Short- and Long-term Health Effects of Air Pollution in Poland (EP-PARTICLES)

March 17, 2024 updated by: Lukasz Kuzma, Medical University of Bialystok
The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack of large industry). The aim of the project is to assess the impact of air pollution in Eastern Poland on regional public health.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

The project will be conducted in Eastern Poland - the area characterized by unique natural features, large areas covered by forests, lack of factories, and relatively low industrialization. On the other hand, the region is also characterized by low socioeconomic status, in the cold season the residents' suboptimal heating choices are in result posing a major anthropogenic threat to air quality in the form of low emissions. The vast majority of studies on air pollution were conducted in highly polluted areas, in which patients are exposed to moderate and extreme concentrations of pollutants. Taking into consideration the scarce number of surveys from areas with a low level of pollution the investigators intend to analyze the relationship between air pollution and cardiovascular and renal outcomes in Eastern Poland. The examination of the impact of so-called "Polish smog" on mortality and morbidity in the study area is not without significance. It would be the first major study of the impact of this type of pollution on human health.

In the subsequent part of the study, we will evaluate the effects of Polish smog in the entire country.

In light of extant body of literature, the following will be considered as the public health indicators: acute coronary syndromes, episodes of atrial fibrillation, kidney disease hospitalizations or emergency room visits, cardiovascular and renal mortality.

Study Type

Observational

Enrollment (Actual)

8300000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Poland
    • Podlaskie
      • Białystok, Podlaskie, Poland, 15-276
        • Department of Invasive Cardiology, Medical University of Bialystok

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

The study population will be based on residents of Eastern Poland. This term covers 5 voivodships - Warmińsko-Mazurskie, Podlaskie, Lubelskie, Świętokrzyskie, Podkarpackie - with total area of 99,004 km2. The inhabitants of this region constitute 21.3% of the population of Poland and 1.6% of the population of the European Union. The area characterized by unique natural features, large areas covered by forests, lack of factories, and relatively low industrialization is not free of air pollution. As the region is also characterized by low socioeconomic status, in the cold season the residents' suboptimal heating choices are in result posing a major anthropogenic threat to air quality in the form of low emissions.

Description

Inclusion Criteria:

  • Residents from the analyzed area

Exclusion Criteria:

  • None

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Patients with hospitalizations or emergency room visits due to acute coronary syndromes
Data on hospitalization for acute coronary syndromes were obtained and extracted from the National Health Fund reports. In the present analysis, we used data from patients registered as residents in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020. The set of variables that were subjected to the analysis included demographic features and ICD-10 codes. The diagnosis was based on reports obtained from to the National Health Fund, and these reports have not been reviewed with patient hospital documentation.
Other: Impact of air pollution
To assess the short- and long- term impact of air pollution
Patients with hospitalizations or emergency room visits due to atrial fibrillation
Data on hospitalization for atrial fibrillation were obtained and extracted from the National Health Fund reports. In the present analysis, we used data from patients registered as residents in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020. The set of variables that were subjected to the analysis included demographic features and ICD-10 codes. The diagnosis was based on reports obtained from to the National Health Fund, and these reports have not been reviewed with patient hospital documentation.
Other: Impact of air pollution
To assess the short- and long- term impact of air pollution
Patients with hospitalizations or emergency room visits due to kidney diseases
Data on hospitalization for kidney diseases were obtained and extracted from the National Health Fund reports. In the present analysis, we used data from patients registered as residents in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020. The set of variables that were subjected to the analysis included demographic features and ICD-10 codes. The diagnosis was based on reports obtained from to the National Health Fund, and these reports have not been reviewed with patient hospital documentation.
Other: Impact of air pollution
To assess the short- and long- term impact of air pollution
Patients who died due to cardiovascular diseases
Data on mortality were collected from the National Statistical Office in Poland. These include information on all the deaths recorded in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020 The records included sex and age of people who had died, and the causes of deaths were classified according to codes in the International Classification of Diseases-10th Revision (ICD-10).
Other: Impact of air pollution
To assess the short- and long- term impact of air pollution
Patients who died due to neoplasm diseases
Data on mortality were collected from the National Statistical Office in Poland. These include information on all the deaths recorded in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020 The records included sex and age of people who had died, and the causes of deaths were classified according to codes in the International Classification of Diseases-10th Revision (ICD-10).
Other: Impact of air pollution
To assess the short- and long- term impact of air pollution
Patients who died due to kidney diseases
Data on mortality were collected from the National Statistical Office in Poland. These include information on all the deaths recorded in the Podlaskie, Lubelskie, Podkarpackie, Świetokrzyskie, and Warminsko-Mazurskie voivodeships from January 1, 2011 to December 31, 2020 The records included sex and age of people who had died, and the causes of deaths were classified according to codes in the International Classification of Diseases-10th Revision (ICD-10).
Other: Impact of air pollution
To assess the short- and long- term impact of air pollution

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of acute coronary syndromes related with impact of air pollution.
Time Frame: Through study completion, an average of 1 year
Short- and long- term influence of air pollution on the number of hospital admissions for acute coronary syndromes.
Through study completion, an average of 1 year
Number of atrial fibrillation episodes related with impact of air pollution.
Time Frame: Through study completion, an average of 1 year
Short- and long- term influence of air pollution on the number of hospital admissions for atrial fibrillation.
Through study completion, an average of 1 year
Number of hospitalizations due to kidney diseases related with impact of air pollution.
Time Frame: Through study completion, an average of 1 year
Long- term influence of air pollution on the number of hospital admissions for kidney disease.
Through study completion, an average of 1 year
Number of hospitalizations due to acute kidney diseases related with impact of air pollution.
Time Frame: Through study completion, an average of 1 year
Long- term influence of air pollution on the number of hospital admissions for kidney disease.
Through study completion, an average of 1 year
Number of patients under hemodialysis related with impact of air pollution.
Time Frame: Through study completion, an average of 1 year
Long- term influence of air pollution on the number of hospital admissions for kidney disease.
Through study completion, an average of 1 year

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cardiovascular mortality
Time Frame: Through study completion, an average of 1 year
Short- and long- term influence of air pollution on the number of cardiovascular mortality.
Through study completion, an average of 1 year
Neoplasm mortality
Time Frame: Through study completion, an average of 1 year
Short- and long- term influence of air pollution on neoplasm mortality.
Through study completion, an average of 1 year
Kidney disease mortality
Time Frame: Through study completion, an average of 1 year
Short- and long- term influence of air pollution on mortality related to renal function.
Through study completion, an average of 1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Medical University of Bialystok

Collaborators

Charles University, Czech Republic
University of Liverpool
University of Skopje
University of Lodz

Investigators

  • Study Director: Łukasz Kuźma, Medical University of Bialystok

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2022

Primary Completion (Estimated)

December 1, 2025

Study Completion (Estimated)

December 1, 2030

Study Registration Dates

First Submitted

January 6, 2022

First Submitted That Met QC Criteria

January 6, 2022

First Posted (Actual)

January 20, 2022

Study Record Updates

Last Update Posted (Actual)

March 19, 2024

Last Update Submitted That Met QC Criteria

March 17, 2024

Last Verified

March 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • UMB-KKI-104

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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