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Interferon Alfa-2b med eller uden Bevacizumab til behandling af patienter med avanceret nyrecellekarcinom (nyrekræft)

1. juli 2016 opdateret af: Alliance for Clinical Trials in Oncology

Et randomiseret fase III-forsøg med Interferon Alfa-2B eller Interferon Alfa-2B Plus Bevacizumab hos patienter med avanceret nyrecarcinom

RATIONALE: Biologiske terapier, såsom interferon alfa-2b, kan interferere med væksten af tumorceller. Bevacizumab kan stoppe væksten af tumorceller ved at standse blodtilførslen til tumoren. Det vides endnu ikke, om interferon alfa-2b er mere effektivt med eller uden bevacizumab til behandling af fremskreden nyrecellekarcinom (nyrekræft).

FORMÅL: Dette randomiserede fase III-studie studerer interferon alfa-2b og bevacizumab for at se, hvor godt de virker sammenlignet med interferon alfa-2b alene til behandling af patienter med fremskreden nyrecellekarcinom.

Studieoversigt

Status

Afsluttet

Betingelser

Nyrekræft

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

Primær

Sammenlign den samlede overlevelse for patienter med fremskreden nyrecellekarcinom behandlet med interferon alfa-2b alene eller interferon alfa-2b med bevacizumab.

Sekundær

Sammenlign tiden til sygdomsprogression og objektive responsrater hos patienter behandlet med disse regimer.
Bestem toksiciteten af interferon alfa-2b i kombination med bevacizumab hos disse patienter.

OVERSIGT: Dette er en randomiseret, multicenter undersøgelse. Patienterne stratificeres efter tidligere nefrektomi (ja vs nej) og antallet af risikofaktorer for sygdomsprogression (0 vs 1-2 vs 3 eller mere). Patienterne randomiseres til 1 ud af 2 behandlingsarme.

Arm I: Patienterne får interferon alfa-2b subkutant (SC) tre gange om ugen.
Arm II: Patienterne får interferon alfa-2b som i arm I og bevacizumab IV over 30-90 minutter på dag 1 og 15.

I begge arme gentages kurser hver 28. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Patienterne følges hver 3. måned i 2 år og derefter årligt i op til 10 år efter undersøgelsens start.

PROJEKTERET TILSLUTNING: I alt 700 patienter (350 pr. behandlingsarm) vil blive akkumuleret til denne undersøgelse inden for 3 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

