Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis (JADE EXTEND)

A PHASE 3 MULTI-CENTER, LONG-TERM EXTENSION STUDY INVESTIGATING THE EFFICACY AND SAFETY OF ABROCITINIB, WITH OR WITHOUT TOPICAL MEDICATIONS, ADMINISTERED TO SUBJECTS AGED 12 YEARS AND OLDER WITH MODERATE TO SEVERE ATOPIC DERMATITIS

B7451015 is a Phase 3 study to evaluate Abrocitinib with or without Topical Medications in patients aged 12 years and older who have moderate to severe atopic dermatitis and have completed a qualifying parent study. The efficacy and safety of two dosage strengths of Abrocitinib, 100 mg and 200 mg taken orally once daily, will be evaluated over variable lengths of study participation. The study consists of a 92 week initial treatment period followed by a variable length secondary treatment period during which subjects will receive treatment with open-label abrocitinib until availability of commercial product in their country, or until the sponsor terminates the study in that country.

The B7451015 study also includes a sub-study evaluating whether abrocitinib has any potential effects on adolescent bone with regard to abnormal bone findings in knee MRI. The sub-study will be conducted in selected countries at selected sites. Eligible subjects are those who were 12 to <18 years of age at the screening visit of the qualifying parent study and who are currently participating in the main B7451015 study. The sub-study will include serial Magnetic Resonance Imaging (MRI) annually and continue until all enrolled subjects are 18 years of age and have been imaged at least once or have discontinued/withdrawn.

Study Overview

• Status: Completed
• Conditions: Dermatitis, Atopic
• Intervention / Treatment: Drug: Abrocitinib 100 mg; Drug: Placebo; Drug: Abrocitinib 100 mg; Drug: Abrocitinib 100 mg; Drug: Abrocitinib 200 mg; Drug: Abrocitinib 200 mg

• Study Type: Interventional
• Enrollment (Actual): 3166
• Phase: Phase 3

Expanded Access

Available outside the clinical trial. See expanded access record.

