Nailfold Capillaroscopic Changes in Psoriasis

Nailfold Capillaroscopic Changes in Psoriasis and Its Correlation With Disease Severity

The goal of this observational study is to evaluate nailfold capillaroscopic changes in patients with psoriasis and to assess their correlation with disease severity. The study will also explore differences in capillaroscopic findings across different clinical types of psoriasis and skin phototypes (Fitzpatrick classification). The study will include patients diagnosed with psoriasis attending dermatology outpatient clinics. Participants will undergo clinical assessment and nailfold capillaroscopy to detect microvascular changes.

Study Overview

• Status: Recruiting
• Conditions: Psoriasis
• Intervention / Treatment: Other: Nailfold Capillaroscopy

• Study Type: Observational
• Enrollment (Estimated): 100

Contacts and Locations

• Study Contact: Name: Ahmed H Nouh, Asst Prof Derm & Venereol; Phone Number: +201062034079; Email: Dr.ahmednouh@azhar.edu.eg
• Study Contact Backup: Name: Hadil J Albarrawi; Phone Number: +201096205545; Email: hadeeljamil71@gmail.com

Study Locations

• Egypt
  • Cairo Governorate
    • Cairo, Cairo Governorate, Egypt
      • Recruiting
      • Al-Hussein University Hospital & Sayed Galal University Hospital
      • Contact: Ahmed H Nouh, Asst Prof Derm & Venereolog; Phone Number: +201062034079; Email: Dr.ahmednouh@azhar.edu.eg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

The study will include patients clinically diagnosed with psoriasis attending the dermatology outpatient clinics at Al-Hussein and Sayed Galal University Hospitals in Cairo, Egypt during the study period.

Description

Inclusion Criteria:

• Patients clinically diagnosed with psoriasis.

Exclusion Criteria:

• Patients with connective tissue diseases (e.g., systemic sclerosis, SLE)
• Diabetes mellitus or peripheral vascular disease
• Current smokers
• Pregnant or lactating women
• Recent use of vasodilators or beta-blockers
• Manual workers exposed to vibrating tools

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Nailfold capillaroscopic abnormalities in psoriasis patients	Detection and description of nailfold capillaroscopic (NFC) abnormalities in patients with psoriasis.	Baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Variation of nailfold capillaroscopic findings among different clinical types of psoriasis and correlation with disease severity (PASI score).	Correlation between PASI score and presence of NFC changes. - Comparison of nailfold capillaroscopic findings in different types of psoriasis	Baseline

Collaborators and Investigators

• Sponsor: Al-Azhar University

Study record dates

Study Major Dates

• Study Start (Estimated): August 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): December 1, 2026

Study Registration Dates

• First Submitted: July 4, 2026
• First Submitted That Met QC Criteria: July 4, 2026
• First Posted (Actual): July 9, 2026

Study Record Updates

• Last Update Posted (Actual): July 31, 2026
• Last Update Submitted That Met QC Criteria: July 30, 2026
• Last Verified: July 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Psoriasis; Investigative Techniques; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Imaging; Diagnostic Techniques, Cardiovascular; Microscopy; Intravital Microscopy; Microscopic Angioscopy; Dermoscopy
• Other Study ID Numbers: PSO-NFC-PASI-2026

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No