732

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- British Columbia
  - Vancouver, British Columbia, Canada, V6T 1Z4
    - University of British Columbia
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 1V8
    - Nova Scotia Cancer Centre at Queen Elizabeth II Health Sciences Centre
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre at Pasqua Hospital
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35294
    - Comprehensive Cancer Center at University of Alabama at Birmingham
  - Huntsville, Alabama, Forenede Stater, 35801
    - Huntsville Hospital
- Arizona
  - Scottsdale, Arizona, Forenede Stater, 85259
    - CCOP - Mayo Clinic Scottsdale Oncology Program
- Arkansas
  - Ft. Smith, Arkansas, Forenede Stater, 72903
    - Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
- California
  - Arroyo Grande, California, Forenede Stater, 93420
    - Arroyo Grande Community Hospital
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente - Fremont
  - Hayward, California, Forenede Stater, 94545
    - Kaiser Permanente Medical Center - Hayward
  - Mission Hills, California, Forenede Stater, 91346-9600
    - Providence Holy Cross Cancer Center
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente Medical Center - Oakland
  - Orange, California, Forenede Stater, 92868
    - St. Joseph Hospital Regional Cancer Center - Orange
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente Medical Center - Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente Medical Center - Richmond
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente Medical Center - Roseville
  - Sacramento, California, Forenede Stater, 95823
    - South Sacramento Kaiser-Permanente Medical Center
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente Medical Center - Sacramento
  - San Diego, California, Forenede Stater, 92161
    - Veterans Affairs Medical Center - San Diego
  - San Diego, California, Forenede Stater, 92134
    - Naval Medical Center - San Diego
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente Medical Office -Vandever Medical Office
  - San Diego, California, Forenede Stater, 92103
    - Rebecca and John Moores UCSD Cancer Center
  - San Francisco, California, Forenede Stater, 94115
    - UCSF Comprehensive Cancer Center
  - San Francisco, California, Forenede Stater, 94121
    - Veterans Affairs Medical Center - San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente Medical Center - San Francisco Geary Campus
  - San Francisco, California, Forenede Stater, 94110
    - San Francisco General Hospital Medical Center
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente Medical Center - Santa Teresa
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Foundation Hospital - San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente Medical Center - Santa Rosa
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente Medical Center - South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente Medical Facility - Stockton
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente Medical Center - Vallejo
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente Medical Center - Walnut Creek
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Aurora Presbyterian Hospital
  - Boulder, Colorado, Forenede Stater, 80301
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - Memorial Hospital Cancer Center
  - Colorado Springs, Colorado, Forenede Stater, 80933
    - Penrose Cancer Center at Penrose Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Cancer Center of Colorado Springs
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - St. Luke's Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - St. Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80224-2522
    - CCOP - Colorado Cancer Research Program, Incorporated
  - Englewood, Colorado, Forenede Stater, 80110
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Front Range Cancer Specialists
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forenede Stater, 80502
    - Hope Cancer Care Center at Longmont United Hospital
  - Pueblo, Colorado, Forenede Stater, 81004
    - St. Mary-Corwin Regional Medical Center
  - Thorton, Colorado, Forenede Stater, 80229
    - North Suburban Medical Center
- Connecticut
  - Hartford, Connecticut, Forenede Stater, 06105
    - Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
  - Middletown, Connecticut, Forenede Stater, 06457
    - Middlesex Hospital Cancer Center
  - New Haven, Connecticut, Forenede Stater, 06520-8032
    - Yale Comprehensive Cancer Center
  - Norwalk, Connecticut, Forenede Stater, 06856
    - Norwalk Hospital
- Delaware
  - Dover, Delaware, Forenede Stater, 19901
    - Kent General Hospital at Bayhealth Medical Center
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19718
    - CCOP - Christiana Care Health Services
  - Wilmington, Delaware, Forenede Stater, 19805
    - St. Francis Hospital
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20307
    - Walter Reed Army Medical Center
  - Washington, District of Columbia, Forenede Stater, 20007
    - Lombardi Cancer Center at Georgetown University Medical Center
- Florida
  - Boca Raton, Florida, Forenede Stater, 33486
    - Lynn Regional Cancer Center of Boca Raton Community Hospital
  - Daytona Beach, Florida, Forenede Stater, 32115
    - Halifax Medical Center
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
  - Gainesville, Florida, Forenede Stater, 32610
    - Shands Cancer Center at the University of Florida - Jacksonville
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Cancer Institute at Memorial Regional Hospital
  - Jacksonville, Florida, Forenede Stater, 32207
    - Baptist Cancer Institute - Jacksonville
  - Jacksonville, Florida, Forenede Stater, 32224-9980
    - Mayo Clinic - Jacksonville
  - Jupiter, Florida, Forenede Stater, 33458
    - Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  - Lakeland, Florida, Forenede Stater, 33805
    - Lakeland Regional Cancer Center at Lakeland Regional Medical Center
  - Lakeland, Florida, Forenede Stater, 33805
    - Watson Clinic
  - Miami Beach, Florida, Forenede Stater, 33140
    - CCOP - Mount Sinai Medical Center
  - Orange Park, Florida, Forenede Stater, 32073
    - Florida Oncology Associates
  - Orlando, Florida, Forenede Stater, 32803
    - Florida Hospital - Orlando
  - Sarasota, Florida, Forenede Stater, 34236
    - Florida Cancer Specialists
  - West Palm Beach, Florida, Forenede Stater, 33401
    - Palm Beach Cancer Institute - West Palm Beach
- Georgia
  - Albany, Georgia, Forenede Stater, 31703
    - Phoebe Cancer Center at Phoebe Putney Memorial Hospital
  - Altanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital - Atlanta
  - Athens, Georgia, Forenede Stater, 30607
    - Hematology and Oncology of Northeast Georgia
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Saint Joseph's Hospital of Atlanta
  - Atlanta, Georgia, Forenede Stater, 30342
    - CCOP - Atlanta Regional
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital Cancer Center
  - Augusta, Georgia, Forenede Stater, 30912
    - MBCCOP-Medical College of Georgia Cancer Center
  - Augusta, Georgia, Forenede Stater, 30901
    - Augusta Oncology Associates
  - Austell, Georgia, Forenede Stater, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, Forenede Stater, 31902
    - John B. Amos Community Cancer Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Charles B. Eberhart Cancer Center at DeKalb Medical Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Veterans Affairs Medical Center - Atlanta (Decatur)
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center
  - Lawrenceville, Georgia, Forenede Stater, 30045
    - Gwinnett Medical Center
  - Macon, Georgia, Forenede Stater, 31208
    - Medical Center of Central Georgia
  - Marietta, Georgia, Forenede Stater, 30060
    - Kennestone Cancer Center at Wellstar Kennestone Hospital
  - Riverdale, Georgia, Forenede Stater, 30274
    - Southern Regional Medical Center
  - Savannah, Georgia, Forenede Stater, 31403
    - Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
  - Savannah, Georgia, Forenede Stater, 31405
    - Cancer Care and Research Pavilion at St. Joseph's/Candler
- Hawaii
  - Aiea, Hawaii, Forenede Stater, 96701
    - Kapiolani Medical Center at Pali Momi
  - Honolula, Hawaii, Forenede Stater, 96813
    - Cancer Research Center of Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96813
    - OnCare Hawaii, Incorporated - Lusitana
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Cancer Institute at Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital, Incorporated
  - Honolulu, Hawaii, Forenede Stater, 96817
    - OnCare Hawaii, Incorporated - Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96817
    - St. Francis Medical Center
- Idaho
  - Boise, Idaho, Forenede Stater, 83712
    - Mountain States Tumor Institute - Boise
- Illinois
  - Alton, Illinois, Forenede Stater, 62002
    - Saint Anthony's Hospital at Saint Anthony's Health Center
  - Aurora, Illinois, Forenede Stater, 60507
    - Rush-Copley Cancer Care Center
  - Bloomington, Illinois, Forenede Stater, 61701
    - St. Joseph Medical Center
  - Canton, Illinois, Forenede Stater, 61520
    - Graham Hospital
  - Carthage, Illinois, Forenede Stater, 62321
    - Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60637-1470
    - University of Chicago Cancer Research Center
  - Chicago, Illinois, Forenede Stater, 60612
    - University Of Illinois Medical Center
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital Cancer Care Institute
  - Elk Grove Village, Illinois, Forenede Stater, 60007
    - Alexian Brothers Cancer Care Center
  - Eureka, Illinois, Forenede Stater, 61530
    - Eureka Hospital
  - Evanston, Illinois, Forenede Stater, 60201
    - Evanston Northwestern Health Care - Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Galesburg Clinic
  - Galesburg, Illinois, Forenede Stater, 61401
    - InterCommunity Cancer Center of Western Illinois
  - Galesburg, Illinois, Forenede Stater, 61401
    - Medical And Surgical Specialists, Llc
  - Havana, Illinois, Forenede Stater, 62644
    - Mason District Hospital
  - Hopedale, Illinois, Forenede Stater, 61747
    - Hopedale Medical Complex
  - Joliet, Illinois, Forenede Stater, 60435
    - Joliet Oncology Hematology Associates, Limited - West
  - Kankakee, Illinois, Forenede Stater, 60901
    - Provena St. Mary's Wasser Regional Cancer Center - Kankakee
  - Kewanee, Illinois, Forenede Stater, 61443
    - Kewanee Hospital
  - La Grange, Illinois, Forenede Stater, 60525
    - La Grange Memorial Hospital
  - Macomb, Illinois, Forenede Stater, 61455
    - Mcdonough District Hospital
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Medical Center - East
  - Naperville, Illinois, Forenede Stater, 60540
    - Hematology Oncology Consultants Ltd.
  - Normal, Illinois, Forenede Stater, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, Forenede Stater, 61761
    - Community Cancer Center
  - Ottawa, Illinois, Forenede Stater, 61350
    - Community Hospital of Ottawa
  - Ottawa, Illinois, Forenede Stater, 61350
    - Oncology Hematology Associates of Central Illinois - Ottawa
  - Pekin, Illinois, Forenede Stater, 61554
    - Cancer Treatment Center at Pekin Hospital
  - Peoria, Illinois, Forenede Stater, 61614
    - Proctor Hospital
  - Peoria, Illinois, Forenede Stater, 61603
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF St. Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - CCOP - Illinois Oncology Research Association
  - Peoria, Illinois, Forenede Stater, 61615
    - Oncology/Hematology Associates of Central Illinois, P.C.
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois Valley Community Hospital
  - Princeton, Illinois, Forenede Stater, 61356
    - Perry Memorial Hospital
  - Rockford, Illinois, Forenede Stater, 61104
    - Swedish American Hospital
  - Spring Valley, Illinois, Forenede Stater, 61362
    - St. Margaret's Hospital
  - Spring Valley, Illinois, Forenede Stater, 61362
    - Valley Cancer Center
  - Springfield, Illinois, Forenede Stater, 62781-0001
    - Regional Cancer Center at Memorial Medical Center
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center at Carle Foundation Hospital
  - Urbana, Illinois, Forenede Stater, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Beech Grove, Indiana, Forenede Stater, 46107
    - St. Francis Hospital and Health Centers
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Fort Wayne, Indiana, Forenede Stater, 46815
    - Fort Wayne Medical Oncology and Hematology, Incorporated
  - La Porte, Indiana, Forenede Stater, 46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - Lafayette, Indiana, Forenede Stater, 47904
    - Oncology Institute of Greater Lafayette
  - Michigan City, Indiana, Forenede Stater, 46360
    - Saint Anthony Memorial Health Centers
  - Plymouth, Indiana, Forenede Stater, 46544
    - Saint Joseph Regional Medical Center - Plymouth Campus
