Fibrinogen to Albumin Ratio and C-reactive Protein to Albumin Ratio in Juvenile Idiopathic Arthritis

October 5, 2023 updated by: Maha Sayed Ibrahim Abdelrahman, Assiut University

Correlation of Fibrinogen to Albumin Ratio and C-reactive Protein to Albumin Ratio With Disease Activity in Juvenile Idiopathic Arthritis

The fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between FAR/CAR and Juvenile arthritis disease activity score (JASDAS27) in Juvenile idiopathic arthritis (JIA)

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

The JADAS27 includes a selected count of the following joints: cervical spine, elbows, wrists, metacarpophalangeal joints (from first to third), proximal interphalangeal joints, hips, knees and ankles.

Study Type

Observational

Enrollment (Estimated)

50

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

All juvenile idiopathic arthritis fulfilling the criteria of International League of Associations for Rheumatology (ILAR) and age and sex matched healthy subjects.

Description

Inclusion Criteria:

  • All juvenile idiopathic arthritis fulfilling the criteria of International League of Associations for Rheumatology (ILAR) and age and sex matched healthy subjects

Exclusion Criteria:

  • Other systemic inflammatory or autoimmune disorders.
  • History of corticosteroid medication in the last 6 months.
  • Liver diseases.
  • Malignancy.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
JIA cases
juvenile idiopathic arthritis cases
Diagnostic test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)
measurement of serum albumin, fibrinogen and CRP
CONTROL
age and sex matched healthy controls
Diagnostic test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)
measurement of serum albumin, fibrinogen and CRP

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The fibrinogen to albumin ratio
Time Frame: 3 months
measurement of serum fibrinogen and albumin
3 months
The CRP to albumin ratio
Time Frame: 3 MONTHS
measurement of serum CRP and albumin
3 MONTHS
Correlation of fibrinogen to albumin and CRP to albumin ratios on one side with disease activity on the other side
Time Frame: 3 MONTHS
correlation of these ratios with JADAS27
3 MONTHS

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

November 1, 2023

Primary Completion (Estimated)

May 1, 2024

Study Completion (Estimated)

July 1, 2024

Study Registration Dates

First Submitted

August 14, 2023

First Submitted That Met QC Criteria

August 29, 2023

First Posted (Actual)

September 6, 2023

Study Record Updates

Last Update Posted (Actual)

October 6, 2023

Last Update Submitted That Met QC Criteria

October 5, 2023

Last Verified

October 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Juvenile arthritis assiut u

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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