Contacts and Locations

Study Locations

• Argentina
  • C.a.b.a, Argentina, C1027AAP
    • CINME Centro de Investigaciones Metabolicas
  • C.a.b.a., Argentina, C1425DKG
    • Psoriahue Medicina Interdisciplinaria
  • Buenos Aires
    • CABA, Buenos Aires, Argentina, C1012AAY
      • Conexa Investigacion Clinica S.A.
    • La Plata, Buenos Aires, Argentina, B1902COS
      • Framingham Centro Medico
    • Pilar, Buenos Aires, Argentina, B1629ODT
      • Hospital Universitario Austral
  • Santa Fe Province
    • Rosario, Santa Fe Province, Argentina, 2000
      • Servicio de Investigacion de Patolog-ias Alergicas del Instituto ABC - Rosario
• Australia
  • Camberwell, Australia, VIC 3124
    • Emeritus Research
  • Parkville, Australia, 3052
    • Royal Melbourne Hospital
  • Saint Leonards NSW, Australia, 2065
    • Royal North Shore Hospital
  • Australian Capital Territory
    • Phillip, Australian Capital Territory, Australia, 2606
      • Woden Dermatology
  • New South Wales
    • Kogarah, New South Wales, Australia, 2217
      • St George Dermatology & Skin Cancer Centre
    • Maroubra, New South Wales, Australia, 2035
      • Australian Clinical Research Network
    • St Leonards, New South Wales, Australia, 2065
      • Royal North Shore Hospital
    • Westmead, New South Wales, Australia, 2145
      • The Skin Hospital
  • Queensland
    • Benowa, Queensland, Australia, 4217
      • The Skin Centre
    • Woolloongabba, Queensland, Australia, 4102
      • Veracity Clinical Research Pty Ltd
  • South Australia
    • Campbelltown, South Australia, Australia, 5074
      • North Eastern Health Specialists
  • Victoria
    • Box Hill, Victoria, Australia, 3128
      • Eastern Health - Box Hill Hospital
    • Carlton, Victoria, Australia, 3053
      • Skin Health Institute Inc.
    • East Melbourne, Victoria, Australia, 3002
      • Sinclair Dermatology
    • Parkville, Victoria, Australia, 3050
      • Royal Melbourne Hospital
    • Parkville, Victoria, Australia, 3052
      • The Royal Children's Hospital
• Belgium
  • Brussels, Belgium, 1090
    • University Hospital Brussels
  • Brussels, Belgium, B 1200
    • Cliniques universitaires Saint-Luc
  • Edegem, Belgium, 2650
    • University Hospital Antwerp
• Brazil
  • Rio de Janeiro, Brazil, 20241-180
    • IBPClin Pesquisa Clinica
  • Rio Grande do Sul
    • Porto Alegre, Rio Grande do Sul, Brazil, 90035-903/90035-003
      • Hospital de Clinicas de Porto Alegre (HCPA)
    • Porto Alegre, Rio Grande do Sul, Brazil, 90160-093
      • Associacao dos Funcionarios Publicos do Estado do Rio Grande do Sul - Hospital Ernesto Dornelles
  • Rio de Janeiro
    • Rio de Janeiro, Rio de Janeiro, Brazil, 22470-220
      • Instituto de Dermatologia e Estética do Brasil LTDA
  • São Paulo
    • Santo André, São Paulo, Brazil, 09060-870
      • Fundacao do ABC - Faculdade de Medicina do ABC
    • Santo André, São Paulo, Brazil, 09070-230
      • Tecnolab Medicina Diagnostica
    • Santo André, São Paulo, Brazil, 09080-110
      • Pesquisare Saúde S/S Ltda
    • São Bernardo do Campo, São Paulo, Brazil, 09750-670
      • Tecnolab - Unidade Matriz
• Bulgaria
  • Dobrich, Bulgaria, 9300
    • MHAT Dobrich AD
  • Dupnitsa, Bulgaria, 2600
    • MC Asklepii" OOD
  • Gabrovo, Bulgaria, 5300
    • MHAT ''Dr. Tota Venkova'' AD
  • Sofia, Bulgaria, 1407
    • "Acibadem City Clinic MHAT Tokuda" EAD
  • Sofia, Bulgaria, 1431
    • "DCC Aleksandrovska" EOOD
  • Sofia, Bulgaria, 1463
    • "DCC Fokus-5-Medical Establishment for OutpatientCare"EOOD
  • Sofia, Bulgaria, 1606
    • Military Medical Academy MHAT Sofia
  • Sofia, Bulgaria, 1756
    • Dermatology Clinic "Sofia" - group practice for specialized outpatient medical care
  • Sofia, Bulgaria, 1784
    • "Mc Synexus Sofia" Eood
  • Sofia, Bulgaria, 1784
    • ACIBADEM City Clinic Diagnostic-Consultative Center EOOD
  • Stara Zagora, Bulgaria, 6000
    • Medical Center Synexus Sofia EOOD-branch Stara Zagora
  • Varna, Bulgaria, 9000
    • "ACIBADEM City Clinic Medical Center Varna" EOOD
  • Varna, Bulgaria, 9000
    • "DCC Mladost-M Varna" OOD
• Canada
  • Québec, Canada, G1W 4R4
    • Centre de Recherche Saint-Louis inc.
  • Alberta
    • Calgary, Alberta, Canada, T3E 0B2
      • Beacon Dermatology
    • Calgary, Alberta, Canada, T1Y0B4
      • Dermatology Research Institute
    • Calgary, Alberta, Canada, T2J7E1
      • Dermatology Research Institute
    • Edmonton, Alberta, Canada, T5K 1X3
      • Stratica Medical
    • Edmonton, Alberta, Canada, T6G 1C3
      • Alberta Dermasurgery Centre
    • Red Deer, Alberta, Canada, T4P-1K4
      • CARE Clinic Ltd
  • British Columbia
    • Surrey, British Columbia, Canada, V3R 6A7
      • Dr. Chih-ho Hong Medical Inc
    • Vancouver, British Columbia, Canada, V5Z 4E8
      • University of British Columbia Department of Dermatology and Skin Science
    • Vancouver, British Columbia, Canada, V6H4E1
      • Pacific Dermaesthetics Inc.
  • Manitoba
    • Winnipeg, Manitoba, Canada, R3M 3Z4
      • Wiseman Dermatology Research Inc.
    • Winnipeg, Manitoba, Canada, R3C 0N2
      • Winnipeg Clinic
  • Newfoundland and Labrador
    • St. John's, Newfoundland and Labrador, Canada, A1A 4Y3
      • Karma Clinical Trials, Inc.
  • Ontario
    • Ajax, Ontario, Canada, L1S 7K8
      • CCA Medical Research
    • Barrie, Ontario, Canada, L4M 7G1
      • SimcoDerm Medical and Surgical Dermatology Center
    • Etobicoke, Ontario, Canada, M8X 1Y9
      • Kingsway Clinical Research
    • Greater Sudbury, Ontario, Canada, P3C 1X3
      • Medicor Research Inc
    • Greater Sudbury, Ontario, Canada, P3C 1X8
      • Sudbury Skin Clinique
    • London, Ontario, Canada, N6H 5L5
      • Derm Effects
    • Markham, Ontario, Canada, L3P 1X2
      • Lynderm Research Inc.
    • Mississauga, Ontario, Canada, L4Y 4C5
      • DermEdge Research
    • North Bay, Ontario, Canada, P1B 3Z7
      • North Bay Dermatology Centre
    • Oakville, Ontario, Canada, L6J 7W5
      • The Centre for Clinical Trials
    • Oshawa, Ontario, Canada, L1H 1B9
      • Oshawa Clinic Dermatology Trials
    • Ottawa, Ontario, Canada, K2C 3N2
      • Dermatology Ottawa Research Centre
    • Peterborough, Ontario, Canada, K9J 5K2
      • SKiN Centre for Dermatology
    • Richmond Hill, Ontario, Canada, L4C 9M7
      • York Dermatology Clinic and Research Centre
    • Richmond Hill, Ontario, Canada, L4B 1A5
      • The Centre for Dermatology
    • Toronto, Ontario, Canada, M4W 2N4
      • Research Toronto
    • Toronto, Ontario, Canada, M2N3A6
      • North York Research Inc.
    • Toronto, Ontario, Canada, M5A 3R6
      • AvantDerm
    • Toronto, Ontario, Canada, M3H5Y8
      • Toronto Research Centre
    • Toronto, Ontario, Canada, M9W 4L6
      • Manna Research Inc.(Toronto)
    • Waterloo, Ontario, Canada, N2J 1C4
      • K.Papp Clinical Research Inc.
    • Windsor, Ontario, Canada, N8T 1E6
      • XLR8 Medical Research Inc.
  • Quebec
    • Chicoutimi, Quebec, Canada, G7H 7Y8
      • INTERMED Groupe Sante
    • Chicoutimi, Quebec, Canada, G7H 6B9
      • Clinique de Radiologie du Saguenay Enr.
    • Montreal, Quebec, Canada, H2X 2V1
      • Innovaderm Research Inc.
    • Québec, Quebec, Canada, G1V 4X7
      • Centre de Recherche Dermatologique du Quebec metropolitain (CRDQ)
    • Sherbrooke, Quebec, Canada, J1L 0H8
      • Diex Research Sherbrooke Inc.
  • Saskatchewan
    • Regina, Saskatchewan, Canada, S4V1R9
      • Dr. Rachel Asiniwasis, Medical Professional Corp.
• Chile
  • Santiago Metropolitan
    • Santiago, Santiago Metropolitan, Chile, 7580206
      • Centro Medico Skinmed Limitada
    • Santiago, Santiago Metropolitan, Chile, 7640881
      • Clinica Dermacross S.A.
    • Santiago, Santiago Metropolitan, Chile, 7750495
      • CEC SpA
    • Santiago, Santiago Metropolitan, Chile, 7750495
      • MIRES (M Y F Estudios Clínicos Limitada)
    • Santiago, Santiago Metropolitan, Chile, 8380456
      • Hospital Clínico Universidad de Chile
    • Santiago, Santiago Metropolitan, Chile, 8420383
      • Centro Internacional de Estudios Clinicos - CIEC
• China
  • Chongqing, China, 400037
    • The Second Affiliated Hospital of Army Medical University,PLA
  • Shanghai, China, 200443
    • Shanghai Dermatology Hospital
  • Shanghai, China, 200003
    • Dermatology Department, Shanghai Changzheng Hospital
  • Shanghai, China, 200092
    • Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine/Dermatology
  • Beijing Municipality
    • Beijing, Beijing Municipality, China, 100034
      • Peking University First Hospital
    • Beijing, Beijing Municipality, China, 100050
      • Beijing Friendship Hospital, Capital Medical University
  • Fujian
    • Fuzhou, Fujian, China, 350005
      • The First Affiliated Hospital of Fujian Medical University
  • Guangdong
    • Guangzhou, Guangdong, China, 510080
      • The First Affiliated Hospital, Sun Yat-sen University
    • Guangzhou, Guangdong, China, 510630
      • The Third Affiliated Hospital, Sun Yat-sen University
    • Shenzhen, Guangdong, China, 518053
      • The University of Hong Kong - Shenzhen Hospital
  • Hubei
    • Wuhan, Hubei, China, 430030
      • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Hunan
    • Changsha, Hunan, China, 410011
      • The second Xiangya Hospital,Central South University