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - CCOP - Northern Indiana CR Consortium
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic, P.C.
  - Bettendorf, Iowa, Forenede Stater, 52722
    - Hematology Oncology Associates of the Quad Cities
  - Carroll, Iowa, Forenede Stater, 51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - St. Luke's Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Cedar Rapids Oncology Associates
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - Iowa Blood and Cancer Care
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Cancer Center at Mercy Medical Center
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Alegent Health Mercy Hospital
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines, Iowa, Forenede Stater, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates at John Stoddard Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50307
    - Mercy Capitol Hospital
  - Dubuque, Iowa, Forenede Stater, 52001
    - Wendt Regional Cancer Center at Finley Hospital
  - Iowa City, Iowa, Forenede Stater, 52242
    - Holden Comprehensive Cancer Center at University of Iowa
  - Missouri Valley, Iowa, Forenede Stater, 51555
    - Alegent Health Community Memorial Hospital
  - Onawa, Iowa, Forenede Stater, 51040
    - Burgess Health Center
  - Ottumwa, Iowa, Forenede Stater, 52501
    - Cancer Center at Ottumwa Regional Health Center
  - Sioux City, Iowa, Forenede Stater, 51104
    - St. Luke's Regional Medical Center
  - Sioux City, Iowa, Forenede Stater, 51104
    - Mercy Medical Center - Sioux City
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Hematology-Oncology Associates
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas, P.A. - El Dorado
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas - Kingman
  - Liberal, Kansas, Forenede Stater, 67901
    - Southwest Medical Center
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas, P.A. - Parsons
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Mount Carmel Regional Cancer Center
  - Pratt, Kansas, Forenede Stater, 67124
    - Pratt Cancer Center of Kansas
  - Salina, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Forenede Stater, 66604
    - Cancer Center at Stormont-Vail Regional Health Center
  - Topeka, Kansas, Forenede Stater, 66606
    - St. Francis Comprehensive Cancer Center
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forenede Stater, 67214
    - CCOP - Wichita
  - Wichita, Kansas, Forenede Stater, 67214
    - Via Christi Cancer Center at Via Christi Regional Medical Center
  - Wichita, Kansas, Forenede Stater, 67203
    - Associates In Womens Health
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas, P.A.
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas, P.A. - Wichita
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70806
    - Baton Rouge General Regional Cancer Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center - Baton Rouge
  - Baton Rouge, Louisiana, Forenede Stater, 708169990
    - Ochsner Clinic of Baton Rouge
  - Houma, Louisiana, Forenede Stater, 70360
    - Terrebonne General Medical Center
  - New Orleans, Louisiana, Forenede Stater, 70121
    - CCOP - Ochsner
  - New Orleans, Louisiana, Forenede Stater, 70112
    - MBCCOP - LSU Health Sciences Center
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Cancer Center at Medical Center of Louisiana - New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Cancer Institute at Ochsner Clinic Foundation
- Maine
  - Bangor, Maine, Forenede Stater, 04401
    - CancerCare of Maine at Eastern Maine Medial Center
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21229
    - St. Agnes Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21201-1595
    - Greenebaum Cancer Center at University of Maryland Medical Center
  - Elkton MD, Maryland, Forenede Stater, 21921
    - Union Hospital Cancer Center at Union Hospital
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02111
    - Cancer Center at Tufts - New England Medical Center
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Clinic Medical Center - Burlington
  - Quincy, Massachusetts, Forenede Stater, 02169
    - Commonwealth Hematology-Oncology P.C. - Quincy
  - Worcester, Massachusetts, Forenede Stater, 01655
    - UMASS Memorial Cancer Center - University Campus
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forenede Stater, 48100
    - CCOP - Michigan Cancer Research Consortium
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Battle Creek Health System
  - Big Rapids, Michigan, Forenede Stater, 49307
    - Mecosta County General Hospital
  - Flint, Michigan, Forenede Stater, 48532
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - CCOP - Grand Rapids
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Lacks Cancer Center at Saint Mary's Mercy Medical Center
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health Cancer Care - Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49506
    - Metropolitan Hospital
  - Grand Rapids, Michigan, Forenede Stater, 49506
    - Spectrum Health Hospital - Blodgett Campus
  - Holland, Michigan, Forenede Stater, 49423
    - Holland Community Hospital
  - Jackson, Michigan, Forenede Stater, 49201
    - Foote Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Lambertville, Michigan, Forenede Stater, 48144
    - Haematology-Oncology Associates of Ohio and Michigan, P.C.
  - Monroe, Michigan, Forenede Stater, 48162
    - Community Cancer Center of Monroe
  - Monroe, Michigan, Forenede Stater, 48162
    - Mercy Memorial Hospital System
  - Muskegon, Michigan, Forenede Stater, 49443
    - Hackley Hospital
  - Petoskey, Michigan, Forenede Stater, 49770
    - Northern Michigan Hospital
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital - Royal Oak Campus
  - Saginaw, Michigan, Forenede Stater, 48601
    - Seton Cancer Institute - Saginaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Oncology Care Associates, P.L.L.C.
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48903
    - St. John Macomb Hospital
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - MeritCare Clinic - Bemidji
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Brainerd Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55802
    - Cancer Care Center at St. Luke's Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Forenede Stater, 55432
    - Mercy and Unity Cancer Center at Mercy and Unity Hospitals
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Litchfield, Minnesota, Forenede Stater, 55355
    - Meeker County Memorial Hospital
  - Maplewood, Minnesota, Forenede Stater, 55109
    - St. John's Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55417
    - Veterans Affairs Medical Center - Minneapolis
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center - Minneapolis
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55455
    - Fairview University Medical Center - University Campus
  - Montevideo, Minnesota, Forenede Stater, 56265
    - Chippewa County - Montevideo Hospital
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - Hubert H. Humphrey Cancer Center at North Memorial Medical Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic Cancer Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - CCOP - Metro-Minnesota
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Cancer Care Center at Regions Hospital
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Cancer Center
  - St Paul, Minnesota, Forenede Stater, 55102
    - St. Joseph's Hospital
  - St. Cloud, Minnesota, Forenede Stater, 56303
    - CentraCare Clinic - River Campus
  - St. Cloud, Minnesota, Forenede Stater, 56303
    - Adult and Pediatric Urology, P.L.L.P.
  - St. Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic
  - St. Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Woodwinds Hospital
- Mississippi
  - Hattiesburg, Mississippi, Forenede Stater, 39401
    - Hattiesburg Clinic, P.A.
  - Hattiesburg, Mississippi, Forenede Stater, 34902
    - Hematology & Oncology Clinic
- Missouri
  - Cape Girardeau, Missouri, Forenede Stater, 63701
    - St. Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63701
    - Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
  - Chesterfield, Missouri, Forenede Stater, 63017-3417
    - Saint Luke's Hospital
  - Columbia, Missouri, Forenede Stater, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Columbia, Missouri, Forenede Stater, 65201
    - Missouri Cancer Associates
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Cancer Institute at Freeman Health System
  - Kansas City, Missouri, Forenede Stater, 64131
    - CCOP - Kansas City
  - Saint Louis, Missouri, Forenede Stater, 63141
    - CCOP - St. Louis-Cape Girardeau
  - Saint Louis, Missouri, Forenede Stater, 63141
    - David C. Pratt Cancer Center at St. John's Mercy
  - Springfield, Missouri, Forenede Stater, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, Forenede Stater, 65807
    - Hulston Cancer Center at Cox Medical Center South
  - St. Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Cancer Center
  - St. Louis, Missouri, Forenede Stater, 63128
    - St. Anthony's Cancer Center
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - CCOP - Montana Cancer Consortium
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Sletten Regional Cancer Institute
- Nebraska
  - Fremont, Nebraska, Forenede Stater, 68025
    - Fremont Area Medical Center
  - Kearney, Nebraska, Forenede Stater, 68847
    - Cancer Center at the Good Samaritan Health Systems
  - Lincoln, Nebraska, Forenede Stater, 68502
    - Bryan LGH Medical Center West
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Cancer Resource Center - Lincoln
  - Lincoln, Nebraska, Forenede Stater, 68510
    - St. Elizabeth Regional Medical Center
  - North Platte, Nebraska, Forenede Stater, 69103
    - Great Plains Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68106
    - CCOP - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Forenede Stater, 68114
    - Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
  - Omaha, Nebraska, Forenede Stater, 68124
    - Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health - Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68131
    - Cancer Center at Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68198
    - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Cancer Center at Midlands Community Hospital
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - CCOP - Southern Nevada Cancer Research Foundation
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Reno, Nevada, Forenede Stater, 89502
    - Washoe Cancer Services at Washoe Medical Center - Reno
- New Hampshire
  - Keene, New Hampshire, Forenede Stater, 03431
    - Kingsbury Center for Cancer Care at Cheshire Medical Center
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Elliot Regional Cancer Center
  - Rochester, New Hampshire, Forenede Stater, 03867
    - Frisbie Memorial Hospital
- New Jersey
  - Camden, New Jersey, Forenede Stater, 08103
    - Cancer Institute of New Jersey at the Cooper University Hospital
  - East Orange, New Jersey, Forenede Stater, 07018-1095
    - Veterans Affairs Medical Center - East Orange
  - Flemington, New Jersey, Forenede Stater, 08822
    - Hunterdon Regional Cancer Center at Hunterdon Medical Center
  - Hackensack, New Jersey, Forenede Stater, 07601
    - CCOP - Northern New Jersey
  - Hamilton, New Jersey, Forenede Stater, 08690
    - Cancer Institute of New Jersey at Hamilton
  - Livingston, New Jersey, Forenede Stater, 07039
    - St. Barnabas Medical Center
  - Montclair, New Jersey, Forenede Stater, 07042
    - Cancer Center at the Mountainside Hospital
  - Morristown, New Jersey, Forenede Stater, 07962
    - Carol G. Simon Cancer Center at Morristown Memorial Hospital
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
  - Phillipsburg, New Jersey, Forenede Stater, 08865
    - Warren Hospital
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - University of New Mexico Cancer Research and Treatment Center
  - Albuquerque, New Mexico, Forenede Stater, 87108
    - Lovelace Medical Center at Lovelace Sandia Health System
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - Hematology-Oncology Associates, PC
  - Albuquerque, New Mexico, Forenede Stater, 87108
    - Veterans Affairs Medical Center - Albuquerque
  - Santa Fe, New Mexico, Forenede Stater, 87505
    - New Mexico Cancer Care Associates
- New York
  - Bronx, New York, Forenede Stater, 10466
    - Comprehensive Cancer Center at Our Lady of Mercy Medical Center
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Cooperstown, New York, Forenede Stater, 13326
    - Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
  - Glens Falls, New York, Forenede Stater, 12801
    - Charles R. Wood Cancer Center at Glens Falls Hospital
  - New York, New York, Forenede Stater, 10003
    - Beth Israel Medical Center - Petrie Division
  - New York, New York, Forenede Stater, 10025
    - St. Luke's-Roosevelt Hospital Center - St.Luke's Division
