Fire versus seks cyklusser af cyclophosphamid/doxorubicin eller paclitaxel i adjuverende brystkræft
12. april 2017 opdateret af: Alliance for Clinical Trials in Oncology
Cyclophosphamid og doxorubicin (CA) (4 versus 6 cyklusser) versus paclitaxel (4 vs 6 cyklusser) som adjuverende terapi for brystkræft hos kvinder med 0-3 positive aksillære lymfeknuder: En 2X2 faktoriel fase III randomiseret undersøgelse
Dette randomiserede fase III-studie undersøger cyclophosphamid og doxorubicinhydrochlorid sammenlignet med paclitaxel som adjuverende behandling til behandling af brystkræft hos kvinder med 0-3 positive aksillære lymfeknuder.
At give yderligere kræftbehandling efter operationen kan være med til at mindske risikoen for, at kræften vender tilbage (adjuverende behandling).
Lægemidler, der bruges i kemoterapi, såsom cyclophosphamid, doxorubicin hydrochlorid og paclitaxel, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig.
Det vides endnu ikke, om standard adjuverende behandling af cyclophosphamid og doxorubicinhydrochlorid er mere effektiv end paclitaxel til behandling af kvinder med brystkræft
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
PRIMÆRE MÅL:
I. At bestemme ækvivalensen af paclitaxel givet hver anden uge med cyclophosphamid og doxorubicin hydrochlorid (CA) givet hver anden uge som adjuverende terapi til kvinder med 0-3 positive aksillære lymfeknuder, for sygdomsfri overlevelse.
II. For at bestemme, om længere terapi, 12 uger, er bedre end kortere terapi, 8 uger, med enten CA eller paclitaxel for sygdomsfri overlevelse for kvinder med primær brystkræft med 0-3 positive aksillære lymfeknuder.
SEKUNDÆRE MÅL:
I. At bestemme ækvivalensen af paclitaxel givet hver anden uge med CA givet hver anden uge, og den potentielle overlegenhed af længere versus kortere behandling i forhold til samlet overlevelse, lokal kontrol (uanset metastatisk status) og tid til fjernmetastaser ( uanset lokal gentagelsesstatus).
II. At sammenligne toksicitet af kort- og langtids-CA og paclitaxel som adjuverende terapi for kvinder med 0-3 positiv aksillær lymfeknude brystcancer.
III. At bestemme effekten af lang og kort forløb CA og paclitaxel på induktion af overgangsalderen for præmenopausale patienter.
IV. At vurdere uoverensstemmelsen mellem myelosuppression blandt de almindelige multilægemiddelresistens protein 1 (MDR1) haplotyper i CA-behandlingsarmen.
V. At vurdere effekten af MDR1-haplotyper på sygdomsfri overlevelse (DFS) justeret for behandling.
VI. Eksploratorisk analyse af effekten af cytokrom P450, familie 3, underfamilie A, polypeptid 5 (CYP3A5), cytokrom P450, familie 2, underfamilie C, polypeptid 8 (CYP2C8) og cytokrom P450, familie 2, underfamilie B, polypeptid 6 (CYP2B6) ) polymorfismer på DFS og toksicitet.
VII. At identificere genetiske markører forbundet med risikoen for at udvikle neutropeni hos adriamycin/cyclophosphamid-behandlede brystkræftpatienter.
VIII. At identificere genetiske markører forbundet med risikoen for at udvikle perifer neuropati hos paclitaxel-behandlede brystkræftpatienter.
IX. At identificere genetiske markører forbundet med forskelle i effektiviteten af hvert kemoterapiregime.
X. At undersøge genetiske associationer med andre respons- og toksicitetsfænotyper, der bliver tydelige under fremtidig analyse af kræft- og leukæmigruppe B (CALGB) 40101-data.
XI. At identificere kopinummervarianter forbundet med adriamycin/cyclophosphamid-induceret neutropeni og paclitaxel-induceret perifer neuropati.
OVERSIGT: Patienterne randomiseres til 1 ud af 4 behandlingsarme.
ARM I: Patienter får cyclophosphamid intravenøst (IV) og doxorubicin hydrochlorid IV på dag 1. Behandlingen gentages hver 14. dag i 4 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
ARM II: Patienter får cyclophosphamid IV og doxorubicin hydrochlorid IV på dag 1. Behandlingen gentages hver 14. dag i 6 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
ARM III: Patienter får paclitaxel IV over 3 timer på dag 1. Behandlingen gentages hver 14. dag i 4 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
ARM IV: Patienter får paclitaxel IV over 3 timer på dag 1. Behandlingen gentages hver 14. dag i 6 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
Bemærk: Randomisering til arme II og IV er ikke længere tilgængelig, med virkning fra 15/12/2007.
Efter afslutning af studiebehandlingen følges patienterne op i 4-6 uger, hver 6. måned i 2 år og derefter årligt i op til 13 år.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
3871
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Anniston, Alabama, Forenede Stater, 36202
- Regional Medical Center
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Birmingham, Alabama, Forenede Stater, 35294
- UAB Comprehensive Cancer Center
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Mobile, Alabama, Forenede Stater, 36608
- Providence Cancer Center at Providence Hospital
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Alaska
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Fairbanks, Alaska, Forenede Stater, 99701
- Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
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Arizona
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Scottsdale, Arizona, Forenede Stater, 85259-5499
- Mayo Clinic Scottsdale
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Arkansas
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Ft. Smith, Arkansas, Forenede Stater, 72903
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
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California
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Comprehensive Cancer Center
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Burlingame, California, Forenede Stater, 94010
- Peninsula Medical Center
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Castro Valley, California, Forenede Stater, 94546
- East Bay Radiation Oncology Center
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Castro Valley, California, Forenede Stater, 94546
- Valley Medical Oncology Consultants - Castro Valley
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Fremont, California, Forenede Stater, 94538
- Valley Medical Oncology
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Fremont, California, Forenede Stater, 94538
- Washington Township Hospital
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Fresno, California, Forenede Stater, 93720
- Cancer Care Associates
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Fresno, California, Forenede Stater, 93720
- California Cancer Center - Woodward Park Office
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Greenbrae, California, Forenede Stater, 94904
- Marin Cancer Institute at Marin General Hospital
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La Jolla, California, Forenede Stater, 92093-0658
- Rebecca and John Moores UCSD Cancer Center
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Los Angeles, California, Forenede Stater, 90089-9181
- USC/Norris Comprehensive Cancer Center and Hospital
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Marysville, California, Forenede Stater, 95901
- Tibotec Therapeutics - Division of Ortho Biotech Products, LP
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Oakland, California, Forenede Stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forenede Stater, 94602
- Highland General Hospital
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Oakland, California, Forenede Stater, 94609
- CCOP - Bay Area Tumor Institute
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Oakland, California, Forenede Stater, 94609
- Bay Area Breast Surgeons, Incorporated
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Oakland, California, Forenede Stater, 94609
- Tom K Lee, Incorporated
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Pleasanton, California, Forenede Stater, 94588
- Valley Care Medical Center
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Pleasanton, California, Forenede Stater, 94588
- Valley Medical Oncology Consultants - Pleasanton
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Redding, California, Forenede Stater, 96049
- Mercy Regional Cancer Center at Mercy Medical Center
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Sacramento, California, Forenede Stater, 95817
- University of California Davis Cancer Center
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San Diego, California, Forenede Stater, 92134
- Naval Medical Center - San Diego
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San Francisco, California, Forenede Stater, 94118
- California Pacific Medical Center - California Campus
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San Pablo, California, Forenede Stater, 94806
- Doctors Medical Center - San Pablo Campus
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San Rafael, California, Forenede Stater, 94903
- Sutter Health - Western Division Cancer Research Group
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Truckee, California, Forenede Stater, 96161
- Tahoe Forest Cancer Center
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Colorado
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Aurora, Colorado, Forenede Stater, 80012
- Aurora Presbyterian Hospital
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Boulder, Colorado, Forenede Stater, 80301-9019
- Boulder Community Hospital
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Colorado Springs, Colorado, Forenede Stater, 80933
- Penrose Cancer Center at Penrose Hospital
