Effects of Vagus Nerve Stimulation on the Autonomic Nervous System

January 23, 2026 updated by: Istanbul Gelisim University

Acute Effects of Post-Exercise Vagus Nerve Stimulation on the Autonomic Nervous System and Recovery in Healthy Young Adults

The aim of this study is to determine the effect of vagus nerve stimulation, applied after running exercise, on recovery and fatigue in healthy young adults.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Being healthy between the ages of 18-35
  • Volunteering to participate in the study
  • Signing the voluntary consent form
  • Being in the inactive category according to the International Physical Activity Questionnaire

Exclusion Criteria:

  • Having a regular exercise habit
  • Being in the very minimally active or active category according to the International Physical Activity Survey
  • Presence of any chronic disease and medication use for this condition
  • History and treatment of current respiratory system disease
  • History and treatment of current cardiac system disease
  • History and treatment of current hearing system disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
No Intervention: Control Group
Experimental: Vagus nerve stimulation group
Device: Stimulation
Recovery in athletes through vagus nerve stimulation

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assessment of the autonomic nervous system.
Time Frame: Periprocedural
Using heart rate variability (HRV) measurements recorded
Periprocedural

Secondary Outcome Measures

Outcome Measure
Time Frame
Lactic acid concentrate indicator
Time Frame: Periprocedural
Periprocedural

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Istanbul Gelisim University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 17, 2024

Primary Completion (Actual)

May 6, 2025

Study Completion (Actual)

December 5, 2025

Study Registration Dates

First Submitted

December 29, 2025

First Submitted That Met QC Criteria

January 23, 2026

First Posted (Actual)

January 28, 2026

Study Record Updates

Last Update Posted (Actual)

January 28, 2026

Last Update Submitted That Met QC Criteria

January 23, 2026

Last Verified

December 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • 19.04.2024/05

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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