  - Nyack, New York, Forenede Stater, 10960
    - Union State Bank Cancer Center at Nyack Hospital
  - Rochester, New York, Forenede Stater, 14621
    - Lipson Cancer and Blood Center at Rochester General Hospital
  - Stony Brook, New York, Forenede Stater, 11794
    - Long Island Cancer Center at Stony Brook University Hospital
  - Syracuse, New York, Forenede Stater, 13210
    - SUNY Upstate Medical University Hospital
  - Syracuse, New York, Forenede Stater, 13057
    - CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
  - Syracuse, New York, Forenede Stater, 13203
    - St. Joseph's Hospital Health Center - Syracuse
  - Utica, New York, Forenede Stater, 13502
    - Faxton Regional Cancer Center
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mission Hospitals - Memorial Campus
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
  - Charlotte, North Carolina, Forenede Stater, 28233
    - Presbyterian Cancer Center at Presbyterian Hospital
  - Concord, North Carolina, Forenede Stater, 28025
    - Batte Cancer Center at Northeast Medical Center
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke Comprehensive Cancer Center
  - Eden, North Carolina, Forenede Stater, 27288
    - John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital
  - Gastonia, North Carolina, Forenede Stater, 28053
    - Comprehensive Cancer Center at Gaston Memorial
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital, Incorporated
  - Greensboro, North Carolina, Forenede Stater, 27401
    - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
  - Greenville, North Carolina, Forenede Stater, 27858
    - Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Pardee Memorial Hospital
  - Kinston, North Carolina, Forenede Stater, 28501
    - Lenoir Memorial Cancer Center
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Cancer Center
  - Rutherfordton, North Carolina, Forenede Stater, 28139
    - Rutherford Hospital
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Comprehensive Cancer Center at Wake Forest University
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Forsyth Regional Cancer Center at Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Medcenter One Health System
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Mid Dakota Clinic, P.C.
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Bismarck Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - CCOP - MeritCare Hospital
  - Fargo, North Dakota, Forenede Stater, 58122
    - MeritCare Medical Group
  - Fargo, North Dakota, Forenede Stater, 58103
    - Dakota Cancer Institute at Innovis Health - Dakota Clinic
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44304
    - Akron City Hospital at Summa Health System
  - Boardman, Ohio, Forenede Stater, 44512
    - St. Elizabeth Boardman Cancer Center
  - Bowling Green, Ohio, Forenede Stater, 43402
    - Wood County Oncology Center
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Hospital Cancer Center at Aultman Health Foundation
  - Canton, Ohio, Forenede Stater, 44708
    - University Hospitals Ireland Cancer Center at Mercy Medical Center
  - Chillicothe, Ohio, Forenede Stater, 54601
    - Adena Regional Medical Center
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth's Cancer Care Center at MetroHealth Medical Center
  - Columbus, Ohio, Forenede Stater, 43215
    - CCOP - Columbus
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital at Ohio Health
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital Cancer Care
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Riverside Cancer Services
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel West Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
  - Dayton, Ohio, Forenede Stater, 45428
    - Veterans Affairs Medical Center - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Cancer Care Center
  - Dayton, Ohio, Forenede Stater, 45429
    - CCOP - Dayton
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Medical Associates
  - Fremont, Ohio, Forenede Stater, 43420
    - Fremont Memorial Hospital
  - Kenton, Ohio, Forenede Stater, 43326
    - Kenton Oncology, Inc.
  - Kettering, Ohio, Forenede Stater, 45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45804
    - Lima Memorial Hospital
  - Lima, Ohio, Forenede Stater, 45801
    - St. Rita's Medical Center
  - Mansfield, Ohio, Forenede Stater, 44903
    - MedCentral - Mansfield Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537
    - Northwest Ohio Oncology Center
  - Maumee, Ohio, Forenede Stater, 43537
    - St. Luke's Hospital
  - Middletown, Ohio, Forenede Stater, 45044
    - Middletown Regional Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - St. Charles Mercy Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - Toledo Clinic
  - Sandusky, Ohio, Forenede Stater, 44870
    - Firelands Regional Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care, Incorporated
  - Springfield, Ohio, Forenede Stater, 45505
    - Community Hospital of Springfield and Clark County
  - Springfield, Ohio, Forenede Stater, 45504
    - Mercy Medical Center Oncology Unit
  - Sylvania, Ohio, Forenede Stater, 43560
    - Promedica Cancer Center at Flower Hospital
  - Tiffin, Ohio, Forenede Stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forenede Stater, 43608
    - St. Vincent Mercy Medical Center
  - Toledo, Ohio, Forenede Stater, 43606
    - Toledo Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - CCOP - Toledo Community Hospital
  - Toledo, Ohio, Forenede Stater, 43614
    - Medical College of Ohio Cancer Institute
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Surgical Specialists
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic, Incorporated
  - Troy, Ohio, Forenede Stater, 45373
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Warren, Ohio, Forenede Stater, 44484
    - St. Joseph Health Care Center
  - Wauseon, Ohio, Forenede Stater, 43567
    - Fulton County Health Center
  - Wright-Patterson Afb, Ohio, Forenede Stater, 45433-5529
    - United States Air Force Medical Center Wright-Patterson
  - Xenia, Ohio, Forenede Stater, 45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Youngstown, Ohio, Forenede Stater, 44510
    - St. Elizabeth Cancer Center at St. Elizabeth Health Center - Youngstown
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Comanche County Memorial Hospital
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - Oklahoma University Medical center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Health Center
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Natalie Warren Bryant Cancer Center at St. Francis Hospital
- Oregon
  - Portland, Oregon, Forenede Stater, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, Forenede Stater, 97232
    - Kaiser Permanente Health Care - Portland
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Abington Memorial Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18105
    - John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - St. Luke's Hospital Cancer Center
  - Danville, Pennsylvania, Forenede Stater, 17822-2001
    - Geisinger Medical Center
  - Dubois, Pennsylvania, Forenede Stater, 15801
    - Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer Center
  - Harrisburg, Pennsylvania, Forenede Stater, 17105
    - PinnacleHealth Regional Cancer Center at Polyclinic Hospital
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Cancer Institute at Milton S. Hershey Medical Center
  - Lancaster, Pennsylvania, Forenede Stater, 17604
    - Lancaster General Hospital
  - Lemoyne, Pennsylvania, Forenede Stater, 17043
    - Central Pennsylvania Hematology and Medical Oncology Associates, PC
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19141
    - Albert Einstein Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Joan Karnell Cancer Center at Pennsylvania Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny Cancer Center at Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224-1791
    - Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Pottstown Memorial Regional Cancer Center
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Medical Center - Sayre
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - Mercy Hospital Cancer Center - Scranton
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Hematology and Oncology Associates
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, Forenede Stater, 16803
    - Mount Nittany Medical Center
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley Medical Center
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02903
    - Rhode Island Hospital
  - Providence, Rhode Island, Forenede Stater, 02906
    - Miriam Hospital at Lifespan
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - Rose Ramer Cancer Clinic at Anderson Area Medical Center
  - Columbia, South Carolina, Forenede Stater, 29210
    - South Carolina Oncology Associates
  - Greenville, South Carolina, Forenede Stater, 29615
    - CCOP - Greenville
  - Greenville, South Carolina, Forenede Stater, 29601
    - Bon Secours St. Francis Health System
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Hospital System Cancer Center
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
  - Spartanburg, South Carolina, Forenede Stater, 29304
    - CCOP - Upstate Carolina
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Medical X-Ray Center
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sioux Valley Hospital and University of South Dakota Medical Center
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Germantown, Tennessee, Forenede Stater, 38138
    - Jones Clinic
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, Forenede Stater, 37920
    - Baptist Hospital of East Tennessee
- Texas
  - Arlington, Texas, Forenede Stater, 76012
    - Arlington Cancer Center - Arlington
  - Dallas, Texas, Forenede Stater, 75230
    - Medical City Dallas Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
  - Temple, Texas, Forenede Stater, 76508
    - CCOP - Scott and White Hospital
- Vermont
  - Berlin, Vermont, Forenede Stater, 05602
    - Mountainview Medical
  - Burlington, Vermont, Forenede Stater, 05401
    - Fletcher Allen Health Care - University Health Center Campus
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - Cancer Center at the University of Virginia
  - Danville, Virginia, Forenede Stater, 24541
    - Danville Regional Medical Center
  - Hampton, Virginia, Forenede Stater, 23666
    - Virginia Oncology Associates - Hampton
  - Kilmarnock, Virginia, Forenede Stater, 22482
    - Rappahannock General Hospital
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Lynchburg Hematology-Oncology Clinic
  - Richmond, Virginia, Forenede Stater, 23298
    - Massey Cancer Center at Virginia Commonwealth University
- Washington
  - Spokane, Washington, Forenede Stater, 99204
    - Providence Cancer Center at Sacred Heart Medical Center
  - Spokane, Washington, Forenede Stater, 99207
    - Providence Cancer Center at Holy Family Hospital
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center
  - Yakima, Washington, Forenede Stater, 98902
    - Washington Hematology - Oncology Specialists
- West Virginia
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
  - Huntington, West Virginia, Forenede Stater, 25702
    - St. Mary's Medical Center
  - Huntington, West Virginia, Forenede Stater, 25701
    - Marshall University Medical Center
  - Morgantown, West Virginia, Forenede Stater, 26506
    - Mary Babb Randolph Cancer Center at West Virginia University Hospitals
- Wisconsin
  - Appleton, Wisconsin, Forenede Stater, 54911-3496
    - Fox Valley Hematology and Oncology
  - Elkhorn, Wisconsin, Forenede Stater, 53121
    - Vince Lombardi Cancer Center - Elkhorn
  - Glendale, Wisconsin, Forenede Stater, 53212
    - Oncology Alliance, S.C. - Milwaukee - East
  - Green Bay, Wisconsin, Forenede Stater, 54311-6519
    - Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Comprehensive Cancer Center
  - Madison, Wisconsin, Forenede Stater, 53715
    - UW Health Oncology
  - Manitowoc, Wisconsin, Forenede Stater, 54221
    - Holy Family Memorial Medical Center
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic - Marshfield Center
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin Cancer Center
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Medical Consultants
  - Milwaukee, Wisconsin, Forenede Stater, 53226-3596
    - Froedtert Hospital and Medical College of Wisconcin
  - Oconomowoc, Wisconsin, Forenede Stater, 53066-3896
    - Oconomowoc Memorial Hospital
  - Racine, Wisconsin, Forenede Stater, 53405
    - All Saints Cancer Center at All Saints Healthcare
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic - Sheboygan
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - Waukesha Memorial Hospital Regional Cancer Center
  - Wausau, Wisconsin, Forenede Stater, 54401
    - University of Wisconsin Cancer Center at Aspirus Wausau Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 120 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