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Colorado Springs, Colorado, Forenede Stater, 80909
- Memorial Hospital Cancer Center - Colorado Springs
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - St. Luke's Medical Center
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Denver, Colorado, Forenede Stater, 80204
- St. Anthony Central Hospital
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Denver, Colorado, Forenede Stater, 80218
- St. Joseph Hospital
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Denver, Colorado, Forenede Stater, 80224-2522
- CCOP - Colorado Cancer Research Program
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Englewood, Colorado, Forenede Stater, 80110
- Swedish Medical Center
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Grand Junction, Colorado, Forenede Stater, 81502
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
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Greeley, Colorado, Forenede Stater, 80631
- North Colorado Medical Center
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Longmont, Colorado, Forenede Stater, 80501
- Hope Cancer Care Center at Longmont United Hospital
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Loveland, Colorado, Forenede Stater, 80539
- McKee Medical Center
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Pueblo, Colorado, Forenede Stater, 81004
- St. Mary - Corwin Regional Medical Center
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Thornton, Colorado, Forenede Stater, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, Forenede Stater, 80033
- Exempla Lutheran Medical Center
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Connecticut
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Hartford, Connecticut, Forenede Stater, 06105
- Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
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Hartford, Connecticut, Forenede Stater, 06102-5037
- Helen and Harry Gray Cancer Center at Hartford Hospital
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Norwich, Connecticut, Forenede Stater, 06360
- Eastern Connecticut Hematology and Oncology Associates
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Delaware
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Lewes, Delaware, Forenede Stater, 19958
- Tunnell Cancer Center at Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19713
- CCOP - Christiana Care Health Services
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20016
- Sibley Memorial Hospital
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Washington, District of Columbia, Forenede Stater, 20307-5001
- Walter Reed Army Medical Center
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Florida
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Daytona Beach, Florida, Forenede Stater, 32114
- Herbert D. Kerman Regional Oncology Center - Daytona Beach
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
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Gainesville, Florida, Forenede Stater, 32610-0232
- University of Florida Shands Cancer Center
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Hollywood, Florida, Forenede Stater, 33021
- Memorial Cancer Institute at Memorial Regional Hospital
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Jacksonville, Florida, Forenede Stater, 32224
- Mayo Clinic - Jacksonville
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Jupiter, Florida, Forenede Stater, 33458
- Ella Milbank Foshay Cancer Center at Jupiter Medical Center
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Lakeland, Florida, Forenede Stater, 33805
- Lakeland Regional Cancer Center at Lakeland Regional Medical Center
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Lakeland, Florida, Forenede Stater, 33805
- Center for Cancer Care and Research at Watson Clinic, LLP
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Miami Beach, Florida, Forenede Stater, 33140
- CCOP - Mount Sinai Medical Center
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Orange Park, Florida, Forenede Stater, 32073
- Integrated Community Oncology Network - Orange Park
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Orlando, Florida, Forenede Stater, 32803-1273
- Florida Hospital Cancer Institute at Florida Hospital Orlando
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West Palm Beach, Florida, Forenede Stater, 33401
- Palm Beach Cancer Institute - West Palm Beach
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Georgia
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Columbus, Georgia, Forenede Stater, 31904
- John B. Amos Cancer Center
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Gainesville, Georgia, Forenede Stater, 30501
- Northeast Georgia Medical Center
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Macon, Georgia, Forenede Stater, 31208
- Medical Center of Central Georgia
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Savannah, Georgia, Forenede Stater, 31403-3089
- Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
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Savannah, Georgia, Forenede Stater, 31405
- Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
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Idaho
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Boise, Idaho, Forenede Stater, 83712
- Mountain States Tumor Institute at St. Luke's Regional Medical Center
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Illinois
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Alton, Illinois, Forenede Stater, 62002
- Saint Anthony's Hospital at Saint Anthony's Health Center
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Aurora, Illinois, Forenede Stater, 60504
- Rush-Copley Cancer Care Center
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Chicago, Illinois, Forenede Stater, 60611-3013
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
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Chicago, Illinois, Forenede Stater, 60612-7243
- University of Illinois Cancer Center
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Chicago, Illinois, Forenede Stater, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, Forenede Stater, 60625
- Swedish Covenant Hospital
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Chicago, Illinois, Forenede Stater, 60611
- Hematology and Oncology Associates
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Chicago, Illinois, Forenede Stater, 60657
- Creticos Cancer Center at Advocate Illinois Masonic Medical Center
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital Cancer Care Institute
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Elk Grove Village, Illinois, Forenede Stater, 60007
- Alexian Brothers Radiation Oncology
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Evanston, Illinois, Forenede Stater, 60202
- St. Francis Hospital
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Harvey, Illinois, Forenede Stater, 60426
- Ingalls Cancer Care Center at Ingalls Memorial Hospital
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Joliet, Illinois, Forenede Stater, 60435
- Joliet Oncology-Hematology Associates, Limited - West
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Joliet, Illinois, Forenede Stater, 60432
- Midwest Center for Hematology/Oncology
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Kankakee, Illinois, Forenede Stater, 60901
- Provena St. Mary's Regional Cancer Center - Kankakee
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Maywood, Illinois, Forenede Stater, 60153
- Cardinal Bernardin Cancer Center at Loyola University Medical Center
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Moline, Illinois, Forenede Stater, 61265
- Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
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Mt. Vernon, Illinois, Forenede Stater, 62864
- Good Samaritan Regional Health Center
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Olympia Fields, Illinois, Forenede Stater, 60461
- Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
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Park Ridge, Illinois, Forenede Stater, 60068-1174
- Advocate Lutheran General Cancer Care Center
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Rockford, Illinois, Forenede Stater, 61104-2315
- Swedish-American Regional Cancer Center
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Rockford, Illinois, Forenede Stater, 61108
- Center for Cancer Care at OSF Saint Anthony Medical Center
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Springfield, Illinois, Forenede Stater, 62781-0001
- Regional Cancer Center at Memorial Medical Center
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Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center at Carle Foundation Hospital
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Urbana, Illinois, Forenede Stater, 61801
- CCOP - Carle Cancer Center
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Indiana
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Beech Grove, Indiana, Forenede Stater, 46107
- St. Francis Hospital and Health Centers - Beech Grove Campus
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Elkhart, Indiana, Forenede Stater, 46515
- Elkhart General Hospital
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Elkhart, Indiana, Forenede Stater, 46514-2098
- Elkhart Clinic, LLC
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Fort Wayne, Indiana, Forenede Stater, 46845
- Fort Wayne Medical Oncology and Hematology
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Kokomo, Indiana, Forenede Stater, 46904
