Interferon Alfa-2b With or Without Bevacizumab in Treating Patients With Advanced Renal Cell Carcinoma (Kidney Cancer)

July 1, 2016 updated by: Alliance for Clinical Trials in Oncology

A Randomized Phase III Trial Of Interferon Alfa-2B Or Interferon Alfa-2B Plus Bevacizumab In Patients With Advanced Renal Carcinoma

RATIONALE: Biological therapies, such as interferon alfa-2b, may interfere with the growth of tumor cells. Bevacizumab may stop the growth of tumor cells by stopping blood flow to the tumor. It is not yet known whether interferon alfa-2b is more effective with or without bevacizumab in treating advanced renal cell carcinoma (kidney cancer).

PURPOSE: This randomized phase III trial is studying interferon alfa-2b and bevacizumab to see how well they work compared to interferon alfa-2b alone in treating patients with advanced renal cell carcinoma.

Study Overview

Status

Completed

Conditions

Kidney Cancer

Intervention / Treatment

Detailed Description

OBJECTIVES:

Primary

Compare the overall survival of patients with advanced renal cell carcinoma treated with interferon alfa-2b alone or interferon alfa-2b with bevacizumab.

Secondary

Compare the time to disease progression and objective response rates in patients treated with these regimens.
Determine the toxicity of interferon alfa-2b in combination with bevacizumab in these patients.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to prior nephrectomy (yes vs no) and number of risk factors for disease progression (0 vs 1-2 vs 3 or more). Patients are randomized to 1 of 2 treatment arms.

Arm I: Patients receive interferon alfa-2b subcutaneously (SC) three times a week.
Arm II: Patients receive interferon alfa-2b as in arm I and bevacizumab IV over 30-90 minutes on days 1 and 15.

In both arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Patients are followed every 3 months for 2 years and then annually for up to 10 years after study entry.

PROJECTED ACCRUAL: A total of 700 patients (350 per treatment arm) will be accrued for this study within 3 years.

Study Type

Interventional

Enrollment (Actual)