    • Changsha, Hunan, China, 410013
      • The Third Xiangya Hospital of Central South University, Dermatological department
  • Jiangsu
    • Nanjing, Jiangsu, China, 210000
      • The First Affiliated Hospital With Nanjing University
  • Jiangxi
    • Nanchang, Jiangxi, China, 330000
      • Dermatology Hospital of Jiangxi Province
  • Shandong
    • Jinan, Shandong, China, 250013
      • Jinan Central Hospital
    • Jinan, Shandong, China, 250022
      • Shandong Provincial Institute of Dermatology and Venereology & Shandong Provincial Hospital for Skin
  • Shanghai Municipality
    • Shanghai, Shanghai Municipality, China, 200040
      • Huashan Hospital Fudan University
  • Tianjin Municipality
    • Tianjin, Tianjin Municipality, China, 300052
      • Tianjin Medical University General Hospital, Dermatological Department
  • Yunnan
    • Kunming, Yunnan, China, 650032
      • First Affiliated Hospital of Kunming Medical University
  • Zhejiang
    • Hangzhou, Zhejiang, China, 310016
      • Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
    • Hangzhou, Zhejiang, China, 310009
      • Hangzhou Third Hospital
    • Hangzhou, Zhejiang, China, 310014
      • Zhejiang Provincial People's Hospital/Dermatology Department
    • Hangzhou, Zhejiang, China, 310003
      • The First Affiliated Hospital of Zhejiang University School of Medicine/Dermatology and STD Dept
    • Hangzhou, Zhejiang, China, 310009
      • The Second Affiliated Hospital of Zhejiang University School of Medicine/Dermatology Dept
• Czechia
  • Kunta Hora, Czechia, 284 01
    • Lékárna Pod Kaňkem
  • Kutná Hora, Czechia, 28401
    • Kozni ambulance Kutna Hora, s.r.o
  • Náchod, Czechia, 547 01
    • DERMAMEDICA s.r.o.
  • Náchod, Czechia, 547 01
    • Lekarna U Stribrneho orla (Pharmacy)
  • Ostrava, Czechia, 702 00
    • CCR Ostrava, s.r.o.
  • Ostrava, Czechia, 702 00
    • Lekarna Rezidence Nova Karolina
  • Ostrava, Czechia, 70200
    • Apavar Lekarna
  • Ostrava - Poruba, Czechia, 708 52
    • Lekarna Fakultni Nemocnice Ostrava
  • Ostrava - Poruba, Czechia, 70852
    • Fakultni Nemocnice Ostrava, Kozni oddeleni
  • Pardubice, Czechia, 530 02
    • BENU Lekarna
  • Pardubice, Czechia, 532 03
    • Lekarna, Nemocnice Pardubickeho kraje, a.s. , Pardubicka nemocnice
  • Pardubice, Czechia, 53203
    • Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice
  • Pardubice, Czechia, 530 02
    • Pratia Pardubice a.s.
  • Prague, Czechia, 101 00
    • Lekarna Pod Platany (Pharmacy)
  • Prague, Czechia, 11000
    • Prof. MUDr.Petr Arenberger, DrSc. MBA
  • Prague, Czechia, 12800
    • Lekarna U Spasitele
  • Prague, Czechia, 130 00
    • PRATIA Prague s.r.o.
  • Svitavy, Czechia, 56802
    • Dermatovenerologicka ambulance
  • Svitavy, Czechia, 56802
    • Lekarna na Hranicni (Pharmacy)
  • Ústí nad Labem, Czechia, 401 13
    • Krajska zdravotni a.s., Masarykova nemocnice o.z.
  • Ústí nad Labem, Czechia, 401 13
    • Lekarna Masarykovy nemocnice v Usti nad Labem, o.z.
• Finland
  • Tampere, Finland, 33100
    • Terveystalo Tampere
  • Turku, Finland, 20520
    • Mehiläinen Neo
  • Turku, Finland, 20520
    • Turun yliopistollinen keskussairaala
• Germany
  • Augsburg, Germany, 86179
    • Licca Clinical Research Institute
  • Augsburg, Germany, 86179
    • Dermazentrum Augsburg
  • Bad Bentheim, Germany, 48455
    • Fachklinik Bad Bentheim
  • Berlin, Germany, 10789
    • ISA GmbH
  • Berlin, Germany, 10783
    • Rothhaar Studien GmbH
  • Berlin, Germany, 10117
    • Charite-Universitaetsmedizin Berlin
  • Berlin, Germany, 10247
    • Hautzentrum Friedrichshain Studien
  • Bielefeld, Germany, 33647
    • Klinikum Bielefeld Rosenhoehe
  • Bonn, Germany, 53105
    • Universitaetsklinikum Bonn
  • Dresden, Germany, 01069
    • Klinische Forschung Dresden GmbH
  • Dresden, Germany, 01307
    • Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden
  • Erlangen, Germany, 91054
    • Universitätsklinikum Erlangen
  • Frankfurt, Germany, 60596
    • IKF Pneumologie GmbH & Co KG; Institut für klinische Forschung
  • Gera, Germany, 07548
    • SRH Wald-Klinikum Gera GmbH
  • Hamburg, Germany, 22391
    • Mensingderma Research Gmbh
  • Hamburg, Germany, 20253
    • Klinische Forschung Hamburg GmbH
  • Hanover, Germany, 30625
    • Medizinische Hochschule Hannover
  • Kiel, Germany, 24105
    • Universitaetsklinikum Schleswig-Holstein, Campus Kiel
  • Langenau, Germany, 89129
    • Praxis Dr. med. Beate Schwarz
  • Leipzig, Germany, 04103
    • Velocity Clinical Research Germany GmbH
  • Lübeck, Germany, 23538
    • Universitaetsklinikum Schleswig-Holstein, Campus Luebeck
  • Mahlow, Germany, 15831
    • Dermatologische Gemeinschaftspraxis
  • Mainz, Germany, 55128
    • Dermatologische Gemeinschaftspraxis Dres. Quist
  • Marburg, Germany, 35043
    • Universitätsklinikum Marburg
  • Munich, Germany, 80337
    • Ludwig-Maximilians-University Munich
  • Münster, Germany, 48149
    • University of Muenster
  • Schwerin, Germany, 19055
    • Klinische forschung Schwerin GmbH
  • Stuttgart, Germany, 70178
    • Hautaerztliche Gemeinschaftspraxis Dres. Leitz und Kollegen
• Hungary
  • Budapest, Hungary, 1033
    • Clinexpert Kft.
  • Budapest, Hungary, 1085
    • SE AOK Bor, Nemikortani es Boronkologiai Klinika
  • Budapest, Hungary, 1195
    • Bp. Főváros XIX. Kerület Önkormányzat Kispesti Eü. Intézete
  • Debrecen, Hungary, 4032
    • Debreceni Egyetem Klinikai Kozpont
  • Encs, Hungary, 3860
    • CRU Hungary Kft.
  • Gyula, Hungary, 5700
    • Synexus Magyarország Egészségügyi Szolgáltató Kft. Synexus Gyula DRS
  • Gyöngyös, Hungary, 3200
    • Bugát Pál Kórház, Bőrgyógyászati Szakrendelés
  • Győr, Hungary, 9026
    • Trial Pharma Kft.
  • Kaposvár, Hungary, 7400
    • Trial Pharma Kft.
  • Miskolc, Hungary, 3526
    • Borsod-Abaúj-Zemplén Megyei Központi Kórház és Gyermek Gasztroenterológia II. emelet
  • Pécs, Hungary, 7632
    • Pecsi Tudomanyegyetem Klinikai Kozpont, Bor-,Nemikortani es Onkodermatologiai Klinika
  • Püspökladány, Hungary, 4150
    • Trial Pharma Kft.
  • Szeged, Hungary, 6720
    • Szegedi Tudomanyegyetem Szent-Györgyi Albert
  • Szolnok, Hungary, 5000
    • Allergo-Derm Bakos Kft.
  • Veszprém, Hungary, 8200
    • Medmare Bt
• Israel
  • Beersheba, Israel, 8410101
    • Soroka University Medical Center
  • Petah Tikva, Israel, 4941492
    • Rabin Medical Center
  • Ramat Gan, Israel, 5265601
    • The Chaim Sheba Medical Center
  • Tel Aviv, Israel, 6423906
    • Tel-Aviv Sourasky Medical Center
• Italy
  • Milan, Italy, 20089
    • Istituto Clinico Humanitas IRCSS - UOC di Dermatologia
  • Milan, Italy, 20157
    • Asst Fatebenefratelli Sacco
  • Roma, Italy, 00144
    • IFO lstituto Dermatologico San Gallicano IRCCS
  • Rome, Italy, 00168
    • Universita del Sacro Cuore, Policlinico Agostino Gemelli, Istituto Di Dermatologia
  • BO
    • Bologna, BO, Italy, 40138
      • AOU Policlinico Sant'Orsola Malpighi
  • CH
    • Chieti, CH, Italy, 66100
      • Universita degli Studi G. D'Annunzio -CeSi-MeT
  • GE
    • Genova, GE, Italy, 16132
      • Ospedale Policlinico San Martino
  • MO
    • Modena, MO, Italy, 41124
      • AOU Policlinico di Modena Struttura complessa di Dermatologia
• Japan
  • Fukuoka, Japan, 814-0171
    • Hoshikuma Dermatology・Allergy Clinic
  • Fukuoka, Japan, 819-0167
    • Matsuda Tomoko Dermatological Clinic
  • Saitama, Japan, 330-0854
    • Sanrui Hifuka
  • Chiba
    • Ichikawa, Chiba, Japan, 272-0033
      • Kawashima Dermatology Clinic
  • Hokkaido
    • Obihiro, Hokkaido, Japan, 080-0013
      • Takagi Dermatological Clinic
  • Hyōgo
    • Kobe, Hyōgo, Japan, 657-0846
      • Dermatology Shimizu Clinic
  • Kanagawa
    • Yokohama, Kanagawa, Japan, 220-6208
      • Queen's square Medical Facilities Queen's square Dermatology and Allergology
  • Kumamoto
    • Kamimashiki-gun, Kumamoto, Japan, 861-3106
      • Noguchi Dermatology Clinic
  • Osaka
    • Habikino, Osaka, Japan, 583-8588
      • Osaka Habikino Medical Center
    • Neyagawa, Osaka, Japan, 572-0838
      • Yoshioka Dermatology Clinic
    • Sakai, Osaka, Japan, 593-8324
      • Dermatology and Ophthalmology Kume Clinic
  • Tokyo
    • Chiyoda-ku, Tokyo, Japan, 102-0072
      • Iidabashi Skin Clinic
    • Chuo-ku, Tokyo, Japan, 104-0031
      • Fukuwa Clinic
    • Edogawa-ku, Tokyo, Japan, 133-0052
      • Sumire Dermatology Clinic
    • Nakano-ku, Tokyo, Japan, 165-0026
      • Matsuyama Dermatology Clinic
    • Shinjyuku-ku, Tokyo, Japan, 160-0023
      • Tokyo Medical University Hospital
• Latvia
  • Riga, Latvia, LV-1003
    • Aesthetic dermatology clinic of prof. J. Kisis
  • Riga, Latvia, LV-1003
    • Health Centre 4 Ltd. Diagnostics Centre
  • Riga, Latvia, LV-1009
    • Health and Aesthetics Ltd
  • Riga, Latvia, LV - 1001
    • Riga 1st Hospital, Clinic of Dermatology and STD
  • Riga, Latvia, LV-1004
    • Childrens Clinical University Hospital State SLLC
  • Riga, Latvia, LV-1013
    • Health Centre 4 Ltd, Dermatology Clinics
  • Ventspils, Latvia, LV3601
    • Outpatient Clinic Of Ventspils
• Mexico
  • Aguascalientes, Mexico, 20127
    • Derma Norte del Bajio S.C.
  • Chihuahua City, Mexico, 31203
    • Centro de Investigacion Integral MEDIVEST, S.C.
  • Chihuahua City, Mexico, 31238
    • Servicios Hospitalarios de México S.A. de C.V. (Hospital Angeles Chihuahua)