SYGDOMS KARAKTERISTIKA:

Histologisk eller cytologisk bekræftet nyrecellekarcinom (RCC)
- Konventionelt klarcellet karcinom
- Metastatisk eller uoperabel sygdom
Følgende egenskaber og cellulære typer er udelukket:
- Ægte papillær
- Sarcomatoide træk uden en klar cellekomponent
- Kromofobe
- Onkocytom
- Samlekanaltumor
- Overgangscellekarcinom
Målbar eller ikke-målbar sygdom, herunder en eller flere af følgende:
- Endimensionelt målbar læsion ≥ 20 mm ved konventionelle teknikker (f.eks. fysisk undersøgelse eller røntgen af thorax) ELLER 10 mm ved spiral CT-scanning eller MR
- Følgende betragtes som ikke-målbar sygdom:
  - Små læsioner
  - Knoglelæsioner
  - Leptomeningeal sygdom
  - Ascites
  - Pleural/pericardial effusion
  - Lymphangitis cutis/pulmonis
  - Abdominale masser, der ikke er bekræftet og efterfulgt af billedbehandlingsteknikker
  - Cystiske læsioner
  - Bestrålede læsioner, medmindre progression er dokumenteret efter strålebehandling
RCC paraffinvævsblokke eller ufarvede objektglas skal være tilgængelige
Ingen tegn på tidligere eller samtidige CNS-metastaser ved MR- eller CT-scanning

