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Stråleterapi plus kemoterapi til behandling af patienter med supratentorial glioblastoma multiforme

9. august 2013 opdateret af: Radiation Therapy Oncology Group

ET FASE III FORSØG, DER SAMMENLIGNER BRUG AF RADIOSIRURGI EFTERFØLGET AF konventionel RADIOTERAPI MED BCNU TIL konventionel RADIOTERAPI MED BCNU TIL SUPRATENTORIAL GLIOBLASTOMA MULTIFORME

RATIONALE: Strålebehandling bruger højenergi-røntgenstråler til at beskadige tumorceller. Kemoterapi bruger forskellige måder til at stoppe tumorceller i at dele sig, så de holder op med at vokse eller dør. Kombination af strålebehandling med kemoterapi kan dræbe flere tumorceller.

FORMÅL: Randomiseret fase III forsøg til undersøgelse af effektiviteten af strålebehandling og carmustin til behandling af patienter, der har supratentorial glioblastoma multiforme.

Studieoversigt

Status

Afsluttet

Betingelser

Tumorer i hjernen og centralnervesystemet

Intervention / Behandling

Detaljeret beskrivelse

MÅL: I. Bestem, om brugen af strålekirurgi (stereotaktisk ekstern strålebestråling) forud for konventionel strålebehandling med carmustin (BCNU) forbedrer den samlede overlevelse sammenlignet med konventionel strålebehandling plus BCNU alene hos patienter med supratentorial glioblastoma multiforme. II. Bestem og sammenlign hyppigheden og sværhedsgraden af toksiciteter forbundet med disse regimer. III. Sammenlign virkningerne af disse to regimer på neurologisk funktion og livskvalitet.

OVERSIGT: Randomiseret undersøgelse. Arm I: Strålebehandling plus enkeltstof kemoterapi. Tumorbestråling ved hjælp af megaspændingsudstyr (mindst 4 MV-fotoner); plus Carmustine, BCNU, NSC-409962. Arm II: Strålekirurgi efterfulgt af strålebehandling plus enkeltstof kemoterapi. Stereotaktisk tumorbestråling; efterfulgt af tumorbestråling som i arm I; plus BCNU.

PROJEKTERET OPSLAG: 200 patienter vil blive optaget over cirka 3 år.

Undersøgelsestype

Interventionel

Tilmelding (Forventet)