  • Cuautitlán Izcalli, Mexico, 54769
    • Phylasis Clinicas Research S. de R.L. de C.V.
  • Mexico City, Mexico, 06090
    • Hospital de Jésus, I.A.P.
  • Mexico City, Mexico, 06100
    • Cryptex Investigación Clínica, S.A. de C.V.
  • Mexico City, Mexico, 06700
    • Trials in Medicine S.C.
  • Mexico City, Mexico, 06700
    • Arke Estudios Clinicos Sa De Cv
  • Monterrey, Mexico, 64718
    • Eukarya Pharmasite S.C.
  • Querétaro, Mexico, 76070
    • SMIQ, S. de R. L. de C.V.
  • Veracruz, Mexico, 91900
    • Sociedad de Metabolismo y Corazón S.C.
  • Coahuila
    • Saltillo, Coahuila, Mexico, 25020
      • Clinical Research Institute S.C.
  • Mexico City
    • Del. Cuauhtemoc, Mexico City, Mexico, 06720
      • Hospital Infantil de Mexico Federico Gomez
  • Morelos
    • Cuernavaca, Morelos, Mexico, 62290
      • JM Research SC
  • Nuevo León
    • Monterrey, Nuevo León, Mexico, 64460
      • Centro de Dermatologia de Monterrey
  • Yucatán
    • Mérida, Yucatán, Mexico, 97000
      • Unidad de Atención Médica e Investigación en Salud
    • Mérida, Yucatán, Mexico, 97130
      • Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan
• Netherlands
  • Utrecht, Netherlands, 3584 CX
    • Universitair Medisch Centrum (UMC) Utrecht
• Poland
  • Bialystok, Poland, 15-453
    • NZOZ Specjalistyczny Osrodek Dermatologiczny DERMAL s.c.
  • Bialystok, Poland, 15-704
    • KLIMED Marek Klimkiewicz
  • Bydgoszcz, Poland, 85-650
    • Clinica Dermatoestetica Prywatny Gabinet Dermatologiczny i Alergologiczny
  • Chorzów, Poland, 41-500
    • DERMAPOLIS Medical Dermatology Center dr n. med. Edyta Gębska
  • Częstochowa, Poland, 42-202
    • Synexus Polska Sp. z o.o. Oddzial w Czestochowie
  • Gdansk, Poland, 80-214
    • Uniwersyteckie Centrum Kliniczne Klinika Dermatologii, Wenerologii i Alergologii
  • Gdansk, Poland, 80-462
    • Neutrum Lekarze M. Hlebowicz i Partnerzy Spolka Partnerska
  • Gdansk, Poland, 80-462
    • Szpital Sw. Wojciecha
  • Gdynia, Poland, 81-537
    • Synexus Polska Sp. z o.o. Oddzial w Gdyni
  • Grodzisk Mazowiecki, Poland, 05-825
    • MCBK
  • Katowice, Poland, 40-040
    • Synexus Polska Sp. Z O.O. Oddzial W Katowicach
  • Katowice, Poland, 40-648
    • Pro Familia Altera Sp. z o.o.
  • Katowice, Poland, 40-611
    • Centrum Medyczne Angelius Provita
  • Katowice, Poland, 40-123
    • MULTIKLINIKA Salute Sp. z o.o.
  • Katowice, Poland, 40-282
    • Silmedic Sp. z o.o., Oddzial w Katowicach
  • Katowice, Poland, 40-568
    • Care Clinic Centrum Medyczne
  • Kielce, Poland, 25-217
    • Gabinet Dermatologiczny Beata Krecisz
  • Krakow, Poland, 30-363
    • Centrum Medyczne Plejady
  • Krakow, Poland, 31-501
    • Krakowskie Centrum Medyczne Sp. z o.o.
  • Krakow, Poland, 30-348
    • Centrum Badan Klinicznych JCI
  • Krakow, Poland, 31-302
    • AWP Klinika Dermatologii Pod Fortem Anna Wojas-Pelc
  • Krakow, Poland, 30-149
    • Malopolskie Centrum Kliniczne
  • Krakow, Poland, 31-011
    • Centrum Nowoczesnych Terapii "Dobry Lekarz" Sp. z o.o.
  • Krakow, Poland, 31-411
    • Centrum Medyczne Promed
  • Ksawerów, Poland, 95-054
    • Prywatna Praktyka Lekarska - Adam Smialowski INTERMED KSAWEROW
  • Lodz, Poland, 90-265
    • NZOZ "DERMED" Centrum Medyczne Sp. z o.o. - Oddzial w Lodzi
  • Lodz, Poland, 90-349
    • Osrodek badan klinicznych AppleTree Clinics
  • Lodz, Poland, 90-436
    • Dermoklinika-Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak
  • Lodz, Poland, 90-338
    • Centrum Terapii Wspolczesnej J.M. Jasnorzewska Spolka Komandytowo-Akcyjna
  • Lublin, Poland, 20-362
    • KO-MED Centra Kliniczne Lublin II
  • Lublin, Poland, 20-406
    • NZOZ "Med-Laser" Borzecki Spolka Jawna
  • Ostrowiec Świętokrzyski, Poland, 27-400
    • Dermedic Jacek Zdybski
  • Poznan, Poland, 60-848
    • Clinical Research Center Sp. z o.o. MEDIC-R Sp. k.
  • Poznan, Poland, 60-702
    • Synexus Polska Sp. z o.o. Oddzial w Poznaniu
  • Poznan, Poland, 61-441
    • Gabinety Lekarskie Rivermed
  • Rybnik, Poland, 44-200
    • LIFT-MED Spolka Akcyjna
  • Rzeszów, Poland, 35-205
    • EMED Centrum Uslug Medycznych Ewa Smialek
  • Rzeszów, Poland, 35-055
    • Kliniczny Szpital Wojewodzki nr 1 im. F. Chopina, Klinika Dermatologii
  • Szczecin, Poland, 70-332
    • Andrzej Krolicki, Tomasz Kochanowski "Laser Clinic" S.C.
  • Szczecin, Poland, 71-500
    • Twoja Przychodnia Szczecinskie Centrum Medyczne
  • Tarnów, Poland, 33-100
    • Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. Z O.O.
  • Warsaw, Poland, 02-793
    • ETG Warszawa
  • Warsaw, Poland, 01-518
    • Centrum Medyczne AMED
  • Warsaw, Poland, 02-953
    • Klinika Ambroziak Sp. Z O.O.
  • Warsaw, Poland, 00-874
    • MICS Centrum Medyczne Warszawa
  • Warsaw, Poland, 02-172
    • MTZ Clinical Research Powered by Pratia
  • Warsaw, Poland, 02-507
    • Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie
  • Warsaw, Poland, 02-657
    • RCMed Oddzial Warszawa
  • Warsaw, Poland, 02-661
    • Carpe Diem Centrum Medycyny Estetycznej
  • Warsaw, Poland, 02-665
    • REUMATIKA - "Centrum Reumatologii" NZOZ 2
  • Warsaw, Poland, 02-672
    • Synexus Polska Sp. z o.o. Oddzial w Warszawie
  • Warsaw, Poland, 04-141
    • Wojskowy Instytut Medyczny, Klinika Dermatologiczna
  • Wroclaw, Poland, 50-381
    • Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
  • Wroclaw, Poland, 52-416
    • Centrum Medyczne Oporow
  • Wroclaw, Poland, 50-220
    • EMC Instytut Medyczny S.A. Przychodnia przy ul. Lowieckiej
  • Wroclaw, Poland, 50-566
    • Lukasz Matusiak "4Health"
  • Zabrze, Poland, 41-800
    • Kliniczny Oddzial Chorob Wewnetrznych, Dermatologii i Alergologii
• Romania
  • Bucharest, Romania, 014142
    • SC Delta Health Care SRL
  • JUD. Brasov
    • Brasov, JUD. Brasov, Romania, 500283
      • SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL
  • JUD. CLUJ
    • Cluj-Napoca, JUD. CLUJ, Romania, 400105
      • Cabinet Medical de Dermatovenerologie Prof. Dr. Orasan Remus Ioan
• Russia
  • Chelyabinsk, Russia, 454048
    • SBIH "Chelyabinsk Regional Clinical Dermatovenerology dispensary"
  • Kemerovo, Russia, 650070
    • Limited Liability Company "Medical Center "Rheuma-Med"
  • Kirov, Russia, 610014
    • Clinic of FSBEI HE Kirov SMU MOH Russia
  • Moscow, Russia, 107076
    • FSBI "State Research Centre of Dermatovenereology and Cosmetology" MoH RF
  • Moscow, Russia, 115522
    • NRC Institute of Immunology FMBA of Russia
  • Rostov-on-Don, Russia, 344007
    • SBI RR "Skin and Venereal Dispensary"
  • Ryazan, Russia, 390046
    • SBI RR "Regional Clinical Skin and Veneral Dispensary"
  • Saint Petersburg, Russia, 191123
    • LLC "Pierre Wolkenstein Clinic of Skin Diseases"
  • Saint Petersburg, Russia, 191123
    • Vitiligo center
  • Saint Petersburg, Russia, 194100
    • FSBEI HE "St. Petersburg State Pediatric Medical University" MoH RF
  • Saint Petersburg, Russia, 194214
    • Limited Liability Company "Sanavita"
  • Saint Petersburg, Russia, 196084
    • "Medical Research Institute", LLC
  • Saint Petersburg, Russia, 197022
    • FSBEI HE I.P.Pavlov SPbSMU MOH Russia
  • Smolensk, Russia, 214018
    • RSBIH "Smolensk Regional Clinical Hospital"
• Serbia
  • Belgrade, Serbia, 11000
    • Military Medical Academy
  • Niš, Serbia, 18000
    • Clinical Centre Nis
  • Pančevo, Serbia, 26000
    • General Hospital Pancevo
• Slovakia
  • Bratislava, Slovakia, 833 40
    • Narodny ustav detskych chorob
  • Bratislava, Slovakia, 841 02
    • BeneDerma s.r.o.
  • Bratislava, Slovakia, 85101
    • Derma therapy spol. s.r.o, Dermatovenerologicka ambulancia
  • Bratislava - Mestská Cast Nove Mesto, Slovakia, 831 01
    • Summit Clinical Research, s.r.o.
  • Bratislava- Mestská Časť Nové Mesto, Slovakia, 83101
    • SKINKLINIK s.r.o.
  • Kosice-Saca, Slovakia, 040 15
    • Nemocnica Kosice-Saca, a.s., 1. sukromna nemocnica, Kozna ambulancia
  • Nitra, Slovakia, 949 01
    • Derma-beauty, s.r.o., Dermatovenerologicka ambulancia
  • Nové Zámky, Slovakia, 940 34
    • Fakultna nemocnica s poliklinikou Nove Zamky, Dermatovenerologicka klinika
  • Svidník, Slovakia, 089 01
    • SANARE spol.s.r.o.
• South Korea
  • Daegu, South Korea, 41944
    • Kyungpook National University Hospital
  • Daejeon, South Korea, 35015
    • Chungnam National University Hospital CNUH
  • Gwangju, South Korea, 61469
    • Chonnam National University Hospital
  • Incheon, South Korea, 21431
    • The Catholic University of Korea, Incheon St. Mary's Hospital
  • Incheon, South Korea, 22332
    • Inha University Hospital
  • Seoul, South Korea, 06591
    • The Catholic University of Korea, Seoul St. Mary's Hospital
  • Seoul, South Korea, 02841
    • Korea University Anam Hospital
  • Seoul, South Korea, 03722
    • Severance Hospital, Yonsei Univ. Health System
  • Seoul, South Korea, 06973
    • Chung-Ang University Hospital
  • Seoul, South Korea, 07441
    • Hallym University Kangnam Sacred Heart Hospital
  • Gyeonggi-do
    • Ansan-si, Gyeonggi-do, South Korea, 15355
      • Korea University Ansan Hospital
    • Bucheon-si, Gyeonggi-do, South Korea, 14584
      • Soon Chun Hyang University Bucheon Hospital
• Spain
  • Alicante, Spain, 03010
    • Hospital General Universitario de Alicante
  • Barcelona, Spain, 08036
    • Hospital Clinic De Barcelona
