Search clinical trials for: Dose decrease

Total 7779 results

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Rennes University Hospital

Completed

National Multicenter, Controlled, Single-blind Study With Two Parallel Groups Evaluating the Safety and Efficacy of Sequential Treatment With Mitoxantrone and Interferon Versus Interferon Alone in Patients With Strong Risk of Progression in the Initial Phase of Multiple Sclerosis (MITOX-REBIF)

Multiple Sclerosis

France
University Ghent
Flemish Interuniversity Council (VLIR); Arba Minch University, Ethiopia

Completed

Iron and Vitamin A in School Children (IronVitA)

Vitamin A Deficiency | Anemia, Iron Deficiency | Cognitive Development | Helminthic Infection

Ethiopia
Nantes University Hospital

Terminated

Post Transplant Cyclophosphamide (PTCY) as Sole Graft Versus Host Disease (GVHD) Prophylaxis for Matched Allotransplant: CYRIC (CYRIC)

Graft Versus Host Disease

France
The Netherlands Cancer Institute
Bristol-Myers Squibb

Active, not recruiting

Nivolumab After Induction Treatment in Triple-negative Breast Cancer (TNBC) Patients (TONIC)

Breast Cancer

Netherlands
Ain Shams University

Completed

Comparison Between Different Doses of Steroids in COVID-19 Patients (COVID-19)

Pneumonia, Viral | Critical Illness

Egypt
Teva Branded Pharmaceutical Products R&D, Inc.
Parexel

Completed

A Cumulative Dose Study to Evaluate the Safety and Efficacy of Albuterol in a Dry Powder Inhaler and an HFA MDI (Hydrofluoroalkane Metered Dose Inhaler)

Asthma

United States
Merck Sharp & Dohme LLC

Completed

Study of Vorinostat (MK0683), an Histone Deacetylase (HDAC) Inhibitor in Combination With Bortezomib in Patients With Relapsed or Refractory Multiple Myeloma (MK-0683-095)

Relapsed or Refractory Multiple Myeloma
Novartis Pharmaceuticals

Completed

Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode. (PIONEER-HF)

Acute Heart Failure

United States
Rafa Laboratories
Teva Branded Pharmaceutical Products R&D, Inc.

Terminated

Comparison of Delta-8-THC to Ondansetron in the Prevention of Acute Nausea From Moderately Emetogenic Chemotherapy

Cancer

Israel
Boehringer Ingelheim
Eli Lilly and Company

Completed

This Study in Healthy People Tests Whether Taking a Low Strength of Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate Pills

Healthy

Germany
GL Pharm Tech Corporation

Completed

Pharmacokinetic Characteristics of GLH1SM Extended Release Tablets in Healthy Volunteers

Healthy

Korea, Republic of
Suez Canal University

Completed

Salbutamol Administration by Nebulizer Versus Metered Dose Inhaler With Spacer in Asthma in Children

Bronchial Asthma

Egypt
Seoul National University Bundang Hospital

Completed

Therapeutic Efficacy of Triple Combination in Drug-naïve Korean Type 2 Diabetic Patients

Type 2 Diabetes

Korea, Republic of
Memorial Sloan Kettering Cancer Center
Astellas Pharma US, Inc.

Completed

Low Dose Daily Erlotinib in Combination With High Dose Twice Weekly Erlotinib in Patients With EGFR-Mutant Lung Cancer

EGFR-Mutant Lung Cancer

United States
University College Dublin
Royal College of Surgeons, Ireland; National Maternity Hospital, Ireland; Perinatal...

Completed

Trial of Early Screening Test for Pre-eclampsia and Growth Restriction (TEST)

Placenta Diseases | Pre-Eclampsia | Fetal Growth Retardation | Eclampsia Preeclampsia | Foetal Growth Restriction

Ireland
University of Michigan
Food and Drug Administration (FDA)

Completed

Modernization of in vivo-in Vitro Oral Bioperformance Prediction and Assessment

Human Gastrointestinal Physiology Data

United States
Chiesi Farmaceutici S.p.A.