732

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Canada
- British Columbia
  - Vancouver, British Columbia, Canada, V6T 1Z4
    - University of British Columbia
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 1V8
    - Nova Scotia Cancer Centre at Queen Elizabeth II Health Sciences Centre
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre at Pasqua Hospital
United States
- Alabama
  - Birmingham, Alabama, United States, 35294
    - Comprehensive Cancer Center at University of Alabama at Birmingham
  - Huntsville, Alabama, United States, 35801
    - Huntsville Hospital
- Arizona
  - Scottsdale, Arizona, United States, 85259
    - CCOP - Mayo Clinic Scottsdale Oncology Program
- Arkansas
  - Ft. Smith, Arkansas, United States, 72903
    - Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
- California
  - Arroyo Grande, California, United States, 93420
    - Arroyo Grande Community Hospital
  - Duarte, California, United States, 91010
    - City of Hope Comprehensive Cancer Center
  - Fremont, California, United States, 94538
    - Kaiser Permanente - Fremont
  - Hayward, California, United States, 94545
    - Kaiser Permanente Medical Center - Hayward
  - Mission Hills, California, United States, 91346-9600
    - Providence Holy Cross Cancer Center
  - Oakland, California, United States, 94611
    - Kaiser Permanente Medical Center - Oakland
  - Orange, California, United States, 92868
    - St. Joseph Hospital Regional Cancer Center - Orange
  - Redwood City, California, United States, 94063
    - Kaiser Permanente Medical Center - Redwood City
  - Richmond, California, United States, 94801
    - Kaiser Permanente Medical Center - Richmond
  - Roseville, California, United States, 95661
    - Kaiser Permanente Medical Center - Roseville
  - Sacramento, California, United States, 95823
    - South Sacramento Kaiser-Permanente Medical Center
  - Sacramento, California, United States, 95825
    - Kaiser Permanente Medical Center - Sacramento
  - San Diego, California, United States, 92161
    - Veterans Affairs Medical Center - San Diego
  - San Diego, California, United States, 92134
    - Naval Medical Center - San Diego
  - San Diego, California, United States, 92120
    - Kaiser Permanente Medical Office -Vandever Medical Office
  - San Diego, California, United States, 92103
    - Rebecca and John Moores UCSD Cancer Center
  - San Francisco, California, United States, 94115
    - UCSF Comprehensive Cancer Center
  - San Francisco, California, United States, 94121
    - Veterans Affairs Medical Center - San Francisco
  - San Francisco, California, United States, 94115
    - Kaiser Permanente Medical Center - San Francisco Geary Campus
  - San Francisco, California, United States, 94110
    - San Francisco General Hospital Medical Center
  - San Jose, California, United States, 95119
    - Kaiser Permanente Medical Center - Santa Teresa
  - San Rafael, California, United States, 94903
    - Kaiser Foundation Hospital - San Rafael
  - Santa Clara, California, United States, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Rosa, California, United States, 95403
    - Kaiser Permanente Medical Center - Santa Rosa
  - South San Francisco, California, United States, 94080
    - Kaiser Permanente Medical Center - South San Francisco
  - Stockton, California, United States, 95210
    - Kaiser Permanente Medical Facility - Stockton
  - Vallejo, California, United States, 94589
    - Kaiser Permanente Medical Center - Vallejo
  - Walnut Creek, California, United States, 94596
    - Kaiser Permanente Medical Center - Walnut Creek
- Colorado
  - Aurora, Colorado, United States, 80012
    - Aurora Presbyterian Hospital
  - Boulder, Colorado, United States, 80301
    - Boulder Community Hospital
  - Colorado Springs, Colorado, United States, 80909
    - Memorial Hospital Cancer Center
  - Colorado Springs, Colorado, United States, 80933
    - Penrose Cancer Center at Penrose Hospital
  - Colorado Springs, Colorado, United States, 80907
    - Cancer Center of Colorado Springs
  - Denver, Colorado, United States, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, United States, 80220
    - Rose Medical Center
  - Denver, Colorado, United States, 80218
    - Presbyterian - St. Luke's Medical Center
  - Denver, Colorado, United States, 80218
    - St. Joseph Hospital
  - Denver, Colorado, United States, 80224-2522
    - CCOP - Colorado Cancer Research Program, Incorporated
  - Englewood, Colorado, United States, 80110
    - Swedish Medical Center
  - Fort Collins, Colorado, United States, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, United States, 80524
    - Front Range Cancer Specialists
  - Lone Tree, Colorado, United States, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, United States, 80502
    - Hope Cancer Care Center at Longmont United Hospital
  - Pueblo, Colorado, United States, 81004
    - St. Mary-Corwin Regional Medical Center
  - Thorton, Colorado, United States, 80229
    - North Suburban Medical Center
- Connecticut
  - Hartford, Connecticut, United States, 06105
    - Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
  - Middletown, Connecticut, United States, 06457
    - Middlesex Hospital Cancer Center
  - New Haven, Connecticut, United States, 06520-8032
    - Yale Comprehensive Cancer Center
  - Norwalk, Connecticut, United States, 06856
    - Norwalk Hospital
- Delaware
  - Dover, Delaware, United States, 19901
    - Kent General Hospital at Bayhealth Medical Center
  - Lewes, Delaware, United States, 19958
    - Beebe Medical Center
  - Newark, Delaware, United States, 19718
    - CCOP - Christiana Care Health Services
  - Wilmington, Delaware, United States, 19805
    - St. Francis Hospital
- District of Columbia
  - Washington, District of Columbia, United States, 20307
    - Walter Reed Army Medical Center
  - Washington, District of Columbia, United States, 20007
    - Lombardi Cancer Center at Georgetown University Medical Center
- Florida
  - Boca Raton, Florida, United States, 33486
    - Lynn Regional Cancer Center of Boca Raton Community Hospital
  - Daytona Beach, Florida, United States, 32115
    - Halifax Medical Center
  - Fort Lauderdale, Florida, United States, 33308
    - Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
  - Gainesville, Florida, United States, 32610
    - Shands Cancer Center at the University of Florida - Jacksonville
  - Hollywood, Florida, United States, 33021
    - Memorial Cancer Institute at Memorial Regional Hospital
  - Jacksonville, Florida, United States, 32207
    - Baptist Cancer Institute - Jacksonville
  - Jacksonville, Florida, United States, 32224-9980
    - Mayo Clinic - Jacksonville
  - Jupiter, Florida, United States, 33458
    - Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  - Lakeland, Florida, United States, 33805
    - Lakeland Regional Cancer Center at Lakeland Regional Medical Center
  - Lakeland, Florida, United States, 33805
    - Watson Clinic
  - Miami Beach, Florida, United States, 33140
    - CCOP - Mount Sinai Medical Center
  - Orange Park, Florida, United States, 32073
    - Florida Oncology Associates
  - Orlando, Florida, United States, 32803
    - Florida Hospital - Orlando
  - Sarasota, Florida, United States, 34236
    - Florida Cancer Specialists
  - West Palm Beach, Florida, United States, 33401
    - Palm Beach Cancer Institute - West Palm Beach
- Georgia
  - Albany, Georgia, United States, 31703
    - Phoebe Cancer Center at Phoebe Putney Memorial Hospital
  - Altanta, Georgia, United States, 30322
    - Emory University Hospital - Atlanta
  - Athens, Georgia, United States, 30607
    - Hematology and Oncology of Northeast Georgia
  - Atlanta, Georgia, United States, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, United States, 30342
    - Saint Joseph's Hospital of Atlanta
  - Atlanta, Georgia, United States, 30342
    - CCOP - Atlanta Regional
  - Atlanta, Georgia, United States, 30342
    - Northside Hospital Cancer Center
  - Augusta, Georgia, United States, 30912
    - MBCCOP-Medical College of Georgia Cancer Center
  - Augusta, Georgia, United States, 30901
    - Augusta Oncology Associates
  - Austell, Georgia, United States, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, United States, 31902
    - John B. Amos Community Cancer Center
  - Decatur, Georgia, United States, 30033
    - Charles B. Eberhart Cancer Center at DeKalb Medical Center
  - Decatur, Georgia, United States, 30033
    - Veterans Affairs Medical Center - Atlanta (Decatur)
  - Gainesville, Georgia, United States, 30501
    - Northeast Georgia Medical Center
  - Lawrenceville, Georgia, United States, 30045
    - Gwinnett Medical Center
  - Macon, Georgia, United States, 31208
    - Medical Center of Central Georgia
  - Marietta, Georgia, United States, 30060
    - Kennestone Cancer Center at Wellstar Kennestone Hospital
  - Riverdale, Georgia, United States, 30274
