Pilot Study of Transcranial Direct Current Stimulation (tDCS)

Inclusion Criteria:

• Ages 18-70
• Definite MS diagnosis, all subtypes [95]
• MS-related changes in cognitive functioning
• A score of 6.5 or lesson the Expanded
• Disability Status Scale (EDSS) OR more than 6.5 with proxy
• Has stable and continuous access to internet service at home compatible with the study laptop (Wi-Fi or ethernet cable)
• Adequate internet capacity for remote monitoring, as tested by http://www.speedtest.net/)
• Adequate home facilities (enough space, access to quiet and distraction free area)
• Able to commit to the two-week period of training sessions with baseline and follow-up visits.
• Able to understand the informed consent process and provide consent to participate in the study

Exclusion Criteria:

• Visual, auditory and motor deficits that would prevent full ability to understand study instructions or operate the tDCS device or study laptop, as judged by treating neurologist or study staff
• Relapse or steroid use in previous month
• History of mental retardation, pervasive developmental disorder or other neurological condition associated with cognitive impairment
• Primary psychiatric disorder that would influence ability to participate
• History of seizures or seizure disorder
• Current chronic headaches or migraines. In addition, if a subject has had a change in the rate or severity of head pressure, headache, or migraine in the past two weeks, they are excluded.
• History of head trauma (e.g., head injury, brain surgery) or medical device implanted in the head (such as Deep Brain Stimulator) or in the neck (such as a Vagus Nerve Stimulator)
• Any skin disorder/sensitive skin (e.g., eczema, severe rashes), blisters, open wounds, burn including sunburns, cuts or irritation, or other skin defects which compromise the integrity of the skin at or near stimulation locations (where electrodes are placed)
• Treatment for a communicable skin disorder currently or over the past 12 months