- Howard Community Hospital
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La Porte, Indiana, Forenede Stater, 46350
- Center for Cancer Therapy at LaPorte Hospital and Health Services
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Michigan City, Indiana, Forenede Stater, 46360
- Saint Anthony Memorial Health Centers
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Richmond, Indiana, Forenede Stater, 47374
- Reid Hospital & Health Care Services
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South Bend, Indiana, Forenede Stater, 46601
- Memorial Hospital of South Bend
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South Bend, Indiana, Forenede Stater, 46601
- CCOP - Northern Indiana CR Consortium
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South Bend, Indiana, Forenede Stater, 46617
- Saint Joseph Regional Medical Center
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South Bend, Indiana, Forenede Stater, 46617
- South Bend Clinic
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South Bend, Indiana, Forenede Stater, 46601
- Michiana Hematology-Oncology, PC - South Bend
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Iowa
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Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic, PC
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Bettendorf, Iowa, Forenede Stater, 52722
- Hematology Oncology Associates of the Quad Cities
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Cedar Rapids, Iowa, Forenede Stater, 52402
- St. Luke's Hospital
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Cedar Rapids, Iowa, Forenede Stater, 52403
- Cedar Rapids Oncology Associates
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Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Regional Cancer Center at Mercy Medical Center
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Cedar Rapids, Iowa, Forenede Stater, 52402
- Iowa Blood and Cancer Care
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Council Bluffs, Iowa, Forenede Stater, 51503
- Heartland Oncology and Hematology
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Davenport, Iowa, Forenede Stater, 52803
- Genesis Regional Cancer Center at Genesis Medical Center
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Des Moines, Iowa, Forenede Stater, 50309
- CCOP - Iowa Oncology Research Association
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Des Moines, Iowa, Forenede Stater, 50309
- John Stoddard Cancer Center at Iowa Methodist Medical Center
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Des Moines, Iowa, Forenede Stater, 50309
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center
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Des Moines, Iowa, Forenede Stater, 50314
- Medical Oncology and Hematology Associates at Mercy Cancer Center
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Des Moines, Iowa, Forenede Stater, 50314
- Mercy Cancer Center at Mercy Medical Center - Des Moines
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Des Moines, Iowa, Forenede Stater, 50316
- John Stoddard Cancer Center at Iowa Lutheran Hospital
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Des Moines, Iowa, Forenede Stater, 50307
- Mercy Capitol Hospital
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Iowa City, Iowa, Forenede Stater, 52242-1002
- Holden Comprehensive Cancer Center at University of Iowa
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Kansas
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Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas, PA - Chanute
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Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas, PA - Dodge City
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El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas, PA - El Dorado
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Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
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Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas, PA - Kingman
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Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
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Liberal, Kansas, Forenede Stater, 67901
- Southwest Medical Center
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Newton, Kansas, Forenede Stater, 67114
- Cancer Center of Kansas, PA - Newton
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Overland Park, Kansas, Forenede Stater, 66209
- Menorah Medical Center
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Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas, PA - Parsons
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Pratt, Kansas, Forenede Stater, 67124
- Cancer Center of Kansas, PA - Pratt
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Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas, PA - Salina
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Shawnee Mission, Kansas, Forenede Stater, 66204
- Shawnee Mission Medical Center
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Topeka, Kansas, Forenede Stater, 66606
- Cotton-O'Neil Cancer Center
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Topeka, Kansas, Forenede Stater, 66606
- St. Francis Comprehensive Cancer Center
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Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas, PA - Wellington
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Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas, PA - Medical Arts Tower
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Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas, PA - Wichita
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Wichita, Kansas, Forenede Stater, 67214
- CCOP - Wichita
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Wichita, Kansas, Forenede Stater, 67214
- Via Christi Cancer Center at Via Christi Regional Medical Center
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Wichita, Kansas, Forenede Stater, 67208
- Associates in Womens Health, PA - North Review
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Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas, PA - Winfield
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Kentucky
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Ashland, Kentucky, Forenede Stater, 41101-0151
- Cancer Resource Center at King's Daughters Medical Center
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Louisiana
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Baton Rouge, Louisiana, Forenede Stater, 70809
- Mary Bird Perkins Cancer Center - Baton Rouge
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Baton Rouge, Louisiana, Forenede Stater, 70809
- Ochsner Health Center - Bluebonnet
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Baton Rouge, Louisiana, Forenede Stater, 70806
- Pennington Cancer Center at Baton Rouge General
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Covington, Louisiana, Forenede Stater, 70433
- Ochsner Health Center - Covington
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New Orleans, Louisiana, Forenede Stater, 70121
- CCOP - Ochsner
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New Orleans, Louisiana, Forenede Stater, 70112
- MBCCOP - LSU Health Sciences Center
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New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Cancer Institute at Ochsner Clinic Foundation
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New Orleans, Louisiana, Forenede Stater, 70112
- Medical Center of Louisiana - New Orleans
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Maine
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Augusta, Maine, Forenede Stater, 04330
- Harold Alfond Center for Cancer Care
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Bangor, Maine, Forenede Stater, 04401
- CancerCare of Maine at Eastern Maine Medical Center
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Scarborough, Maine, Forenede Stater, 04074
- Maine Center for Cancer Medicine and Blood Disorders - Scarborough
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Maryland
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Baltimore, Maryland, Forenede Stater, 21231-2410
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
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Baltimore, Maryland, Forenede Stater, 21201
- Greenebaum Cancer Center at University of Maryland Medical Center
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Elkton MD, Maryland, Forenede Stater, 21921
- Union Hospital Cancer Program at Union Hospital
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Frederick, Maryland, Forenede Stater, 21701
- Frederick Memorial Hospital Regional Cancer Therapy Center
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Salisbury, Maryland, Forenede Stater, 21801
- Peninsula Regional Medical Center
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Massachusetts
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Attleboro, Massachusetts, Forenede Stater, 02703
- Sturdy Memorial Hospital
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Boston, Massachusetts, Forenede Stater, 02114
- Massachusetts General Hospital
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Boston, Massachusetts, Forenede Stater, 02115
- Dana-Farber/Brigham and Women's Cancer Center
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Boston, Massachusetts, Forenede Stater, 02115
- Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
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Brighton, Massachusetts, Forenede Stater, 02135-2997
- Caritas St. Elizabeth's Medical Center
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Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Clinic Medical Center - Burlington
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Fall River, Massachusetts, Forenede Stater, 02721
- Hudner Oncology Center at Saint Anne's Hospital - Fall River
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Gloucester, Massachusetts, Forenede Stater, 01930
- Addison Gilbert Hospital
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Hyannis, Massachusetts, Forenede Stater, 02601
- Cape Cod Hospital
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Lowell, Massachusetts, Forenede Stater, 01854
- Lowell General Hospital
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Norwood, Massachusetts, Forenede Stater, 02062
- Caritas Norwood Hospital
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Peabody, Massachusetts, Forenede Stater, 01960
- NSMC Cancer Center - Peabody
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Pittsfield, Massachusetts, Forenede Stater, 01201
- Berkshire Hematology Oncology, PC
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Westfield, Massachusetts, Forenede Stater, 01085
- Noble Hospital
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Worcester, Massachusetts, Forenede Stater, 01655
- UMASS Memorial Cancer Center - University Campus
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Michigan
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Adrian, Michigan, Forenede Stater, 49221
- Hickman Cancer Center at Bixby Medical Center
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Ann Arbor, Michigan, Forenede Stater, 48109-0942
- University Of Michigan Comprehensive Cancer Center
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Ann Arbor, Michigan, Forenede Stater, 48106-0995
- Saint Joseph Mercy Cancer Center
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Ann Arbor, Michigan, Forenede Stater, 48106
- CCOP - Michigan Cancer Research Consortium
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Dearborn, Michigan, Forenede Stater, 48123-2500
- Oakwood Cancer Center at Oakwood Hospital and Medical Center
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Detroit, Michigan, Forenede Stater, 48201-1379
- Barbara Ann Karmanos Cancer Institute
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Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
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Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
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Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Van Elslander Cancer Center at St. John Hospital and Medical Center
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Jackson, Michigan, Forenede Stater, 49201
- Foote Memorial Hospital
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Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
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Kalamazoo, Michigan, Forenede Stater, 49001
- Borgess Medical Center
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Kalamazoo, Michigan, Forenede Stater, 49007-3731
- West Michigan Cancer Center
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Lambertville, Michigan, Forenede Stater, 48144
- Haematology-Oncology Associates of Ohio and Michigan, PC
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Lansing, Michigan, Forenede Stater, 48912-1811
- Sparrow Regional Cancer Center
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Livonia, Michigan, Forenede Stater, 48154
- St. Mary Mercy Hospital
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Monroe, Michigan, Forenede Stater, 48162
- Community Cancer Center of Monroe
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Monroe, Michigan, Forenede Stater, 48162
- Mercy Memorial Hospital - Monroe
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Petoskey, Michigan, Forenede Stater, 49770
- Northern Michigan Hospital
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Pontiac, Michigan, Forenede Stater, 48341-2985
- St. Joseph Mercy Oakland
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Port Huron, Michigan, Forenede Stater, 48060
- Mercy Regional Cancer Center at Mercy Hospital
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Royal Oak, Michigan, Forenede Stater, 48073
- William Beaumont Hospital - Royal Oak Campus
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Saginaw, Michigan, Forenede Stater, 48601
- Seton Cancer Institute at Saint Mary's - Saginaw
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeside Cancer Specialists, PLLC
-
St. Joseph, Michigan, Forenede Stater, 49085
- Lakeland Regional Cancer Care Center - St. Joseph
-
Warren, Michigan, Forenede Stater, 48093
- St. John Macomb Hospital
-
-
Minnesota
-
Bemidji, Minnesota, Forenede Stater, 56601
- MeritCare Bemidji
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy and Unity Cancer Center at Mercy Hospital
-
Duluth, Minnesota, Forenede Stater, 55805
- CCOP - Duluth
-
Duluth, Minnesota, Forenede Stater, 55805-1983
- Duluth Clinic Cancer Center - Duluth
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller - Dwan Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- St. Luke's Hospital Cancer Care Center
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Fergus Falls Medical Group, PA
-
Fridley, Minnesota, Forenede Stater, 55432
- Mercy and Unity Cancer Center at Unity Hospital
-
Hutchinson, Minnesota, Forenede Stater, 55350
- Hutchinson Area Health Care
-
Mankato, Minnesota, Forenede Stater, 56002
- Immanuel St. Joseph's
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology, PA - Maplewood
-
Maplewood, Minnesota, Forenede Stater, 55109
- HealthEast Cancer Care at St. John's Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55455
- Masonic Cancer Center at University of Minnesota
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center - Minneapolis
-
Robbinsdale, Minnesota, Forenede Stater, 55422-2900
- Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic Cancer Center
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- CentraCare Clinic - River Campus
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- CCOP - Metro-Minnesota
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Cancer Center
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forenede Stater, 55379
- St. Francis Cancer Center at St. Francis Medical Center
-
St. Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital Cancer Care Center
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology, PA - Woodbury
-
-
Mississippi
-
Hattiesburg, Mississippi, Forenede Stater, 39401
- Hattiesburg Clinic, PA at Forrest General
-
Hattiesburg, Mississippi, Forenede Stater, 39402
- Hematology & Oncology Clinic
-
Jackson, Mississippi, Forenede Stater, 39216
- University of Mississippi Cancer Clinic
-
Pascagoula, Mississippi, Forenede Stater, 39581
- Regional Cancer Center at Singing River Hospital
-
-
Missouri
-
Branson, Missouri, Forenede Stater, 65616
- Skaggs Cancer Center at Skaggs Regional Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Chesterfield, Missouri, Forenede Stater, 63017
- Saint Luke's Hospital
-
Columbia, Missouri, Forenede Stater, 65203
- Ellis Fischel Cancer Center at University of Missouri - Columbia
-
Joplin, Missouri, Forenede Stater, 64804
- St. John's Regional Medical Center
-
Kansas City, Missouri, Forenede Stater, 64131
- CCOP - Kansas City
-
Kansas City, Missouri, Forenede Stater, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, Forenede Stater, 64132
- Research Medical Center
-
Kansas City, Missouri, Forenede Stater, 64108
- Truman Medical Center - Hospital Hill
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Cancer Institute at Saint Luke's Hospital
-
Kansas City, Missouri, Forenede Stater, 64114
- St. Joseph Medical Center
-
Kansas City, Missouri, Forenede Stater, 64116
- Parvin Radiation Oncology
-
Kansas City, Missouri, Forenede Stater, 64118
- Heartland Hematology Oncology Associates, Incorporated
-
Saint Joseph, Missouri, Forenede Stater, 64506
- Heartland Regional Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Cancer Center
-
Saint Louis, Missouri, Forenede Stater, 63141
- CCOP - St. Louis-Cape Girardeau
-
Saint Louis, Missouri, Forenede Stater, 63110
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
-
Saint Louis, Missouri, Forenede Stater, 63141
- Arch Medical Services, Incorporated at Center for Cancer Care and Research
-
Saint Louis, Missouri, Forenede Stater, 63109
- Midwest Hematology Oncology Group, Incorporated
-
Saint Louis, Missouri, Forenede Stater, 63141
- David C. Pratt Cancer Center at St. John's Mercy
-
Springfield, Missouri, Forenede Stater, 65802
- CCOP - Cancer Research for the Ozarks
-
Springfield, Missouri, Forenede Stater, 65804
- St. John's Regional Health Center
-
Springfield, Missouri, Forenede Stater, 65807
- Hulston Cancer Center at Cox Medical Center South
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- CCOP - Montana Cancer Consortium
-
Billings, Montana, Forenede Stater, 59101
- Hematology-Oncology Centers of the Northern Rockies - Billings
-
Billings, Montana, Forenede Stater, 59101
- Northern Rockies Radiation Oncology Center
-
Billings, Montana, Forenede Stater, 59101
- St. Vincent Healthcare Cancer Care Services
-
Billings, Montana, Forenede Stater, 59107-7000
- Billings Clinic - Downtown
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Cancer Center