    - Southern Regional Medical Center
  - Savannah, Georgia, United States, 31403
    - Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
  - Savannah, Georgia, United States, 31405
    - Cancer Care and Research Pavilion at St. Joseph's/Candler
- Hawaii
  - Aiea, Hawaii, United States, 96701
    - Kapiolani Medical Center at Pali Momi
  - Honolula, Hawaii, United States, 96813
    - Cancer Research Center of Hawaii
  - Honolulu, Hawaii, United States, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, United States, 96813
    - OnCare Hawaii, Incorporated - Lusitana
  - Honolulu, Hawaii, United States, 96813
    - Queen's Cancer Institute at Queen's Medical Center
  - Honolulu, Hawaii, United States, 96813
    - Straub Clinic and Hospital, Incorporated
  - Honolulu, Hawaii, United States, 96817
    - OnCare Hawaii, Incorporated - Kuakini
  - Honolulu, Hawaii, United States, 96817
    - St. Francis Medical Center
- Idaho
  - Boise, Idaho, United States, 83712
    - Mountain States Tumor Institute - Boise
- Illinois
  - Alton, Illinois, United States, 62002
    - Saint Anthony's Hospital at Saint Anthony's Health Center
  - Aurora, Illinois, United States, 60507
    - Rush-Copley Cancer Care Center
  - Bloomington, Illinois, United States, 61701
    - St. Joseph Medical Center
  - Canton, Illinois, United States, 61520
    - Graham Hospital
  - Carthage, Illinois, United States, 62321
    - Memorial Hospital
  - Chicago, Illinois, United States, 60637-1470
    - University of Chicago Cancer Research Center
  - Chicago, Illinois, United States, 60612
    - University Of Illinois Medical Center
  - Decatur, Illinois, United States, 62526
    - Decatur Memorial Hospital Cancer Care Institute
  - Elk Grove Village, Illinois, United States, 60007
    - Alexian Brothers Cancer Care Center
  - Eureka, Illinois, United States, 61530
    - Eureka Hospital
  - Evanston, Illinois, United States, 60201
    - Evanston Northwestern Health Care - Evanston Hospital
  - Galesburg, Illinois, United States, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, United States, 61401
    - Galesburg Clinic
  - Galesburg, Illinois, United States, 61401
    - InterCommunity Cancer Center of Western Illinois
  - Galesburg, Illinois, United States, 61401
    - Medical And Surgical Specialists, Llc
  - Havana, Illinois, United States, 62644
    - Mason District Hospital
  - Hopedale, Illinois, United States, 61747
    - Hopedale Medical Complex
  - Joliet, Illinois, United States, 60435
    - Joliet Oncology Hematology Associates, Limited - West
  - Kankakee, Illinois, United States, 60901
    - Provena St. Mary's Wasser Regional Cancer Center - Kankakee
  - Kewanee, Illinois, United States, 61443
    - Kewanee Hospital
  - La Grange, Illinois, United States, 60525
    - La Grange Memorial Hospital
  - Macomb, Illinois, United States, 61455
    - Mcdonough District Hospital
  - Moline, Illinois, United States, 61265
    - Trinity Medical Center - East
  - Naperville, Illinois, United States, 60540
    - Hematology Oncology Consultants Ltd.
  - Normal, Illinois, United States, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, United States, 61761
    - Community Cancer Center
  - Ottawa, Illinois, United States, 61350
    - Community Hospital of Ottawa
  - Ottawa, Illinois, United States, 61350
    - Oncology Hematology Associates of Central Illinois - Ottawa
  - Pekin, Illinois, United States, 61554
    - Cancer Treatment Center at Pekin Hospital
  - Peoria, Illinois, United States, 61614
    - Proctor Hospital
  - Peoria, Illinois, United States, 61603
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, United States, 61637
    - OSF St. Francis Medical Center
  - Peoria, Illinois, United States, 61615
    - CCOP - Illinois Oncology Research Association
  - Peoria, Illinois, United States, 61615
    - Oncology/Hematology Associates of Central Illinois, P.C.
  - Peru, Illinois, United States, 61354
    - Illinois Valley Community Hospital
  - Princeton, Illinois, United States, 61356
    - Perry Memorial Hospital
  - Rockford, Illinois, United States, 61104
    - Swedish American Hospital
  - Spring Valley, Illinois, United States, 61362
    - St. Margaret's Hospital
  - Spring Valley, Illinois, United States, 61362
    - Valley Cancer Center
  - Springfield, Illinois, United States, 62781-0001
    - Regional Cancer Center at Memorial Medical Center
  - Urbana, Illinois, United States, 61801
    - Carle Cancer Center at Carle Foundation Hospital
  - Urbana, Illinois, United States, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Beech Grove, Indiana, United States, 46107
    - St. Francis Hospital and Health Centers
  - Elkhart, Indiana, United States, 46515
    - Elkhart General Hospital
  - Fort Wayne, Indiana, United States, 46815
    - Fort Wayne Medical Oncology and Hematology, Incorporated
  - La Porte, Indiana, United States, 46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - Lafayette, Indiana, United States, 47904
    - Oncology Institute of Greater Lafayette
  - Michigan City, Indiana, United States, 46360
    - Saint Anthony Memorial Health Centers
  - Plymouth, Indiana, United States, 46544
    - Saint Joseph Regional Medical Center - Plymouth Campus
  - South Bend, Indiana, United States, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, United States, 46601
    - CCOP - Northern Indiana CR Consortium
- Iowa
  - Ames, Iowa, United States, 50010
    - McFarland Clinic, P.C.
  - Bettendorf, Iowa, United States, 52722
    - Hematology Oncology Associates of the Quad Cities
  - Carroll, Iowa, United States, 51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids, Iowa, United States, 52402
    - St. Luke's Hospital
  - Cedar Rapids, Iowa, United States, 52403
    - Cedar Rapids Oncology Associates
  - Cedar Rapids, Iowa, United States, 52402
    - Iowa Blood and Cancer Care
  - Cedar Rapids, Iowa, United States, 52403
    - Mercy Cancer Center at Mercy Medical Center
  - Council Bluffs, Iowa, United States, 51503
    - Alegent Health Mercy Hospital
  - Davenport, Iowa, United States, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, United States, 50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines, Iowa, United States, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, United States, 50309
    - Medical Oncology and Hematology Associates at John Stoddard Cancer Center
  - Des Moines, Iowa, United States, 50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines, Iowa, United States, 50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines, Iowa, United States, 50316
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Des Moines, Iowa, United States, 50307
    - Mercy Capitol Hospital
  - Dubuque, Iowa, United States, 52001
    - Wendt Regional Cancer Center at Finley Hospital
  - Iowa City, Iowa, United States, 52242
    - Holden Comprehensive Cancer Center at University of Iowa
  - Missouri Valley, Iowa, United States, 51555
    - Alegent Health Community Memorial Hospital
  - Onawa, Iowa, United States, 51040
    - Burgess Health Center
  - Ottumwa, Iowa, United States, 52501
    - Cancer Center at Ottumwa Regional Health Center
  - Sioux City, Iowa, United States, 51104
    - St. Luke's Regional Medical Center
  - Sioux City, Iowa, United States, 51104
    - Mercy Medical Center - Sioux City
  - Sioux City, Iowa, United States, 51101
    - Siouxland Hematology-Oncology Associates
- Kansas
  - Chanute, Kansas, United States, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, United States, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, United States, 67042
    - Cancer Center of Kansas, P.A. - El Dorado
  - Kingman, Kansas, United States, 67068
    - Cancer Center of Kansas - Kingman
  - Liberal, Kansas, United States, 67901
    - Southwest Medical Center
  - Newton, Kansas, United States, 67114
    - Cancer Center of Kansas - Newton
  - Parsons, Kansas, United States, 67357
    - Cancer Center of Kansas, P.A. - Parsons
  - Pittsburg, Kansas, United States, 66762
    - Mount Carmel Regional Cancer Center
  - Pratt, Kansas, United States, 67124
    - Pratt Cancer Center of Kansas
  - Salina, Kansas, United States, 67042
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, United States, 66604
    - Cancer Center at Stormont-Vail Regional Health Center
  - Topeka, Kansas, United States, 66606
    - St. Francis Comprehensive Cancer Center
  - Wellington, Kansas, United States, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, United States, 67214
    - CCOP - Wichita
  - Wichita, Kansas, United States, 67214
    - Via Christi Cancer Center at Via Christi Regional Medical Center
  - Wichita, Kansas, United States, 67203
    - Associates In Womens Health
  - Wichita, Kansas, United States, 67208
    - Cancer Center of Kansas, P.A.
  - Wichita, Kansas, United States, 67214
    - Cancer Center of Kansas, P.A. - Wichita