200

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N2
    - Tom Baker Cancer Center - Calgary
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute
- British Columbia
  - Victoria, British Columbia, Canada, V8R 1J8
    - British Columbia Cancer Agency - Vancouver Island Cancer Centre
- New Brunswick
  - Moncton, New Brunswick, Canada, E1C 8X3
    - Doctor Leon Richard Oncology Centre
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Saint John Regional Hospital
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 1V7
    - Nova Scotia Cancer Centre
- Ontario
  - Hamilton, Ontario, Canada, L8V 5C2
    - Cancer Care Ontario-Hamilton Regional Cancer Centre
  - Kingston, Ontario, Canada, K7L 5P9
    - Kingston Regional Cancer Centre
  - London, Ontario, Canada, N6A 4L6
    - Cancer Care Ontario-London Regional Cancer Centre
  - Ottawa, Ontario, Canada, K1Y 4K7
    - Ottawa Regional Cancer Centre - Civic Campus
  - Sudbury, Ontario, Canada, P3E 5J1
    - Northeastern Ontario Regional Cancer Centre, Sudbury
  - Thunder Bay, Ontario, Canada, P7A 7T1
    - Northwestern Ontario Regional Cancer Centre, Thunder Bay
  - Toronto, Ontario, Canada, M4N 3M5
    - Toronto Sunnybrook Regional Cancer Centre
  - Toronto, Ontario, Canada, M5G 2M9
    - Princess Margaret Hospital
- Quebec
  - Montreal, Quebec, Canada, H2W 1S6
    - McGill University Department of Oncology
  - Montreal, Quebec, Canada, H2L-4M1
    - Centre Hospitalier de l'Universite de Montreal
- Saskatchewan
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - Veterans Affairs Medical Center - Birmingham
  - Birmingham, Alabama, Forenede Stater, 35294
    - University of Alabama Comprehensive Cancer Center
  - Huntsville, Alabama, Forenede Stater, 35801
    - Huntsville Hospital System
  - Mobile, Alabama, Forenede Stater, 36688
    - MBCCOP - University of South Alabama
  - Mobile, Alabama, Forenede Stater, 36640
    - Urology Associates - Mobile AL
  - Montgomery, Alabama, Forenede Stater, 36106-2801
    - Alabama Oncology, LLC
  - Tuscallosa, Alabama, Forenede Stater, 35401
    - Radiation Oncology Associates of West Alabama
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Cancer Therapy Center
- Arizona
  - Phoenix, Arizona, Forenede Stater, 85001-2071
    - St. Joseph's Hospital and Medical Center
  - Tucson, Arizona, Forenede Stater, 85724
    - Arizona Cancer Center
- California
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center - Burbank
  - Concord, California, Forenede Stater, 94524-4110
    - Mount Diablo Medical Center
  - Fresno, California, Forenede Stater, 93720
    - California Cancer Center
  - Fresno, California, Forenede Stater, 93720
    - Saint Agnes Cancer Center
  - Glendale, California, Forenede Stater, 91204
    - Glendale Memorial Hospital and Health Center
  - Greenbrae, California, Forenede Stater, 94904
    - Sutter Health Western Division Cancer Research Group
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Medical Center
  - Long Beach, California, Forenede Stater, 90822
    - Veterans Affairs Medical Center - Long Beach
  - Los Angeles, California, Forenede Stater, 90033-0800
    - USC/Norris Comprehensive Cancer Center
  - Los Angeles, California, Forenede Stater, 90095-1781
    - Jonsson Comprehensive Cancer Center, UCLA
  - Los Angeles, California, Forenede Stater, 91010
    - Beckman Research Institute, City of Hope
  - Los Angeles, California, Forenede Stater, 90027
    - Kaiser Permanente Medical Center - Los Angeles
  - Martinez, California, Forenede Stater, 94553
    - Veterans Affairs Outpatient Clinic - Martinez
  - Oakland, California, Forenede Stater, 94609-3305
    - CCOP - Bay Area Tumor Institute
  - Pomona, California, Forenede Stater, 91767
    - Cancer Care Center
  - Redding, California, Forenede Stater, 96099-6009
    - Mercy Medical Center - Redding
  - Sacramento, California, Forenede Stater, 95816
    - Radiation Oncology Center - Sacramento
  - San Francisco, California, Forenede Stater, 94115-0128
    - UCSF Cancer Center and Cancer Research Institute
  - San Jose, California, Forenede Stater, 95128
    - O'Connor Hospital
  - Santa Cruz, California, Forenede Stater, 95065
    - Santa Cruz Radiation Oncology Medical Group, Inc.
  - Santa Rosa, California, Forenede Stater, 95403
    - CCOP - Santa Rosa Memorial Hospital
  - Stanford, California, Forenede Stater, 94305
    - Stanford University
  - Travis Air Force Base, California, Forenede Stater, 94535
    - David Grant Medical Center
  - Walnut Creek, California, Forenede Stater, 94598
    - Radiation Oncology Center - Walnut Creek
- Colorado
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - Memorial Hospital Cancer Center
  - Denver, Colorado, Forenede Stater, 80262
    - University of Colorado Cancer Center
- Connecticut
  - Bridgeport, Connecticut, Forenede Stater, 06610
    - Bridgeport Hospital
  - Norwalk, Connecticut, Forenede Stater, 06856
    - Whittingham Cancer Center
- Delaware
  - Wilmington, Delaware, Forenede Stater, 19899
    - CCOP - Christiana Care Health Services
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20307-5000
    - Walter Reed Army Medical Center
- Florida
  - Clearwater, Florida, Forenede Stater, 33757-0210
    - Lykes Center for Radiation Therapy
  - Daytona Beach, Florida, Forenede Stater, 32114
    - Halifax Medical Center
  - Fort Myers, Florida, Forenede Stater, 33901
    - Radiation Therapy Associates - Fort Myers
  - Gainesville, Florida, Forenede Stater, 32610-0296
    - University of Florida Health Science Center
  - Melbourne, Florida, Forenede Stater, 32901
