Clinical Practices of Extubation After Invasive Mechanical Ventilation (EPP/EPP = 1)

Clinical Practices of Extubation After Invasive Mechanical Ventilation in Anesthesia and Intensive Care

Extubation is a delicate and complex phase of airway management in anesthesia and critical care. A variety of complications are of concern, ranging from transient hypoxemia to the need for reintubation, which can then become life-threatening for the patient.

For this procedure, it may be recommended to use the positive end-expiratory pressure (PEEP) extubation technique to reduce the risks of hypoxemia, atelectasis, and aspiration. However, no specific technique is preferred given the diversity of described procedures (spontaneous ventilation on an auxiliary circuit, PEEP-assisted spontaneous ventilation, adjustment of the APL valve). However, results may vary depending on the patient population (children, adults) and the setting (operating room, intensive care unit).

Given the lack of a preferred technique for performing extubation under positive end-expiratory pressure, the aim of this study is to describe the techniques used by healthcare professionals (physicians, nurse anesthetists, nurses) during the extubation of a surgical or intensive care patient.

Study Overview

• Status: Not yet recruiting
• Conditions: Anesthesia; Extubation; Mechanical Ventilation; Critical Care, Intensive Care

• Study Type: Observational
• Enrollment (Estimated): 200

Contacts and Locations

• Study Contact: Name: Jean Yves LEFRANT, PHD; Phone Number: +33 466 68 30 50; Email: jean.yves.lefrant@chu-nimes.fr

Study Locations

• France
  • Nîmes, France, 30000
    • CHU de Nîmes
    • Contact: Jean Yves LEFRANT, PHD; Phone Number: +33 4 66 68 30 50; Email: jean.yves.lefrant@chu-nimes.fr
    • Sub-Investigator: Manon LUCHESI, MSC
    • Sub-Investigator: Jordan ALES, MSC

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Healthcare personnel responsible for routinely extubating surgical patients during the recovery and resuscitation phases as they are weaned off invasive ventilation.

Description

Inclusion Criteria:

• Physicians and students in anesthesiology and critical care,
• Critical care physicians,
• State-certified nurse anesthetists (IADE),
• State-certified nurses (IDE) working in an anesthesia or intensive care team
• Students (medical or nurse anesthetist) with at least 1 year of extubation experience.

Exclusion Criteria:

• Healthcare professionals with no experience in extubation (less than one year of practice) Refusal to participate

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Caregivers performing extubation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Extubation technique	Frequency of use of the simple suction extubation technique compared to the positive-pressure extubation technique (%)	baseline

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Nīmes
• Investigators: Study Director: Anissa MEGZARI, Centre Hospitalier Universitaire de Nīmes

Study record dates

Study Major Dates

• Study Start (Estimated): April 28, 2026
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): October 1, 2026

Study Registration Dates

• First Submitted: April 21, 2026
• First Submitted That Met QC Criteria: April 21, 2026
• First Posted (Actual): April 28, 2026

Study Record Updates

• Last Update Posted (Actual): May 4, 2026
• Last Update Submitted That Met QC Criteria: April 28, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: IRB_26.04.01

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No