  - Winfield, Kansas, United States, 67156
    - Cancer Center of Kansas - Winfield
- Louisiana
  - Baton Rouge, Louisiana, United States, 70806
    - Baton Rouge General Regional Cancer Center
  - Baton Rouge, Louisiana, United States, 70809
    - Mary Bird Perkins Cancer Center - Baton Rouge
  - Baton Rouge, Louisiana, United States, 708169990
    - Ochsner Clinic of Baton Rouge
  - Houma, Louisiana, United States, 70360
    - Terrebonne General Medical Center
  - New Orleans, Louisiana, United States, 70121
    - CCOP - Ochsner
  - New Orleans, Louisiana, United States, 70112
    - MBCCOP - LSU Health Sciences Center
  - New Orleans, Louisiana, United States, 70112
    - Cancer Center at Medical Center of Louisiana - New Orleans
  - New Orleans, Louisiana, United States, 70121
    - Ochsner Cancer Institute at Ochsner Clinic Foundation
- Maine
  - Bangor, Maine, United States, 04401
    - CancerCare of Maine at Eastern Maine Medial Center
- Maryland
  - Baltimore, Maryland, United States, 21229
    - St. Agnes Cancer Center
  - Baltimore, Maryland, United States, 21201-1595
    - Greenebaum Cancer Center at University of Maryland Medical Center
  - Elkton MD, Maryland, United States, 21921
    - Union Hospital Cancer Center at Union Hospital
- Massachusetts
  - Boston, Massachusetts, United States, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, United States, 02111
    - Cancer Center at Tufts - New England Medical Center
  - Burlington, Massachusetts, United States, 01805
    - Lahey Clinic Medical Center - Burlington
  - Quincy, Massachusetts, United States, 02169
    - Commonwealth Hematology-Oncology P.C. - Quincy
  - Worcester, Massachusetts, United States, 01655
    - UMASS Memorial Cancer Center - University Campus
- Michigan
  - Adrian, Michigan, United States, 49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor, Michigan, United States, 48106-0995
    - St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
  - Ann Arbor, Michigan, United States, 48100
    - CCOP - Michigan Cancer Research Consortium
  - Battle Creek, Michigan, United States, 49017
    - Battle Creek Health System
  - Big Rapids, Michigan, United States, 49307
    - Mecosta County General Hospital
  - Flint, Michigan, United States, 48532
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, United States, 49503
    - CCOP - Grand Rapids
  - Grand Rapids, Michigan, United States, 49503
    - Lacks Cancer Center at Saint Mary's Mercy Medical Center
  - Grand Rapids, Michigan, United States, 49503
    - Spectrum Health Cancer Care - Butterworth Campus
  - Grand Rapids, Michigan, United States, 49506
    - Metropolitan Hospital
  - Grand Rapids, Michigan, United States, 49506
    - Spectrum Health Hospital - Blodgett Campus
  - Holland, Michigan, United States, 49423
    - Holland Community Hospital
  - Jackson, Michigan, United States, 49201
    - Foote Hospital
  - Kalamazoo, Michigan, United States, 49007
    - West Michigan Cancer Center
  - Lambertville, Michigan, United States, 48144
    - Haematology-Oncology Associates of Ohio and Michigan, P.C.
  - Monroe, Michigan, United States, 48162
    - Community Cancer Center of Monroe
  - Monroe, Michigan, United States, 48162
    - Mercy Memorial Hospital System
  - Muskegon, Michigan, United States, 49443
    - Hackley Hospital
  - Petoskey, Michigan, United States, 49770
    - Northern Michigan Hospital
  - Royal Oak, Michigan, United States, 48073
    - William Beaumont Hospital - Royal Oak Campus
  - Saginaw, Michigan, United States, 48601
    - Seton Cancer Institute - Saginaw
  - Saint Joseph, Michigan, United States, 49085
    - Oncology Care Associates, P.L.L.C.
  - Traverse City, Michigan, United States, 49684
    - Munson Medical Center
  - Warren, Michigan, United States, 48903
    - St. John Macomb Hospital
- Minnesota
  - Bemidji, Minnesota, United States, 56601
    - MeritCare Clinic - Bemidji
  - Brainerd, Minnesota, United States, 56401
    - Brainerd Medical Center
  - Burnsville, Minnesota, United States, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, United States, 55433
    - Mercy Hospital
  - Duluth, Minnesota, United States, 55802
    - Cancer Care Center at St. Luke's Hospital
  - Edina, Minnesota, United States, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, United States, 55432
    - Mercy and Unity Cancer Center at Mercy and Unity Hospitals
  - Hutchinson, Minnesota, United States, 55350
    - Hutchinson Area Health Care
  - Litchfield, Minnesota, United States, 55355
    - Meeker County Memorial Hospital
  - Maplewood, Minnesota, United States, 55109
    - St. John's Hospital
  - Minneapolis, Minnesota, United States, 55417
    - Veterans Affairs Medical Center - Minneapolis
  - Minneapolis, Minnesota, United States, 55415
    - Hennepin County Medical Center - Minneapolis
  - Minneapolis, Minnesota, United States, 55407
    - Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, United States, 55455
    - Fairview University Medical Center - University Campus
  - Montevideo, Minnesota, United States, 56265
    - Chippewa County - Montevideo Hospital
  - Robbinsdale, Minnesota, United States, 55422
    - Hubert H. Humphrey Cancer Center at North Memorial Medical Center
  - Rochester, Minnesota, United States, 55905
    - Mayo Clinic Cancer Center
  - Saint Louis Park, Minnesota, United States, 55416
    - CCOP - Metro-Minnesota
  - Saint Paul, Minnesota, United States, 55101
    - Cancer Care Center at Regions Hospital
  - Shakopee, Minnesota, United States, 55379
    - Saint Francis Cancer Center
  - St Paul, Minnesota, United States, 55102
    - St. Joseph's Hospital
  - St. Cloud, Minnesota, United States, 56303
    - CentraCare Clinic - River Campus
  - St. Cloud, Minnesota, United States, 56303
    - Adult and Pediatric Urology, P.L.L.P.
  - St. Louis Park, Minnesota, United States, 55416
    - Park Nicollet Clinic
  - St. Paul, Minnesota, United States, 55102
    - United Hospital
  - Waconia, Minnesota, United States, 55387
    - Ridgeview Medical Center
  - Woodbury, Minnesota, United States, 55125
    - Woodwinds Hospital
- Mississippi
  - Hattiesburg, Mississippi, United States, 39401
    - Hattiesburg Clinic, P.A.
  - Hattiesburg, Mississippi, United States, 34902
    - Hematology & Oncology Clinic
- Missouri
  - Cape Girardeau, Missouri, United States, 63701
    - St. Francis Medical Center
  - Cape Girardeau, Missouri, United States, 63701
    - Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
  - Chesterfield, Missouri, United States, 63017-3417
    - Saint Luke's Hospital
  - Columbia, Missouri, United States, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Columbia, Missouri, United States, 65201
    - Missouri Cancer Associates
  - Joplin, Missouri, United States, 64804
    - Freeman Cancer Institute at Freeman Health System
  - Kansas City, Missouri, United States, 64131
    - CCOP - Kansas City
  - Saint Louis, Missouri, United States, 63141
    - CCOP - St. Louis-Cape Girardeau
  - Saint Louis, Missouri, United States, 63141
    - David C. Pratt Cancer Center at St. John's Mercy
  - Springfield, Missouri, United States, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, United States, 65807
    - Hulston Cancer Center at Cox Medical Center South
  - St. Louis, Missouri, United States, 63131
    - Missouri Baptist Cancer Center
  - St. Louis, Missouri, United States, 63128
    - St. Anthony's Cancer Center
- Montana
  - Billings, Montana, United States, 59101
    - CCOP - Montana Cancer Consortium
  - Great Falls, Montana, United States, 59405
    - Great Falls Clinic
  - Great Falls, Montana, United States, 59405
    - Sletten Regional Cancer Institute
- Nebraska
  - Fremont, Nebraska, United States, 68025
    - Fremont Area Medical Center
  - Kearney, Nebraska, United States, 68847
    - Cancer Center at the Good Samaritan Health Systems
  - Lincoln, Nebraska, United States, 68502
    - Bryan LGH Medical Center West
  - Lincoln, Nebraska, United States, 68510
    - Cancer Resource Center - Lincoln
  - Lincoln, Nebraska, United States, 68510
    - St. Elizabeth Regional Medical Center
  - North Platte, Nebraska, United States, 69103
    - Great Plains Regional Medical Center
  - Omaha, Nebraska, United States, 68106
    - CCOP - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, United States, 68114
    - Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
  - Omaha, Nebraska, United States, 68124
    - Bergan Mercy Medical Center
  - Omaha, Nebraska, United States, 68122
    - Alegent Health - Immanuel Medical Center
  - Omaha, Nebraska, United States, 68131
    - Cancer Center at Creighton University Medical Center
  - Omaha, Nebraska, United States, 68198
    - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
  - Papillion, Nebraska, United States, 68046
    - Midlands Cancer Center at Midlands Community Hospital
- Nevada
  - Las Vegas, Nevada, United States, 89106