    - Health First Holmes Regional Medical Center
  - Miami, Florida, Forenede Stater, 33136
    - Sylvester Cancer Center, University of Miami
  - Miami, Florida, Forenede Stater, 33176-2197
    - Baptist Hospital of Miami
  - Miami Beach, Florida, Forenede Stater, 33140
    - CCOP - Mount Sinai Medical Center
  - Orange Park, Florida, Forenede Stater, 32073
    - Florida Radiation Oncology Group
  - Orlando, Florida, Forenede Stater, 32806
    - MD Anderson Cancer Center Orlando
  - Panama City, Florida, Forenede Stater, 32405-4587
    - Gulf Coast Cancer Treatment Center
  - Pensacola, Florida, Forenede Stater, 32514
    - West Florida Cancer Institute - Pensacola
  - Saint Petersburg, Florida, Forenede Stater, 33701
    - Bayfront Medical Center
  - Sarasota, Florida, Forenede Stater, 34233
    - Sarasota Radiation and Medical Oncology Center
  - Tampa, Florida, Forenede Stater, 33612
    - H. Lee Moffitt Cancer Center and Research Institute
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital - Atlanta
  - Atlanta, Georgia, Forenede Stater, 30342-1701
    - CCOP - Atlanta Regional
  - Columbus, Georgia, Forenede Stater, 31902
    - Medical Center/John B. Amos Community Cancer Center
  - Rome, Georgia, Forenede Stater, 30161
    - InterCommunity Cancer Center at Rome
  - Valdosta, Georgia, Forenede Stater, 31603
    - South Georgia Medical Center
- Illinois
  - Arlington Heights, Illinois, Forenede Stater, 60005
    - Northwest Community Hospital
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Cancer Research Center
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - Park Ridge, Illinois, Forenede Stater, 60068
    - Lutheran General Cancer Care Center
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Springfield, Illinois, Forenede Stater, 62526
    - CCOP - Central Illinois
  - Urbana, Illinois, Forenede Stater, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Anderson, Indiana, Forenede Stater, 46016
    - St. John's Medical Center
  - Indianapolis, Indiana, Forenede Stater, 46206-1367
    - Clarion Health Partners Inc.
  - Indianapolis, Indiana, Forenede Stater, 46219
    - Community Hospitals of Indianapolis - Regional Cancer Center
  - Muncie, Indiana, Forenede Stater, 47303-3499
    - Ball Memorial Hospital
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46617
    - St. Joseph's Radiation Oncology Center
- Iowa
  - Dubuque, Iowa, Forenede Stater, 52001
    - Wendt Regional Cancer Center of Finley Hospital
  - Iowa City, Iowa, Forenede Stater, 52242
    - University of Iowa Hospitals and Clinics
- Kentucky
  - Bowling Green, Kentucky, Forenede Stater, 42102
    - Medical Center at Bowling Green
  - Lexington, Kentucky, Forenede Stater, 40511-1093
    - Veterans Affairs Medical Center - Lexington
  - Lexington, Kentucky, Forenede Stater, 40536-0084
    - Albert B. Chandler Medical Center, University of Kentucky
  - Louisville, Kentucky, Forenede Stater, 40202
    - James Graham Brown Cancer Center
  - Louisville, Kentucky, Forenede Stater, 40215
    - Louisville Radiation Oncology
  - Madisonville, Kentucky, Forenede Stater, 42431
    - Merle M. Mahr Cancer Center
  - Paducah, Kentucky, Forenede Stater, 42001
    - Western Baptist Hospital
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Lafayette, Louisiana, Forenede Stater, 70501
    - Romagosa Radiation Oncology Center
  - Metairie, Louisiana, Forenede Stater, 70011
    - East Jefferson General Hospital
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Tulane University School of Medicine
  - New Orleans, Louisiana, Forenede Stater, 70112
    - MBCCOP - LSU Medical Center
  - New Orleans, Louisiana, Forenede Stater, 70121
    - CCOP - Ochsner
- Maine
  - Portland, Maine, Forenede Stater, 04102
    - Maine Medical Center
- Maryland
  - Annapolis, Maryland, Forenede Stater, 21401
    - Anne Arundel Oncology Center
  - Baltimore, Maryland, Forenede Stater, 21201
    - Marlene & Stewart Greenebaum Cancer Center, University of Maryland
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center and Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21225
    - Harbor Hospital Center
  - Baltimore, Maryland, Forenede Stater, 21237
    - Radiation Oncology Affiliates of Maryland, P.A.
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins Oncology Center
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02114
    - Massachusetts General Hospital Cancer Center
  - Boston, Massachusetts, Forenede Stater, 02215
    - Joint Center for Radiation Therapy
  - Hyannis, Massachusetts, Forenede Stater, 02601
    - Cape Cod Hospital
  - Jamaica Plain, Massachusetts, Forenede Stater, 02130
    - Veterans Affairs Medical Center - Boston (Jamaica Plain)
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48109-0752
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48105
    - Veterans Affairs Medical Center - Ann Arbor
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - CCOP - Ann Arbor Regional
  - Detroit, Michigan, Forenede Stater, 48201
    - Barbara Ann Karmanos Cancer Institute
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48432
    - McLaren Regional Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007-3731
    - CCOP - Kalamazoo
  - Lansing, Michigan, Forenede Stater, 48909
    - Sparrow Regional Cancer Center
  - Marquette, Michigan, Forenede Stater, 49855
    - Marquette General Hospital
  - Midland, Michigan, Forenede Stater, 48670
    - MidMichigan Regional Medical Center
  - Saginaw, Michigan, Forenede Stater, 48601
    - St. Mary's Medical Center
- Minnesota