  • Barcelona, Spain, 08041
    • Hospital de la Santa Creu i Sant Pau Servicio de Dermatologia
  • Córdoba, Spain, 14004
    • Hospital Universitario Reina Sofía
  • Madrid, Spain, 28041
    • Hospital Universitario 12 de Octubre
  • Madrid, Spain, 28046
    • Hospital Universitario La Paz
  • Madrid, Spain, 28006
    • Hospital Universitario de La Princesa
  • Madrid, Spain, 28007
    • Hospital General Universitario Gregorio Marañón
  • Madrid, Spain, 28009
    • Hospital del Niño Jesus
  • Pontevedra, Spain, 36001
    • Centro de Especialidades Mollabao (Area Sanitaria de Pontevedra e O Salnes)
  • Pontevedra, Spain, 36071
    • Hospital De Montecelo
  • Seville, Spain, 41009
    • Hospital Universitario Virgen De La Macarena
  • Valencia, Spain, 46026
    • Hospital Universitario y Politécnico La FE
  • Valencia, Spain, 46014
    • Consorcio Hospital General Universitario de Valencia
  • Zaragoza, Spain, 50009
    • Hospital Universitario Miguel Servet
  • Barcelona
    • Badalona, Barcelona, Spain, 08916
      • Hospital Universitari Germans Trias i Pujol
    • Esplugues de Llobregat, Barcelona, Spain, 08950
      • Hospital Sant Joan de Déu
  • LAS Palmas
    • Las Palmas de Gran Canaria, LAS Palmas, Spain, 35010
      • Hospital Universitario de Gran Canaria Dr. Negrin
  • Madrid
    • Alcorcón, Madrid, Spain, 28922
      • Hospital Universitario Fundacion Alcorcon
    • Majadahonda, Madrid, Spain, 28222
      • Hospital Universitario Puerta de Hierro de Majadahonda
• Taiwan
  • Kaohsiung City, Taiwan, 807
    • Kaohsiung Medical University Chung-Ho Memorial Hospital
  • New Taipei City, Taiwan, 23561
    • Taipei Medical University-Shuang Ho Hospital
  • Taichung, Taiwan, 40705
    • Taichung Veterans General Hospital
  • Taichung, Taiwan, 402
    • Chung Shan Medical University Hospital
  • Tainan, Taiwan, 704
    • National Cheng-Kung University Hospital
  • Taipei, Taiwan, 100
    • National Taiwan University Hospital
  • Taipei, Taiwan, 10449
    • Mackay Memorial Hospital
  • Taoyuan, Taiwan, 333
    • Chang Gung Memorial Hospital Linkou Branch
  • Taiwan (r.o.c)
    • Taipei, Taiwan (r.o.c), Taiwan, 11217
      • Taipei Veterans General Hospital
• United Kingdom
  • Blackpool, United Kingdom, FY2 0JH
    • MAC Clinical Research
  • Bristol, United Kingdom, BS2 8HW
    • University Hospital Bristol NHS Foundation Trust
  • Cannock, United Kingdom, WS11 0BN
    • MAC Clinical Research
  • Coventry, United Kingdom, CV3 4FJ
    • Accellacare Warwickshire
  • Glasgow, United Kingdom, G3 8SJ
    • West Glasgow Ambulatory Care Hospital
  • London, United Kingdom, SE1 9RT
    • Guy's Hospital-Guy's and St Thomas NHS Foundation Trust
  • Manchester, United Kingdom, M13 9NQ
    • MAC Clinical Research Ltd
  • Orpington, United Kingdom, BR5 3QG
    • Accellacare South London
  • Shipley, United Kingdom, BD18 3SA
    • Accellacare Yorkshire
  • Berkshire
    • Wokingham, Berkshire, United Kingdom, RG40 1XS
      • Medinova Research
    • Wokingham, Berkshire, United Kingdom, RG40 1XS
      • MeDiNova West London Quality Research Sites
  • Devon
    • Plymouth, Devon, United Kingdom, PL6 8DH
      • Plymouth Hospitals NHS Trust, Derriford Hospital
  • Greater London
    • London, Greater London, United Kingdom, NW3 2QG
      • Royal Free London NHS Foundation Trust
  • KENT
    • Orpington, KENT, United Kingdom, BR5 3QG
      • MeDiNova South London Quality Research Site
  • Middlesex
    • Northwood, Middlesex, United Kingdom, HA6 2RN
      • Accellacare North London
  • South Yorkshire
    • Barnsley, South Yorkshire, United Kingdom, S75 2EP
      • Barnsley Hospital NHS Foundation Trust
    • Sheffield, South Yorkshire, United Kingdom, S10 2TH
      • Sheffield Children's NHS Foundation Trust
    • Sheffield, South Yorkshire, United Kingdom, S5 7AU
      • Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital
• United States
  • Alabama
    • Birmingham, Alabama, United States, 35209
      • Clinical Research Center of Alabama, LLC
    • Birmingham, Alabama, United States, 35205
      • Total Skin and Beauty Dermatology Center, PC
    • Birmingham, Alabama, United States, 35294
      • The University of Alabama at Birmingham, Department of Dermatology
    • Birmingham, Alabama, United States, 35233
      • University of Alabama at Birmingham - Dermatology Research Clinic
    • Birmingham, Alabama, United States, 35233
      • University of Alabama at Birmingham Hospital Outreach Lab
    • Birmingham, Alabama, United States, 35244
      • Clinical Research Center of Alabama, LLC
  • California
    • Anaheim, California, United States, 92804
      • Emmaus Research Center, Inc.
    • Encinitas, California, United States, 92024
      • California Dermatology & Clinical Research Institute
    • Fountain Valley, California, United States, 92708
      • First OC Dermatology Research Inc
    • Huntington Beach, California, United States, 92647
      • Marvel Research, LLC
    • Irvine, California, United States, 92612
      • Tilda Research Inc.
    • Long Beach, California, United States, 90808
      • Beach Allergy and Asthma Specialty Group, A Medical Corporation
    • Los Angeles, California, United States, 90033
      • Keck School of Medicine of University of Southern California
    • Los Angeles, California, United States, 90056
      • Wallace Medical Group, Inc
    • Mission Viejo, California, United States, 92691
      • Allergy & Asthma Associates of Southern California dba Southern California Research
    • Oceanside, California, United States, 92056
      • Dermatology Specialists, Inc.
    • Rolling Hills Estates, California, United States, 90274
      • Peninsula Headlands LLC
    • Sacramento, California, United States, 95816
      • UC Davis Health
    • San Diego, California, United States, 92103
      • MedDerm Associates
    • San Diego, California, United States, 92122
      • University of California San Diego Dermatology
    • San Francisco, California, United States, 94132
      • Synergy Dermatology
    • San Luis Obispo, California, United States, 93405
      • San Luis Dermatology and Laser Clinic
    • Santa Ana, California, United States, 92705
      • Wolverine Clinical Trials, Llc
    • Santa Ana, California, United States, 92701
      • Southern California Dermatology, Inc.
    • Santa Monica, California, United States, 90404
      • Clinical Science Institute
    • Santa Monica, California, United States, 90403
      • Mosaic Dermatology
  • Colorado
    • Colorado Springs, Colorado, United States, 80907
      • Asthma and Allergy Associates, PC
    • Colorado Springs, Colorado, United States, 80910
      • Colorado Springs Dermatology Clinic, PC
  • Florida
    • Boca Raton, Florida, United States, 33486
      • Skin Care Research
    • Cape Coral, Florida, United States, 33991
      • Renaissance Research and Medical Group, Inc
    • Coral Gables, Florida, United States, 33134
      • Florida Academic Centers Research and Education, LLC
    • Coral Gables, Florida, United States, 33146
      • Skin Research Institute
    • Doral, Florida, United States, 33166
      • Moonshine Research Center, Inc.
    • Homestead, Florida, United States, 33030
      • Homestead Research Institute
    • Jacksonville, Florida, United States, 32256
      • Clinical Neuroscience Solutions, Inc.
    • Jacksonville, Florida, United States, 32256
      • Solutions Through Advanced Research, Inc.
    • Kendall, Florida, United States, 33183
      • C & R Research Services USA, Inc
    • Miami, Florida, United States, 33155
      • Nicklaus Children's Hospital
    • Miami, Florida, United States, 33137
      • Baumann Cosmetic and Research Institute
    • Miami, Florida, United States, 33135
      • Global Health Clinical Trials Corp
    • Miami, Florida, United States, 33126
      • Clinical Trials Solutions
    • Miami, Florida, United States, 33155
      • La Salud Research Clinic, Inc.
    • Miami, Florida, United States, 33155
      • South Miami Medical & Research Group, Inc.
    • Miami, Florida, United States, 33173
      • Ciocca Dermatology, PA
    • Miami, Florida, United States, 33173
      • Miami Dermatology & Laser Research, LLC
    • Miami, Florida, United States, 33175
      • INTERMED Medical Research Center, Inc
    • Miami, Florida, United States, 33184
      • Suncoast Research Associates
    • Miami, Florida, United States, 33144
      • Suncoast Research Associates
    • Miami Lakes, Florida, United States, 33014
      • Savin Medical Group LLC
    • Miami Lakes, Florida, United States, 33016
      • Wellness Clinical Research, LLC
    • Orange Park, Florida, United States, 32073
      • Park Avenue Dermatology
    • Orlando, Florida, United States, 32803
      • AdventHealth Orlando
    • Orlando, Florida, United States, 32801
      • Clinical Neuroscience Solutions, Inc.
    • Orlando, Florida, United States, 32803
      • AdventHealth Pediatric Dermatology Orlando
    • Orlando, Florida, United States, 32804
      • Advent Health Orlando - Investigational Drug Services
    • Orlando, Florida, United States, 32804
      • Outpatient Services Center - AdventHealth Orlando
    • Orlando, Florida, United States, 32804
      • Pediatric Outpatient Procedures and Sedation
    • Orlando, Florida, United States, 32829