PATIENT KARAKTERISTIKA:

Alder

18 og derover

Præstationsstatus

Karnofsky 70-100 %

Forventede levealder

Ikke specificeret

Hæmatopoietisk

Granulocyttal ≥ 1.500/mm^3
Blodpladeantal ≥ 100.000/mm^3
Ingen historie med klinisk signifikant blødning

Hepatisk

AST/ALT ≤ 2,5 gange øvre normalgrænse (ULN)
Alkalisk fosfatase ≤ 2,5 gange ULN
Bilirubin ≤ 1,5 gange ULN

Renal

Kreatinin ≤ 1,5 gange ULN
Ingen proteinuri > 1+
- Proteinuri ≥ 2+ tilladt, forudsat at protein er < 2 g/24-timers urinopsamling

Kardiovaskulær

Ingen dyb venetrombose inden for det seneste år
Ingen cerebrovaskulær ulykke inden for det seneste år
Ingen perifer karsygdom med claudicatio på < 1 blok
Ingen ukontrolleret hypertension defineret som blodtryk ≥160 mm Hg (systolisk) og/eller ≥ 90 mm Hg (diastolisk), mens du er på medicin
Ingen New York Heart Association klasse II-IV kongestiv hjertesvigt
Ingen angina pectoris, der kræver nitratbehandling
Ingen myokardieinfarkt inden for de seneste 6 måneder
Ingen anden væsentlig hjerte-kar-sygdom