-
Butte, Montana, Forenede Stater, 59701
- St. James Healthcare Cancer Care
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic - Main Facility
-
Great Falls, Montana, Forenede Stater, 59405
-
Great Falls, Montana, Forenede Stater, 59405
- Sletten Cancer Institute at Benefis Healthcare
-
Helena, Montana, Forenede Stater, 59601
- St. Peter's Hospital
-
Kalispell, Montana, Forenede Stater, 59901
- Glacier Oncology, PLLC
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Medical Oncology at KRMC
-
Missoula, Montana, Forenede Stater, 59801
- Community Medical Center
-
Missoula, Montana, Forenede Stater, 59807-7877
- Montana Cancer Specialists at Montana Cancer Center
-
Missoula, Montana, Forenede Stater, 59807
- Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
-
Kearney, Nebraska, Forenede Stater, 68848-1990
- Good Samaritan Cancer Center at Good Samaritan Hospital
-
Lincoln, Nebraska, Forenede Stater, 68510
- Cancer Resource Center - Lincoln
-
North Platte, Nebraska, Forenede Stater, 69103
- Callahan Cancer Center at Great Plains Regional Medical Center
-
Omaha, Nebraska, Forenede Stater, 68198-6805
- UNMC Eppley Cancer Center at the University of Nebraska Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegant Health Cancer Center at Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68131-2197
- Creighton University Medical Center
-
Omaha, Nebraska, Forenede Stater, 68114
- Methodist Estabrook Cancer Center
-
Omaha, Nebraska, Forenede Stater, 68106
- CCOP Missouri Valley Cancer Consortium
-
-
Nevada
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- CCOP - Nevada Cancer Research Foundation
-
-
New Hampshire
-
Concord, New Hampshire, Forenede Stater, 03301
- New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
-
Exeter, New Hampshire, Forenede Stater, 03833
- Center for Cancer Care at Exeter Hospital
-
Hooksett, New Hampshire, Forenede Stater, 03106
- New Hampshire Oncology - Hematology, PA - Hooksett
-
Keene, New Hampshire, Forenede Stater, 03431
- Kingsbury Center for Cancer Care at Cheshire Medical Center
-
Laconia, New Hampshire, Forenede Stater, 03246
- Lakes Region General Hospital
-
Lebanon, New Hampshire, Forenede Stater, 03756-0002
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
-
Londonderry, New Hampshire, Forenede Stater, 03053
- Dana-Farber Cancer Institute at Londonderry
-
Manchester, New Hampshire, Forenede Stater, 03103
- Elliot Regional Cancer Center at Elliot Hospital
-
-
New Jersey
-
Hackensack, New Jersey, Forenede Stater, 07601
- CCOP - Northern New Jersey
-
Morristown, New Jersey, Forenede Stater, 07962
- Carol G. Simon Cancer Center at Morristown Memorial Hospital
-
Newark, New Jersey, Forenede Stater, 07103
- UMDNJ University Hospital
-
Somerville, New Jersey, Forenede Stater, 08876
- Somerset Medical Center
-
Summit, New Jersey, Forenede Stater, 07902
- Overlook Hospital
-
Vineland, New Jersey, Forenede Stater, 08360
- Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
-
Voorhees, New Jersey, Forenede Stater, 08043
- Cancer Institute of New Jersey at Cooper - Voorhees
-
-
New York
-
Bronx, New York, Forenede Stater, 10461
- Albert Einstein Cancer Center at Albert Einstein College of Medicine
-
Bronx, New York, Forenede Stater, 10466
- Our Lady of Mercy Medical Center Comprehensive Cancer Center
-
Buffalo, New York, Forenede Stater, 14263-0001
- Roswell Park Cancer Institute
-
East Syracuse, New York, Forenede Stater, 13057
- CCOP - Hematology-Oncology Associates of Central New York
-
Elmhurst, New York, Forenede Stater, 11373
- Elmhurst Hospital Center
-
Jamaica, New York, Forenede Stater, 11432
- Queens Cancer Center of Queens Hospital
-
New York, New York, Forenede Stater, 10065
- Memorial Sloan-Kettering Cancer Center
-
New York, New York, Forenede Stater, 10029
- Mount Sinai Medical Center
-
New York, New York, Forenede Stater, 10032
- Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
-
Plattsburgh, New York, Forenede Stater, 12901
- Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center
-
Rochester, New York, Forenede Stater, 14642
- James P. Wilmot Cancer Center at University of Rochester Medical Center
-
Rochester, New York, Forenede Stater, 14620
- Highland Hospital of Rochester
-
Rochester, New York, Forenede Stater, 14621
- Lipson Cancer and Blood Center at Rochester General Hospital
-
Stony Brook, New York, Forenede Stater, 11794-9446
- Stony Brook University Cancer Center
-
Syracuse, New York, Forenede Stater, 13210
- SUNY Upstate Medical University Hospital
-
Utica, New York, Forenede Stater, 13502
- Faxton Regional Cancer Center
-
-
North Carolina
-
Asheboro, North Carolina, Forenede Stater, 27203-5400
- Randolph Hospital
-
Burlington, North Carolina, Forenede Stater, 27216
- Alamance Cancer Center at Alamance Regional Medical Center
-
Chapel Hill, North Carolina, Forenede Stater, 27599-7295
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
-
Concord, North Carolina, Forenede Stater, 28025
- Batte Cancer Center at Northeast Medical Center
-
Durham, North Carolina, Forenede Stater, 27710
- Duke Comprehensive Cancer Center
-
Fayetteville, North Carolina, Forenede Stater, 28302-2000
- Cape Fear Valley Medical Center Cancer Center
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Memorial Hospital, Incorporated
-
Greensboro, North Carolina, Forenede Stater, 27403-1198
- Moses Cone Regional Cancer Center at Wesley Long Community Hospital
-
Greenville, North Carolina, Forenede Stater, 27834
- Leo W. Jenkins Cancer Center at ECU Medical School
-
Henderson, North Carolina, Forenede Stater, 27536
- Maria Parham Medical Center
-
Hendersonville, North Carolina, Forenede Stater, 28791
- Pardee Memorial Hospital
-
Kinston, North Carolina, Forenede Stater, 28501
- Kinston Medical Specialists
-
Lumberton, North Carolina, Forenede Stater, 28359
- Southeastern Regional Medical Center
-
Oxford, North Carolina, Forenede Stater, 27565
- Granville Medical Center
-
Raleigh, North Carolina, Forenede Stater, 27609
- Duke Health Raleigh Hospital
-
Reidsville, North Carolina, Forenede Stater, 27320
- Annie Penn Cancer Center
-
Roxboro, North Carolina, Forenede Stater, 27573
- Person Memorial Hospital
-
Statesville, North Carolina, Forenede Stater, 28677
- Iredell Memorial Hospital
-
Washington, North Carolina, Forenede Stater, 27889
- Marion L. Shepard Cancer Center at Beaufort County Hospital
-
Wilmington, North Carolina, Forenede Stater, 28401
- Zimmer Cancer Center at New Hanover Regional Medical Center
-
Winston-Salem, North Carolina, Forenede Stater, 27157-1096
- Wake Forest University Comprehensive Cancer Center
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Bismarck Cancer Center
-
Bismarck, North Dakota, Forenede Stater, 58501
- Medcenter One Hospital Cancer Care Center
-
Bismarck, North Dakota, Forenede Stater, 58501
- Mid Dakota Clinic, PC
-
Bismarck, North Dakota, Forenede Stater, 58502
- St. Alexius Medical Center Cancer Center
-
Fargo, North Dakota, Forenede Stater, 58122
- CCOP - MeritCare Hospital
-
Fargo, North Dakota, Forenede Stater, 58122
- MeritCare Broadway
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Cancer Center at Altru Hospital
-
Minot, North Dakota, Forenede Stater, 58701
- Trinity CancerCare Center
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44309-2090
- Summa Center for Cancer Care at Akron City Hospital
-
Barberton, Ohio, Forenede Stater, 44203
- Barberton Citizens Hospital
-
Bowling Green, Ohio, Forenede Stater, 43402
- Wood County Oncology Center
-
Canton, Ohio, Forenede Stater, 44710-1799
- Aultman Cancer Center at Aultman Hospital
-
Canton, Ohio, Forenede Stater, 44708
- Mercy Cancer Center at Mercy Medical Center
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Taussig Cancer Center
-
Cleveland, Ohio, Forenede Stater, 44106-5065
- Case Comprehensive Cancer Center
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Cancer Care Center at MetroHealth Medical Center
-
Clyde, Ohio, Forenede Stater, 43410
- North Coast Cancer Care - Clyde
-
Columbus, Ohio, Forenede Stater, 43214-3998
- Riverside Methodist Hospital Cancer Care
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health - West Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- CCOP - Columbus
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center Cancer Care
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital at Ohio Health
-
Columbus, Ohio, Forenede Stater, 43210-1240
- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
-
Dayton, Ohio, Forenede Stater, 45405
- Grandview Hospital
-
Dayton, Ohio, Forenede Stater, 45406
- Good Samaritan Hospital
-
Dayton, Ohio, Forenede Stater, 45409
- David L. Rike Cancer Center at Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Samaritan North Cancer Care Center
-
Dayton, Ohio, Forenede Stater, 45420
- CCOP - Dayton
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Medical Associates
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Middletown Regional Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Kettering, Ohio, Forenede Stater, 45429
- Charles F. Kettering Memorial Hospital
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lima, Ohio, Forenede Stater, 45804
- Lima Memorial Hospital
-
Lima, Ohio, Forenede Stater, 45801
- St. Rita's Medical Center
-
Marietta, Ohio, Forenede Stater, 45750
- Strecker Cancer Center at Marietta Memorial Hospital
-
Maumee, Ohio, Forenede Stater, 43537
- St. Luke's Hospital
-
Maumee, Ohio, Forenede Stater, 43537-1839
- Northwest Ohio Oncology Center
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
-
Norwalk, Ohio, Forenede Stater, 44857
