Glycemic and Insulinemic Response of Pasta Products in Comparison to Asian Foods

Glycemic and Insulinemic Response of Pasta Products in Comparison to Asian

The aim of the study is to determine the glycaemic and insulinaemic index of pasta products and local foods. It is hypothesized that different pasta cuts and wholegrain composition of pasta and local foods have different GI depending on the nature of the carbohydrate content and the food structure within each food.

Study Overview

• Status: Completed
• Conditions: Diabetes
• Intervention / Treatment: Other: Glucose Reference 1; Other: Glucose Reference 2; Other: Glucose Reference 3; Other: Semolina Penne; Other: Wholegrain Penne; Other: Semolina Spaghetti; Other: Wholegrain Spaghetti; Other: Jasmine Rice; Other: Asian Noodles

Detailed Description

There will be a total of 9 test sessions and each session will last up to 3.5 hours. The order of sessions will be determined with an online randomizer. At each test session, the following procedures will be performed: two finger-prick blood samples, five minutes apart to measure baseline blood glucose and insulin concentrations Subject will be served the test food and to consume within15 minutes Following the test meal, blood samples will be collected at the following time points: 15, 30, 45, 60, 90, 120, 150 and 180min for glucose measurements and insulin measurements will be collected at 30, 60, 90, 120, 150 and 180min.

• Study Type: Interventional
• Enrollment (Actual): 32
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Singapore
  • Singapore, Singapore, 117599
    • Clinical Nutrition Research Centre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy Asian - Indian and Chinese ethnicity
• Age between 21-40 years
• Body mass index between 18.5 to 25 kg/m2
• Normal blood pressure (<140/90 mmHg)
• Fasting blood glucose < 6 mmol/L

Exclusion Criteria:

• Is a current smoker
• Is currently pregnant
• Have any metabolic diseases (such as diabetes, hypertension etc)
• Have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
• Have medical conditions and/or taking medications known to affect glycemia(glucocorticoids, thyroid hormones, thiazide diuretics)
• Have any major organ dysfunction (e.g. cardiovascular, respiratory, hepatic, renal, gastrointestinal) that may influence taste, olfaction, appetite, digestion, metabolism, absorption or elimination of test foods, nutraceutical or drug
• Have any severe food allergy (e.g. anaphylaxis to peanuts)
• Have any known allergies to any food components of the study protocol
• Have active Tuberculosis (TB) or currently receiving treatment for TB
• Have any known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
• Is a study team member or an immediate family of any study team member. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
• enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study.
• Have partake in sports at the competitive and/or endurance levels
• Have intentionally restrict food intake

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

9

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Glucose Reference 1; 50g of glucose dissolved in 250ml of water to be consumed.	Other: Glucose Reference 1; Glucose contains 50g of available carbohydrates
Other: Glucose Reference 2; 50g of glucose dissolved in 250ml of water to be consumed.	Other: Glucose Reference 2; Glucose contains 50g of available carbohydrates
Other: Glucose Reference 3; 50g of glucose dissolved in 250ml of water to be consumed.	Other: Glucose Reference 3; Glucose contains 50g of available carbohydrates
Experimental: Semolina Penne; 70g of semolina penne boiled in 1 Litre of water for 11 minutes. Drained and consume immediately.	Other: Semolina Penne; Semolina Penne contains 50g of available carbohydrates
Experimental: Wholegrain Penne; 76g of wholegrain penne boiled in 1 Litre of water for 9 minutes. Drained and consume immediately.	Other: Wholegrain Penne; Wholegrain Penne contains 50g of available carbohydrates
Experimental: Semolina Spaghetti; 71g of semolina spaghetti boiled in 1 Litre of water for 8 minutes. Drained and consume immediately.	Other: Semolina Spaghetti; Semolina Spaghetti contains 50g of available carbohydrates
Experimental: Wholegrain Spaghetti; 76g of wholegrain spaghetti boiled in 1 Litre of water for 8 minutes. Drained and consume immediately.	Other: Wholegrain Spaghetti; Wholegrain Spaghetti contains 50g of available carbohydrates
Experimental: Jasmine rice; 63g of rice cook with 150g of water. Served and consume immediately.	Other: Jasmine Rice; Jasmine Rice contains 50g of available carbohydrates
Experimental: Asian Noodles; 92.4g of Asian Noodles cook in boiling water for 45 seconds. Drained and consume immediately	Other: Asian Noodles; Asian Noodles contains 50g of available carbohydrates

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Glucose	Blood will be collected and measured using hemocue analyzer.	up to 180 minutes
Insulin	Blood will be collected and measured using COBAS analyzer.	up to 180 minutes

Collaborators and Investigators

• Sponsor: Clinical Nutrition Research Centre, Singapore
• Collaborators: Barilla Singapore Pte Ltd

Study record dates

Study Major Dates

• Study Start (Actual): August 10, 2018
• Primary Completion (Actual): June 1, 2020
• Study Completion (Actual): June 1, 2020

Study Registration Dates

• First Submitted: August 23, 2018
• First Submitted That Met QC Criteria: August 23, 2018
• First Posted (Actual): August 24, 2018

Study Record Updates

• Last Update Posted (Actual): August 31, 2023
• Last Update Submitted That Met QC Criteria: August 29, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: 2018/00622

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No