Angiography Derived Index of Microcirculatory Resistance in Patients With Acute Myocardial Infarction

January 13, 2023 updated by: Second Affiliated Hospital, School of Medicine, Zhejiang University
Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of acute myocardial infarction (AMI) patients, and has been shown to be associated with poor prognosis. Angiography derived index of micro-circulatory resistance (Angio-IMR) is a novel pressure-wire free approach to assess coronary microvascular disease with great diagnostic performance. The current study will further investigate the prognostic value of Angio-IMR in patients with AMI in multicenter retrospective cohort.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

5000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310009
        • Second Affiliated Hospital, School of Medicine, Zhejiang University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Patients admitted with a diagnosis of acute myocardial infarction underwent successful percutaneous coronary intervention.

Description

Inclusion Criteria:

  • Acute myocardial infarction patients who underwent successful percutaneous coronary intervention

Exclusion Criteria:

  • No appropriate coronary angiography images (inferior image quality, image loss, severe arteries overlap, or significant artifact)
  • Previous coronary artery bypass graft

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Retrospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
STEMI with high Angio-IMR
Patients with ST segment elevation myocardial infarction and high Angio-IMR
Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)
Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.
STEMI with low Angio-IMR
Patients with ST segment elevation myocardial infarction and low Angio-IMR
Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)
Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.
NSTEMI with high Angio-IMR
Patients with non-ST segment elevation myocardial infarction and high Angio-IMR
Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)
Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.
NSTEMI with low Angio-IMR
Patients with non-ST segment elevation myocardial infarction and low Angio-IMR
Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)
Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cardiac death or readmission for heart failure in 1 month
Time Frame: 1 month
Incidence of cardiac death or readmission for heart failure during first 1 month follow-up.
1 month
Cardiac death or readmission for heart failure in 6 months
Time Frame: 6 month
Incidence of cardiac death or readmission for heart failure during first 6 months follow-up.
6 month
Cardiac death or readmission for heart failure in 1 year
Time Frame: 1 year
Incidence of cardiac death or readmission for heart failure during first 1 year follow-up.
1 year
Cardiac death or readmission for heart failure in 2 years
Time Frame: 2 year
Incidence of cardiac death or readmission for heart failure during first 2 years follow-up.
2 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Collaborators

RenJi Hospital
Shengjing Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 1, 2017

Primary Completion (Actual)

May 31, 2022

Study Completion (Actual)

May 31, 2022

Study Registration Dates

First Submitted

December 13, 2022

First Submitted That Met QC Criteria

January 13, 2023

First Posted (Estimate)

January 24, 2023

Study Record Updates

Last Update Posted (Estimate)

January 24, 2023

Last Update Submitted That Met QC Criteria

January 13, 2023

Last Verified

December 1, 2022

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2022-0878

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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