- Fisher-Titus Medical Center
-
Oregon, Ohio, Forenede Stater, 43616
- St. Charles Mercy Hospital
-
Oregon, Ohio, Forenede Stater, 43616
- Toledo Clinic - Oregon
-
Sandusky, Ohio, Forenede Stater, 44870
- North Coast Cancer Care, Incorporated
-
Springfield, Ohio, Forenede Stater, 45505
- Community Hospital of Springfield and Clark County
-
Springfield, Ohio, Forenede Stater, 45504
- Mercy Medical Center
-
Sylvania, Ohio, Forenede Stater, 43560
- Flower Hospital Cancer Center
-
Tiffin, Ohio, Forenede Stater, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, Forenede Stater, 43608
- St. Vincent Mercy Medical Center
-
Toledo, Ohio, Forenede Stater, 43606
- Toledo Hospital
-
Toledo, Ohio, Forenede Stater, 43614
- Medical University of Ohio Cancer Center
-
Toledo, Ohio, Forenede Stater, 43617
- CCOP - Toledo Community Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Toledo Clinic, Incorporated - Main Clinic
-
Toledo, Ohio, Forenede Stater, 43623
- St. Anne Mercy Hospital
-
Troy, Ohio, Forenede Stater, 45373-1300
- UVMC Cancer Care Center at Upper Valley Medical Center
-
Wauseon, Ohio, Forenede Stater, 43567
- Fulton County Health Center
-
Westerville, Ohio, Forenede Stater, 43081
- Mount Carmel St. Ann's Cancer Center
-
Wilmington, Ohio, Forenede Stater, 45177
- Clinton Memorial Hospital
-
Wooster, Ohio, Forenede Stater, 44691
- Cleveland Clinic - Wooster
-
Wright-Patterson Afb, Ohio, Forenede Stater, 45433-5529
- United States Air Force Medical Center - Wright-Patterson
-
Xenia, Ohio, Forenede Stater, 45385
- Ruth G. McMillan Cancer Center at Greene Memorial Hospital
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cleo Craig Cancer Research Clinic
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- Oklahoma University Cancer Institute
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Cancer Care Associates - Mercy Campus
-
Tulsa, Oklahoma, Forenede Stater, 74136
- Natalie Warren Bryant Cancer Center at St. Francis Hospital
-
-
Oregon
-
Grants Pass, Oregon, Forenede Stater, 97527
- Three Rivers Community Hospital
-
Gresham, Oregon, Forenede Stater, 97030
- Legacy Mount Hood Medical Center
-
Medford, Oregon, Forenede Stater, 97504
- Dubs Cancer Center at Rogue Valley Medical Center
-
Medford, Oregon, Forenede Stater, 97504
- Providence Cancer Center at PMCC
-
Milwaukie, Oregon, Forenede Stater, 97222
- Providence Milwaukie Hospital
-
Portland, Oregon, Forenede Stater, 97216
- Adventist Medical Center
-
Portland, Oregon, Forenede Stater, 97210
- Legacy Good Samaritan Hospital & Comprehensive Cancer Center
-
Portland, Oregon, Forenede Stater, 97213-2967
- Providence Cancer Center at Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- CCOP - Columbia River Oncology Program
-
Portland, Oregon, Forenede Stater, 97225
- Providence St. Vincent Medical Center
-
Portland, Oregon, Forenede Stater, 97227
- Legacy Emanuel Hospital and Health Center and Children's Hospital
-
Portland, Oregon, Forenede Stater, 97232
- Kaiser Permanente Health Care - Portland
-
Tualatin, Oregon, Forenede Stater, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Cancer Institute at Milton S. Hershey Medical Center
-
Lancaster, Pennsylvania, Forenede Stater, 17604
- Lancaster General Hospital
-
Lewistown, Pennsylvania, Forenede Stater, 17044
- Lewistown Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19111-2497
- Fox Chase Cancer Center - Philadelphia
-
Philadelphia, Pennsylvania, Forenede Stater, 19107-5541
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Joan Karnell Cancer Center at Pennsylvania Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- UPMC Cancer Centers
-
Pittsburgh, Pennsylvania, Forenede Stater, 15212
- Allegheny Cancer Center at Allegheny General Hospital
-
Reading, Pennsylvania, Forenede Stater, 19605
- St. Joseph Medical Center
-
Scranton, Pennsylvania, Forenede Stater, 18501
- Mercy Hospital Cancer Center - Scranton
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Hematology and Oncology Associates of Northeastern Pennsylvania
-
Sellersville, Pennsylvania, Forenede Stater, 18960
- Grand View Hospital
-
State College, Pennsylvania, Forenede Stater, 16803
- Mount Nittany Medical Center
-
-
Rhode Island
-
Pawtucket, Rhode Island, Forenede Stater, 02860
- Memorial Hospital of Rhode Island
-
Providence, Rhode Island, Forenede Stater, 02906
- Miriam Hospital
-
Providence, Rhode Island, Forenede Stater, 02903
- Rhode Island Hospital Comprehensive Cancer Center
-
Warwick, Rhode Island, Forenede Stater, 02886
- Kent County Memorial Hospital
-
-
South Carolina
-
Charleston, South Carolina, Forenede Stater, 29401
- Roper St. Francis Cancer Center at Roper Hospital
-
Columbia, South Carolina, Forenede Stater, 29203
- Palmetto Health South Carolina Cancer Center
-
Florence, South Carolina, Forenede Stater, 29501
- McLeod Regional Medical Center
-
Greenville, South Carolina, Forenede Stater, 29615
- CCOP - Greenville
-
-
South Dakota
-
Aberdeen, South Dakota, Forenede Stater, 57401
- Oncology Services of Aberdeen
-
Rapid City, South Dakota, Forenede Stater, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Medical X-Ray Center, PC
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5039
- Sanford Cancer Center at Sanford USD Medical Center
-
-
Tennessee
-
Knoxville, Tennessee, Forenede Stater, 37916
- Thompson Cancer Survival Center
-
Nashville, Tennessee, Forenede Stater, 37208-3599
- MBCCOP - Meharry Medical College - Nashville
-
Nashville, Tennessee, Forenede Stater, 37203
- Nashville Oncology Associates, PC
-
-
Texas
-
Amarillo, Texas, Forenede Stater, 79106
- Harrington Cancer Center
-
Dallas, Texas, Forenede Stater, 75390
- Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
-
-
Virginia
-
Charlottesville, Virginia, Forenede Stater, 22901
- Martha Jefferson Hospital Cancer Care Center
-
Fredericksburg, Virginia, Forenede Stater, 22401
- Fredericksburg Oncology, Incorporated
-
Hampton, Virginia, Forenede Stater, 23666
- Virginia Oncology Associates - Hampton
-
Lynchburg, Virginia, Forenede Stater, 24501
- Lynchburg Hematology-Oncology Clinic
-
Richmond, Virginia, Forenede Stater, 23230
- Virginia Cancer Institute - West End
-
Roanoke, Virginia, Forenede Stater, 24014
- Carilion Cancer Center of Western Virginia
-
-
Washington
-
Auburn, Washington, Forenede Stater, 98002
- Auburn Regional Center for Cancer Care
-
Bellingham, Washington, Forenede Stater, 98225
- St. Joseph Cancer Center
-
Bremerton, Washington, Forenede Stater, 98310
- Olympic Hematology and Oncology
-
Centralia, Washington, Forenede Stater, 98531-9027
- Providence Centralia Hospital
-
Federal Way, Washington, Forenede Stater, 98003
- St. Francis Hospital
-
Kennewick, Washington, Forenede Stater, 99336
- Columbia Basin Hematology
-
Kirkland, Washington, Forenede Stater, 98033
- Cascade Cancer Center at Evergreen Hospital Medical Center
-
Mt. Vernon, Washington, Forenede Stater, 98273
- Skagit Valley Hospital Cancer Care Center
-
Olympia, Washington, Forenede Stater, 98506-5166
- Providence St. Peter Hospital Regional Cancer Center
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison Poulsbo Hematology and Onocology
-
Puyallup, Washington, Forenede Stater, 98372
- Good Samaritan Cancer Center
-
Renton, Washington, Forenede Stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forenede Stater, 98101
- CCOP - Virginia Mason Research Center
-
Seattle, Washington, Forenede Stater, 98104
- Minor and James Medical, PLLC
-
Seattle, Washington, Forenede Stater, 98112
- Group Health Central Hospital
-
Seattle, Washington, Forenede Stater, 98122-4307
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
-
Seattle, Washington, Forenede Stater, 98122
- Polyclinic First Hill
-
Seattle, Washington, Forenede Stater, 98195
- University Cancer Center at University of Washington Medical Center
-
Spokane, Washington, Forenede Stater, 99202
- Cancer Care Northwest - Spokane South
-
Spokane, Washington, Forenede Stater, 99218
- Evergreen Hematology and Oncology, PS
-
Spokane, Washington, Forenede Stater, 99204-2967
- Rockwood Clinic Cancer Treatment Center
-
Spokane, Washington, Forenede Stater, 99204
- Providence Cancer Center at Sacred Heart Medical Center
-
Spokane, Washington, Forenede Stater, 99207
- Providence Cancer Center at Holy Family Hospital
-
Tacoma, Washington, Forenede Stater, 98405-3004
- Franciscan Cancer Center at St. Joseph Medical Center
-
Tacoma, Washington, Forenede Stater, 98405
- Allenmore Hospital
-
Tacoma, Washington, Forenede Stater, 98405
- CCOP - Northwest
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Regional Cancer Center at Tacoma General Hospital
-
Tacoma, Washington, Forenede Stater, 98499
- St. Clare Hospital
-
Tacoma, Washington, Forenede Stater, 98431
- Madigan Army Medical Center - Tacoma
-
Vancouver, Washington, Forenede Stater, 98668
- Southwest Washington Medical Center Cancer Center
-
Wenatchee, Washington, Forenede Stater, 98801-2028
- Wenatchee Valley Medical Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
West Virginia
-
Huntington, West Virginia, Forenede Stater, 25701
- Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
-
-
Wisconsin
-
Chippewa Falls, Wisconsin, Forenede Stater, 54729
- Marshfield Clinic - Chippewa Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Clinic Cancer Care at Regional Cancer Center
-
Eau Claire, Wisconsin, Forenede Stater, 54703-1510
- Midelfort Clinic - Luther
-
Eau Claire, Wisconsin, Forenede Stater, 54702
- Luther Midlelfort Hospital
-
Elkhorn, Wisconsin, Forenede Stater, 53121
- Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
-
Janesville, Wisconsin, Forenede Stater, 53547
