Comparative Evaluation of Functional and Aesthetic Outcomes of Box and Mini-Wing Genioplasty Techniques (MWBOX)

July 21, 2026 updated by: Merve Gaye Akgök, Istanbul Medipol University Hospital
This retrospective cohort study aims to compare the effects of Mini Wing and Box genioplasty performed in conjunction with bimaxillary orthognathic surgery on upper airway area and soft tissue profile in adult patients with skeletal Class II dentofacial deformity. Preoperative and postoperative radiographic measurements will be evaluated to determine changes in upper airway area, mentolabial angle, and submental angle. The study also aims to assess whether either genioplasty technique provides superior postoperative functional and esthetic outcomes.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

Skeletal Class II dentofacial deformity is commonly treated with bimaxillary orthognathic surgery combined with genioplasty to improve facial harmony and functional outcomes. Among the available genioplasty techniques, Mini Wing and Box genioplasty differ in their osteotomy design and the direction of chin advancement, which may influence postoperative soft tissue profile and upper airway morphology.

This retrospective cohort study includes adult patients who underwent bimaxillary orthognathic surgery with either Mini Wing or Box genioplasty at Istanbul Medipol University between 2019 and 2025. Patients meeting the predefined inclusion and exclusion criteria will be identified through hospital records. Preoperative and postoperative cone-beam computed tomography (CBCT) images will be analyzed to evaluate changes in upper airway area, mentolabial angle, and submental angle.

Demographic characteristics and baseline measurements will be compared between groups to ensure similarity before surgery. Postoperative changes within each group and differences between the two surgical techniques will be statistically analyzed. The findings are expected to provide evidence regarding the effects of Mini Wing and Box genioplasty on upper airway dimensions and soft tissue profile, thereby supporting surgical planning and technique selection in patients with skeletal Class II deformity.

Study Type

Observational

Enrollment (Actual)

40

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey (Türkiye)
    • Istanbul
      • Bağcılar, Istanbul, Turkey (Türkiye), 34214
        • Istanbul Medipol University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Adult patients with skeletal Class II dentofacial deformity who underwent bimaxillary orthognathic surgery combined with Mini Wing or Box genioplasty at Istanbul Medipol University between 2019 and 2025.

Description

Inclusion Criteria:

  • Adults aged 18 years or older.
  • Diagnosis of skeletal Class II dentofacial deformity.
  • Underwent bimaxillary orthognathic surgery combined with either Mini Wing or Box genioplasty.
  • Available preoperative and postoperative CBCT images obtained 6 months after surgery.
  • Complete clinical and radiographic records.

Exclusion Criteria:

  • Previous orthognathic or genioplasty surgery.
  • Craniofacial syndromes or congenital craniofacial anomalies.
  • History of facial trauma affecting craniofacial morphology.
  • Incomplete clinical records or missing CBCT data.
  • Poor-quality CBCT images unsuitable for analysis.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Mini Wing Genioplasty
Patients with skeletal Class II dentofacial deformity who underwent bimaxillary orthognathic surgery combined with Mini Wing genioplasty.
Procedure: Mini Wing Genioplasty
Mini Wing genioplasty performed in conjunction with bimaxillary orthognathic surgery for correction of skeletal Class II dentofacial deformity.
Box Genioplasty
Patients with skeletal Class II dentofacial deformity who underwent bimaxillary orthognathic surgery combined with Box genioplasty.
Procedure: Box Genioplasty
Box genioplasty performed in conjunction with bimaxillary orthognathic surgery for correction of skeletal Class II dentofacial deformity.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Upper Airway Area
Time Frame: Preoperative and 6 months after surgery
Change in upper airway area measured on cone-beam computed tomography (CBCT) images obtained before surgery and 6 months after surgery.
Preoperative and 6 months after surgery

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Mentolabial Angle
Time Frame: Preoperative and 6 months after surgery
Change in the mentolabial angle measured on CBCT images before surgery and 6 months after surgery.
Preoperative and 6 months after surgery
Change in Submental Angle
Time Frame: Preoperative and 6 months after surgery
Change in the submental angle measured on CBCT images before surgery and 6 months after surgery.
Preoperative and 6 months after surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Istanbul Medipol University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 1, 2019

Primary Completion (Actual)

July 20, 2026

Study Completion (Estimated)

July 20, 2026

Study Registration Dates

First Submitted

July 21, 2026

First Submitted That Met QC Criteria

July 21, 2026

First Posted (Actual)

July 24, 2026

Study Record Updates

Last Update Posted (Actual)

July 24, 2026

Last Update Submitted That Met QC Criteria

July 21, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MEDIPOL-GENIO-2026-001
  • E-10840098-50.04-1779 (Other Identifier: Istanbul Medipol University Non-Interventional Clinical Research Ethics Committee)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data will not be shared because the study is retrospective and contains confidential patient information. Data sharing is restricted to protect participant privacy and is subject to institutional and ethical regulations.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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