    - CCOP - Southern Nevada Cancer Research Foundation
  - Las Vegas, Nevada, United States, 89102
    - University Medical Center of Southern Nevada
  - Reno, Nevada, United States, 89502
    - Washoe Cancer Services at Washoe Medical Center - Reno
- New Hampshire
  - Keene, New Hampshire, United States, 03431
    - Kingsbury Center for Cancer Care at Cheshire Medical Center
  - Lebanon, New Hampshire, United States, 03756
    - Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
  - Manchester, New Hampshire, United States, 03103
    - Elliot Regional Cancer Center
  - Rochester, New Hampshire, United States, 03867
    - Frisbie Memorial Hospital
- New Jersey
  - Camden, New Jersey, United States, 08103
    - Cancer Institute of New Jersey at the Cooper University Hospital
  - East Orange, New Jersey, United States, 07018-1095
    - Veterans Affairs Medical Center - East Orange
  - Flemington, New Jersey, United States, 08822
    - Hunterdon Regional Cancer Center at Hunterdon Medical Center
  - Hackensack, New Jersey, United States, 07601
    - CCOP - Northern New Jersey
  - Hamilton, New Jersey, United States, 08690
    - Cancer Institute of New Jersey at Hamilton
  - Livingston, New Jersey, United States, 07039
    - St. Barnabas Medical Center
  - Montclair, New Jersey, United States, 07042
    - Cancer Center at the Mountainside Hospital
  - Morristown, New Jersey, United States, 07962
    - Carol G. Simon Cancer Center at Morristown Memorial Hospital
  - New Brunswick, New Jersey, United States, 08903
    - Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
  - Phillipsburg, New Jersey, United States, 08865
    - Warren Hospital
  - Summit, New Jersey, United States, 07902
    - Overlook Hospital
- New Mexico
  - Albuquerque, New Mexico, United States, 87106
    - University of New Mexico Cancer Research and Treatment Center
  - Albuquerque, New Mexico, United States, 87108
    - Lovelace Medical Center at Lovelace Sandia Health System
  - Albuquerque, New Mexico, United States, 87106
    - Hematology-Oncology Associates, PC
  - Albuquerque, New Mexico, United States, 87108
    - Veterans Affairs Medical Center - Albuquerque
  - Santa Fe, New Mexico, United States, 87505
    - New Mexico Cancer Care Associates
- New York
  - Bronx, New York, United States, 10466
    - Comprehensive Cancer Center at Our Lady of Mercy Medical Center
  - Buffalo, New York, United States, 14263
    - Roswell Park Cancer Institute
  - Cooperstown, New York, United States, 13326
    - Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
  - Glens Falls, New York, United States, 12801
    - Charles R. Wood Cancer Center at Glens Falls Hospital
  - New York, New York, United States, 10003
    - Beth Israel Medical Center - Petrie Division
  - New York, New York, United States, 10025
    - St. Luke's-Roosevelt Hospital Center - St.Luke's Division
  - Nyack, New York, United States, 10960
    - Union State Bank Cancer Center at Nyack Hospital
  - Rochester, New York, United States, 14621
    - Lipson Cancer and Blood Center at Rochester General Hospital
  - Stony Brook, New York, United States, 11794
    - Long Island Cancer Center at Stony Brook University Hospital
  - Syracuse, New York, United States, 13210
    - SUNY Upstate Medical University Hospital
  - Syracuse, New York, United States, 13057
    - CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
  - Syracuse, New York, United States, 13203
    - St. Joseph's Hospital Health Center - Syracuse
  - Utica, New York, United States, 13502
    - Faxton Regional Cancer Center
- North Carolina
  - Asheboro, North Carolina, United States, 27203
    - Randolph Hospital
  - Asheville, North Carolina, United States, 28801
    - Mission Hospitals - Memorial Campus
  - Chapel Hill, North Carolina, United States, 27599
    - Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
  - Charlotte, North Carolina, United States, 28233
    - Presbyterian Cancer Center at Presbyterian Hospital
  - Concord, North Carolina, United States, 28025
    - Batte Cancer Center at Northeast Medical Center
  - Durham, North Carolina, United States, 27710
    - Duke Comprehensive Cancer Center
  - Eden, North Carolina, United States, 27288
    - John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital
  - Gastonia, North Carolina, United States, 28053
    - Comprehensive Cancer Center at Gaston Memorial
  - Goldsboro, North Carolina, United States, 27534
    - Wayne Memorial Hospital, Incorporated
  - Greensboro, North Carolina, United States, 27401
    - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
  - Greenville, North Carolina, United States, 27858
    - Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital
  - Hendersonville, North Carolina, United States, 28791
    - Pardee Memorial Hospital
  - Kinston, North Carolina, United States, 28501
    - Lenoir Memorial Cancer Center
  - Reidsville, North Carolina, United States, 27320
    - Annie Penn Cancer Center
  - Rutherfordton, North Carolina, United States, 28139
    - Rutherford Hospital
  - Winston-Salem, North Carolina, United States, 27157
    - Comprehensive Cancer Center at Wake Forest University
  - Winston-Salem, North Carolina, United States, 27103
    - Forsyth Regional Cancer Center at Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, United States, 58501
    - Medcenter One Health System
  - Bismarck, North Dakota, United States, 58501
    - Mid Dakota Clinic, P.C.
  - Bismarck, North Dakota, United States, 58501
    - Bismarck Cancer Center
  - Fargo, North Dakota, United States, 58122
    - CCOP - MeritCare Hospital
  - Fargo, North Dakota, United States, 58122
    - MeritCare Medical Group
  - Fargo, North Dakota, United States, 58103
    - Dakota Cancer Institute at Innovis Health - Dakota Clinic
  - Minot, North Dakota, United States, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, United States, 44304
    - Akron City Hospital at Summa Health System
  - Boardman, Ohio, United States, 44512
    - St. Elizabeth Boardman Cancer Center
  - Bowling Green, Ohio, United States, 43402
    - Wood County Oncology Center
  - Canton, Ohio, United States, 44710
    - Aultman Hospital Cancer Center at Aultman Health Foundation
  - Canton, Ohio, United States, 44708
    - University Hospitals Ireland Cancer Center at Mercy Medical Center
  - Chillicothe, Ohio, United States, 54601
    - Adena Regional Medical Center
  - Cleveland, Ohio, United States, 44109
    - MetroHealth's Cancer Care Center at MetroHealth Medical Center
  - Columbus, Ohio, United States, 43215
    - CCOP - Columbus
  - Columbus, Ohio, United States, 43228
    - Doctors Hospital at Ohio Health
  - Columbus, Ohio, United States, 43214
    - Riverside Methodist Hospital Cancer Care
  - Columbus, Ohio, United States, 43215
    - Grant Riverside Cancer Services
  - Columbus, Ohio, United States, 43222
    - Mount Carmel West Hospital
  - Columbus, Ohio, United States, 43210
    - Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
  - Dayton, Ohio, United States, 45428
    - Veterans Affairs Medical Center - Dayton
  - Dayton, Ohio, United States, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, United States, 45405
    - Grandview Hospital
  - Dayton, Ohio, United States, 45406
    - Good Samaritan Hospital
  - Dayton, Ohio, United States, 45415
    - Samaritan North Cancer Care Center
  - Dayton, Ohio, United States, 45429
    - CCOP - Dayton
  - Delaware, Ohio, United States, 43015
    - Grady Memorial Hospital
  - Findlay, Ohio, United States, 45840
    - Blanchard Valley Medical Associates
  - Fremont, Ohio, United States, 43420
    - Fremont Memorial Hospital
  - Kenton, Ohio, United States, 43326
    - Kenton Oncology, Inc.
  - Kettering, Ohio, United States, 45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster, Ohio, United States, 43130
    - Fairfield Medical Center
  - Lima, Ohio, United States, 45804
    - Lima Memorial Hospital
  - Lima, Ohio, United States, 45801
    - St. Rita's Medical Center
  - Mansfield, Ohio, United States, 44903
    - MedCentral - Mansfield Hospital
  - Marietta, Ohio, United States, 45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Maumee, Ohio, United States, 43537
    - Northwest Ohio Oncology Center
  - Maumee, Ohio, United States, 43537
    - St. Luke's Hospital
  - Middletown, Ohio, United States, 45044
    - Middletown Regional Hospital
  - Newark, Ohio, United States, 43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Oregon, Ohio, United States, 43616
    - St. Charles Mercy Hospital
  - Oregon, Ohio, United States, 43616
    - Toledo Clinic
  - Sandusky, Ohio, United States, 44870
    - Firelands Regional Medical Center
  - Sandusky, Ohio, United States, 44870
    - North Coast Cancer Care, Incorporated
  - Springfield, Ohio, United States, 45505
    - Community Hospital of Springfield and Clark County
  - Springfield, Ohio, United States, 45504