- Mercy Regional Cancer Center
-
Johnson Creek, Wisconsin, Forenede Stater, 53038
- UW Cancer Center Johnson Creek
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Center for Cancer and Blood
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Franciscan Skemp Healthcare - La Crosse Campus
-
Madison, Wisconsin, Forenede Stater, 53792-6164
- University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
-
Madison, Wisconsin, Forenede Stater, 53717
- Dean Medical Center - Madison
-
Manitowoc, Wisconsin, Forenede Stater, 54221-1450
- Holy Family Memorial Medical Center Cancer Care Center
-
Marinette, Wisconsin, Forenede Stater, 54143
- Vince Lombardi Cancer Clinic - Marinette
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Saint Joseph's Hospital
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Clinic - Marshfield Center
-
Mequon, Wisconsin, Forenede Stater, 53097
- Columbia Saint Mary's Hospital - Ozaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53201-0342
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Medical Consultants, Limited
-
Milwaukee, Wisconsin, Forenede Stater, 53211
- Columbia-Saint Mary's Cancer Care Center
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic - Lakeland Center
-
Oconomowoc, Wisconsin, Forenede Stater, 53066
- Regional Cancer Center at Oconomowoc Memorial Hospital
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Ministry Medical Group at Saint Mary's Hospital
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Clinic - Indianhead Center
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic - Sheboygan
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Saint Michael's Hospital Cancer Center
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic - Two Rivers
-
Waukesha, Wisconsin, Forenede Stater, 53188
- Waukesha Memorial Hospital Regional Cancer Center
-
Wausau, Wisconsin, Forenede Stater, 54401
- Marshfield Clinic - Wausau Center
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center at Sheridan Memorial Hospital
-
-
-
-
-
Pretoria, Sydafrika, 0002
- Pretoria Academic Hospital
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Kvinde
Beskrivelse
Kvalifikationskriterier:
- Patienterne skal have histologisk bekræftet invasivt karcinom i det kvindelige bryst med 0-3 positive aksillære lymfeknuder
- Patienter skal have 0-3 positive aksillære lymfeknuder for at være berettiget til denne undersøgelse; patienter med node-negativ brystkræft bør have tilstrækkelig "højrisiko" sygdom til at berettige kemoterapi; som generelle retningslinjer kan node-negative patienter med tumorer på >= 1 cm eller østrogen- eller progesteronreceptornegative tumorer af enhver størrelse være kvalificerede; i sidste ende kan definitionen af "høj risiko" dog bestemmes af den behandlende læge, og hvis den behandlende læge føler, at patienten berettiger til kemoterapi, er patienten berettiget; for patienter med 1-3 positive aksillære knuder er patienten berettiget uanset primære brysttumorkarakteristika, hvis kemoterapi efter den behandlende læges vurdering vurderes at være potentielt gavnlig for patienten
- Hvis patienten har haft en negativ sentinel node biopsi, så er der ikke behov for yderligere aksillær dissektion, og patienten er bestemt til at være node-negativ; hvis en aksillær dissektion, uden en sentinel node biopsi, udføres for at bestemme nodal status, skal mindst seks aksillære lymfeknuder fjernes og analyseres og være negative, for at patienten kan anses for node-negativ; aksillære knuder med enkeltceller eller tumorklynger =< 0,2 mm ved enten hæmatoxylin og eosinfarvning (H&E) eller immunhistokemi (IHC), vil blive betragtet som knudenegative; lymfeknuder positive for polymerasekædereaktion (PCR) med tumorceller/klynger =< 0,2 mm vil blive betragtet som node-negative; enhver aksillær lymfeknude med tumorklynger > 0,2 mm vil blive betragtet som positiv
- Hvis patienten får foretaget en sentinel node biopsi og en af sentinel noderne er positiv, som defineret ved tumorclusters > 0,2 mm, skal der foretages en aksillær dissektion; i alt skal der fjernes mindst 6 aksillære lymfeknuder, inklusive sentinel noder plus den efterfølgende dissektion, for at patienten er berettiget; af alle de lymfeknuder, der er fjernet fra både sentinel node procedure og aksillær dissektion, skal 1-3 være positive for, at patienten er kvalificeret som en node-positiv patient; hvis en aksillær dissektion udføres uden en vagtkirtelindgrebsprocedure, skal mindst 6 lymfeknuder fjernes, og 1-3 noder skal være positive, for at patienten kan anses for at være nodepositiv og kvalificeret til denne undersøgelse
- Bestemmelse af involvering af aksillære knuder med metastatisk cancer vil følge det reviderede tumor-node-metastasis (TNM) stadiesystem: aksillære knuder med enkeltceller med tumorklynger =< 0,2 mm, af enten H&E eller immunhistokemi (IHC), vil blive betragtet som negative aksillær knude; lymfeknuder positive for PCR med tumorceller/klynger < 0,2 mm vil blive betragtet som negativ aksillær knude; enhver aksillær lymfeknude med klynger > 0,2 mm vil blive betragtet som positiv
- Patienter med østrogenreceptor- og/eller progesteronreceptornegative, positive eller ukendte tumorer er kvalificerede; østrogen-receptor (ER) og progesteron receptor (PgR) assays bør udføres ved immunhistokemiske metoder i henhold til den lokale institutions standardprotokol
- Patienter med human epidermal vækstfaktor receptor 2 (HER2) positiv, negativ eller ukendt sygdom er kvalificerede til dette forsøg; patienter, hvis tumorer er HER2 positive ved enten immunhistokemi 3+ farvning eller demonstrerer genamplifikation ved fluorescens in situ hybridisering (FISH) kan modtage trastuzumab
- Der skal være negative tumormargener for invasiv cancer og ductal carcinoma in situ (DCIS) i tilfælde af mastektomi eller lumpektomi; lobulært karcinom in situ (LCIS) er acceptabelt i marginen
- Patienter med multicentrisk brystkræft er berettigede, så længe al kendt sygdom er resekeret med negative marginer og har 0-3 positive aksillære lymfeknuder
Patienter skal registreres inden for 84 dage efter den sidste brystoperation; patienter skal have gennemgået enten modificeret radikal mastektomi eller lumpektomi; for patienter, der gennemgår stikprøveudtagning eller aksillær dissektion, er en simpel mastektomi acceptabel; lumpektomipatienter skal modtage strålebehandling; for patienter, der er behandlet med strålebehandling før kemoterapi, bør patienterne registreres i denne undersøgelse efter afslutningen af strålingen, med kemoterapi, der begynder inden for 7 dage efter registreringen
* Al primær bryst- og aksillær knudeoperation skal være afsluttet før tilmelding til undersøgelse
- Ingen tidligere trastuzumab, kemoterapi eller hormonbehandling for denne malignitet, undtagen tamoxifenbehandling
- Ingen tidligere antracyklin kemoterapi for nogen sygdom
- Patienter med lokalt fremskreden brystkræft, inflammatorisk brystkræft eller metastatisk brystkræft er ikke kvalificerede; patienter med involvering af dermale lymfeceller på patologi er ikke kvalificerede, selvom der ikke er kliniske tegn på inflammatorisk cancer
- Patienter med bilateral, synkron invasiv brystkræft er berettiget, så længe begge primære tumorer; hvis en patient har en invasiv cancer på den ene side, der opfylder berettigelseskriterierne, og DCIS eller LCIS på den kontralaterale side, er patienten berettiget; DCIS eller LCIS bør styres i overensstemmelse med institutionelle retningslinjer
- Patienter skal være sygdomsfri for tidligere maligniteter i > 5 år, undtagen kurativt behandlet basalcelle- eller pladecellecarcinom i huden eller carcinom-in-situ i livmoderhalsen; patienter med en historie med invasiv brystkræft eller DCIS er berettigede, hvis de har været sygdomsfri i > 5 år; patienter med en historie med LCIS er berettigede uanset intervallet fra diagnosen
- Common Toxicity Criteria (CTC) præstationsstatus 0-1
- Kvinder må ikke være gravide eller ammende
- Samtidig eksogen hormonbehandling, inklusive orale præventionsmidler, postmenopausal hormonsubstitutionsterapi og raloxifen skal stoppes, før patienter kan indskrives
Patienter kan have modtaget op til 4 ugers tamoxifenbehandling for denne malignitet og stadig være berettiget til denne undersøgelse; patienter, der modtog tamoxifen eller en anden selektiv østrogenreceptormodulator (SERM) til forebyggelse eller til andre indikatorer (f. osteoporose) er berettigede; tamoxifenbehandling eller andre SERM'er skal seponeres, før patienten optages i denne undersøgelse
* Brug af bisfosfonater til behandling af osteoporose er tilladt; brugen af raloxifen er ikke tilladt ved tilmelding til denne undersøgelse
- Patienter skal have tilstrækkelig organfunktion inklusive ingen aktiv kongestiv hjerteinsufficiens og intet myokardieinfarkt < 6 måneder fra registreringstidspunktet
- Absolut neutrofiltal (ANC) >= 1.000/mm^3
- Blodpladetal >= 100,00/mm^3
- Kreatinin =< 2,0 mg/dl
- Bilirubin =< 1,5 x øvre grænser for institutionel normal
- Patienter kan blive optaget i adjuverende bisfosfonatundersøgelser; patienter kan indskrives sideløbende eller sekventielt i 40101- og bisfosfonatforsøg
- Patienter kan blive optaget i adjuverende hormonundersøgelser godkendt af CALGB eller Cancer Trials Support Unit (CTSU), såsom undersøgelsen med undertrykkelse af ovariefunktion (SOFT) og forsøg med Tamoxifen og Exemestan (TEXT)
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Faktoriel opgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Aktiv komparator: Arm I (CA for 4 kurser)
Patienter får cyclophosphamid IV og doxorubicin hydrochlorid IV på dag 1.
