Evaluation Skin Stiffness Gradient on Skin After LLLT

June 25, 2026 updated by: Gilang Titah Ramadhan, Asia University

Optimization of Low-Level Laser Therapy Via Biomechanical Properties Analysis Using Optical Coherence Tomography on Skin

This study evaluates the effects of Low-Level Laser Therapy (LLLT) on skin elasticity by measuring a 3x3 stiffness gradient across 9 points spaced 1 cm apart. Using an air-pressure pump integrated with an Optical Coherence Tomography (OCT) system, a deep learning model is utilized to automatically segment and track micro-scale skin movement during deformation.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Taiwan
    • Wufeng
      • Taichung, Wufeng, Taiwan, 41354
        • Asia University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Healthy adult

Exclusion Criteria:

  • People with wound and ulcers

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Three different LLLT Duration (2 min, 3 min and 5 min)
Measuring biomechanical changes on skin after LLLT for three different duration (2 min, 3 min and 5 min) using stiffness gradient
Other: LLLT intervention on skin biomechanical properties in different duration and wavelength
LLLT intervention on skin biomechanical properties in three different duration and two LLLT wavelength
Active Comparator: Two different LLLT wavelength (660 and 808 nm)
Measuring biomechanical changes on skin after LLLT for two different LLLT wavelength (660 and 808 nm) using stiffness gradient
Other: LLLT intervention on skin biomechanical properties in different duration and wavelength
LLLT intervention on skin biomechanical properties in three different duration and two LLLT wavelength
Active Comparator: Three different duty cycle (100%, 30% and 50%)
Measuring biomechanical changes on skin after LLLT for three duty cycle (100%, 30% and 50%) using stiffness gradient
Other: LLLT intervention on skin biomechanical properties in different duty cycle and applied frequency
LLLT intervention on skin biomechanical properties in three different duty cycle and two applied frequency
Active Comparator: Two different applied frequency (1 Hz and 50 Hz)
Measuring biomechanical changes on skin after LLLT for two different applied frequency (1 Hz and 50 Hz) using stiffness gradient
Other: LLLT intervention on skin biomechanical properties in different duty cycle and applied frequency
LLLT intervention on skin biomechanical properties in three different duty cycle and two applied frequency

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Measurements skin stiffness gradient
Time Frame: Through study completion, an average of 1 year
This study evaluates the effects of Low-Level Laser Therapy (LLLT) on skin elasticity by measuring a 3x3 stiffness gradient across 9 points spaced 1 cm apart. Using an air-pressure pump integrated with an Optical Coherence Tomography (OCT) system, a deep learning model is utilized to automatically segment and track micro-scale skin movement during deformation.
Through study completion, an average of 1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Asia University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 10, 2025

Primary Completion (Actual)

June 15, 2025

Study Completion (Estimated)

August 15, 2026

Study Registration Dates

First Submitted

June 25, 2026

First Submitted That Met QC Criteria

June 25, 2026

First Posted (Actual)

July 2, 2026

Study Record Updates

Last Update Posted (Actual)

July 2, 2026

Last Update Submitted That Met QC Criteria

June 25, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CRREC-112-130/2

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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