Completed

A Study in Patients With Chronic Obstructive Pulmonary Disease (FUTURE)

Chronic Obstructive Pulmonary Disease

Italy
Assiut University

Completed

The Effect of Omega 3 on Pregnancy Complicated by Asymmetrical Intrauterine Growth Restriction

Intrauterine Growth Restriction

Egypt
University of Oxford
Kinshasa School of Public Health

Completed

Bio-availability of Rectal Artesunate in Children With Severe Falciparum Malaria (REACH)

Malaria

Congo, The Democratic Republic of the
Janssen-Cilag G.m.b.H

Completed

A Study of Bortezomib, Cyclophosphamide, and Dexamethasone in Patients With Untreated Multiple Myeloma and Planned for a High Dose Chemotherapy

Multiple Myeloma

Germany
Royal Brompton & Harefield NHS Foundation Trust
Chelsea and Westminster NHS Foundation Trust; Imperial College Healthcare NHS...

Unknown

Oral Verses Patch Trial In Menopausal Women - Individualisation of Oestrogen Therapy (OPTIMISE)

Venous Thrombosis | Insulin Resistance

United Kingdom
Pfizer

Completed

Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis

Aspergillosis

United States, Australia, Canada, Greece, Belgium, Germany, Korea, Republic of, Poland, Russian Federation, Spain, Turkey, Thailand, Brazil, Czech Republic, France, India, Italy, Netherlands, Peru, Portugal, Singapore, Switzerland, ... and more
Sheba Medical Center

Completed

Efficacy Study of Prophylactic Ibuprofen Versus Placebo on Pain Relief and Success Rates of Medical Abortion

Pain | Pregnancy

Israel
University of Ioannina

Unknown

Comparison of High-Dose Rosuvastatin Versus Low Statin Dose Plus Fenofibrate Versus Low Statin Dose Plus Niacin in the Treatment of Mixed Hyperlipidemia

Dyslipidemia

Greece
Sohag University

Recruiting

Type VI Secretion System in Klebsiella Pneumoniae (Klebsiella)

Detection of Type VI Secretion System in K.Pneumoniae | Detection of Relation to Ab Resistance, Biofilm

Egypt
University of Colorado, Denver
National Institutes of Health (NIH); American Diabetes Association

Completed

Influence of Endothelial Function on Central and Peripheral Causes Of Exercise Impairment in Type 2 Diabetes (InsITE)

Type 2 Diabetes

United States
Instituto Nacional de Ciencias Medicas y Nutricion...

Unknown

Use of Bezafibrate in Patients With Primary Biliary Cirrhosis to Archive Complete Biochemical Response in Non-responders

Primary Biliary Cirrhosis

Mexico
Thomas Jefferson University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH) (DASH)

Preterm Birth | Preeclampsia

United States
Tianjin Medical University General Hospital

Not yet recruiting

FcRn Antagonists (Efgartigimod) for Acute NMOSD Attack (FACT)

Neuromyelitis Optica | Neuromyelitis Optica Spectrum Disorder | NMO Spectrum Disorder
Cairo University

Not yet recruiting

Fractional Carbon Dioxide Laser: A Novel Therapeutic Option for Lichen Simplex Chronicus

Lichen Simplex Chronicus

Egypt
Effector Therapeutics

Recruiting

Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies (Zotatifin)

Solid Tumor, Adult

United States
Robert Nickel
The Hospital for Sick Children; Columbia University; Ann & Robert H Lurie Children... and other collaborators

Recruiting

Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease (SUN)

Sickle Cell Disease

United States, Canada
Laboratorios Silanes S.A. de C.V.