    - Mercy Medical Center Oncology Unit
  - Sylvania, Ohio, United States, 43560
    - Promedica Cancer Center at Flower Hospital
  - Tiffin, Ohio, United States, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, United States, 43608
    - St. Vincent Mercy Medical Center
  - Toledo, Ohio, United States, 43606
    - Toledo Hospital
  - Toledo, Ohio, United States, 43623
    - CCOP - Toledo Community Hospital
  - Toledo, Ohio, United States, 43614
    - Medical College of Ohio Cancer Institute
  - Toledo, Ohio, United States, 43623
    - Toledo Surgical Specialists
  - Toledo, Ohio, United States, 43623
    - Toledo Clinic, Incorporated
  - Troy, Ohio, United States, 45373
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Warren, Ohio, United States, 44484
    - St. Joseph Health Care Center
  - Wauseon, Ohio, United States, 43567
    - Fulton County Health Center
  - Wright-Patterson Afb, Ohio, United States, 45433-5529
    - United States Air Force Medical Center Wright-Patterson
  - Xenia, Ohio, United States, 45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Youngstown, Ohio, United States, 44510
    - St. Elizabeth Cancer Center at St. Elizabeth Health Center - Youngstown
- Oklahoma
  - Lawton, Oklahoma, United States, 73505
    - Comanche County Memorial Hospital
  - Oklahoma City, Oklahoma, United States, 73104
    - Oklahoma University Medical center
  - Oklahoma City, Oklahoma, United States, 73120
    - Mercy Health Center
  - Tulsa, Oklahoma, United States, 74136
    - Natalie Warren Bryant Cancer Center at St. Francis Hospital
- Oregon
  - Portland, Oregon, United States, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, United States, 97232
    - Kaiser Permanente Health Care - Portland
- Pennsylvania
  - Abington, Pennsylvania, United States, 19001
    - Abington Memorial Hospital
  - Allentown, Pennsylvania, United States, 18105
    - John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
  - Bethlehem, Pennsylvania, United States, 18015
    - St. Luke's Hospital Cancer Center
  - Danville, Pennsylvania, United States, 17822-2001
    - Geisinger Medical Center
  - Dubois, Pennsylvania, United States, 15801
    - Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer Center
  - Harrisburg, Pennsylvania, United States, 17105
    - PinnacleHealth Regional Cancer Center at Polyclinic Hospital
  - Hershey, Pennsylvania, United States, 17033-0850
    - Penn State Cancer Institute at Milton S. Hershey Medical Center
  - Lancaster, Pennsylvania, United States, 17604
    - Lancaster General Hospital
  - Lemoyne, Pennsylvania, United States, 17043
    - Central Pennsylvania Hematology and Medical Oncology Associates, PC
  - Lewistown, Pennsylvania, United States, 17044
    - Lewistown Hospital
  - Philadelphia, Pennsylvania, United States, 19141
    - Albert Einstein Cancer Center
  - Philadelphia, Pennsylvania, United States, 19107
    - Joan Karnell Cancer Center at Pennsylvania Hospital
  - Pittsburgh, Pennsylvania, United States, 15212
    - Allegheny Cancer Center at Allegheny General Hospital
  - Pittsburgh, Pennsylvania, United States, 15224-1791
    - Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
  - Pottstown, Pennsylvania, United States, 19464
    - Pottstown Memorial Regional Cancer Center
  - Sayre, Pennsylvania, United States, 18840
    - Guthrie Medical Center - Sayre
  - Scranton, Pennsylvania, United States, 18501
    - Mercy Hospital Cancer Center - Scranton
  - Scranton, Pennsylvania, United States, 18510
    - Hematology and Oncology Associates
  - State College, Pennsylvania, United States, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, United States, 16803
    - Mount Nittany Medical Center
  - Wilkes-Barre, Pennsylvania, United States, 18711
    - Geisinger Wyoming Valley Medical Center
- Rhode Island
  - Providence, Rhode Island, United States, 02903
    - Rhode Island Hospital
  - Providence, Rhode Island, United States, 02906
    - Miriam Hospital at Lifespan
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - Rose Ramer Cancer Clinic at Anderson Area Medical Center
  - Columbia, South Carolina, United States, 29210
    - South Carolina Oncology Associates
  - Greenville, South Carolina, United States, 29615
    - CCOP - Greenville
  - Greenville, South Carolina, United States, 29601
    - Bon Secours St. Francis Health System
  - Greenville, South Carolina, United States, 29605
    - Greenville Hospital System Cancer Center
  - Spartanburg, South Carolina, United States, 29303
    - Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
  - Spartanburg, South Carolina, United States, 29304
    - CCOP - Upstate Carolina
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, United States, 57105
    - Medical X-Ray Center
  - Sioux Falls, South Dakota, United States, 57104
    - Sioux Valley Hospital and University of South Dakota Medical Center
  - Sioux Falls, South Dakota, United States, 57105
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Germantown, Tennessee, United States, 38138
    - Jones Clinic
  - Knoxville, Tennessee, United States, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, United States, 37920
    - Baptist Hospital of East Tennessee
- Texas
  - Arlington, Texas, United States, 76012
    - Arlington Cancer Center - Arlington
  - Dallas, Texas, United States, 75230
    - Medical City Dallas Hospital
  - Dallas, Texas, United States, 75390
    - Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
  - Temple, Texas, United States, 76508
    - CCOP - Scott and White Hospital
- Vermont
  - Berlin, Vermont, United States, 05602
    - Mountainview Medical
  - Burlington, Vermont, United States, 05401
    - Fletcher Allen Health Care - University Health Center Campus
- Virginia
  - Charlottesville, Virginia, United States, 22908
    - Cancer Center at the University of Virginia
  - Danville, Virginia, United States, 24541
    - Danville Regional Medical Center
  - Hampton, Virginia, United States, 23666
    - Virginia Oncology Associates - Hampton
  - Kilmarnock, Virginia, United States, 22482
    - Rappahannock General Hospital
  - Lynchburg, Virginia, United States, 24501
    - Lynchburg Hematology-Oncology Clinic
  - Richmond, Virginia, United States, 23298
    - Massey Cancer Center at Virginia Commonwealth University
- Washington
  - Spokane, Washington, United States, 99204
    - Providence Cancer Center at Sacred Heart Medical Center
  - Spokane, Washington, United States, 99207
    - Providence Cancer Center at Holy Family Hospital
  - Yakima, Washington, United States, 98902
    - North Star Lodge Cancer Center
  - Yakima, Washington, United States, 98902
    - Washington Hematology - Oncology Specialists
- West Virginia
  - Charleston, West Virginia, United States, 25304
    - West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
  - Huntington, West Virginia, United States, 25702
    - St. Mary's Medical Center
  - Huntington, West Virginia, United States, 25701
    - Marshall University Medical Center
  - Morgantown, West Virginia, United States, 26506
    - Mary Babb Randolph Cancer Center at West Virginia University Hospitals
- Wisconsin
  - Appleton, Wisconsin, United States, 54911-3496
    - Fox Valley Hematology and Oncology
  - Elkhorn, Wisconsin, United States, 53121
    - Vince Lombardi Cancer Center - Elkhorn
  - Glendale, Wisconsin, United States, 53212
    - Oncology Alliance, S.C. - Milwaukee - East
  - Green Bay, Wisconsin, United States, 54311-6519
    - Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
  - La Crosse, Wisconsin, United States, 54601
    - Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
  - Madison, Wisconsin, United States, 53792
    - University of Wisconsin Comprehensive Cancer Center
  - Madison, Wisconsin, United States, 53715
    - UW Health Oncology
  - Manitowoc, Wisconsin, United States, 54221
    - Holy Family Memorial Medical Center
  - Marshfield, Wisconsin, United States, 54449
    - Marshfield Clinic - Marshfield Center
  - Milwaukee, Wisconsin, United States, 53226
    - Medical College of Wisconsin Cancer Center
  - Milwaukee, Wisconsin, United States, 53215
    - Medical Consultants
  - Milwaukee, Wisconsin, United States, 53226-3596
    - Froedtert Hospital and Medical College of Wisconcin
  - Oconomowoc, Wisconsin, United States, 53066-3896
    - Oconomowoc Memorial Hospital
  - Racine, Wisconsin, United States, 53405
    - All Saints Cancer Center at All Saints Healthcare
  - Sheboygan, Wisconsin, United States, 53081
    - Vince Lombardi Cancer Clinic - Sheboygan
  - Waukesha, Wisconsin, United States, 53188
    - Waukesha Memorial Hospital Regional Cancer Center
  - Wausau, Wisconsin, United States, 54401
    - University of Wisconsin Cancer Center at Aspirus Wausau Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 120 years (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Description