      • Accel Research Sites - Nona Pediatric Center
    • St. Petersburg, Florida, United States, 33709
      • Olympian Clinical Research
    • Tampa, Florida, United States, 33613
      • ForCare Clinical Research
    • Tampa, Florida, United States, 33607
      • Clinical Research Trials of Florida, Inc.
    • Tampa, Florida, United States, 33615
      • Olympian Clinical Research
    • Tampa, Florida, United States, 33607
      • Clinical Research Trials of Florida
    • Tampa, Florida, United States, 33613
      • University of South Florida; Asthma, Allergy and Immunology Clinical Research Unit
    • West Palm Beach, Florida, United States, 33406
      • Integrated Clinical Research
  • Georgia
    • Columbus, Georgia, United States, 31904
      • Columbus Regional Research Institute
    • Columbus, Georgia, United States, 31904
      • IACT Health
    • Johns Creek, Georgia, United States, 30097
      • One Health Research Clinic Atlanta, LLC
    • Macon, Georgia, United States, 31217
      • Dermatologic Surgery Specialists, PC
    • Savannah, Georgia, United States, 31406
      • Meridian Clinical Research
  • Idaho
    • Nampa, Idaho, United States, 83687
      • ASR, LLC
  • Illinois
    • Normal, Illinois, United States, 61761
      • Midwest Allergy Sinus Asthma, Sc
    • Skokie, Illinois, United States, 60077
      • NorthShore University HealthSystem Dermatology Clinical Trials Unit
    • Skokie, Illinois, United States, 60077
      • NorthShore University HealthSystem - Dermatology
    • West Dundee, Illinois, United States, 60118
      • Dundee Dermatology
  • Indiana
    • Clarksville, Indiana, United States, 47129
      • DS Research
    • Indianapolis, Indiana, United States, 46250
      • Dawes Fretzin Clinical Research Group, LLC
    • Plainfield, Indiana, United States, 46168
      • The Indiana Clinical Trials Center
    • South Bend, Indiana, United States, 46617
      • The South Bend Clinic Center for Research
  • Kansas
    • Overland Park, Kansas, United States, 66215
      • Kansas City Dermatology, PA
  • Kentucky
    • Louisville, Kentucky, United States, 40217
      • Skin Sciences, PLLC
    • Owensboro, Kentucky, United States, 42301
      • Qualmedica Research, LLC.
    • Owensboro, Kentucky, United States, 42303
      • Owensboro Dermatology Associates
  • Louisiana
    • Baton Rouge, Louisiana, United States, 70808
      • Meridian Clinical Research, LLC
    • Crowley, Louisiana, United States, 70526
      • Avant Research Associates LLC
    • New Orleans, Louisiana, United States, 70112
      • Tulane University Health Sciences Center
  • Maryland
    • Chevy Chase, Maryland, United States, 20815
      • Institute for Asthma and Allergy
    • Rockville, Maryland, United States, 20850
      • DermAssociates, LLC
    • White Marsh, Maryland, United States, 21162
      • Chesapeake Clinical Research, Inc.
  • Massachusetts
    • Boston, Massachusetts, United States, 02111
      • Tufts Medical Center
    • Boston, Massachusetts, United States, 02114
      • Massachusetts General Hospital - Clinical Unit for Research Trials in Skin (CURTIS)
    • Brighton, Massachusetts, United States, 02135
      • MetroBoston Clinical Partners, LLC
  • Michigan
    • Clarkston, Michigan, United States, 48346
      • Clarkston Skin Research
    • Detroit, Michigan, United States, 48202
      • Henry Ford Medical Center, New Center One
    • Flint, Michigan, United States, 48507
      • Onyx Clinical Research
    • Fort Gratiot, Michigan, United States, 48059
      • Hamzavi Dermatology
    • Troy, Michigan, United States, 48084
      • Somerset Skin Centre
    • Troy, Michigan, United States, 48084
      • Revival Research Institute, LLC
    • West Bloomfield, Michigan, United States, 48322
      • Henry Ford Medical Center - Farmington Road
  • Minnesota
    • Minneapolis, Minnesota, United States, 55402
      • Clinical Research Institute, Inc.
    • Rochester, Minnesota, United States, 55905
      • Mayo Clinic
  • Missouri
    • Saint Joseph, Missouri, United States, 64506
      • MediSearch Clinical Trials
    • St Louis, Missouri, United States, 63104
      • Saint Louis University Dermatology
  • Nebraska
    • Omaha, Nebraska, United States, 68144
      • Skin Specialists PC
  • New York
    • Kew Gardens, New York, United States, 11415
      • Forest Hills Dermatology Group
    • New York, New York, United States, 10029
      • Icahn School of Medicine at Mount Sinai
    • Rochester, New York, United States, 14642
      • Investigational Drug Service
    • Rochester, New York, United States, 14620
      • UR Dermatology Clinical Trials Unit at College Town
  • North Carolina
    • Cary, North Carolina, United States, 27511
      • Cary Dermatology Center, PA
    • Cary, North Carolina, United States, 27518
      • Accellacare - Cary
    • Greensboro, North Carolina, United States, 27408
      • Medication Management, LLC
    • Raleigh, North Carolina, United States, 27612
      • M3-Wake Research, Inc.
    • Shelby, North Carolina, United States, 28150
      • Carolina Research Center, Inc.
    • Wilmington, North Carolina, United States, 28411
      • PMG Research of Wilmington, LLC
    • Wilmington, North Carolina, United States, 28411
      • PMG Research of Wilmington LLC
    • Winston-Salem, North Carolina, United States, 27103
      • PMG Research of Winston-Salem, LLC
    • Winston-Salem, North Carolina, United States, 27103
      • Winston-Salem Dermatology and Surgery Center, PLLC
  • Ohio
    • Bexley, Ohio, United States, 43209
      • Bexley Dermatology Research
    • Columbus, Ohio, United States, 43210
      • The Ohio State University Wexner Medical Center
    • Gahanna, Ohio, United States, 43230
      • The Ohio State University Dermatology East
  • Oklahoma
    • Oklahoma City, Oklahoma, United States, 73112
      • Lynn Health Science Institute
    • Oklahoma City, Oklahoma, United States, 73120
      • Newton Clinical Research
    • Tulsa, Oklahoma, United States, 74136
      • Vital Prospects Clinical Research Institute, P.C.
  • Oregon
    • Clackamas, Oregon, United States, 97015
      • Portland Clinical Research dba Columbia Asthma & Allergy Clinic
    • Medford, Oregon, United States, 97504
      • Velocity Clinical Research, Medford
    • Portland, Oregon, United States, 97239
      • Oregon Health & Science University
    • Portland, Oregon, United States, 97201
      • Oregon Medical Research Center
  • Pennsylvania
    • Philadelphia, Pennsylvania, United States, 19103
      • Paddington Testing Co, Inc.
  • South Carolina
    • Anderson, South Carolina, United States, 29621
      • Synexus Clinical Research US, Inc.
    • Charleston, South Carolina, United States, 29425
      • MUSC SCTR Research Nexus Clinic and Laboratory
  • South Dakota
    • Rapid City, South Dakota, United States, 57702
      • Health Concepts
  • Tennessee
    • Memphis, Tennessee, United States, 38117
      • Tanenbaum Dermatology Center
    • Memphis, Tennessee, United States, 38119
      • Clinical Neuroscience Solutions, Inc.
    • Murfreesboro, Tennessee, United States, 37130
      • International Clinical Research - Tennessee LLC
  • Texas
    • Arlington, Texas, United States, 76011
      • Arlington Research Center, Inc.
    • Bellaire, Texas, United States, 77401
      • The University of Texas Health Science Center Houston
    • Dallas, Texas, United States, 75246
      • Menter Dermatology Research Institute
    • Houston, Texas, United States, 77004
      • Center for Clinical Studies, LTD. LLP
    • Hurst, Texas, United States, 76054
      • Ventavia Research Group
    • Pflugerville, Texas, United States, 78660
      • Austin Institute for Clinical Research, Inc.
    • San Antonio, Texas, United States, 78218
      • Texas Dermatology and Laser Specialists
    • San Antonio, Texas, United States, 78229
      • Dermatology Clinical Research Center of San Antonio
    • Webster, Texas, United States, 77598
      • Center for Clinical Studies, LTD.LLP
  • Virginia
    • Franklin, Virginia, United States, 23851
      • Summit Clinical Research, LLC
    • Norfolk, Virginia, United States, 23502
      • Virginia Dermatology and Skin Cancer Center
    • Norfolk, Virginia, United States, 23502
      • Virginia Clinical Research, Inc
    • Norfolk, Virginia, United States, 23510
      • Fort Norfolk Diagnostic Center
  • Washington
    • Lakewood, Washington, United States, 98499
      • Pace Dermatology Associates
    • Seattle, Washington, United States, 98101
      • Dermatology Associates of Seattle
    • Spokane, Washington, United States, 99202
      • Dermatology Specialists of Spokane
    • Spokane, Washington, United States, 99204
      • Principle Research Solutions
    • Tacoma, Washington, United States, 98405
      • MultiCare Allenmore Hospital
    • Tacoma, Washington, United States, 98405
      • MultiCare Institute for Research and Innovation
    • Tacoma, Washington, United States, 98405
      • Pace Dermatology Associates
  • Wisconsin
    • Milwaukee, Wisconsin, United States, 53226
      • Children's Hospital of Wisconsin Investigational Drug Service
    • Milwaukee, Wisconsin, United States, 53226
      • Children's Hospital of Wisconsin Translational Research Unit