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic Cancer Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - CCOP - Metro-Minnesota
- Missouri
  - Columbia, Missouri, Forenede Stater, 65203
    - Ellis Fischel Cancer Center - Columbia
  - Kansas City, Missouri, Forenede Stater, 64131
    - CCOP - Kansas City
  - Saint Louis, Missouri, Forenede Stater, 63110-0250
    - St. Louis University Health Sciences Center
  - Saint Louis, Missouri, Forenede Stater, 63106
    - Veterans Affairs Medical Center - Saint Louis
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Mallinckrodt Institute of Radiology
  - Springfield, Missouri, Forenede Stater, 65807
    - CCOP - Cancer Research for the Ozarks
  - Springfield, Missouri, Forenede Stater, 65807
    - Cancer Research for the Ozarks
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - CCOP - Montana Cancer Consortium
- Nebraska
  - Omaha, Nebraska, Forenede Stater, 68114
    - Methodist Cancer Center - Omaha
  - Omaha, Nebraska, Forenede Stater, 68131
    - CCOP - Missouri Valley Cancer Consortium
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - CCOP - Southern Nevada Cancer Research Foundation
- New Hampshire
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Norris Cotton Cancer Center
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Elliot Regional Cancer Center
- New Jersey
  - East Orange, New Jersey, Forenede Stater, 07018-1095
    - Veterans Affairs Medical Center - East Orange
  - Edison, New Jersey, Forenede Stater, 08818
    - John F. Kennedy Medical Center
  - Elizabeth, New Jersey, Forenede Stater, 07201
    - Trinitas Hosptial - Jersey Street Campus
  - Millville, New Jersey, Forenede Stater, 08332
    - South Jersey Hospital - Millville
  - Mount Holly, New Jersey, Forenede Stater, 08060
    - Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Toms River, New Jersey, Forenede Stater, 08755
    - Community Medical Center
  - Trenton, New Jersey, Forenede Stater, 08629
    - St. Francis Medical Center
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - Saint Joseph Medical Center
- New York
  - Albany, New York, Forenede Stater, 12208
    - Cancer Center of Albany Medical Center
  - Albany, New York, Forenede Stater, 12208
    - Veterans Affairs Medical Center - Albany
  - Bronx, New York, Forenede Stater, 10461
    - Albert Einstein Comprehensive Cancer Center
  - Brooklyn, New York, Forenede Stater, 11203
    - State University of New York Health Science Center at Brooklyn
  - Brooklyn, New York, Forenede Stater, 11215-3609
    - New York Methodist Hospital
  - Buffalo, New York, Forenede Stater, 14263-0001
    - Roswell Park Cancer Institute
  - Clifton Springs, New York, Forenede Stater, 14432
    - Finger Lakes Radiation Oncology, P.C.
  - Manhasset, New York, Forenede Stater, 11030
    - CCOP - North Shore University Hospital
  - New York, New York, Forenede Stater, 10021
    - Memorial Sloan-Kettering Cancer Center
  - New York, New York, Forenede Stater, 10003
    - Beth Israel Medical Center
  - New York, New York, Forenede Stater, 10016
    - Kaplan Cancer Center
  - Plattsburgh, New York, Forenede Stater, 12901
    - Champlain Valley Physicians Hospital Medical Center
  - Poughkeepsie, New York, Forenede Stater, 12601
    - Vassar Brothers Hospital
  - Rochester, New York, Forenede Stater, 14607
    - Genesee Hospital - Rochester
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester Cancer Center
  - Valhalla, New York, Forenede Stater, 10595
    - New York Medical College
- North Carolina
  - Chapel Hill, North Carolina, Forenede Stater, 27599-7295
    - Lineberger Comprehensive Cancer Center, UNC
  - Concord, North Carolina, Forenede Stater, 28025
    - Northeast Medical Center
  - Greenville, North Carolina, Forenede Stater, 27858-4354
    - East Carolina University School of Medicine
  - Hickory, North Carolina, Forenede Stater, 28601
    - Catawba Memorial Hospital
  - Winston-Salem, North Carolina, Forenede Stater, 27104-4241
    - CCOP - Southeast Cancer Control Consortium
  - Winston-Salem, North Carolina, Forenede Stater, 27157-1082
    - Comprehensive Cancer Center of Wake Forest University Baptist Medical Center
- North Dakota
  - Fargo, North Dakota, Forenede Stater, 58122
    - Meritcare Roger Maris Cancer Center
  - Minot, North Dakota, Forenede Stater, 58701
    - UNI-MED Medical Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44302
    - Akron General Medical Center
  - Akron, Ohio, Forenede Stater, 44309
    - Akron City Hospital
  - Cincinnati, Ohio, Forenede Stater, 45219
    - Christ Hospital
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Cancer Center
  - Cleveland, Ohio, Forenede Stater, 44106
    - University Hospitals of Cleveland
  - Cleveland, Ohio, Forenede Stater, 44106-5065
    - Ireland Cancer Center
  - Columbus, Ohio, Forenede Stater, 43206
    - CCOP - Columbus
  - Columbus, Ohio, Forenede Stater, 43210
    - Arthur G. James Cancer Hospital - Ohio State University
  - Dayton, Ohio, Forenede Stater, 45428
    - Veterans Affairs Medical Center - Dayton
  - Kettering, Ohio, Forenede Stater, 45429
    - CCOP - Dayton
  - Toledo, Ohio, Forenede Stater, 43623-3456
    - CCOP - Toledo Community Hospital Oncology Program
- Oklahoma
  - Tulsa, Oklahoma, Forenede Stater, 74104
    - St. John Medical Center
- Oregon
  - Corvallis, Oregon, Forenede Stater, 97339
    - Samaritan Regional Cancer Center
  - Portland, Oregon, Forenede Stater, 97213
    - CCOP - Columbia River Program
- Pennsylvania
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - St. Luke's Hospital Regional Cancer Center
  - Danville, Pennsylvania, Forenede Stater, 17822-2001