Pulmonal

Ingen lungeemboli inden for det seneste år
Ingen igangværende hæmoptyse

Andet

Ikke gravid eller ammende
Negativ graviditetstest
Fertile patienter skal bruge effektiv prævention under og i 3 måneder efter undersøgelsesbehandlingen
Ingen allerede eksisterende skjoldbruskkirtelabnormitet, hvor normal skjoldbruskkirtelfunktion ikke kan opretholdes med medicin
Ingen forsinket sårheling, sår eller knoglebrud
Ingen ukontrolleret psykiatrisk lidelse
Ingen anden aktuelt aktiv* malignitet undtagen ikke-melanom hudkræft BEMÆRK: *Sygdommen anses ikke for at være aktiv, hvis patienten har gennemført anticancerbehandling og anses for at have < 30 % risiko for tilbagefald

FORUDSÆTNING SAMTYDLIG TERAPI:

Biologisk terapi

Ingen tidligere systemisk immunterapi for RCC
Ingen tidligere behandling med thalidomid, anti-vaskulær endotelvækstfaktor (VEGF), VEGF-receptorhæmmere eller antiangiogene behandling af nogen art
Ingen samtidig profylaktisk filgrastim (G-CSF) eller sargramostim (GM-CSF)

Kemoterapi

Ingen tidligere systemisk kemoterapi for RCC
Ingen samtidig kemoterapi

Endokrin terapi

Ingen samtidig systemisk kortikosteroidbehandling bortset fra følgende:
- Aktuelle og inhalerede steroider
- Erstatningsterapi ved binyrebarkinsufficiens
Ingen samtidige hormoner undtagen dem, der administreres til ikke-sygdomsrelaterede tilstande (f.eks. insulin til diabetes)

Strålebehandling

Se Sygdomskarakteristika
Mindst 4 uger siden tidligere strålebehandling og restitueret
Forudgående palliativ strålebehandling til metastatiske læsioner tilladt, forudsat at mindst 1 målbar eller ikke-målbar læsion forbliver ubehandlet
Ingen samtidig palliativ strålebehandling

Kirurgi

Mindst 4 uger siden tidligere større operation og restitueret

Andet

Ingen anden tidligere systemisk undersøgelsesterapi for RCC
Ingen anden tidligere adjuverende eller neoadjuverende systemisk behandling for RCC
Ingen samtidig fulddosis oral eller parenteral antikoagulering* BEMÆRK: *Lavdosis (1 mg) warfarin til opretholdelse af kateterets åbenhed og/eller daglig profylaktisk aspirin er tilladt

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Interferon Behandling med interferon alfa 2b	Biologisk: rekombinant interferon alfa 9 millioner enheder subQ-injektion 3 x/uge i 4 uger
Eksperimentel: Interferon + bevacizumab Tilføjelse af bevacizumab til interferon alfa 2b-behandling	Biologisk: rekombinant interferon alfa 9 millioner enheder subQ-injektion 3 x/uge i 4 uger Biologisk: bevacizumab 10 mg/kg IV-infusion på dag 1 og 15 i hver cyklus

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Tidsramme
Samlet overlevelse Tidsramme: 5 år	5 år

Sekundære resultatmål

Resultatmål	Tidsramme
Tid til progression Tidsramme: q 3 cyklusser	q 3 cyklusser
Toksicitet Tidsramme: q cyklus	q cyklus

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

National Cancer Institute (NCI)

NCIC Clinical Trials Group

Efterforskere

Studiestol: Brian I. Rini, MD, University of California, San Francisco

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Archer L, Atkins JN, Picus J, Czaykowski P, Dutcher J, Small EJ. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol. 2010 May 1;28(13):2137-43. doi: 10.1200/JCO.2009.26.5561. Epub 2010 Apr 5.
Rini BI, Halabi S, Rosenberg J, et al.: Bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in patients with metastatic renal cell carcinoma: results of overall survival for CALGB 90206. [Abstract] J Clin Oncol 27 (Suppl 15): A-LBA5019, 2009.
Rini BI, Halabi S, Rosenberg JE, et al.: CALGB 90206: a phase III trial of bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in metastatic renal cell carcinoma. [Abstract] American Society of Clinical Oncology 2008 Genitourinary Cancers Symposium, Feb 14-16, 2008, San Francisco, CA. A-350, 2008.
Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Ou SS, Archer L, Atkins JN, Picus J, Czaykowski P, Dutcher J, Small EJ. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol. 2008 Nov 20;26(33):5422-8. doi: 10.1200/JCO.2008.16.9847. Epub 2008 Oct 20.
Rini BI, Halabi S, Taylor J, Small EJ, Schilsky RL; Cancer and Leukemia Group B. Cancer and Leukemia Group B 90206: A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma. Clin Cancer Res. 2004 Apr 15;10(8):2584-6. doi: 10.1158/1078-0432.ccr-03-0605.
Nixon AB, Halabi S, Liu Y, Starr MD, Brady JC, Shterev I, Luo B, Hurwitz HI, Febbo PG, Rini BI, Beltran H, Small EJ, Morris MJ, George DJ. Predictive Biomarkers of Overall Survival in Patients with Metastatic Renal Cell Carcinoma Treated with IFNalpha +/- Bevacizumab: Results from CALGB 90206 (Alliance). Clin Cancer Res. 2022 Jul 1;28(13):2771-2778. doi: 10.1158/1078-0432.CCR-21-2386.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. oktober 2003

Primær færdiggørelse (Faktiske)

1. januar 2004

Studieafslutning (Faktiske)

1. november 2012

Datoer for studieregistrering

Først indsendt

4. november 2003

Først indsendt, der opfyldte QC-kriterier

5. november 2003

Først opslået (Skøn)

6. november 2003

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

6. juli 2016

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

1. juli 2016

Sidst verificeret

1. juli 2016

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

CALGB-90206
U10CA031946 (U.S. NIH-bevilling/kontrakt)
CAN-NCIC-REC1
CDR0000335292 (Registry Identifier: NCI Physician Data Query)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Nyrekræft

Zhen Li

Tilmelding efter invitation

For at undersøge værdien af magnetisk resonansafbildning i ikke-invasiv kvantitativ evaluering af transplantatfunktion efter samtidig pancreas-Kidney-transplantation