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years and older (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Evidence of a personally signed and dated informed consent document indicating that the subject or their parent(s)/legal guardian, if applicable, have been informed of all pertinent aspects of the study.
2. Male or female subjects of 12 years of age or older, at the time of informed consent and meets inclusion criterion for minimum body weight (if applicable) from qualifying Parent study. Adolescent subjects below the age of 18 years old (or country-specific age of majority) will only be enrolled in this study if instructed by the sponsor and approved by the country or regulatory/health authority. If these approvals have not been granted, only subjects aged 18 years (or country-specific age of majority) and older will be enrolled.
3. Willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures.
4. Must have completed the full treatment period of a qualifying Parent study OR must have completed the full rescue treatment period of a qualifying Parent study (if applicable) OR must have completed the full open-label run-in period in B7451014 and did not meet the protocol-specified response criteria at Week 12.

5. Female subjects who are of childbearing potential (which includes all female subjects aged 12 years and older, regardless of whether they have experienced menarche) must ot be intending to become pregnant, currently pregnant, or lactating. The following onditions apply:

   1. Female subjects of childbearing potential must have a confirmed negative pregnancy test prior to allocation to treatment.
   2. Female subjects of childbearing potential must agree to use a highly effective method of contraception (as per Section 4.4.1) for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.

For Czech Republic only, 5 b. is revised and 5 c. is added to require:

Female subjects of childbearing potential 15 years of age who are at risk of pregnancy must agree to use a highly effective method of contraception for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.

c. Female subjects less than 15 years of age must not be sexually active, and abstinence per the below definition should be confirmed prior to enrollment. NOTE: Sexual abstinence, defined as completely and persistently refraining from all heterosexual intercourse (including during the entire period of risk associated with the study treatments) may obviate the need for contraception ONLY if this is the preferred and usual lifestyle of the subject.

6. Female subjects of non-childbearing potential must meet at least 1 of the following criteria:

1. Have undergone a documented hysterectomy and/or bilateral oophorectomy;
2. Have medically confirmed ovarian failure; or

3. Achieved postmenopausal status, defined as follows: cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause and have a serum follicle-stimulating hormone (FSH) level confirming the postmenopausal state. All other female subjects (including female subjects with tubal ligations) are considered to be of childbearing potential. 7. Must agree to avoid prolonged exposure to the sun and not to use tanning booths, sun lamps or other ultraviolet light sources during the study.

