A Study of NatureU Burn on Satiety in Healthy Adults (NUBURN)

A Single-Center, Single-Blind, Non-Randomized Crossover Exploratory Study of NatureU Burn With Glucose on Postprandial Satiety in Healthy Adults

This single-center, single-blind, non-randomized crossover exploratory study evaluated the short-term effects of NatureU Burn on postprandial satiety in healthy adults. NatureU Burn is an oral dietary supplement containing Irvingia gabonensis seed extract and high-molecular-weight inulin. Fourteen healthy adults were enrolled, and 12 participants completed the study and were included in the effectiveness analysis. Each participant completed two test sessions separated by at least 48 hours: a reference food session with 75 g medical anhydrous glucose in 250 mL warm purified water and a test food session with one capsule of NatureU Burn plus 75 g glucose in 250 mL warm purified water. Satiety-related questionnaire scores were assessed at fasting baseline and at 30, 60, 90, 120, 180, and 240 minutes after the first bite in each session. The study assessed fullness, hunger, desire for food, and prospective food consumption, and monitored adverse reactions.

Study Overview

• Status: Completed
• Conditions: Food Intake; Satiety; Appetite; Fat Disorder; Obesity & Overweight
• Intervention / Treatment: Other: Glucose Reference Food; Dietary supplement: NatureU Burn Plus Glucose

Detailed Description

This exploratory clinical study was conducted to assess whether NatureU Burn, when consumed with a glucose reference food, was associated with changes in satiety-related subjective indicators compared with glucose alone. Eligible healthy adults completed screening, signed informed consent, and underwent two independent test sessions. For 2 days before each test, participants were instructed to maintain regular routines and a normal diet. On the day before testing, participants ate dinner between 18:00 and 20:00, avoided high-fiber and high-sugar foods, and fasted after 20:00. On the test morning, participants avoided strenuous exercise, sat quietly for 10 minutes before testing, and completed a fasting satiety scale before taking the assigned food. Participants consumed the assigned food and water within 5 to 10 minutes, and completed the satiety scale at 30, 60, 90, 120, 180, and 240 minutes after the first bite. The four evaluated satiety indicators were fullness, hunger, desire for food, and prospective food consumption. Food-affected changes were calculated relative to fasting baseline and compared between the NatureU Burn plus glucose session and the glucose reference session. Safety monitoring included adverse reactions throughout the testing process.

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Not Applicable

Contacts and Locations

Study Locations

• China
  • Hunan
    • Yongzhou, Hunan, China, 425300
      • Dao County People's Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy adults aged 18 to 50 years.
• Male or female participants.
• Body mass index within the normal range of 18.5 to 23.9 kg/m2.
• Regular habit of eating breakfast.
• Able to fast for at least 10 hours after dinner.
• Signed informed consent before enrollment.

Exclusion Criteria:

• Pregnant or breastfeeding women.
• Individuals engaged in heavy physical labor or high-intensity exercise.
• Chronic sleep deprivation during the previous 3 months.
• Self-reported body weight increase or decrease of at least 4 kg during the previous 3 months.
• Current use of weight-loss medications.
• Special dietary patterns, such as low-carbohydrate diet or intermittent fasting.
• Abnormal eating attitude based on eating attitude assessment.
• Serious cardiovascular, hepatic, renal, gastrointestinal, hematologic, or neurologic dysfunction.
• History of bariatric surgery.
• Major surgery or hospitalization within the previous 3 months.
• Eating disorders, including binge eating disorder, anorexia nervosa, or bulimia nervosa.
• Abnormal glucose metabolism or lipid metabolism.
• Intolerance or allergy to the test foods.
• Excessive smoking, defined as more than 15 cigarettes per day.
• Alcohol consumption greater than 15 g alcohol per day.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Non-Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Reference Food Session; Participants consumed 75 g medical anhydrous glucose dissolved in 250 mL warm purified water during the reference food session.	Other: Glucose Reference Food; The reference food consisted of 75 g medical anhydrous glucose dissolved in 250 mL warm purified water.
Experimental: NatureU Burn Plus Glucose Session; Participants consumed one capsule of NatureU Burn with 75 g medical anhydrous glucose dissolved in 250 mL warm purified water during the test food session.	Dietary supplement: NatureU Burn Plus Glucose; The test food consisted of one capsule of NatureU Burn plus 75 g medical anhydrous glucose dissolved in 250 mL warm purified water. NatureU Burn is an oral dietary supplement containing Irvingia gabonensis seed extract and high-molecular-weight inulin.; Other Names: NatureU Burn; Irvingia gabonensis seed extract and inulin supplement

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Food-Affected Fullness Score After NatureU Burn Plus Glucose Compared With Glucose Alone	Fullness was assessed using the satiety scale. Food-affected fullness was calculated as the change from fasting baseline at each postprandial time point and compared between the NatureU Burn plus glucose test session and the glucose reference session. Fullness was assessed using the fullness item of the 100-point Satiety Rating Scale. The scale ranges from 0 to 100, with higher scores indicating greater fullness and a better satiety outcome. Food-affected fullness was calculated as the change from fasting baseline at each postprandial time point and compared between the NatureU Burn plus glucose test session and the glucose reference session. A larger positive change from baseline indicates a greater increase in fullness	Fasting baseline before food intake and 30, 60, 90, 120, 180, and 240 minutes after the first bite in each test session.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Food-Affected Hunger Score After NatureU Burn Plus Glucose Compared With Glucose Alone	Hunger was assessed using the satiety scale. Food-affected hunger was calculated as the change from fasting baseline at each postprandial time point and compared between the NatureU Burn plus glucose test session and the glucose reference session.Hunger was assessed using the hunger item of the 100-point Satiety Rating Scale. The scale ranges from 0 to 100, with higher scores indicating greater hunger and a worse satiety outcome. Food-affected hunger was calculated as the change from fasting baseline at each postprandial time point and compared between the NatureU Burn plus glucose test session and the glucose reference session. A larger negative change from baseline indicates a greater reduction in hunger.	Fasting baseline before food intake and 30, 60, 90, 120, 180, and 240 minutes after the first bite in each test session
Food-Affected Desire for Food Score After NatureU Burn Plus Glucose Compared With Glucose Alone	Desire for food was assessed using the satiety scale. Food-affected desire for food was calculated as the change from fasting baseline at each postprandial time point and compared between the NatureU Burn plus glucose test session and the glucose reference session.Desire for food was assessed using the desire-for-food item of the 100-point Satiety Rating Scale. The scale ranges from 0 to 100, with higher scores indicating greater desire for food and a worse satiety outcome. Food-affected desire for food was calculated as the change from fasting baseline at each postprandial time point and compared between the NatureU Burn plus glucose test session and the glucose reference session. A larger negative change from baseline indicates a greater reduction in desire for food	Fasting baseline before food intake and 30, 60, 90, 120, 180, and 240 minutes after the first bite in each test session
Food-Affected Prospective Food Consumption Score After NatureU Burn Plus Glucose Compared With Glucose Alone	Prospective food consumption was assessed using the satiety scale. Food-affected prospective food consumption was calculated as the change from fasting baseline at each postprandial time point and compared between the NatureU Burn plus glucose test session and the glucose reference session.	Fasting baseline before food intake and 30, 60, 90, 120, 180, and 240 minutes after the first bite in each test session

Collaborators and Investigators

• Sponsor: OmniSolutions Laboratory Holdings Limited
• Investigators: Study Director: Luke Law, Dr, OmniSolutions Laboratory Holdings Limited

Publications and helpful links

General Publications

• Luo L, Law L, Yu M, Zhang N, Yang M. Participant Experiences from Chronic Administration of Irvingia Gabonensis Seed Extract and Inulin on the Body's Satiety: An Exploratory Analysis of a Single-Blind Clinical Trial. Current Topics in Nutraceutical Research. 2025;23(1):56-63. doi:10.37290/ctnr2641-452X.22:56-63.

Helpful Links

• Published article in Current Topics in Nutraceutical Research

Study record dates

Study Major Dates

• Study Start (Actual): April 22, 2024
• Primary Completion (Actual): April 26, 2024
• Study Completion (Actual): May 5, 2024

Study Registration Dates

• First Submitted: May 11, 2026
• First Submitted That Met QC Criteria: May 15, 2026
• First Posted (Actual): May 19, 2026

Study Record Updates

• Last Update Posted (Actual): May 19, 2026
• Last Update Submitted That Met QC Criteria: May 15, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: dietary supplement; satiety; NatureU; NatureU Burn; Irvingia gabonensis seed extract; high-molecular-weight inulin; prospective food consumption
• Additional Relevant MeSH Terms: Nutrition Disorders; Metabolic Diseases; Overnutrition; Body Weight; Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Signs and Symptoms; Overweight; Obesity; Lipid Metabolism Disorders; Carbohydrates; Sugars; Hexoses; Monosaccharides; Glucose
• Other Study ID Numbers: NATUREU-BURN-2024-SAT; 2024041001 (Other Identifier: Dao County People's Hospital Ethics Committee)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Individual participant data will not be shared due to privacy protection and ethical considerations.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No