    - Penn State Geisinger Medical Center
  - Darby, Pennsylvania, Forenede Stater, 19023
    - Mercy Catholic Medical Center, Mercy Fitzgerald Divison
  - Drexel Hill, Pennsylvania, Forenede Stater, 19026
    - Delaware County Memorial Hospital
  - Hershey, Pennsylvania, Forenede Stater, 17033
    - Penn State Geisinger Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19102-1192
    - Allegheny University Hospitals- Hahnemann
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - Veterans Affairs Medical Center - Philadelphia
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
  - Philadelphia, Pennsylvania, Forenede Stater, 19141
    - Albert Einstein Cancer Center
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - Western Pennsylvania Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - University of Pittsburgh Cancer Institute
  - Pittsburgh, Pennsylvania, Forenede Stater, 15219
    - Mercy Hospital of Pittsburgh
  - Reading, Pennsylvania, Forenede Stater, 19612-6052
    - Reading Hospital and Medical Center
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - Mercy Hospital Cancer Center - Scranton
  - Sellersville, Pennsylvania, Forenede Stater, 18960
    - Grand View Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18764
    - Wilkes Barre General Hospital
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - CCOP - MainLine Health
  - York, Pennsylvania, Forenede Stater, 17315
    - York Hospital
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02908-4735
    - Roger Williams Medical Center/BUSM
- South Carolina
  - Charleston, South Carolina, Forenede Stater, 29425-0721
    - Medical University of South Carolina
  - Greenville, South Carolina, Forenede Stater, 29615
    - CCOP - Greenville
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - CCOP - Upstate Carolina
- Tennessee
  - Jackson, Tennessee, Forenede Stater, 38301
    - Jackson-Madison County General Hospital
  - Knoxville, Tennessee, Forenede Stater, 37901
    - Baptist Regional Cancer Center - Knoxville
  - Memphis, Tennessee, Forenede Stater, 38117
    - CCOP - Baptist Cancer Institute
  - Memphis, Tennessee, Forenede Stater, 38163
    - University of Tennessee, Memphis Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37232-6838
    - Vanderbilt Cancer Center
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - Harrington Cancer Center
  - Beaumont, Texas, Forenede Stater, 77701
    - Julie and Ben Rogers Cancer Institute
  - Galveston, Texas, Forenede Stater, 77555-1329
    - University of Texas Medical Branch
  - Houston, Texas, Forenede Stater, 77030
    - University of Texas - MD Anderson Cancer Center
  - Lackland Air Force Base, Texas, Forenede Stater, 78236-5300
    - Wilford Hall - 59th Medical Wing
  - Lubbock, Texas, Forenede Stater, 79410-1894
    - Joe Arrington Cancer Research and Treatment Center
  - Pasadena, Texas, Forenede Stater, 77504
    - Bayshore Medical Center
  - Tyler, Texas, Forenede Stater, 75701
    - East Texas Medical Center - Cancer Institute
- Utah
  - Saint George, Utah, Forenede Stater, 84770
    - Dixie Regional Medical Center
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
- Vermont
  - Bennington, Vermont, Forenede Stater, 05201
    - CCOP - Southwestern Vermont Regional Cancer Center
  - Burlington, Vermont, Forenede Stater, 05401-3498
    - Vermont Cancer Center
  - Rutland, Vermont, Forenede Stater, 05701
    - Green Mountain Oncology Group
  - White River Junction, Vermont, Forenede Stater, 05009
    - Veterans Affairs Medical Center - White River Junction
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22901
    - Martha Jefferson Hospital
  - Charlottesville, Virginia, Forenede Stater, 22908
    - Cancer Center, University of Virginia HSC
  - Lynchburg, Virginia, Forenede Stater, 24503
    - Virginia Baptist Hospital
  - Portsmouth, Virginia, Forenede Stater, 23708-2197
    - Naval Medical Center, Portsmouth
  - Richmond, Virginia, Forenede Stater, 23298-0037
    - Massey Cancer Center
- Washington
  - Seattle, Washington, Forenede Stater, 98104
    - Swedish Cancer Institute
  - Seattle, Washington, Forenede Stater, 98111
    - Virginia Mason Medical Center
  - Spokane, Washington, Forenede Stater, 99210-0248
    - Deaconess Medical Center
  - Yakima, Washington, Forenede Stater, 98902
    - Yakima Valley Memorial Hospital
- West Virginia
  - Wheeling, West Virginia, Forenede Stater, 26003
    - Schiffler Oncology Center
- Wisconsin
  - Green Bay, Wisconsin, Forenede Stater, 54307-3508
    - St. Vincent Hospital
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Foundation
  - Madison, Wisconsin, Forenede Stater, 53705
    - Veterans Affairs Medical Center - Madison
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Comprehensive Cancer Center
  - Madison, Wisconsin, Forenede Stater, 53713
    - Southern Wisconsin Radiotherapy Center
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic
  - Menomonee Falls, Wisconsin, Forenede Stater, 53051
    - Community Memorial Hospital
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53210
    - St. Joseph's Hospital
  - Milwaukee, Wisconsin, Forenede Stater, 53211
    - Columbia Hospital
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - St. Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53295
    - Veterans Affairs Medical Center - Milwaukee (Zablocki)
  - Racine, Wisconsin, Forenede Stater, 53405
    - Southeastern Wisconsin Regional Cancer Center
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - Waukesha Memorial Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