Behandlingen gentages hver 14. dag i 4 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
|
Givet IV
Givet IV
|
|
Eksperimentel: Arm II (CA for 6 kurser [lukket for optjening 15/12/2007])
Patienter får cyclophosphamid IV og doxorubicin hydrochlorid IV på dag 1.
Behandlingen gentages hver 14. dag i 6 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
|
Givet IV
Givet IV
Givet IV
|
|
Eksperimentel: Arm III (paclitaxel i 4 kurser)
Patienterne får paclitaxel IV over 3 timer på dag 1.
Behandlingen gentages hver 14. dag i 4 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
|
Givet IV
Givet IV
|
|
Eksperimentel: Arm IV (paclitaxel i 6 kurser [lukket 15/12/2007])
Patienterne får paclitaxel IV over 3 timer på dag 1.
Behandlingen gentages hver 14. dag i 6 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
|
Givet IV
Givet IV
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Relapse Free Survival (RFS) 4 vs. 6 cyklusser
Tidsramme: fra baseline op til 4 år
|
For at bestemme, om længere terapi, 12 uger, er bedre end kortere terapi, 8 uger, med enten CA eller paclitaxel for tilbagefaldsfri overlevelse for kvinder med primær brystkræft med 0-3 positive aksillære lymfeknuder.
En vurdering af overlegenheden af 6 cyklusser over 4 cyklusser vil blive udført.
Denne analyse kombinerer Arm I og Arm III sammen, og Arm II og Arm IV sammen.
|
fra baseline op til 4 år
|
|
Varighed af sygdomsfri overlevelse (RFS)
Tidsramme: fra baseline op til 6,4 år
|
At bestemme ækvivalensen af paclitaxel til CA som adjuverende terapi for kvinder med 0-3 positive aksillære lymfeknuder, for sygdomsfri overlevelse.
Objektiv progression er defineret som forekomsten af lokale (brystvæg, aksillære, supraklavikulære knuder) eller fjernmetastaser.
Forsøget er designet til at vise ækvivalensen af det eksperimentelle middel T med standardmiddelkombinationen CA, således vil de 4 og 6 forløbsarme af hvert lægemiddel blive kombineret for at udføre denne analyse.
|
fra baseline op til 6,4 år
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Samlet overlevelse (OS)
Tidsramme: fra baseline op til 5 år
|
At bestemme ækvivalensen mellem paclitaxel og CA som adjuverende terapi for kvinder med 0-3 positive aksillære lymfeknuder, for samlet overlevelse.
OS vil blive målt fra studiestart til død på grund af en hvilken som helst årsag.
Overlevende vil blive censureret på datoen for sidste opfølgning..
Forsøget er designet til at vise ækvivalensen af det eksperimentelle middel T med standardmiddelkombinationen CA, således vil de 4 og 6 forløbsarme af hvert lægemiddel blive kombineret for at udføre denne analyse.
|
fra baseline op til 5 år
|
|
Uønskede hændelser
Tidsramme: fra baseline op til 6 uger efter behandling
|
At sammenligne toksicitet af kortforløbs CA og paclitaxel med langforløbs CA og paclitaxel som adjuverende terapi for kvinder med 0-3 positiv aksillær lymfeknudebrystkræft.
Procentdelen af patienter, der modtog en hæmatologisk hændelse af grad 3 eller højere, vil blive rapporteret her.
Vi vil kombinere arm I med arm III, samt arm II med arm IV.
For en komplet liste over bivirkninger henvises til afsnittet om bivirkninger.
|
fra baseline op til 6 uger efter behandling
|
|
Tid til fjernmetastaser
Tidsramme: fra baseline op til 15 år
|
Lokal kontrol og fjernmetastaser vil blive beregnet som den kumulative forekomst af henholdsvis første lokale tilbagefald og første fjernmetastase.
|
fra baseline op til 15 år
|
|
Lokal kontrol
Tidsramme: fra baseline op til 15 år
|
Lokal kontrol vil blive beregnet som den kumulative forekomst af første lokale tilbagefald.
|
fra baseline op til 15 år
|
|
Samlet overlevelse (OS) i 4 vs. 6 cyklusser
Tidsramme: fra baseline op til 4 år
|
For at bestemme, om længere terapi, 12 uger, er bedre end kortere terapi, 8 uger, med enten CA eller paclitaxel for den samlede overlevelse for kvinder med primær brystkræft med 0-3 positive aksillære lymfeknuder.
En vurdering af overlegenheden af 6 cyklusser over 4 cyklusser vil blive udført.
Denne analyse kombinerer Arm I og Arm III sammen, og Arm II og Arm IV sammen.
|
fra baseline op til 4 år
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Samarbejdspartnere
Efterforskere
- Studiestol: Lawrence N. Shulman, MD, Dana-Farber Cancer Institute
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Baldwin RM, Owzar K, Zembutsu H, Chhibber A, Kubo M, Jiang C, Watson D, Eclov RJ, Mefford J, McLeod HL, Friedman PN, Hudis CA, Winer EP, Jorgenson EM, Witte JS, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL. A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101. Clin Cancer Res. 2012 Sep 15;18(18):5099-109. doi: 10.1158/1078-0432.CCR-12-1590. Epub 2012 Jul 27.
- Shulman LN, Cirrincione CT, Berry DA, Becker HP, Perez EA, O'Regan R, Martino S, Atkins JN, Mayer E, Schneider CJ, Kimmick G, Norton L, Muss H, Winer EP, Hudis C. Six cycles of doxorubicin and cyclophosphamide or Paclitaxel are not superior to four cycles as adjuvant chemotherapy for breast cancer in women with zero to three positive axillary nodes: Cancer and Leukemia Group B 40101. J Clin Oncol. 2012 Nov 20;30(33):4071-6. doi: 10.1200/JCO.2011.40.6405. Epub 2012 Jul 23.
- Barginear M, Dueck AC, Allred JB, Bunnell C, Cohen HJ, Freedman RA, Hurria A, Kimmick G, Le-Rademacher JG, Lichtman S, Muss HB, Shulman LN, Copur MS, Biggs D, Ramaswamy B, Lafky JM, Jatoi A. Age and the Risk of Paclitaxel-Induced Neuropathy in Women with Early-Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101. Oncologist. 2019 May;24(5):617-623. doi: 10.1634/theoncologist.2018-0298. Epub 2018 Nov 8.
- Shulman LN, Berry DA, Cirrincione CT, Becker HP, Perez EA, O'Regan R, Martino S, Shapiro CL, Schneider CJ, Kimmick G, Burstein HJ, Norton L, Muss H, Hudis CA, Winer EP. Comparison of doxorubicin and cyclophosphamide versus single-agent paclitaxel as adjuvant therapy for breast cancer in women with 0 to 3 positive axillary nodes: CALGB 40101 (Alliance). J Clin Oncol. 2014 Aug 1;32(22):2311-7. doi: 10.1200/JCO.2013.53.7142. Epub 2014 Jun 16.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. maj 2002
Primær færdiggørelse (Faktiske)
1. april 2012
Studieafslutning (Faktiske)
1. juni 2014
Datoer for studieregistrering
Først indsendt
8. juli 2002
Først indsendt, der opfyldte QC-kriterier
26. januar 2003
Først opslået (Skøn)
27. januar 2003
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
18. maj 2017
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
12. april 2017
Sidst verificeret
1. april 2017
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Hudsygdomme
- Neoplasmer
- Neoplasmer efter sted
- Brystsygdomme
- Brystneoplasmer
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Enzymhæmmere
- Antirheumatiske midler
- Antineoplastiske midler
- Immunsuppressive midler
- Immunologiske faktorer
- Tubulin modulatorer
- Antimitotiske midler
- Mitose modulatorer
- Antineoplastiske midler, Alkylering
- Alkyleringsmidler
- Myeloablative agonister
- Antineoplastiske midler, fytogene
- Topoisomerase II-hæmmere
- Topoisomerasehæmmere
- Antibiotika, antineoplastisk
- Cyclofosfamid
- Paclitaxel
- Doxorubicin
- Liposomal doxorubicin
Andre undersøgelses-id-numre
- CALGB-40101
- U10CA180821 (U.S. NIH-bevilling/kontrakt)
- CDR0000069444 (Registry Identifier: PDQ (Physician Data Query))
- NCI-2009-00474 (Registry Identifier: CTRP (Clinical Trials Reporting System))
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .