Triglyceride-Glucose Indices and Left Ventricular Speckle Tracking in Predicting Coronary Artery Disease Severity

July 12, 2025 updated by: Rehab Werida, Damanhour University

Comparative Assessment of Triglyceride-Glucose Indices and Left Ventricular Speckle Tracking in Predicting Coronary Artery Disease Severity: Insights From Gensini Scoring

Our study specifically will address the value of modified triglyceride glucose indices versus left ventricular speckle tracking in prediction of severity of coronary artery disease assessed by Gensini score.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

A cross sectional study that will be conducted in Cardiovascular Department of Tanta University in Egypt in the period from May to July 2025 . Two hundred patients diagnosed with coronary artery diseases were included in the study. Patients were considered to have confirmed coronary artery disease through angiographically proven CAD.

Provision of privacy:

Privacy of all data is guaranteed and there will be a code number for every patient and include all of his or her investigations.

Informed consent:

Informed written consent will be obtained from all patients after full explanation of benefits and risks of the study.

Methods: Study patients and procedures:

Selection criteria included any patient with chronic stable angina and proved coronary artery disease by coronary angiography Exclusion criteria included: Any patients with acute coronary syndrome, arrhythmias, previous Percutaneous coronary intervention (PCI) or Coronary Artery Bypass Graft (CABG) surgery

All the participants were subjected to following:

  1. History taking for presence of risk factors of cardio vascular disease as age, sex, smoking, physical inactivity, diabetes and hypertension.
  2. Physical examination including height, weight and waste circumference
  3. Resing 12 leads ECG

  4. Laboratory investigations:

    • Fasting blood glucose (FBG)
    • Triglyceride (TG), TG index.
    • Total Cholesterol level
    • Renal Function test . Echocardiographic evaluation

6. Coronary angiography 7. Gensini score calculated by summation of the individual coronary segment scores.

Study Type

Observational

Enrollment (Actual)

508

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Elbehairah
      • Damanhūr, Elbehairah, Egypt, 31527
        • Rehab Hussein Werida

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Probability Sample

Study Population

Two hundred adult patients with chronic stable angina and angiographically confirmed coronary artery disease (CAD) were enrolled.

Description

Inclusion Criteria:

  • diagnosis of CAD with ≥50% stenosis in at least one major coronary artery.

Exclusion Criteria:

  • Patients with acute coronary syndrome, arrhythmias, previous coronary interventions (PCI or CABG), or inability to undergo echocardiographic assessment.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
triglyceride-glucose (TyG) index
Time Frame: 2 months
predictive value of the triglyceride-glucose (TyG) index and its modified forms (TyG×BMI, TyG×WC, TyG, ×, W,Ht,R ) with global longitudinal strain (GLS) in assessing coronary artery disease (CAD) severity, as quantified by the Gensini score.
2 months
longitudinal strain (GLS)
Time Frame: 2 months
Echocardiography parameter in assessing coronary artery disease (CAD) severity
2 months
Gensini score.
Time Frame: 2 months
Score assessing coronary artery disease (CAD) severity
2 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Damanhour University

Collaborators

Tanta University

Investigators

  • Principal Investigator: Eman Elshaikh, Ass. Prof., Tanta University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 30, 2025

Primary Completion (Actual)

July 1, 2025

Study Completion (Actual)

July 3, 2025

Study Registration Dates

First Submitted

July 3, 2025

First Submitted That Met QC Criteria

July 3, 2025

First Posted (Actual)

July 14, 2025

Study Record Updates

Last Update Posted (Actual)

July 16, 2025

Last Update Submitted That Met QC Criteria

July 12, 2025

Last Verified

July 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Predicting CAD Severity

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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