SYGDOMSKARAKTERISTIKA: Histopatologisk bekræftet supratentorial glioblastoma multiforme eller gliosarkom Diagnose ved kirurgisk biopsi eller resektion er påkrævet Følgende tumortyper er specifikt udelukket: Astrocytom med atypiske eller anaplastiske træk Veldifferentierede astrocytomer Tumorer, der stammer fra hjernestammen i den optiske tumor1 mm0m. tumorer Multifokalt malignt gliom Tilbagevendende malignt gliom Velomskrevet kontrastforstærkende tumor på præ- og postoperativ kontrastforstærket CT eller MR med en maksimal diameter (i enhver retning) på 40 mm påkrævet Tumorer, der ikke forstærkes ved postoperativ CT eller MR udelukket Samtidig tilmelding på RTOG-9308 opmuntret

PATIENT KARAKTERISTIKA: Alder: 18 og derover Ydeevnestatus: Karnofsky 60-100% Forventet levetid: Mindst 3 måneder Hæmatopoietisk: ANC mindst 1.500 Blodplader mindst 100.000 Hb mindst 10 g/dl (kan give transfusion) Lever: Biliru 2,0 mg/dl SGOT eller SGPT ikke mere end 2 x normal Nyre: Kreatinin ikke større end 1,5 mg/dl BUN ikke større end 25 mg/dl Lunge: Røntgen af thorax normal Hvis unormalt, eller hvis der er en historie med lungesygdom, lungefunktionsundersøgelser (inklusive DLCO) skal være mindst 75 % af forventet Andet: Neurologisk funktionsstatus 0-3 Ingen AIDS Ingen større medicinsk eller psykiatrisk sygdom, der vil udelukke protokolbehandling eller opfølgning Ingen anden malignitet inden for 5 år undtagen: Ikke-melanomatøs hud cancer In situ carcinom i livmoderhalsen

FORUDGÅENDE SAMTYDENDE BEHANDLING: Biologisk terapi: Ikke specificeret Kemoterapi: Ingen forudgående kemoterapi Endokrin terapi: Ikke specificeret Strålebehandling: Ingen forudgående strålebehandling til hoved og nakke Operation: Ikke mere end 5 uger mellem operation og påbegyndelse af behandling Genopretning efter operation og eventuelle postoperative komplikationer påkrævet