DISEASE CHARACTERISTICS:

Histologically or cytologically confirmed renal cell carcinoma (RCC)
- Conventional clear cell carcinoma
- Metastatic or unresectable disease
The following characteristics and cellular types are excluded:
- True papillary
- Sarcomatoid features without a clear cell component
- Chromophobe
- Oncocytoma
- Collecting duct tumor
- Transitional cell carcinoma
Measurable or nonmeasurable disease, including any of the following:
- Unidimensionally measurable lesion ≥ 20 mm by conventional techniques (e.g., physical exam or chest x-ray) OR 10 mm by spiral CT scan or MRI
- The following are considered nonmeasurable disease:
  - Small lesions
  - Bone lesions
  - Leptomeningeal disease
  - Ascites
  - Pleural/pericardial effusion
  - Lymphangitis cutis/pulmonis
  - Abdominal masses that are not confirmed and followed by imaging techniques
  - Cystic lesions
  - Irradiated lesions, unless progression is documented after radiotherapy
RCC paraffin tissue blocks or unstained slides must be available
No evidence of prior or concurrent CNS metastases by MRI or CT scan

PATIENT CHARACTERISTICS:

Age

18 and over

Performance status

Karnofsky 70-100%

Life expectancy

Not specified

Hematopoietic

Granulocyte count ≥ 1,500/mm^3
Platelet count ≥ 100,000/mm^3
No history of clinically significant bleeding

Hepatic

AST/ALT ≤ 2.5 times upper limit of normal (ULN)
Alkaline phosphatase ≤ 2.5 times ULN
Bilirubin ≤ 1.5 times ULN

Renal

Creatinine ≤ 1.5 times ULN
No proteinuria > 1+
- Proteinuria ≥ 2+ allowed provided protein is < 2 g/24-hour urine collection

Cardiovascular

No deep venous thrombosis within the past year
No cerebrovascular accident within the past year
No peripheral vascular disease with claudication on < 1 block
No uncontrolled hypertension defined as blood pressure ≥160 mm Hg (systolic) and/or ≥ 90 mm Hg (diastolic) while on medication
No New York Heart Association class II-IV congestive heart failure
No angina pectoris requiring nitrate therapy
No myocardial infarction within the past 6 months
No other significant cardiovascular disease

Pulmonary

No pulmonary embolus within the past year
No ongoing hemoptysis

Other

Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception during and for 3 months after study treatment
No preexisting thyroid abnormality in which normal thyroid function cannot be maintained by medication
No delayed wound healing, ulcers, or bone fractures
No uncontrolled psychiatric disorder
No other currently active* malignancy except nonmelanoma skin cancer NOTE: *Disease is not considered currently active if patient completed anticancer therapy and is considered to have < 30% risk of relapse

PRIOR CONCURRENT THERAPY:

Biologic therapy

No prior systemic immunotherapy for RCC
No prior thalidomide, anti-vascular endothelial growth factor (VEGF) therapy, VEGF receptor inhibitors, or antiangiogenic treatment of any kind
No concurrent prophylactic filgrastim (G-CSF) or sargramostim (GM-CSF)

Chemotherapy

No prior systemic chemotherapy for RCC
No concurrent chemotherapy

Endocrine therapy

No concurrent systemic corticosteroid therapy except the following:
- Topical and inhaled steroids
- Replacement therapy for adrenal insufficiency
No concurrent hormones except those administered for nondisease-related conditions (e.g., insulin for diabetes)

Radiotherapy

See Disease Characteristics
At least 4 weeks since prior radiotherapy and recovered
Prior palliative radiotherapy to metastatic lesions allowed provided at least 1 measurable or nonmeasurable lesion remains untreated
No concurrent palliative radiotherapy

Surgery

At least 4 weeks since prior major surgery and recovered

Other

No other prior systemic investigational therapy for RCC
No other prior adjuvant or neoadjuvant systemic therapy for RCC
No concurrent full-dose oral or parenteral anticoagulation* NOTE: *Low-dose (1 mg) warfarin for maintenance of catheter patency and/or daily prophylactic aspirin is allowed

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Interferon Treatment with interferon alfa 2b	Biological: recombinant interferon alfa 9 million units subQ injection 3 x/week for 4 weeks
Experimental: Interferon + bevacizumab Addition of bevacizumab to interferon alfa 2b treatment	Biological: recombinant interferon alfa 9 million units subQ injection 3 x/week for 4 weeks Biological: bevacizumab 10mg/kg IV infusion on Days 1 & 15 of each cycle

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Overall Survival Time Frame: 5 years	5 years

Secondary Outcome Measures

Outcome Measure	Time Frame
Time to progression Time Frame: q 3 cycles	q 3 cycles
Toxicity Time Frame: q cycle	q cycle

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Alliance for Clinical Trials in Oncology

Collaborators

National Cancer Institute (NCI)

NCIC Clinical Trials Group

Investigators

Study Chair: Brian I. Rini, MD, University of California, San Francisco

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Archer L, Atkins JN, Picus J, Czaykowski P, Dutcher J, Small EJ. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol. 2010 May 1;28(13):2137-43. doi: 10.1200/JCO.2009.26.5561. Epub 2010 Apr 5.
Rini BI, Halabi S, Rosenberg J, et al.: Bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in patients with metastatic renal cell carcinoma: results of overall survival for CALGB 90206. [Abstract] J Clin Oncol 27 (Suppl 15): A-LBA5019, 2009.
Rini BI, Halabi S, Rosenberg JE, et al.: CALGB 90206: a phase III trial of bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in metastatic renal cell carcinoma. [Abstract] American Society of Clinical Oncology 2008 Genitourinary Cancers Symposium, Feb 14-16, 2008, San Francisco, CA. A-350, 2008.
Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Ou SS, Archer L, Atkins JN, Picus J, Czaykowski P, Dutcher J, Small EJ. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol. 2008 Nov 20;26(33):5422-8. doi: 10.1200/JCO.2008.16.9847. Epub 2008 Oct 20.
Rini BI, Halabi S, Taylor J, Small EJ, Schilsky RL; Cancer and Leukemia Group B. Cancer and Leukemia Group B 90206: A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma. Clin Cancer Res. 2004 Apr 15;10(8):2584-6. doi: 10.1158/1078-0432.ccr-03-0605.
Nixon AB, Halabi S, Liu Y, Starr MD, Brady JC, Shterev I, Luo B, Hurwitz HI, Febbo PG, Rini BI, Beltran H, Small EJ, Morris MJ, George DJ. Predictive Biomarkers of Overall Survival in Patients with Metastatic Renal Cell Carcinoma Treated with IFNalpha +/- Bevacizumab: Results from CALGB 90206 (Alliance). Clin Cancer Res. 2022 Jul 1;28(13):2771-2778. doi: 10.1158/1078-0432.CCR-21-2386.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2003

Primary Completion (Actual)

January 1, 2004

Study Completion (Actual)

November 1, 2012

Study Registration Dates

First Submitted

November 4, 2003

First Submitted That Met QC Criteria

November 5, 2003

First Posted (Estimate)

November 6, 2003

Study Record Updates

Last Update Posted (Estimate)

July 6, 2016

Last Update Submitted That Met QC Criteria

July 1, 2016

Last Verified

July 1, 2016

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

CALGB-90206
U10CA031946 (U.S. NIH Grant/Contract)
CAN-NCIC-REC1
CDR0000335292 (Registry Identifier: NCI Physician Data Query)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Advanced Kidney Cancer

China
Cedars-Sinai Medical Center

Recruiting

Patient-Centered Communication of Life Expectancy Estimates in Genitourinary Malignancies

Prostate Cancer Stage II | Prostate Cancer Stage I | Bladder Cancer Stage II | Kidney Cancer Stage I

United States
Dana-Farber Cancer Institute

Completed

Personal Web Page In Clinical Trial Participant Education

Kidney Cancer | Prostate Cancer | Genitourinary Cancer

United States
Intuitive Surgical

Completed

Prospective Investigation of Robotic Single-port System

Prostate and Kidney Cancer

France
Yale University

Completed

Active Surveillance of the Small Renal Mass

Small Renal Mass, Kidney Cancer

United States
University of Texas Southwestern Medical Center

Completed

SBRT (Stereotactic Body Radiation Therapy) in Combination With Nivolumab/Ipilimumab in Renal Cell Carcinoma (RCC) / Kidney Cancer Patients (RADVAX)

Kidney Cancer | Kidney Cancer Metastatic | Kidney Cancer, Stage IV

United States
Stanford University
National Cancer Institute (NCI)

Withdrawn

Imaging During Surgery in Diagnosing Patients With Prostate, Bladder, or Kidney Cancer

Prostate Cancer | Bladder Cancer | Kidney Tumor

Clinical Trials on recombinant interferon alfa

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas

Brain and Central Nervous System Tumors

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Short-Term Low-Dose Interferon Alfa in Treating Patients With Cancer of the Urothelium

Bladder Cancer | Urethral Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Capecitabine and Pegylated Interferon Alfa-2a in Treating Patients With Recurrent or Progressive Brain Metastases Due to Breast Cancer

Breast Cancer | Metastatic Cancer

United States
Institute of Hematology & Blood Diseases Hospital...

Recruiting

Pegylated Interferon Alfa-2b Versus Interferon Alfa Therapy in Adult Essential Thrombocythemia

Essential Thrombocytopenia

China
Institute of Hematology & Blood Diseases Hospital...

Recruiting

Pegylated Interferon Alfa-2b Versus Interferon Alfa Therapy in Childhood and Adolescent Essential Thrombocythemia

Essential Thrombocytopenia

China
Hoffmann-La Roche

Completed

A Study of Continued Treatment Among Participants Who Have Responded to Peginterferon Alfa-2a (Pegasys®) or Recombinant Interferon Alfa-2a (Roferon-A®) in Prior Clinical Studies

Renal Cell Carcinoma | Chronic Myelogenous Leukemia | Malignant Melanoma

Canada, India, Bulgaria, Russian Federation, Spain, South Africa, Slovakia
Institute of Cancer Research, United Kingdom

Completed

Interferon Alfa or No Further Therapy Following Surgery in Treating Patients With Stage II, Stage III, or Recurrent Melanoma

Melanoma (Skin)

United Kingdom
Hackensack Meridian Health
National Cancer Institute (NCI)

Withdrawn

High-Dose Interferon Alfa in Treating Patients With Stage II or StageIII Melanoma

Melanoma (Skin)

United States
National Cancer Institute (NCI)

Completed

Vaccine Therapy, GM-CSF, and Interferon Alfa-2b in Treating Patients With Locally Advanced or Metastatic Cancer That Expresses Carcinoembryonic Antigen (CEA)

Adult Solid Neoplasm

United States
The Cleveland Clinic
National Cancer Institute (NCI)

Completed

Interferon Alfa in Treating Patients With Stage IV Solid Tumors, Lymphoma, or Myeloma (IFNa)

Melanoma | Sarcoma | Lymphoma | Kidney Cancer | Breast Cancer | Multiple Myeloma | Unspecified Adult Solid Tumor, Protocol Specific

United States

Interferon Alfa-2b With or Without Bevacizumab in Treating Patients With Advanced Renal Cell Carcinoma (Kidney Cancer)

A Randomized Phase III Trial Of Interferon Alfa-2B Or Interferon Alfa-2B Plus Bevacizumab In Patients With Advanced Renal Carcinoma

Study Overview

Status

Conditions

Intervention / Treatment

Detailed Description

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Genders Eligible for Study

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Time Frame

Secondary Outcome Measures

Outcome Measure

Time Frame

Collaborators and Investigators

Sponsor

Collaborators

Investigators

Publications and helpful links

General Publications

Study record dates

Study Major Dates

Study Start

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Estimate)

Study Record Updates

Last Update Posted (Estimate)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Clinical Trials on Kidney Cancer

Clinical Trials on recombinant interferon alfa

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Medical Conditions

Drug Interventions

CROs by country

CROs in Trinidad & Tobago

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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