- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05610618
Study of Brain Activity Underlying Predictive Mechanisms During the Perception of Visual Scenes (PREPER)
March 25, 2024 updated by: University Hospital, Grenoble
Etude de l'activité cérébrale Sous-jacente Aux mécanismes prédictifs Lors de la Perception de scènes Visuelles
This study aims to clarify the mechanisms by which the predictions we have about our visual environment influence the processing of expected or unexpected visual stimuli at the cerebral level.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
Current models of visual perception agree that perception is a proactive process.
According to these models, perception of the visual environment would allow to continuously generate expectations or "predictions" about the likely characteristics of a visual scene, which would facilitate their processing and visual recognition.
At the neurobiological level, these models postulate that visual perception is the result of a permanent exchange between prediction signals (i.e., predicted characteristics of the visual stimulus) and prediction error signals (i.e., unprovevised characteristics of the stimulus to update predictions) between consecutive levels of the hierarchy of cortical visual areas.
However, the neurophysiological correlates of these mechanisms remain debated.
The results of some work suggest that the prediction signals generated by high-level cortical areas would make it possible to pre-process the predicted characteristics of a stimulus within lower-level areas, by inhibiting the activity of neurons dedicated to their processing.
Conversely, other work postulates that the prediction signals generated by high-level areas would increase the sensitivity of neurons encoding expected characteristics while inhibiting the response of neurons encoding unexpected features in lower-level areas.
Accordingly, brain activity in these regions would rather reflect the processing of expected features of visual stimuli.
It has also been proposed that these two mechanisms coexist but that they intervene alternately during the temporal course of brain processing and depending on the quality of the visual signal.
However, this hypothesis has never been systematically tested.
The objective of the project is to improve fundamental knowledge about the mechanisms of visual perception by studying at the cerebral level how predictions about the visual environment influence its visual perception.
Specifically, investigators will use electroencephalography (EEG) recordings from healthy volunteer participants to measure how brain activity related to visual processing of images of objects and scenes is modulated by their expected or unexpected character, taking into account the temporal course of brain processing and considering the quality of visual signals.
Study Type
Interventional
Enrollment (Estimated)
80
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Louise KAUFFMANN
- Phone Number: +33 (0)4 76 74 81 35
- Email: louise.kauffmann@univ-grenoble-alpes.fr
Study Locations
-
-
Grenoble Cedex 9
-
Grenoble, Grenoble Cedex 9, France, 38043
- Recruiting
- Louise KAUFFMANN
-
Contact:
- Louise KAUFFMANN
- Phone Number: +33476748135
- Email: louise.kauffmann@univ-grenoble-alpes.fr
-
Principal Investigator:
- Laurent VERCUEIL
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 35 years (Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- Participants between 18 and 35 years old
- Normal or corrected-to-normal visual acuity
- Ability to consent or oppose to the research
- No opposition to the research
Exclusion Criteria:
- Important visual impairments
- Neuropsychiatric pathology
- Use of drug or medication with neurocognitive effects
- Minors, or persons under psychiatric care, or protected persons
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Healthy adults
A single group of healthy adults will undergo all experimental conditions (within subject design)
|
Participants will be displayed with photographs of scenes and objects which predictability and sharpness will be manipulated
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Performance (% of correct classification) of a support vector machine algorithm in classifying the category of objects and scenes based on electroencephalography signals evoked by the visual perception of expected and unexpected objects and scenes
Time Frame: Through study completion, an average of 1.5 year
|
We will use EEG data acquired while participants look at neutral objects and scenes of different categories to train a classifier in decoding the category of these objects and scenes.
This classifier will then be tested using EEG data acquired while participants look at novel expected and unexpected objects and scenes.
We will record the % accuracy of the classifier in this test phase.
|
Through study completion, an average of 1.5 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Laurent VERCUEIL, Grenoble Alpes University Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
March 20, 2023
Primary Completion (Estimated)
March 1, 2025
Study Completion (Estimated)
March 1, 2025
Study Registration Dates
First Submitted
September 12, 2022
First Submitted That Met QC Criteria
November 8, 2022
First Posted (Actual)
November 9, 2022
Study Record Updates
Last Update Posted (Actual)
March 26, 2024
Last Update Submitted That Met QC Criteria
March 25, 2024
Last Verified
March 1, 2024
More Information
Terms related to this study
Other Study ID Numbers
- 38RC22.0207
- 2022-A01418-35 (Other Identifier: ID RCB)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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