Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football

January 21, 2022 updated by: St Mary's University College
A total genotype risk score was generated based on the findings of previous research for non-contact injury, non-contact muscle injury, tendon injury, ligament injury, fracture injury and apophysitis injury. This score was then compared with the incidence of injury between those with high, medium and low risk scores for each injury. The influence of different rates of growth, stages of physical maturation and loading exposure were then also included in the risk model to see if any interaction effects could be observed between genetic risk score and susceptibility to injury in different categories of growth, maturation and loading exposure.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

95

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
    • New Malden
      • London, New Malden, United Kingdom, KT3 6PT
        • Fulham Football Club
    • Twickenham
      • London, Twickenham, United Kingdom, TW1 4SX
        • St Mary's University, Twickenham

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

12 years to 40 years (Child, Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Sampling Method

Non-Probability Sample

Study Population

Elite male football players aged 12-40

Description

Inclusion Criteria:

  • Elite male football players

Exclusion Criteria:

  • Female
  • non-elite

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Elite male youth footballers
Elite male youth footballers at an English championship / premier league football club
Genetic: Total Genotype Risk Score
A total genotype risk score has been generated based on the results of previously observed genetic association studies

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Fracture Injury Risk
Time Frame: 8 Years
Did the risk of fracture differ between total genotype risk score categories? was this affected by maturation?
8 Years
Non-Contact Injury Risk
Time Frame: 8 Years
Did the risk of non-contact injury differ between total genotype risk score categories? was this affected by maturation, and loading?
8 Years
Non-Contact Muscle Injury Risk
Time Frame: 8 Years
Did the risk of non-contact muscle injury differ between total genotype risk score categories? was this affected by maturation, and loading?
8 Years
Tendon Injury Risk
Time Frame: 8 Years
Did the risk of tendon injury differ between total genotype risk score categories? was this affected by maturation, and loading?
8 Years
Ligament Injury Risk
Time Frame: 8 Years
Did the risk of ligament injury differ between total genotype risk score categories? was this affected by maturation?
8 Years
Apophysitis Injury Risk
Time Frame: 8 Years
Did the risk of ligament injury differ between total genotype risk score categories? was this affected by maturation?
8 Years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

St Mary's University College

Collaborators

Fulham Football Club

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2019

Primary Completion (Actual)

July 31, 2021

Study Completion (Actual)

July 31, 2021

Study Registration Dates

First Submitted

January 21, 2022

First Submitted That Met QC Criteria

January 21, 2022

First Posted (Actual)

February 2, 2022

Study Record Updates

Last Update Posted (Actual)

February 2, 2022

Last Update Submitted That Met QC Criteria

January 21, 2022

Last Verified

January 1, 2022

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SMEC_2019-20_003

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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