Comparison of Cyanocobalamin in Avocado Oil Cream With Steroid Combination Ointment

Comparison of Cyanocobalamin in Avocado Oil Cream With Steroid Combination Ointment in the Treatment of Chronic Plaque Psoriasi-A Randomized Clinical Trial in Tertiary Care Hospital

A randomized clinical trial with two groups. Group A Group B Group A is being treated with conventional Steroid combination ointment for the treatment of chronic Plaque Psoriasis.

Group B is being treated with Cyanocobalamin in Avocado Oil cream for the treatment of chronic Plaque Psoriasis.

Each group having 45 patients.

Study Overview

• Status: Completed
• Conditions: Plaque Psoriasis
• Intervention / Treatment: Combination product: Potent topical steroid

Detailed Description

Outcome is being measured by PASI Score calculation with monthly follow up.

• Study Type: Interventional
• Enrollment (Actual): 90
• Phase: Early Phase 1

Contacts and Locations

Study Locations

• Pakistan
  • Punjab
    • Rawalpindi, Punjab, Pakistan, 92
      • PakEmiratesMH

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 60 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Age bracket (18-60 years)
• Non psoriatic Arthritis
• No oral Retinoids

Exclusion Criteria:

• pregnancy
• Malignancy
• Body surface area involving >50%

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Group A; Steroid combination ointment in the treatment of chronic Plaque Psoriasis	Combination product: Potent topical steroid; Cyanocobalamin in Avocado Oil Cream
Active Comparator: Group B; Cyanocobalamin in Avocado Oil cream in the treatment of chronic Plaque	Combination product: Potent topical steroid; Cyanocobalamin in Avocado Oil Cream

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Efficacy and tolerability of steroids as compared to Avacado Oil Cream	Compariaon of Efficacy of Steroid combination ointment in the treatment of chronic Plaque Psoriasis	12 weeks

Collaborators and Investigators

• Sponsor: Pak Emirates Military Hospital
• Investigators: Study Director: Qamar ud din Khan, MBBS,FCPS, Pak Emirates Military Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2021
• Primary Completion (Actual): September 1, 2022
• Study Completion (Actual): September 1, 2022

Study Registration Dates

• First Submitted: March 23, 2022
• First Submitted That Met QC Criteria: April 10, 2022
• First Posted (Actual): April 15, 2022

Study Record Updates

• Last Update Posted (Actual): May 24, 2023
• Last Update Submitted That Met QC Criteria: May 22, 2023
• Last Verified: May 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Skin Diseases; Skin Diseases, Papulosquamous; Psoriasis
• Other Study ID Numbers: PakEmiratesMH

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No