Completed

Comparative Bioavailability Study Between Etoricoxib / Betamethasone Administered Individually or in Combination

Healthy

Mexico
BPGbio
BPGbio

Active, not recruiting

A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)

Glioblastoma | Glioblastoma Multiforme

United States
AstraZeneca
Parexel

Completed

Study to Assess Efficacy and Safety of Aclidinium Bromide and Aclidinium Bromide/Formoterol Fumarate in Stabile COPD Patients (AVANT)

COPD

Philippines, Vietnam, China, Taiwan, India
NEAT ID Foundation
ViiV Healthcare

Completed

Open-Label Multi-Centre Randomised Switch Study to Evaluate Virological Efficacy Over 96Weeks Of 2-Drug Therapy With Dolutegravir(DTG)/Rilpivirine(RPV) Fixed Dose Combination(FDC) in Antiretroviral Treatment-Experienced HIV-1 Infected Subjects Virologically Suppressed With NNRTI Mutation K103N (WISARD)

HIV-1-infection

Spain, Belgium, France, Germany, Italy, United Kingdom
University of Lagos, Nigeria

Completed

Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE) (PIPSICKLE)

Pregnancy Complications | Sickle Cell Disease | Preeclampsia | Intrauterine Growth Restriction

Nigeria
NICHD Global Network for Women's and Children's...
Thomas Jefferson University; Jawaharlal Nehru Medical College

Completed

Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN) (ASPIRIN)

Premature Birth

United States, Zambia, Congo, The Democratic Republic of the, India, Kenya, Pakistan, Guatemala
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Completed

Low-Dose Atropine for Treatment of Myopia (MTS1)

Myopia

United States
Combined Military Hospital Abbottabad

Completed

Comparative Study Between Pulse Therapy With Oral Itraconazole Versus Continuous Oral Terbinafine Therapy for Treatment of Onychomycosis

Onychomycosis

Pakistan
Axel Diederichsen

Completed

The Aortic Valve DECalcification (AVADEC) Trial (AVADEC)

Aortic Valve Stenosis | Multidetector Computed Tomography | Vitamin K 2 | Randomised Clinical Trial

Denmark
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Drug Levels of Tablet and Liquid Forms of Lamivudine, Nevirapine, and Stavudine in HIV Infected Thai Children

HIV Infections

Thailand
Indonesia University

Completed

Intranasal Dexmedetomidine Sedation at Dose of 2 mcg/kg Versus 4 mcg/kg in Children Undergoing MRI

Magnetic Resonance Imaging | Pediatric ALL | Anesthesia | Deep Sedation

Indonesia
AstraZeneca

Completed

PK Study of Ticagrelor in Children Aged Less Than 24 Months, With Sickle Cell Disease (HESTIA4) (HESTIA4)

Sickle Cell Disease

Belgium, United Kingdom, Italy, Spain, Kenya, Lebanon
Philip Grant

Withdrawn

Effect of Reducing Nucleotide Exposure on Bone Health (ReNew) (ReNew)

HIV/AIDS | Osteopenia | HIV-1-infection

United States
Bayer

Completed

Study to Evaluate How Patients Regard the Benefits and Risks of Low-dose Aspirin for the Prevention of Heart and Blood Vessels Disease and for the Prevention of Cancer of the Colon and Rectum

Cardiovascular Disease | Colorectal Cancer

Italy
Peking University People's Hospital

Completed

Efficacy Study of Low-dose Glucocorticoid Prophylaxis for Acute Graft-versus-host Disease(GVHD)

Leukemia

China
Chong Kun Dang Pharmaceutical

Completed

Trial to Evaluate the Efficacy and Safety of a Combination Therapy of Candesartan and Amlodipine Versus Candesartan Monotherapy in Hypertensive Patients Inadequately Controlled by Candesartan Monotherapy

Hypertension

Korea, Republic of
GL Pharm Tech Corporation

Completed

Pharmacokinetic Characteristics of GLH1SM Extended Release Tablets in Healthy Volunteers(Fed)

Healthy

Korea, Republic of
M.D. Anderson Cancer Center
Otsuka Pharmaceutical Development & Commercialization, Inc.

Completed

A Randomized Trial to Compare Busulfan + Melphalan 140 mg/m2 With Melphalan 200 mg/m2 as Preparative Regimen for Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma

Myeloma

United States

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