andre navn:
Undergo CT scan
Andre navn:
Undergo colonoscopy Undergo digital rectal examination
Andre navn:
Undergo anoscopy
Andre navn:
Undergo proctoscopy Undergo sigmoidoscopy
Andre navn:
|
|
Annen: Arm B (clinical observation)
Patients undergo observation while on study. Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study. |
Undergo blood sample collection
Andre navn:
Undergo MRI
Andre navn:
Undergo chest x-ray
Andre navn:
Undergo CT scan
Andre navn:
Undergo colonoscopy Undergo digital rectal examination
Andre navn:
Undergo anoscopy
Andre navn:
Undergo proctoscopy Undergo sigmoidoscopy
Andre navn:
Undergo observation
Andre navn:
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Disease free survival
Tidsramme: Up to 7 years
|
Will be defined as the occurrence of progression of local disease, distant metastases, second primary or death from the date of randomization. |
Up to 7 years
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Total overlevelse
Tidsramme: Inntil 7 år
|
Inntil 7 år
|
|
|
Objective response rate
Tidsramme: Up to 7 years
|
Will be defined by complete and partial response. |
Up to 7 years
|
|
Severe toxicity interval
Tidsramme: The time between randomization and the occurrence of late severe side effects (up to 7 years)
|
The following late side effects are considered as severe: any anal/rectal damage (ulcer, fistula, or perforation), rectal stenosis that required colostomy, skin ulceration, and severe fibrosis. This parameter estimates the probability of being free of late side effects for patients under loco-regional control. |
The time between randomization and the occurrence of late severe side effects (up to 7 years)
|
|
Colostomy-free survival
Tidsramme: Up to 7 years
|
Up to 7 years
|
|
|
Incidence of toxicities
Tidsramme: Up to 7 years
|
Will be assessed by National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. |
Up to 7 years
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Lakshmi Rajdev, ECOG-ACRIN Cancer Research Group
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
5. juli 2018
Primær fullføring (Antatt)
31. desember 2027
Studiet fullført (Antatt)
31. desember 2027
Datoer for studieregistrering
Først innsendt
28. juli 2017
Først innsendt som oppfylte QC-kriteriene
28. juli 2017
Først lagt ut (Faktiske)
31. juli 2017
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
2. november 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
30. oktober 2026
Sist bekreftet
1. oktober 2026
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Neoplasmer etter nettsted
- Neoplasmer
- Tarmsykdommer
- Gastrointestinale neoplasmer
- Neoplasmer i fordøyelsessystemet
- Sykdommer i fordøyelsessystemet
- Gastrointestinale sykdommer
- Kolorektale neoplasmer
- Intestinale neoplasmer
- Rektale sykdommer
- Anus sykdommer
- Rektale neoplasmer
- Neoplasmer i anus
- Analkanalkarsinom
- Health Services Administration
- Aminosyrer, peptider og proteiner
- Proteiner
- Undersøkelsesteknikker
- Metoder
- Kliniske laboratorieteknikker
- Diagnostiske teknikker og prosedyrer
- Diagnose
- Kirurgiske prosedyrer, operativ
- Minimalt invasive kirurgiske inngrep
- Cytologiske teknikker
- Cytodiagnose
- Kvalitet på helsehjelpen
- Fysiske fenomener
- Utstyr og forsyninger
- Antistoffer, monoklonalt, humanisert
- Antistoffer, monoklonalt
- Antistoffer
- Immunoglobuliner
- Immunoproteiner
- Blodproteiner
- Serumglobuliner
- Globuliner
- Diagnostiske teknikker, kirurgisk
- Endoskopi, gastrointestinal
- Endoskopi, fordøyelsessystem
- Diagnostiske teknikker, fordøyelsessystem
- Endoskopi
- Fordøyelsessystem kirurgiske inngrep
- Kjemisteknikker, analytisk
- Spektrumanalyse
- Elektromagnetiske fenomener
- Magnetiske fenomener
- Resultatvurdering, helsehjelp
- Resultat og prosessvurdering, helsehjelp
- Elektromagnetisk stråling
- Stråling
- Stråling, ioniserende
- Nivolumab
- Observasjon
- Biopsi
- Prøvehåndtering
- Koloskopi
- Magnetisk resonansspektroskopi
- Vakelig venting
- Røntgenbilder
- Fantomer, avbildning
- Proktoskopi
- Sigmoidoskopi
Andre studie-ID-numre
- NCI-2017-01347
- U10CA180820 (U.S. NIH-stipend/kontrakt)
- NCI-2017-01347 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
- EA2165 (Annen identifikator: CTEP)
- EA2165 (Annen identifikator: ECOG-ACRIN Cancer Research Group)
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Ja
Studerer et amerikansk FDA-regulert enhetsprodukt
Nei
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .