Influence of Sevoflurane and Desflurane on Postoperative Sore Throat

August 21, 2017 updated by: Hyun-Chang Kim, Keimyung University Dongsan Medical Center
This investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of sevoflurane or desflurane.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

100

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • ASA I-III
  • Patients scheduled for general anesthesia with endotracheal intubation

Exclusion Criteria:

  • Difficult airway
  • Friable teeth
  • Rapid sequence induction
  • Recent sore throat
  • Recent upper respiratory infection
  • Asthma
  • Chronic obstructive pulmonary disease
  • Chronic cough
  • Arrhythmia
  • Coronary disease
  • Heart failure
  • Pregnancy
  • Allergy to sevoflurane
  • Allergy to desflurane
  • Fever after halogenated anesthetics
  • Jaundice after halogenated anesthetics
  • Malignant hyperthremia
  • Allergy to remifentanil
  • Friable teeth
  • History of head and neck surgery
  • Multiple intubation attempts
  • Regional anesthetic agents
  • Gastric tube
  • Dexamethasone
  • Severe hypovolemia

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Sevoflurane
Drug: Sevoflurane
Sevoflurane was used as a maintenance anesthetic agent.
Experimental: Desflurane
Drug: Desflurane
Desflurane was used as a maintenance anesthetic agent.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Number of participants with postoperative sore throat
Time Frame: At 24 hr
At 24 hr

Secondary Outcome Measures

Outcome Measure
Time Frame
Number of participants with additional pain medication
Time Frame: At 0, 2, 4 and 24 hr
At 0, 2, 4 and 24 hr
Visual analogue scale of postoperative pain
Time Frame: At 0, 2, 4 and 24 hr
At 0, 2, 4 and 24 hr
Number of participants with shivering
Time Frame: At 0, 2, 4 and 24 hr
At 0, 2, 4 and 24 hr
Requirements of analgesics
Time Frame: At 0, 2, 4 and 24 hr
At 0, 2, 4 and 24 hr
Number of participants with postoperative sore throat
Time Frame: At 0, 2, 4 and 24 hr
At 0, 2, 4 and 24 hr
Number of participants with postoperative hoarseness
Time Frame: At 0, 2, 4 and 24 hr
At 0, 2, 4 and 24 hr
Number of participants with postoperative cough
Time Frame: At 0, 2, 4 and 24 hr
At 0, 2, 4 and 24 hr
Number of participants with postoperative nausea
Time Frame: At 0, 2, 4 and 24 hr
At 0, 2, 4 and 24 hr
Number of participants with postoperative vomiting
Time Frame: At 0, 2, 4 and 24 hr
At 0, 2, 4 and 24 hr

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Keimyung University Dongsan Medical Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

October 1, 2017

Primary Completion (Anticipated)

October 1, 2018

Study Completion (Anticipated)

November 1, 2018

Study Registration Dates

First Submitted

August 21, 2017

First Submitted That Met QC Criteria

August 21, 2017

First Posted (Actual)

August 24, 2017

Study Record Updates

Last Update Posted (Actual)

August 24, 2017

Last Update Submitted That Met QC Criteria

August 21, 2017

Last Verified

August 1, 2017

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SevoDesPOST

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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