Samtidig pancreas-Kidney-transplantation

Kina
University Hospital, Basel, Switzerland

Ikke rekrutterer endnu

Swiss Cardiovascular-Kidney-Liver-Metabolic (CKLM) registreringsdatabase

Kardiovaskulær-Kidney-metabolsk syndrom | Cradiovascular-Kidney-Liver-Metabolic (CKLM) syndrom

Schweiz
Chung Shan Medical University
National Science and Technology Council, Taiwan

Ikke rekrutterer endnu

Early GLP-1 Receptor Agonist and SGLT2 Inhibitor Add-On Strategies in Adults With Obesity, Type 2 Diabetes, Cardiovascular-Kidney-Metabolic Syndrome Stage 2-3, and Metabolic Dysfunction-Associated Steatotic Liver Disease

Fedme type 2 diabetes mellitus | Metabolisk dysfunktion-associeret steatotisk leversygdom | Kardiovaskulær-Kidney-metabolsk syndrom

Taiwan
CHU de Reims

Ikke rekrutterer endnu

Sammenbrudseindeks for den underordnede vena cava og nyretransplantation (CIVC-KT)

Fluid reaktionsevne i tidlig transplantationsperiode efter Kidney

Frankrig
Camille N. Kotton, MD
Kamada, Ltd.; University of Texas Southwestern Medical Center

Rekruttering

Strategisk hjælp til immunoglobulin for at forbedre beskyttelse mod sen sygdom (CMV) (SHIELD)

Cytomegalovirus | Nyretransplantation; Komplikationer | Organtransplantation | Levertransplantationskomplikationer | Samtidig lever-Kidney-transplantation; Komplikationer

Forenede Stater
Changhai Hospital
Rui Therapeutics Co., Ltd

Rekruttering

Et undersøgende klinisk studie om sikkerheden og effektiviteten af anti-CD19/BCMA U CAR-T-celler i behandlingen af recidiverende/refraktær immunmedieret nyresygdom

Relapseret/Refraktær Immun Nefropati | Relapsed/Refractory Immune-mediated Kidney Disease

Kina
Nanjing Medical University

Ikke rekrutterer endnu

Mekanismer og interventioner til fysisk aktivitet i skrøbelige kardiovaskulære-Kidney-metaboliske syndrompatienter: En tidsmæssig selvreguleringsmetode (CKM)

Kardiovaskulær-Kidney-metabolsk syndrom
First Affiliated Hospital of Fujian Medical University

Rekruttering

Studie om opbygning af fuld livscyklus kohorte, big data management og klinisk prognose for cardio-renal-metabolisk (CKM) syndrom (CKM-LCBP)

Metaboliske sygdomme | Kronisk nyresygdom | Hjerte-kar-sygdomme (CVD) | Kardiovaskulær-Kidney-metabolsk syndrom

Kina
Chung Shan Medical University
National Science and Technology Council, Taiwan

Afsluttet

Tidlig tilføjelseskombination af GLP-1-receptoragonist og SGLT2-hæmmer hos personer med kardiovaskulær-nyre-metabol stadie 2-3 (GLP1-SGLT2-CKM)

Type 2 diabetes | Nyre sygdom | Fedme & Overvægt | Risikofaktor for hjertekarsygdomme | Kardiovaskulær-Kidney-metabolsk syndrom
University of Alabama at Birmingham
Ohio State University; American Heart Association; Tuskegee University

Rekruttering

Inspirer hende: inspirere hjertet og følelserne til radikal sundhed

Hjerte-kar-sygdomme | Rygning | Forhøjet blodtryk | Fedme | Diabetes | Hyperlipidæmi | Nyre sygdom | Kardiovaskulær-Kidney-metabolsk syndrom

Forenede Stater

Kliniske forsøg med rekombinant interferon alfa

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Afsluttet

Interferon Alfa til behandling af patienter med tilbagevendende ikke-operable meningiomer og maligne meningiomer

Tumorer i hjernen og centralnervesystemet

Forenede Stater
Ainos, Inc. (f/k/a Amarillo Biosciences Inc.
CytoPharm, Inc.

Afsluttet

Interferon-alfa sugetabletter til forebyggelse af tilbagefald ved hepatitis C

Hepatitis C, kronisk

Taiwan
Abramson Cancer Center of the University of Pennsylvania
National Cancer Institute (NCI)

Afsluttet

Intrapleural genoverførsel til pleural mesotheliom (IFN-alpha)

Malignt pleura mesotheliom

Forenede Stater
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Afsluttet

Capecitabin og pegyleret interferon alfa-2a til behandling af patienter med tilbagevendende eller progressive hjernemetastaser på grund af brystkræft

Brystkræft | Metastatisk kræft

Forenede Stater
Mongolian National University of Medical Sciences
Mongolian National Cancer Center

Afsluttet

Interferon alfa-terapi til cervikal CINI og HPV-infektion

HPV-infektion | Cervikal dysplasi

Mongoliet
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Afsluttet

Kortvarig lavdosis interferon alfa til behandling af patienter med kræft i urothelium

Blærekræft | Urethral kræft

Forenede Stater
Ainos, Inc. (f/k/a Amarillo Biosciences Inc.
Texas Tech University Health Sciences Center

Afsluttet

Interferon-alfa-behandling af kronisk hoste ved kronisk obstruktiv lungesygdom og idiopatisk lungefibrose

Lungesygdom, kronisk obstruktiv | Hoste | Lungefibrose

Forenede Stater
ImmunityBio, Inc.

Rekruttering

Resq133a-nmibc: Intravesical Recombinant Mycobacterium (RMBCG) hos deltagere med NMIBC berettiget til at modtage intravesical tice BCG

NMIBC

Forenede Stater
University Hospital Tuebingen
Dermatologic Cooperative Oncology Group

Afsluttet

Pegyleret interferon-alpha-2a hos patienter med malignt melanom trin IIA-IIIB

Melanom

Tyskland
University of Pittsburgh
Schering-Plough

Afsluttet

Pilot Study of IFN α2b for Melanoma Patients

Melanom

Forenede Stater

Interferon Alfa-2b med eller uden Bevacizumab til behandling af patienter med avanceret nyrecellekarcinom (nyrekræft)

Et randomiseret fase III-forsøg med Interferon Alfa-2B eller Interferon Alfa-2B Plus Bevacizumab hos patienter med avanceret nyrecarcinom

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Tidsramme

Sekundære resultatmål

Resultatmål

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Nyrekræft

Kliniske forsøg med rekombinant interferon alfa

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Indonesia

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer