Demographics and Clinical Characteristics of Ocular Inflammatory Diseases in Singapore

September 9, 2025 updated by: Samanthila Waduthantri, Singapore National Eye Centre
This is a retrospective study analyzing demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases that presented to the Singapore National Eye Centre (SNEC).

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

This is a retrospective, cross-sectional study. In this study, the investigators aim to investigate demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases, including masquerade syndromes such as ocular neoplasms (e.g., vitreoretinal and uveal lymphoma) and endophthalmitis that presented to the Singapore National Eye Centre (SNEC). Data on demographics, clinical features, diagnosis, investigations, secondary complications, treatment received, and outcomes will be analyzed using statistical software. The results of this study will lead to an improved clinical practice with better treatment selections and an optimized monitoring protocol for follow-up care for patients with ocular inflammatory diseases, including masquerade syndromes such as ocular neoplasms (e.g.,vitreoretinal and uveal lymphoma) and endophthalmitis. This will lead to better clinical outcomes and prevention of serious sight-threatening complications.

Study Type

Observational

Enrollment (Estimated)

200

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Singapore
      • Singapore, Singapore
        • Singapore National Eye Centre

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients diagnosed with ocular inflammatory diseases, including masquerade syndromes such as ocular neoplasms (e.g., vitreoretinal and uveal lymphoma) and endophthalmitis, at the Singapore National Eye Centre.

Description

Inclusion Criteria:

  • Patients diagnosed with uveitis
  • Patients diagnosed with scleritis or episcleritis
  • Patients diagnosed with ocular neoplasms e.g., vitreoretinal and uveal lymphoma
  • Patients diagnosed with endophthalmitis
  • Diagnosis confirmed by laboratory testing or histopathological examination
  • Patients diagnosed and managed at the Singapore National Eye Centre (SNEC)

Exclusion Criteria:

  • Patients with less than two years of clinical follow-up
  • Patients with incomplete diagnostic confirmation (i.e., lacking laboratory or histopathological evidence)
  • Patients diagnosed outside of Singapore National Eye Centre (SNEC)
  • Cases with missing key clinical or outcome data

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Uveitis
Patients diagnosed with uveitis at Singapore National Eye Centre
Other: No Intervention: Observational Cohort
Not applicable, No intervention. Observational study.
Scleritis and Episcleritis
Patients diagnosed with scleritis or episcleritis at Singapore National Eye Centre
Other: No Intervention: Observational Cohort
Not applicable, No intervention. Observational study.
Intraocular lymphoma
Patients diagnosed with ocular neoplasms at Singapore National Eye Centre
Other: No Intervention: Observational Cohort
Not applicable, No intervention. Observational study.
Endophthalmitis
Patients diagnosed with endophthalmitis at Singapore National Eye Centre
Other: No Intervention: Observational Cohort
Not applicable, No intervention. Observational study.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Distribution of demographics, diagnosis, clinical features, treatment and outcomes
Time Frame: January 1987 and January 2025
Percentage ethnic distribution, percentage of gender distribution, percentage of age distribution, percentage of etiology, percentage of clinical features, percentage of investigations, percentage of diagnosis, percentage of secondary complications, percentage of treatment received, percentage of outcomes
January 1987 and January 2025

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Correlation of demographics, diagnosis, clinical features, and treatment outcomes
Time Frame: January 1987 and January 2025
To evaluate the independent and combined effects of demographic factors, diagnostic categories, and clinical features on treatment outcomes using multivariate logistic and cox regression analysis
January 1987 and January 2025

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Singapore National Eye Centre

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 19, 2025

Primary Completion (Estimated)

September 30, 2025

Study Completion (Estimated)

October 30, 2025

Study Registration Dates

First Submitted

August 30, 2025

First Submitted That Met QC Criteria

September 9, 2025

First Posted (Estimated)

September 16, 2025

Study Record Updates

Last Update Posted (Estimated)

September 16, 2025

Last Update Submitted That Met QC Criteria

September 9, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2019/2811

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

IPD will not be shared. Anonymous data.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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