Biomarkers for Predicting Mortality in Patients With Suspected Sepsis
The Use of Biomarkers for Predicting Mortality in Patients With Suspected Sepsis
This retrospective study aimes to analyze the association of a number of routinely performed biomarkers with mortality in patients admitted to ICU with suspected sepsis.
The study includes patients >18 years of age, who had been admitted to the ICU with suspected sepsis. At ICU admission, baseline levels of PCT, CRP, albumin and lactate as well as WBC, neutrophil and lymphocyte counts will recorded.
Study Overview
Status
Conditions
Detailed Description
This study aimes to investigate the association of a number of biomarkers with 28-day mortality of patients admitted to the ICU with suspected sepsis, which included C-reactive protein (CRP), procalcitonin (PCT), WBC count, neutrophil count, lymphocyte count, albumin and lactate.
Data will obtained from hospital electronic medical records. Data includes age, sex, duration of ICU stay, origin of infection (urinary, abdominal, pulmonary, soft tissue, central nervous system, catheter-related, mixed, others) and comorbidities (hypertension, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure, heart failure, coronary artery disease, malignancies, others). Whether patients were admitted to the ICU following a scheduled surgery or emergency surgery will also recorded.
At admission, baseline levels of PCT, CRP, albumin and lactate as well as WBC, neutrophil and lymphocyte counts will recorded.
The primary outcome is 28-day mortality. For patients with multiple episodes requiring ICU admission, only the most recent episode will taken into consideration.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Niğde Province
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Niğde, Niğde Province, Turkey (Türkiye), 51200
- Niğde Ömer Halisdemir University Training and Research Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- >18 years of age
- admission to the ICU with suspected sepsis
Exclusion Criteria:
- ICU admission following cardiopulmonary resuscitation or cardiac surgery
- Having a positive test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
- Interruption of the treatment process because of transfer to another healthcare facility
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
28-day mortality
Time Frame: 28 days
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mortality within 28 days after intensive care admission
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28 days
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Collaborators and Investigators
Investigators
- Principal Investigator: Sümeyye Uğur, Antalya Training And Research Hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- SU2024
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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