   8. Must agree to avoid use of prohibited medications throughout the duration of the study. Exclusion Criteria

   1. Other acute or chronic medical or psychiatric condition including recent (within the past year) or active suicidal ideation or behavior or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study.
   2. Currently have active forms of other inflammatory skin diseases, ie, not AD or have evidence of skin conditions (eg, psoriasis, seborrheic dermatitis, Lupus) at the time of Day -1 that would interfere with evaluation of atopic dermatitis or response to treatment.
   3. Discontinued from treatment (or rescue treatment period/open-label run-in period, if applicable) early in a qualifying Parent study OR triggered a discontinuation criterion at any point during the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
   4. Ongoing adverse event in the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
   5. Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or subjects who are Pfizer employees, including their family members, directly involved in the conduct of the study.

   There are also additional separate inclusion and exclusion criteria to assess eligibility specifically for the B7451015 MRI sub-study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Abrocitinib 100 mg; Abrocitinib 100 mg QD PO	Drug: Abrocitinib 100 mg; In the initial treatment period, Abrocitinib 100 mg, administered as two tablets to be taken orally once daily.; Drug: Placebo; For subjects whose dose was changed from 100 mg Abrocitinib to placebo, one tablet will be administered to be taken orally once daily for the remainder of the study.; Drug: Abrocitinib 100 mg; For subjects whose dose was changed from 200 mg Abrocitinib to 100 mg PF-04965842, one tablet will be administered to be taken orally once daily for the remainder of the study.; Drug: Abrocitinib 100 mg; In the secondary treatment period, Abrocitinib 100 mg, administered as one tablet to be taken orally once daily.
Experimental: Abrocitinib 200 mg; Abrocitinib 200 mg QD PO	Drug: Abrocitinib 100 mg; In the initial treatment period, Abrocitinib 100 mg, administered as two tablets to be taken orally once daily.; Drug: Abrocitinib 100 mg; For subjects whose dose was changed from 200 mg Abrocitinib to 100 mg PF-04965842, one tablet will be administered to be taken orally once daily for the remainder of the study.; Drug: Abrocitinib 100 mg; In the secondary treatment period, Abrocitinib 100 mg, administered as one tablet to be taken orally once daily.; Drug: Abrocitinib 200 mg; In the initial treatment period, Abrocitinib 200 mg, administered as two tablets to be taken orally once daily.; Drug: Abrocitinib 200 mg; In the secondary treatment period, Abrocitinib 200 mg, administered as two tablets to be taken orally once daily.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Treatment emergent adverse events	The incidence of treatment emergent adverse events	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Serious adverse events and adverse events leading to discontinuation	The incidence of serious adverse events and adverse events leading to discontinuation	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Change from baseline in clinical laboratory values	Change from baseline in clinical laboratory values	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Change from baseline in electrocardiogram (ECG) measurements	Change from baseline in electrocardiogram (ECG) measurements	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Change from baseline in vital signs	Change from baseline in vital signs	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Investigator's Global Assessment (IGA)	Response based on the IGA score of clear (0) or almost clear (1) (on a 5 point scale) and a reduction from baseline of >=2 points at all scheduled time points	Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
Eczema Area and Severity Index (EASI)	Response based on greater than or equal to 50%, 75% and 90% improvement from baseline in the EASI total score (EASI50, EASI75, and EASI90) at all scheduled time points	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Pruritus Numerical Rating Scale (NRS)	Response based on an improvement greater than or equal to 3 points and greater than or equal to 4 points from baseline in the pruritus NRS at all scheduled time points	Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
Patient Global Assessment (PtGA)	Change from baseline of PtGA at all scheduled time points	Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
Body Surface Area (BSA) affected	Change from baseline in the percentage BSA affected at all scheduled time points	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Dermatology Life Quality Index (DLQI) or Children's DLQI (CDLQI)	Change from baseline in DLQI or CDLQI at all scheduled time points	Baseline, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
Patient Oriented Eczema Measure (POEM)	Change from baseline in POEM at all scheduled time points	Baseline, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
Hospital Anxiety and Depression Scale (HADS)	Change from baseline in HADS at all scheduled time points	Baseline, Week 12, Week 24, Week 36, Week 48, Week 60, Week 64, Week 72, Week 84, Week 92, Week 96
EuroQol Quality of Life 5 Dimension 5 Level Scale (EQ-5D-5L) or EuroQol Quality of Life 5 Dimension Youth Scale (EQ-5D-Y)	Change from baseline of EQ-5D-5L or EQ-5D-Y at all scheduled time points	Baseline, Week 24, Week 48, Week 60, Week 72, Week 92
Steroid-Free Days	Number of steroid-free days will be assessed throughout the duration of the study.	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Serum Hs-CRP Levels	Serum Hs-CRP levels at all scheduled time points	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Change in height standard deviation score (SDS)	Change in height standard deviation score (SDS) at all scheduled time points	Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Proportion of abnormal findings in knee MRI in adolescent subjects exposed to abrocitinib 100mg and 200mg QD	Proportion of abnormal findings in knee MRI in adolescent subjects exposed to abrocitinib 100mg and 200mg QD	Throughout sub-study until all enrolled subjects are 18 years of age and have been imaged at least once or have discontinued or withdrawn; an estimated maximum of 4 years

Collaborators and Investigators

• Sponsor: Pfizer
• Investigators: Study Director: Pfizer CT.gov Call Center, Pfizer

Publications and helpful links

General Publications

• Simpson EL, Silverberg JI, Nosbaum A, Winthrop KL, Guttman-Yassky E, Hoffmeister KM, Egeberg A, Valdez H, Zhang M, Farooqui SA, Romero W, Thorpe AJ, Rojo R, Johnson S. Integrated Safety Analysis of Abrocitinib for the Treatment of Moderate-to-Severe Atopic Dermatitis From the Phase II and Phase III Clinical Trial Program. Am J Clin Dermatol. 2021 Sep;22(5):693-707. doi: 10.1007/s40257-021-00618-3. Epub 2021 Aug 18.
• Paller AS, Eichenfield LF, Irvine AD, Flohr C, Wollenberg A, Barbarot S, Bangert C, Spergel JM, Selfridge A, Biswas P, Fan H, Alderfer J, Watkins M, Koppensteiner H. Integrated Efficacy and Safety Analysis of Abrocitinib in Adolescents With Moderate-to-Severe Atopic Dermatitis. Allergy. 2025 Aug;80(8):2213-2224. doi: 10.1111/all.16512. Epub 2025 Mar 3.
• Silverberg JI, Simpson EL, Pink AE, Weidinger S, Chan G, Biswas P, Clibborn C, Guler E. Switching from Dupilumab to Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis: A Post Hoc Analysis of Efficacy After Treatment With Dupilumab in JADE DARE. Dermatol Ther (Heidelb). 2025 Feb;15(2):367-380. doi: 10.1007/s13555-024-01320-y. Epub 2025 Feb 4.
• Silverberg JI, Thyssen JP, Lazariciu I, Myers DE, Guler E, Chovatiya R. Abrocitinib may improve itch and quality of life in patients with itch-dominant atopic dermatitis. Skin Health Dis. 2024 May 5;4(4):e382. doi: 10.1002/ski2.382. eCollection 2024 Aug.

Helpful Links

• To obtain contact information for a study center near you, click here.

Study record dates

Study Major Dates

• Study Start (Actual): March 8, 2018
• Primary Completion (Actual): December 22, 2025
• Study Completion (Actual): December 22, 2025

Study Registration Dates

• First Submitted: December 20, 2017
• First Submitted That Met QC Criteria: January 30, 2018
• First Posted (Actual): February 6, 2018

Study Record Updates

• Last Update Posted (Actual): January 15, 2026
• Last Update Submitted That Met QC Criteria: January 14, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Keywords: MRI; atopic dermatitis; eczema; Magnetic Resonance Imaging; atopic eczema; JAK; janus kinase
• Additional Relevant MeSH Terms: Genetic Diseases, Inborn; Immune System Diseases; Hypersensitivity, Immediate; Hypersensitivity; Skin Diseases; Skin Diseases, Genetic; Skin Diseases, Eczematous; Dermatitis; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Dermatitis, Atopic; Eczema; Substandard Drugs; Pharmaceutical Preparations; abrocitinib
• Other Study ID Numbers: B7451015; JADE EXTEND (Other Identifier: Alias Study Number); 2023-508955-37-00 (Registry Identifier: CTIS (EU))

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No