Biphasic and Combined Effect of Aging & Obesity With Development of Effective Exercise Intervention Protocol

Effect of Aging & Obesity With Exercise Intervention

Sponsors

Lead sponsor: Seoul National University Bundang Hospital

Collaborator: National Research Foundation of Korea

Source Seoul National University Bundang Hospital
Brief Summary

Obesity leads to a vicious circle that increases intramuscular fat, insulin resistance, promotes muscular dysfunction resulting in increased muscle fat accumulation. The study of muscle function and intramyocellular lipids is insufficient for obesity. Particularly, the study of mechanisms in muscle function and intramyocellular lipids is few nationally and internationally.

Detailed Description

This study is prospective study. The goal of this study is

1. To examine the distribution and contractile properties (cross-sectional area, maximal force, specific force, maximal shortening velocity) of single muscle fiber sex/Myosin heavy chain (MHC) type-related differences, by extracting a single muscle fiber from the vastus lateralis in young men and women.

2. To examine the effects of intramyocellular lipids on physical activity ability, muscle dysfunction, and metabolic disorders in relation to aging and obesity.

3. To examine the effects of intramyocellular lipids on physical activity ability, muscular dysfunction, and metabolic disorders after 12 weeks resistance exercise intervention.

Overall Status Completed
Start Date November 18, 2016
Completion Date February 29, 2020
Primary Completion Date February 29, 2020
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Total droplet area Before intervention / after 12weeks intervention
Number of lipid droplets Before intervention / after 12weeks intervention
Single muscle fiber cross-sectional area (CSA) Before intervention / after 12weeks intervention
Single muscle fiber maximal force (Po) Before intervention / after 12weeks intervention
Single muscle fiber specific force (SF) Before intervention / after 12weeks intervention
Single muscle fiber maximal shortening velocity (Vo) Before intervention / after 12weeks intervention
Single muscle fiber MHC type distribution Before intervention / after 12weeks intervention
Secondary Outcome
Measure Time Frame
Hand grip strength Before intervention / after 12weeks intervention
Isokinetic knee extension strength Before intervention / after 12weeks intervention
Enrollment 28
Condition
Intervention

Intervention type: Other

Intervention name: Resistance exercise with a gym stick

Description: Exercise intervention: The resistance exercise intervention is performed with a gym stick for 3 times a week for 12 weeks. Exercise load is gradually increased by the number of times the band is wound and the speed of motion by dividing into three stages in 1-4 weeks (1st stage), 5-8 weeks (2nd stage) and 9-12 weeks (3rd stage).

Other name: Exercise training

Eligibility

Criteria:

Inclusion Criteria:

- Young men: Age (20-35 yrs), BMI (19-23 Kg/m2)

- Young women: Age (20-35 yrs), BMI (19-23 Kg/m2)

- Elderly women: Age (65-80 yrs), BMI (19-23 Kg/m2)

- Elderly obese women: Age (65-80 yrs), BMI ( >25 Kg/m2)

- Subjects who can agree voluntarily.

Exclusion Criteria:

- Acute coronary syndrome.

- Uncontrolled hypertension.

- Subjects who took drugs which can affects neuromuscular system.

- Severely impaired cognition

- Subjects who cannot agree voluntarily

Gender: All

Gender based: Yes

Gender description: This study is divided into two purposes. To examine the distribution and contractile properties (CSA, Po, SF, Vo) of single muscle fiber sex/MHC type-related differences in youn men and women. To examine effects of 12-week resistance exercise on single muscle fiber funtion and intramyocellular lipids in aging and obese elderly women. For the purposes of the first study, young men and women (age 20-35 yrs) should be participated in this study. aimed to examine the distribution and contractile properties (CSA, Po, SF, Vo) of single muscle fiber sex/MHC type-related differences, by extracting a single muscle fiber from the vastus lateralis in young men and women

Minimum age: 20 Years

Maximum age: 80 Years

Healthy volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Jae-Youn Lim, Ph.D. Study Director Seoul National University Bundang Hospital
Location
facility Seoul National University Bundang Hospital
Location Countries

Korea, Republic of

Verification Date

March 2020

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: Seoul National University Bundang Hospital

Investigator full name: Jae-Young Lim

Investigator title: Professor, Department of Rehabilitation Medicine

Keywords
Has Expanded Access No
Condition Browse
Number Of Arms 4
Arm Group

Arm group label: Young men

Arm group type: No Intervention

Description: Range of age is 20-35 years, young men (BMI 19-23 Kg/m2) They did not suffer from musculoskeletal or metabolic diseases, and had not performed regular exercise within the previous 3 months.

Arm group label: Young women

Arm group type: No Intervention

Description: Range of age is 20-35 years, young women (BMI 19-23 Kg/m2) They did not suffer from musculoskeletal or metabolic diseases, and had not performed regular exercise within the previous 3 months.

Arm group label: Elderly women (control)

Arm group type: Experimental

Description: Range of age is 65-80 years, Elderly women (BMI 19-23 Kg/m2) They did not suffer from musculoskeletal or metabolic diseases, and had not performed regular exercise within the previous 3 months.

Arm group label: Elderly obese women

Arm group type: Experimental

Description: Range of age is 65-80 years,Elderly obese women (BMI ≥25 Kg/m2) They did not suffer from musculoskeletal or metabolic diseases, and had not performed regular exercise within the previous 3 months.

Patient Data No
Study Design Info

Allocation: Non-Randomized

Intervention model: Parallel Assignment

Primary purpose: Supportive Care

Masking: Triple (Participant, Care Provider, Outcomes Assessor)

Source: ClinicalTrials.gov