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Radiation Therapy Oncology Group

Samarbejdspartnere

National Cancer Institute (NCI)

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Souhami L, Seiferheld W, Brachman D, Podgorsak EB, Werner-Wasik M, Lustig R, Schultz CJ, Sause W, Okunieff P, Buckner J, Zamorano L, Mehta MP, Curran WJ Jr. Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protocol. Int J Radiat Oncol Biol Phys. 2004 Nov 1;60(3):853-60. doi: 10.1016/j.ijrobp.2004.04.011.
Chinnaiyan P, Wang M, Rojiani AM, Tofilon PJ, Chakravarti A, Ang KK, Zhang HZ, Hammond E, Curran W Jr, Mehta MP. The prognostic value of nestin expression in newly diagnosed glioblastoma: report from the Radiation Therapy Oncology Group. Radiat Oncol. 2008 Sep 25;3:32. doi: 10.1186/1748-717X-3-32.
Seiferheld W, Chakravarti A, Ang KK, et al.: Overexpression of the epidermal growth factor receptor (EGFR), as determined by EGFR immunostaining on tissue microarrays, fails to demonstrate prognostic value for patients with glioblastoma multiforme: a report from RTOG 7401, 7918, 8302, 8409, 9006, 9305, 9602, and 9806. [Abstract] Int J Radiat Oncol Biol Phys 54(2 suppl 1): A-166, 616, 2002.
Anker CJ, Hymas RV, Hazard LJ, Boucher KM, Jensen RL, Shrieve DC. Stereotactic radiosurgery eligibility and selection bias in the treatment of glioblastoma multiforme. J Neurooncol. 2010 Jun;98(2):253-63. doi: 10.1007/s11060-010-0176-y. Epub 2010 Apr 10.
Chakravarti A, Seiferheld W, Tu X, Wang H, Zhang HZ, Ang KK, Hammond E, Curran W Jr, Mehta M. Immunohistochemically determined total epidermal growth factor receptor levels not of prognostic value in newly diagnosed glioblastoma multiforme: report from the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 2005 Jun 1;62(2):318-27. doi: 10.1016/j.ijrobp.2004.10.037.
Souhami L, Scott C, Brachman D, et al.: Randomized prospective comparison of stereotactic radiosurgery (SRS) followed by conventional radiotherapy (RT) with BCNU to RT with BCNU alone for selected patients with supratentorial glioblastoma multiforme (GBM): report of RTOG 93-05 protocol. [Abstract] Int J Radiat Oncol Biol Phys 54(2 suppl 1): A-163, 94-95, 2002.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. februar 1994

Primær færdiggørelse (Faktiske)

1. december 2004

Datoer for studieregistrering

Først indsendt

1. november 1999

Først indsendt, der opfyldte QC-kriterier

16. juli 2004

Først opslået (Skøn)

19. juli 2004

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

13. august 2013

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

9. august 2013

Sidst verificeret

1. august 2013

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

RTOG-9305
CDR0000063286

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Tumorer i hjernen og centralnervesystemet

City of Hope Medical Center

Aktiv, ikke rekrutterende

Busulfan, Melphalan, topotecanhydrochlorid og en stamcelletransplantation til behandling af patienter med nyligt diagnosticeret eller recidiverende solid tumor

Uspecificeret fast tumor i barndommen, protokolspecifik | Solid tumor | Ewing Sarkom | Uspecificeret fast tumor hos voksne, protokolspecifik | Tilbagevendende medulloblastom i barndommen | Tilbagevendende Childhood Ependymoma | Tilbagevendende neuroblastom | Tilbagevendende bløddelssarkom hos voksne | Tilbagevendende... og andre forhold

Forenede Stater
National Cancer Institute (NCI)

Afsluttet

Gamma-sekretasehæmmer RO4929097 til behandling af unge patienter med recidiverende eller refraktære solide tumorer, CNS-tumorer, lymfom eller T-celleleukæmi

Uspecificeret fast tumor i barndommen, protokolspecifik | Tilbagevendende medulloblastom i barndommen | Tilbagevendende Childhood Ependymoma | Atypisk teratoid/rhabdoide tumor i barndommen | Tilbagevendende akut lymfatisk leukæmi i barndommen | T-celle stor granulær lymfocytleukæmi | T-celle akut... og andre forhold

Forenede Stater, Canada
National Cancer Institute (NCI)

Afsluttet

Oxaliplatin til behandling af unge patienter med tilbagevendende solide tumorer, der ikke har reageret på tidligere behandling

Tilbagevendende Childhood Ependymoma | Tilbagevendende neuroblastom | Tilbagevendende osteosarkom | Tilbagevendende rhabdomyosarkom i barndommen | Tilbagevendende nyrecellekræft | Tilbagevendende tyktarmskræft | Tilbagevendende endetarmskræft | Tilbagevendende bløddelssarkom i barndommen | Tilbagevendende... og andre forhold

Forenede Stater

Kliniske forsøg med karmustin

Duke University
National Cancer Institute (NCI)

Afsluttet

Gliadel Wafer og O6-Benzylguanine til behandling af patienter med tilbagevendende Glioblastoma Multiforme

Tilbagevendende voksen hjernetumor

Forenede Stater
University of Nebraska

Afsluttet

BEAM+131I-Anti-B1 og autolog hæmatopoietisk stamcelletransplantation for recidiverende non-Hodgkins lymfom

Lymfom

Forenede Stater
National Cancer Institute (NCI)

Afsluttet

O6-benzylguanin og topisk karmustin til behandling af patienter med tidligt stadium IA-IIA kutan T-celle lymfom

Tilbagevendende primær kutan T-celle non-Hodgkin lymfom | Stage I Mycosis Fungoides og Sezary Syndrome AJCC v7 | Stage II Mycosis Fungoides og Sezary Syndrome AJCC v7

Forenede Stater
Memorial Sloan Kettering Cancer Center
Sanofi; Columbia University; Medical College of Wisconsin; University of Rochester og andre samarbejdspartnere

Aktiv, ikke rekrutterende

Undersøgelse af indvirkningen af CD34+ celledosis på absolut lymfocyttal efter højdosisterapi og autolog stamcelletransplantation for recidiverende og refraktært diffust stort B-cellet lymfom (DLBCL)

Diffust storcellet B-celle lymfom (DLBCL) | Recidiverende diffust stort B-cellet lymfom (DLBCL) | Refraktært diffust stort B-cellet lymfom (DLBCL)

Forenede Stater
University of Nebraska
Millennium Pharmaceuticals, Inc.

Afsluttet

VELCADE®-BEAM og autolog hæmatopoietisk stamcelletransplantation for non-Hodgkins lymfom eller mantelcellelymfom

Mantelcellelymfom | Non-hodgkins lymfom

Forenede Stater
National Institute of Allergy and Infectious Diseases...
Immune Tolerance Network (ITN)

Afsluttet

Højdosis immunosuppression og autolog transplantation for multipel sklerose (HALT MS) undersøgelse

Recidiverende-remitterende multipel sklerose

Forenede Stater
National Research Center for Hematology, Russia

Rekruttering

RL-MPV efterfulgt af BBC HCT ved brug af autologe stamceller og vedligeholdelsesterapi med nivolumab til nydiagnosticeret PCNSL

Primært CNS lymfom

Den Russiske Føderation
Thomas Jefferson University

Rekruttering

Transarteriel kemoembolisering til behandling af uveal melanom med levermetastaser

Metastatisk uveal melanom | Metastatisk malign neoplasma i leveren | Stadie IV Choroidal og ciliær kropsmelanom AJCC V8

Forenede Stater
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Trukket tilbage

HIV-resistente genmodificerede stamceller og kemoterapi til behandling af patienter med lymfom med HIV-infektion

Stadie III voksen Hodgkin lymfom | Stadie IV voksen Hodgkin lymfom | Humant immundefektvirus 1 positiv | Stadie I voksen Hodgkin lymfom | Stadie II voksen Hodgkin lymfom | Stadie I Voksen non-Hodgkin lymfom | Fase II Voksen non-Hodgkin lymfom | Stadie III Voksen non-Hodgkin lymfom | Stadie IV Voksen non-Hodgkin...

Forenede Stater
Fred Hutchinson Cancer Center

Afsluttet

O6-benzylguanin-medieret tumorsensibilisering med kemobeskyttet autolog stamcelle ved behandling af patienter med maligne gliomer

Glioblastom | Gliosarkom

Forenede Stater

Stråleterapi plus kemoterapi til behandling af patienter med supratentorial glioblastoma multiforme

ET FASE III FORSØG, DER SAMMENLIGNER BRUG AF RADIOSIRURGI EFTERFØLGET AF konventionel RADIOTERAPI MED BCNU TIL konventionel RADIOTERAPI MED BCNU TIL SUPRATENTORIAL GLIOBLASTOMA MULTIFORME

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Forventet)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart

Primær færdiggørelse (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Tumorer i hjernen og centralnervesystemet

Kliniske forsøg med karmustin

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Lebanon

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer